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Isolation of cabbage exosome-like nanovesicles and investigation of their biological activities in human cells

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Bioactive Materials 2021年第12期6卷 4321-4332页

作者： Jae Young You su jin kang Won Jong Rhee Department of Bioengineering and Nano-Bioengineering Incheon National University Incheon22012Republic of Korea Division of Bioengineering Incheon National University Incheon 22012Republic of Korea

There are extensive studies on the applications of extracellular vesicles(EVs)produced in cell culture for therapeutic drug ***,large quantities of EVs are needed for in vivo applications,which requires high production costs and ***,the development of new EV sources is essential to facilitate their ***,plant-derived exosome-like nanovesicles are an emerging alternative for culture-derived *** now,however,few studies have explored their biological functions and ***,it is necessary to elucidate biological activities of plant-derived exosome-like nanovesicles and harness vesicles for biomedical ***,cabbage and red cabbage were used as nanovesicle sources owing to their easy ***,an efficient method for nanovesicle isolation from cabbage(Cabex)and red cabbage(Rabex)was ***,isolated nanovesicles were characterized,and their biological functions were *** Cabex and Rabex promoted mammalian cell proliferation and,interestingly,suppressed inflammation in immune cells and apoptosis in human keratinocytes and ***,therapeutic drugs were encapsulated in Cabex or Rabex and successfully delivered to human cells,demonstrating the potential of these vesicles as alternative drug delivery ***,the current results provide strong evidence for the wide application of Cabex and Rabex as novel therapeutic biomaterials.

关键词： Exosome-like nanovesicles Cabbage Inflammation Apoptosis Drug delivery

Brain endothelial cell-derived extracellular vesicles with a mitochondria-targeting photosensitizer effectively treat glioblastoma by hijacking the blood-brain barrier

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Acta Pharmaceutica Sinica B 2023年第9期13卷 3834-3848页

作者： Thuy Giang Nguyen Cao Ji Hee kang su jin kang Quan Truong Hoang Han Chang kang Won Jong Rhee Yu Shrike Zhang Young Tag Ko Min suk Shim Division of Bioengineering Incheon National UniversityIncheon 22012Republic of Korea College of Pharmacy Gachon UniversityIncheon 21936Republic of Korea Department of Pharmacy Integrated Research Institute of Pharmaceutical Sciencesand BK21 PLUS Team for Creative Leader Program for Pharmacomics-based Future PharmacyCollege of Pharmacythe Catholic University of KoreaGyeonggi-do 14662Republic of Korea Research Center for Bio Materials&Process Development Incheon National UniversityIncheon 22012Republic of Korea Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMA 02139USA

Glioblastoma(GBM)is the most aggressive malignant brain tumor and has a high mortality *** therapy(PDT)has emerged as a promising approach for the treatment of malignant brain ***,the use of PDT for the treatment of GBM has been limited by its low blood-brain barrier(BBB)permeability and lack of cancer-targeting ***,brain endothelial cell-derived extracellular vesicles(bEVs)were used as a biocompatible nanoplatform to transport photosensitizers into brain tumors across the *** enhance PDT efficacy,the photosensitizer chlorin e6(Ce6)was linked to mitochondria-targeting triphenylphosphonium(TPP)and entrapped into *** Ce6(TPP-Ce6)selectively accumulated in the mitochondria,which rendered brain tumor cells more susceptible to reactive oxygen species-induced apoptosis under light ***,the encapsulation of TPP-Ce6 into b EVs markedly improved the aqueous stability and cellular internalization of TPP-Ce6,leading to significantly enhanced PDT efficacy in U87MG GBM *** in vivo biodistribution study using orthotopic GBM-xenografted mice showed that b EVs containing TPP-Ce6[b EV(TPP-Ce6)]substantially accumulated in brain tumors after BBB penetration via transferrin receptor-mediated *** such,b EV(TPP-Ce6)-mediated PDT considerably inhibited the growth of GBM without causing adverse systemic toxicity,suggesting that mitochondria are an effective target for photodynamic GBM therapy.

