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Effects of Korean ginseng berry extract （GB0710） on penile erection： evidence from in vitro and in vivo studies

Asian Journal of Andrology 2013年第4期15卷 503-507,I0008页

作者： Kang su Cho Chan woong Park Chun-Ki Kimt Hee Young Jeon Wan Gi Kim Sang Jun lee Young-Myeong Kim Joo Yong lee Young Deuk Choi Department of Urology Severance Hospital Urological Science Institute Yonsei University College of Medicine Seou1120-752 Korea R&D Center Amorepacific Corporation Yongin Gyeonggi-do 446-729 Korea Vascular System Research Center and Department of Molecular and Cellular Biochemistry School of Medicine Kangwon National University Chunchon 200-701 Korea and Clinical Trial Center for Medical Devices Yonsei University College of Medicine Seoul 120-752 Korea

Several reports have promoted the root-derived Korean red ginseng （KRG; Panax ginseng） as alternative treatment for erectile dysfunction （ED）, and ginsenosides are known to be the principal active ingredients of ginseng. Recent studies showed that ginseng berries produce more ginsenosides than KRG; thus, we investigated the ability of the Korean ginseng berry extract GB0710 to relax the penile corpus cavernosum smooth muscle （CCSM） in this study. As a comparative control, the results were compared to those obtained using KRG. In addition, possible mechanisms of action for GB0710 were investigated. While KRG and GB0710 both displayed dose-dependent relaxation effects on precontracted rabbit CCSM in vitro, GB0710 was shown to be more potent than KRG. The GBO710-induced relaxation could be partially reduced by removing the endothelium. In addition, pre-treatment with several nitric oxide （NO） inhibitors significantly inhibited the relaxation of muscle strips. Furthermore, administration of GB0710 increased intracavernosal pressure （ICP） in a rat in vivo model in both a dose- and duration-dependent manner. Intracellular NO production in human microvascular endothelial cells could be induced by GB0710 and inhibited by NG-monomethyI-L-arginine. In conclusion, GB0710 had a greater relaxation effect on rabbit CCSM than did KRG extract, and increased ICP in a rat model in both a dose- and a duration-dependent manner. This relaxine effect might be mediated bv NO production.

关键词： corpus cavernosum erectile dysfunction (ED) ginseng berry nitric oxide (NO) smooth muscle

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Stratigraphic Implications of Skeletal Microfossils from the Cambrian of Korea:A Preliminary Report

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Acta Geologica Sinica(English Edition) 2008年第6期82卷 1152-1159页

作者： Byung-su lee Department of Earth Science Education Chonbuk National UniversityJeonju 561-756Korea

Diverse small shelly fossils and other associated fossils were recently recovered from the Cambrian Hanaeri section, southwestern Mungyeong, Korea. The fauna includes conoidal problematica, poriferans （sponge spicules）, coeloscleritophorans （chancelioriids）, brachiopods, monoplacophorans, trilobite （？） fragments, echinoderms, and conodonts. A preliminary assessment of faunal associations, stratigraphic implications, and the correlation of these skeletal fossils is given, based on occurrences of Actinotheca cf. mira （He）, Microcornus sp., Torellela laevigata （Linnarsson）, Torellela sp., Archiasterella quadratina lee, Chancelloria sp., LinguleUa sp., Prototreta sp., Phakelodus tenuis （Miiller）, Phakelodus elongates （An）, Hertzina sp., and Furnishina sp.

关键词： small shelly fossils (ssf) conodonts correlation Lower and Middle Cambrian Korea

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Characteristics of bifurcation and buckling load of space truss in consideration of initial imperfection and load mode

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第3期14卷 206-218页

作者： su-deok SHON Seung-jae lee Kang-guk lee School of Architectural Engineering Korea University of Technology and Education1800 ChungjeolroCheonan ChungnamRepublic of Korea Research Center for Urban Affair Kyungil UniversityGyeongsan-city GyeongbukRepublic of Korea

