检索结果-南通市图书馆

SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2021年第3期18卷 613-620页

作者： Yu-Zhi Fu su-yun wang Zhou-Qin Zheng Yi Huang Wei-Wei Li Zhi-Sheng Xu Yan-Yi wang Key Laboratory of Special Pathogens and Biosafety Center for Biosafety Mega-ScienceWuhan Institute of VirologyChinese Academy of Sciences430071 WuhanChina University of Chinese Academy of Sciences 100049 BdjingChina

A novel SARS-related coronavirus(SARS-CoV-2)has recently emerged as a serious pathogen that causes high morbidity and substantial ***,the mechanisms by which SARS-CoV-2 evades host immunity remain poorly ***,we identified SARS-CoV-2 membrane glycoprotein M as a negative regulator of the innate immune *** found that the M protein interacted with the central adaptor protein MAVS in the innate immune response *** interaction impaired MAVS aggregation and its recruitment of downstream TRAF3,TBK1,and IRF3,leading to attenuation of the innate antiviral *** findings reveal a mechanism by which SARS-CoV-2 evades the innate immune response and suggest that the M protein of SARSCoV-2 is a potential target for the development of SARS-CoV-2 interventions.

关键词： SARS-CoV-2 Membrane glycoprotein M MAVS TypeⅠinterferon Innate immunity

Recent Advances in Moirésuperlattice Structures of Twisted Bilayer and Multilayer Graphene

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics Letters 2022年第3期39卷 54-81页

作者： Xiao-Feng Li Ruo-Xuan sun su-yun wang Xiao Li Zhi-Bo Liu Jian-Guo Tian The Key Laboratory of Weak Light Nonlinear Photonics(Ministry of Education) School of Physics and Teda Applied Physics InstituteNankai UniversityTianjin 300071China Department of Physics City University of Hong KongKowloonHong KongChina Renewable Energy Conversion and Storage Center Nankai UniversityTianjin 300071China The Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China

Twisted bilayer graphene(TBG),which has drawn much attention in recent years,arises from van der Waals materials gathering each component together via van der Waals *** is composed of two sheets of graphene rotated relatively to each ***épotential,resulting from misorientation between layers,plays an essential role in determining the band structure of TBG,which directly relies on the twist *** the twist angle approaches a certain critical value,flat bands will show up,indicating the suppression of kinetic energy,which significantly enhances the importance of Coulomb interaction between *** a result,correlated states like correlated insulators emerge from ***,superconductivity in TBG is also reported in many experiments,which drags researchers into thinking about the underlying ***,the interest in the atomic reconstruction of TBG at small twist angles comes up and reinforces further understandings of properties of *** addition,twisted multilayer graphene receives more and more attention,as they could likely outperform TBG although they are more difficult to handle *** this review,we mainly introduce theoretical and experimental progress on *** the basic knowledge of TBG,we emphasize the essential role of atomic reconstruction in both experimental and theoretical *** consideration of atomic reconstruction in small-twist situations can provide us with another aspect to have an insight into physical mechanism in *** addition,we cover the recent hot topic,twisted multilayer *** the bilayer situation can be relatively easy to resolve,multilayer situations can be really complicated,which could foster more unique and novel ***,in the end of the review,we look forward to future development of twisted multilayer graphene.

关键词： twist twisted multilayer

在线全文

学校读者我要写书评

暂无评论

变截面管内激波串的预测理论及其验证

航空动力学报 2018年第1期33卷 131-136页

作者：陈云苏纬仪王赫王磊张堃元南京航空航天大学能源与动力学院江苏省航空动力系统重点实验室南京210016

现有等直管内激波串的预测理论并未考虑截面积变化以及壁面传热等条件,因此发展了考虑壁面温度、附面层分离和截面积变化的激波串理论分析模型,并与实验结果进行了对比。研究表明,该模型可快速计算隔离段参数的沿程变化,激波串前缘位置... 详细信息