关键词： Extracellular vesicle Chlorin e6 Triphenylphosphonium Mitochondria-targeting photosensitizer Photodynamic therapy Blood-brain barrier Glioblastoma Transferrin receptor

Tidal Current Energy Resource Assessment Technique and Procedure Applied in Western Coastal Region, South Korea

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Journal of Energy and Power Engineering 2015年第4期9卷 358-366页

作者： Chul Hee Jo su jin Hwang kang Hee Lee Department of Naval Architecture and Ocean Engineering Inha University Incheon 402-751 South Korea

After the nuclear power plant accident in Japan, Korean government has set the national goal to produce the electricity by renewable energy sources up to 11% by 2035 which is not easy to achieve without ocean energy development. The demand on the clean energy supply has been increased recently and there are many renewable energy development projects and plans announced worldwide. The ocean energy can be produced from tidal current, wave, tidal barrage and ocean thermal sources. The first step is to estimate the resource assessment for each energy source. There are several assessment methods introduced from IEA （International Energy Agency）, IRENA （International Renewable Energy Agency）, NREL （National Renewable Energy Laboratory）, EU ERENE （European Community for Renewable Energy）, Bonn University, DLR （German Aerospace Center）, etc.. Even these known methods have some sort of similarity; there are different definitions and classifications among them. In this paper, the four-step energy potentials are defined and introduced as theoretical, geographical, technical and market potentials. The theories for each step are presented for ocean energies together with clear definitions. As the tidal current energy research and development are active in Korea having very strong tidal current speed along the west and south coastal regions, the detail procedure for each step of energy potential assessment is introduced for tidal current energy. The paper will illustrate the case study of tidal current power assessment in western coastal region, South Korea with highlighting the key aspects in determining the resource potentials.

关键词： TCP (tidal current power) resource assessment API (averaged power intercepted) tidal current farm planning.

APPLICATION OF VIDEO ANAGLYPH MAKER FOR 3-D FLOW SIMULATION

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Journal of Hydrodynamics 2010年第2期22卷 289-294页

作者： kang su-hai jin Sheng State Key Laboratory of Coastal and Offshore Engineering Dalian University of Technology Dalian 116024China Key Laboratory of Engineering Sediment of Ministry of Communications Tianjin Research Institute for WaterTransport Engineering Tianjin 300456 China

In this article,the anaglyph video maker is employed for generating realistic 3-D flows and the software FlowAnimator is developed using that *** on Microsoft Windows Presentation Foundation（WPF）,the real 3-D scene is set up and marker particles are distributed in it randomly in order to create a more natural flow *** trajectory of the particle motion is calculated with Lagrangian description in 3-D *** the simulation,the viewport can be changed in order to focus on different parts of the model by panning,zooming,rotating and inclination variation *** particles may appear in different shapes：spheres,tracking-balls,cylinders and ribbons in order to fit different *** is the first time that the video anaglyph technology is employed in the 3-D hydrodynamic simulation,which removes the obstacles for 3-D scenes to be rendered on a flat-panel display.

关键词： 3-D simulation flow simulation anaglyph stereoscopy Windows Presentation Foundation(WPF)

Boosting aqueous nickel-zinc battery stability with bimetallic ion-integrated 1D metal-organic nanowires

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Science China Chemistry 2025年

作者： Yihao Chen jin Liang Yichun su Guoyin Zhu Hengyue Xu Hongye Ding Guangxun Zhang Dianheng Yu Zizhou Shen Yizhou Zhang Wei Huang Huan Pang School of Chemistry and Chemical Engineering Yangzhou University Key Laboratory of Flexible Electronics (KLoFE) & Institute of Advanced Materials (IAM) School of Flexible Electronics (Future Technologies) Nanjing Tech University (NanjingTech) Institute of Advanced Materials and Flexible Electronics (IAMFE) School of Chemistry and Materials Science Nanjing University of Information Science & Technology Department of Chemistry Tsinghua University State Key Laboratory of Coordination Chemistry Nanjing University