This study investigated characteristics of bifurcation and critical buckling load by shape imperfection of space truss,which were sensitive to initial *** critical point and buckling load were computed by the analysis of the eigenvalues and determinants of the tangential stiffness *** two-free-nodes example and star dome were selected for the case study in order to examine the nodal buckling and global buckling by the sensitivity to the eigen buckling mode and the analyses of the influence,and characteristics of the parameters as defined by the load ratio of the center node and surrounding node,as well as rise-span ratio were *** sensitivity to the imperfection of the initial shape of the two-free-nodes example,which occurs due to snapping at the critical point,resulted in bifurcation before the limit point due to the buckling mode,and the buckling load was reduced by the increase in the amount of *** two sensitive buckling patterns of the numerical model are established by investigating the displaced position of the free nodes,and the asymmetric eigenmode greatly influenced the behavior of the imperfection shape whether it was at limit point or ***,the sensitive mode of the two-free-nodes example was similar to the in-extensional basis mechanism of a simplified *** star dome,which was used to examine the influence among several nodes,indicated that the influence of nodal buckling was greater than that of global buckling as the rise-span ratio was ***,global buckling is occurred with reaching bifurcation point as the value of load ratio was higher,and the buckling load level was about 50%-70% of load level at limit point.

关键词： Space truss Geometric nonlinearity Initial imperfection Snap-through Bifurcation Global buckling

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Deep Learning in DXA Image Segmentation

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Computers, Materials & Continua 2021年第3期66卷 2587-2598页

作者： Dildar Hussain Rizwan Ali Naqvi woong-Kee Loh Jooyoung lee School of Computational Science Korea Institute for Advanced Study(KIAS)85 HoegiroDongdaemun-guSeoul02455South Korea Department of Unmanned Vehicle Engineering Sejong University209Neungdong-roGwangjin-guSeoul05006South Korea Department of Software Gachon UniversitySeongnam13120South Korea

Many existing techniques to acquire dual-energy X-ray absorptiometry(DXA)images are unable to accurately distinguish between bone and soft *** the most part,this failure stems from bone shape variability,noise and low contrast in DXA images,inconsistent X-ray beam penetration producing shadowing effects,and person-to-person *** work explores the feasibility of using state-of-the-art deep learning semantic segmentation models,fully convolutional networks(FCNs),SegNet,and U-Net to distinguish femur bone from soft *** investigated the performance of deep learning algorithms with reference to some of our previously applied conventional image segmentation techniques(i.e.,a decision-tree-based method using a pixel label decision tree[PLDT]and another method using Otsu’s thresholding)for femur DXA images,and we measured accuracy based on the average Jaccard index,sensitivity,and *** learning models using SegNet,U-Net,and an FCN achieved average segmentation accuracies of 95.8%,95.1%,and 97.6%,respectively,compared to PLDT(91.4%)and Otsu’s thresholding(72.6%).Thus we conclude that an FCN outperforms other deep learning and conventional techniques when segmenting femur bone from soft tissue in DXA *** femur segmentation improves bone mineral density computation,which in turn enhances the diagnosing of osteoporosis.

关键词： Segmentation deep learning osteoporosis dual-energy X-ray absorptiometry

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Cardiac rehabilitation in a heart failure patient after left ventricular assist device insertion and subsequent heart transplantation:A case report

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World Journal of Clinical Cases 2022年第8期10卷 2577-2583页

作者： Tae woong Yang Seunghwan Song Hye Won lee Byeong-Ju lee Department of Rehabilitation Medicine Biomedical Research InstitutePusan National University HospitalPusan 602-739South Korea Department of Thoracic and Cardiovascular surgery Pusan National University School of MedicinePusan National University HospitalPusan 602-739South Korea Division of Cardiology Department of Internal MedicinePusan National University School of MedicinePusan National University HospitalPusan 602-739South Korea

BACKGROUND Insertion of a left ventricular assist device(LVAD)and heart transplantation(HT)improve the survival of patients with heart *** addition,cardiac rehabilitation(CR)further increases the functional *** case report describes a successful case of CR after LVAD insertion and subsequent *** suMMARY In the present case,during the LVAD insertion period,peak oxygen consumption(VO2)increased by 12.16%after *** was performed 7 mo after the LVAD insertion,and the patient participated in phases I and II *** peak VO2 increased from 17.24 to 22.29 m L/kg/*** improvement was more significant than that reported in previous studies on CR after LVAD insertion or *** patient’s quality of life also *** total average score of the short form-36 questionnaire increased from 29.5 points at admission to 53.3 points 9 mo after *** A tailored CR program after LVAD insertion or HT may improve the patients’quality of life and increase survival.