现有等直管内激波串的预测理论并未考虑截面积变化以及壁面传热等条件,因此发展了考虑壁面温度、附面层分离和截面积变化的激波串理论分析模型,并与实验结果进行了对比。研究表明,该模型可快速计算隔离段参数的沿程变化,激波串前缘位置的差值在2.6%以内。此外,对变截面管道激波串进行了理论分析和数值模拟,研究发现数值解和理论解的差值为11%。

关键词：激波串变截面管壁温附面层分离理论模型风洞实验

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan wang Bin wang Ju-yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

PPAR-γagonist pioglitazone improves memory impairment in streptozocin-induced diabetic mice

在线全文

学校读者我要写书评

暂无评论

PPAR-γagonist pioglitazone improves memory impairment in st...

2011全国老年痴呆与衰老相关疾病学术会议第三届山东省神经内科医师（学术）论坛

作者： Li Ying Jiang,su su Tang,Xiao yun wang,Hao Hong1,Chao wang,Ting Ting Zhang,Qing Li,Mei Hu,Jia Chang Li,Guo Qing Xiang,Hao wang (Department of Pharmacology,China Pharmaceutical University,Nanjing 210009,China)

This study was conducted to evaluate the effects of exposure to pioglitazone,a peroxisome proliferator-activated receptorγ(PPARγ) agonist,on streptozotocin-induced diabetic ***(9 mg/kg,18 mg/kg) was orally administered for 4-6 *** function was evaluated by the passive avoidance test and the Morris water maze test on the 5th week after *** significantly increased step-through latency and reduced the number of errors in passive avoidance *** Morris water maze,pioglitazone significantly decreased the escape latency,and increased the time spent in the platform quadrant when compared with the vehicle diabetic *** further study showed that pioglitazone decreased the Aβ40 and Aβ42 levels of the hippocampus via inhibiting BACE1 mediated by the NF-κB *** effects of pioglitazone on blood glucose and serum insulin were not observed in diabetic *** data indicated that the improvement of cognitive impairments by pioglitazone resulted from alleviation of the Aβburden in the brain instead of its regulation of hyperglycaemia and hypoinsulinemia in streptozotocin-induced diabetic *** results suggest that pioglitazone may be useful for the treatment of cognitive impairment that may hold significant therapeutic value in alleviating certain memory deficits observed in diabetes.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

海底地形实时绘制技术研究和实现

中国海洋大学学报（自然科学版） 2016年第12期46卷 142-150页

作者：王晨明苏天赟王国宇宋庆磊青岛朗讯科技通讯设备有限公司山东青岛266100 国家海洋局第一海洋研究所山东青岛266061 中国海洋大学信息科学与工程学院山东青岛266100

为了提高大规模海底地形的绘制效率,LOD(细节层次,Levels of Details)技术必不可少。在ROAM(Real-time Optimally Adapting Meshes,实时优化自适应网格)算法的基础上,通过数据加载、视域剪裁、建立评价方法等技术手段,根据视点位置实时... 详细信息

为了提高大规模海底地形的绘制效率,LOD(细节层次,Levels of Details)技术必不可少。在ROAM(Real-time Optimally Adapting Meshes,实时优化自适应网格)算法的基础上,通过数据加载、视域剪裁、建立评价方法等技术手段,根据视点位置实时更新可视区域,避免了多余三角面片的生成和绘制。同时,采用对不共斜边节点强制分割的方法处理裂缝问题,通过索引坐标与实际坐标转换以及无效值处理实现任意范围海底地形对ROAM算法的应用,消除了传统ROAM算法对数据网格大小的限制,保证了绘制的效果和正确性。最后,通过GPU实时计算和绘制各顶点的法线和颜色,实现了大规模海底地形的实时建模和高效绘制,满足了高精度、海量海底地形漫游浏览的需求,特别是针对起伏比较大的地形漫游浏览。