Limited by low conductivity,designing cathode materials with excellent electron transfer efficiency for high-performance nickel-zinc batteries （NZBs） remains *** this study,a series of bimetallic metal-organic nanowires were fabricated by doping M ions in NiNTA,resulting in NiMNTA (M=Mg2+,Mn2+,Co2+,Zn2+,Ag+),and NixCo6-xNTA （x=1,2,3,4,5）.The proportions and types of metal ions can be modified without altering the initial coordination structure.X-ray absorption fine structure spectroscopy （XAFS） revealed that only M–O bonds,not metal bonds,were present in the *** performance of Ni2Co4NTA as the cathode for aqueous NZBs was significantly improved,achieving the maximum energy density of 279.17Wh kg-1with the high cycle stability （retention rate of 72.0%after 1,000 cycles）.The flexible Ni2Co4NTA//Zn@carbon cloth battery employing gel electrolyte also exhibits the excellent Coulombic efficiency of 96%after 350 *** approach shows considerable potential for designing one-dimensional materials with bimetallic modifications,providing new strategies for developing cathode materials for NZBs with high specific capacity and cycle stability.

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早产儿视网膜病变注射雷珠单抗后荧光素眼底血管造影表现

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眼科新进展 2015年第12期35卷 1145-1148页

作者：佘洁婷张国明苏康进田汝银陈懿赵东升暨南大学附属深圳眼科医院、深圳市眼科医院、深圳眼科学重点实验室广东省深圳市518000

目的了解早产儿视网膜病变（retinopathy of prematurity,ROP）注射雷珠单抗后的荧光素眼底血管造影（fundus fluorescein angiography,FFA）表现。方法选取2014年3月至11月在深圳市眼科医院确诊为ROP的15例（30眼）患者纳入研究,其中... 详细信息

目的了解早产儿视网膜病变（retinopathy of prematurity,ROP）注射雷珠单抗后的荧光素眼底血管造影（fundus fluorescein angiography,FFA）表现。方法选取2014年3月至11月在深圳市眼科医院确诊为ROP的15例（30眼）患者纳入研究,其中急进性后部型ROP（aggressive posterior retinopathy of prematurity,AP-ROP）8眼,阈值期ROP 13眼,阈值前期Ⅰ型ROP 9眼。在表面麻醉下,经颞下方睫状体平坦部进针,向玻璃体内注射雷珠单抗0.03 m L。在注药术后1~2个月,气管插管全身麻醉下行FFA检查,观察附加病变消退情况及视网膜周边血管发育情况。结果注射雷珠单抗后,所有眼底附加病变消退,但周边视网膜均存在不同程度的无血管区。8眼AP-ROP中6眼Ⅲ区无血管形成,继续随访观察;2眼Ⅱ区大范围无血管形成,血管末梢分支增多呈毛刷样,无荧光素渗漏,1周后再次注射雷珠单抗。13眼阈值期ROP中,1眼可见颞下方牵拉性视网膜脱离,行局部激光光凝;12眼嵴完全消退,其中2眼视网膜血管基本发育完全;4眼Ⅲ区无血管形成,4眼Ⅲ区及Ⅱ区鼻侧2个钟点无血管形成,均无荧光素渗漏,继续随访观察;2眼Ⅱ区累计4个钟点无血管区伴末梢血管扩张及新生血管荧光素渗漏,行激光光凝。9眼阈值前期Ⅰ型ROP中7眼嵴全部消退,2眼嵴变低平;4眼Ⅲ区及Ⅱ区鼻侧2个钟点范围无血管形成,5眼Ⅲ区无血管形成,均见末梢血管扩张,但无荧光素渗漏,继续随访观察。结论注射雷珠单抗可促使ROP病变消退,且不干扰周边视网膜血管化。

关键词：早产儿视网膜病变雷珠单抗荧光素眼底血管造影

计算机视觉技术赋能大学英语课堂展示中的学习投入研究

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新疆师范大学学报（哲学社会科学版） 2025年第2期46卷 144-151页

作者：谭苏燕王晋军广州大学外国语学院广东广州510010

学习投入是预测学习者学习效果的重要指标,学术界对其与课堂展示间的相关性研究鲜有涉猎。文本以某综合性大学303名非英语专业本科生为研究对象,采用人工智能与计算机视觉技术模型YOLOv7对大学英语课堂中的课堂展示实录进行学习投入多... 详细信息

学习投入是预测学习者学习效果的重要指标,学术界对其与课堂展示间的相关性研究鲜有涉猎。文本以某综合性大学303名非英语专业本科生为研究对象,采用人工智能与计算机视觉技术模型YOLOv7对大学英语课堂中的课堂展示实录进行学习投入多模态数据分析,并辅以问卷调查,形成双向印证。研究发现,学生课堂展示中的行为投入、认知投入和情感投入值均等于或高于3.78,投入结果均值达4.01,说明学生在课堂展示中的学习投入情况良好。此外,不同时段课堂展示对学生行为投入的影响显著,学生专注度及参与度在课堂前10分钟的课堂展示中效果最佳。文本为课堂展示的有效性提供了智能化、多模态、多维度的实证支持,为课堂教学的数智技术应用提供了新视角。

关键词：大学英语课堂展示学习投入计算机视觉技术展示时段

Laser transformation hardening on rod-shaped carbon steel by Gaussian beam

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中国有色金属学会会刊：英文版 2009年第4期19卷 941-945页

作者： Jong-Do KIM Myeong-Hoon LEE su-jin LEE Woon-Ju kang Division of Marine System Engineering College of Maritime SciencesKorea Maritime University Graduate School Korea Maritime University

Laser transformation hardening(LTH) is one of the laser surface modification *** surface hardening of rod-shaped carbon steel(SM45C) was performed by lathe-based laser composite processor with Gaussian-beam optical *** LTH characteristics by dominant processes,longitudinal and depth directional hardness distributions and behaviors of phase transformation in hardened zones were ***,two concepts of circumferential speed and theoretical overlap rate were *** laser power increased or circumferential speed decreased,the surface hardening depth gradually increases due to the increased heat ***,the longitudinal hardness distribution particularly shows periodicity of repetitive increase and decrease,which results from tempering effect by ***,the feasibility of laser transformation hardening is verified by using the beam with Gaussian intensity distribution.

关键词：激光相变硬化高斯光束碳素钢表面强化硬度分布圆周速度改性过程相变行为

WRA-Net:Wide Receptive Field Attention Network for Motion Deblurring in Crop and Weed Image

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Plant Phenomics 2023年第2期5卷 174-194页

作者： Chaeyeong Yun Yu Hwan Kim sung Jae Lee su jin Im kang Ryoung Park Division of Electronics and Electrical Engineering Dongguk University30 Pildong-ro 1-gilJung-guSeoul 04620Republic of Korea

Automatically segmenting crops and weeds in the image input from cameras accurately is essential in various agricultural technology fields,such as herbicide spraying by farming robots based on crop and weed segmentation ***,crop and weed images taken with a camera have motion blur due to various causes(e.g.,vibration or shaking of a camera on farming robots,shaking of crops and weeds),which reduces the accuracy of crop and weed ***,robust crop and weed segmentation for motion-blurred images is ***,previous crop and weed segmentation studies were performed without considering motion-blurred *** solve this problem,this study proposed a new motion-blur image restoration method based on a wide receptive field attention network(WRA-Net),based on which we investigated improving crop and weed segmentation accuracy in motion-blurred ***-Net comprises a main block called a lite wide receptive field attention residual block,which comprises modified depthwise separable convolutional blocks,an attention gate,and a learnable skip *** conducted experiments using the proposed method with 3 open databases:BoniRob,crop/weed field image,and rice seedling and weed *** to the results,the crop and weed segmentation accuracy based on mean intersection over union was 0.7444,0.7741,and 0.7149,respectively,demonstrating that this method outperformed the state-of-the-art methods.

关键词： Net shaking image