关键词：细节层次(LOD) 二叉树实时优化自适应网格(ROAM) 海底地形评价因子

QTL Analysis of Resistance to Asian Corn Borer in Maize

在线全文

学校读者我要写书评

暂无评论

QTL Analysis of Resistance to Asian Corn Borer in Maize

中西医结合护理对缺血性中风恢复期气虚血瘀症的疗效观察

2003年全国作物遗传育种学术研讨会

作者： YU Yong-Tao SONG Yan-Chun SHI yun-su wang Tian-Yu LI Yu (Institute of Crop Germplasm Resources, Chinese Academy of Agricultural Sciences, Beijing 100081)

Asian corn borer (Ostrinia furnacalis., ACB) endangers maize production seriously in China, which has resulted in a great loss of grain yield of maize. Breeding for Asian corn borer resistance should

关键词： maize Asian Corn Borer resistance QTL agronomic trait molecular marker

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

中医药导报 2017年第13期23卷 121-123页

作者：朱素云王应军宁乡县中医医院湖南长沙410600

目的:探讨中西医结合康复护理应用于缺血性中风恢复期气虚血瘀症患者的临床效果。方法:抽取60例缺血性中风恢复期气虚血瘀症患者,分为治疗组和对照组,每组各30例,对照组进行基础护理干预结合现代康复护理,治疗组在对照组的基础上,联合... 详细信息

目的:探讨中西医结合康复护理应用于缺血性中风恢复期气虚血瘀症患者的临床效果。方法:抽取60例缺血性中风恢复期气虚血瘀症患者,分为治疗组和对照组,每组各30例,对照组进行基础护理干预结合现代康复护理,治疗组在对照组的基础上,联合中医康复护理,观察2组患者2个月后的Fugl-meyer运动功能评分和日常生活活动能力(改良的Barthel指数)的变化。结果:2组患者的Fugl-meyer运动功能评分较护理前显著增加,治疗组护理后Fugl-meyer运动功能评分较对照组明显升高,差异有统计学意义(P<0.01)。2组患者护理后改良Barthel指数均较护理前显著上升,治疗组护理后改良的的Barthel指数评分较对照组明显升高,差异有统计学意义(P<0.01)。结论:对缺血性中风恢复期气虚血瘀症患者进行中西医结合康复护理干预,能够有效改善患者的生活质量。

关键词：缺血性中风恢复期气虚血瘀症中西医结合护理

窒息新生儿血浆β-EP、β2-MG值变化与脑、肾损伤的关系

在线全文

学校读者我要写书评

暂无评论

新疆医科大学学报 2000年第4期23卷 315-317页

作者：沈书韵刘素云王莉新疆医科大学第一附属医院新生儿科新疆乌鲁木齐830054

目的 :探讨新生儿窒息后血浆β-内啡呔 (β- EP)、β2 -微球蛋白 (β2 - MG)浓度的变化与脑、肾损伤的关系。方法 :用放射免疫法监测窒息新生儿重度组 15例、轻度组 12例和对照组 10例血浆β- EP、β2 - MG的浓度 ,分别于生后 8～ 12 h... 详细信息

目的 :探讨新生儿窒息后血浆β-内啡呔 (β- EP)、β2 -微球蛋白 (β2 - MG)浓度的变化与脑、肾损伤的关系。方法 :用放射免疫法监测窒息新生儿重度组 15例、轻度组 12例和对照组 10例血浆β- EP、β2 - MG的浓度 ,分别于生后 8～ 12 h、72～ 96 h采血两次。结果 :窒息组 β- EP、β2 - MG值均明显增高 ,经方差分析各组间存在总体差异 (P<0 .0 1～ 0 .0 0 1)。经 q检验 ,8～ 12 h轻度组与对照组比较 ,P <0 .0 1～ 0 .0 0 1;重度组与轻度组比较 ,P <0 .0 0 1。脑病组与非脑病组 β- EP值比较 ,P <0 .0 0 1。结论 :新生儿窒息可致 β- EP、β2 - MG值增高 ,且与窒息程度有关。 β-EP可能参与并加重了脑损伤的病理生理过程。β2 - MG的浓度变化 ,对早期反映窒息后引起肾小球滤过率障碍较为敏感。

关键词：新生儿窒息脑损伤肾损伤 β2-MG β-EP