关键词： Left ventricular assist device Heart transplantation Cardiac rehabilitation Case report

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Development of seismic fragility curves for low-rise masonry infilled reinforced concrete buildings by a coefficient-based method

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Earthquake Engineering and Engineering Vibration 2013年第2期12卷 319-332页

作者： Ray Kai Leung su Chien-Liang lee Department of Civil Engineering The University of Hong Kong

This study presents a seismic fragility analysis and ultimate spectral displacement assessment of regular low-rise masonry infilled （MI） reinforced concrete （RC） buildings using a coefficient-based method. The coefficient-based method does not require a complicated finite element analysis; instead, it is a simplifed procedure for assessing the spectral acceleration and displacement of buildings subjected to earthquakes. A regression analysis was first performed to obtain the best-fitting equations for the inter-story drift ratio （IDR） and period shift factor of low-rise MI RC buildings in response to the peak ground acceleration of earthquakes using published results obtained from shaking table tests. Both spectral acceleration- and spectral displacement-based fragility curves under various damage states （in terms of IDR） were then constructed using the coefficient-based method. Finally, the spectral displacements of low-rise MI RC buildings at the ultimate （or near- collapse） state obtained from this paper and the literature were compared. The simulation results indicate that the fragility curves obtained from this study and other previous work correspond well. Furthermore, most of the spectral displacements of low-rise MI RC buildings at the ultimate state from the literature fall within the bounded spectral displacements predicted by the coefficient-based method.

关键词： seismic fragility analysis masonry spectral displacement

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Relationship between intraocular pressure and parameters of obesity in ocular hypertension

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International Journal of Ophthalmology(English edition) 2020年第5期13卷 794-800页

作者： Min Won Ahn Ji woong lee Jong Hoon Shin Jong Soo lee Busan sungmo Eye Hospital Busan 48064Korea Department of Ophthalmology Pusan National University College of Medicine and Medical Research Institute of Pusan National University HospitalBusan 49241Korea Department of Ophthalmology Pusan National University Yangsan HospitalYangsan 50612Korea

AIM:To evaluate the correlation between intraocular pressure(IOP)and various obesity-related health factors in patients with ocular hypertension in ***:A total of 40850 subjects underwent age,sex,body weight,and height assessments and automated multiphasic tests,including non-contact tonometry,automated perimetry,fundus photography,systolic/diastolic blood pressure measurement,and evaluation of obesity-related health parameters such as obesity index,body mass index(BMI),a body shape index(ABSI),and waist-to-height ratio(WtHR).subjects were divided into ocular hypertension group and normal IOP group according to IOP after matching of age and ***:Of 40850 participants,1515(3.7%)had ocular hypertension,and 1515 with normal IOP were selected as controls using propensity score *** mean IOP of control group was 15.3±2.3 mm Hg,compared with 23.3±1.6 mm Hg in ocular hypertension ***,obesity index,BMI,and WtHR in the ocular hypertension group were significantly higher than in the normal IOP group(Psure(Psure(β=0.022,Psubjects,but sex(male;β=-0.231,P=0.008)and obesity index(β=-0.007,P=0.017)were precursors of ocular hypertension according to multiple regression ***:Among various obesity-related health parameters,obesity index is the best indicator for further increase in IOP in ocular hypertension group.

关键词： intraocular pressure ocular hypertension body mass index body shape index waist-to-height ratio

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Application of an Artificial Neural Network for a Direct Estimation of Atmospheric Instability from a Next-Generation Imager

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Advances in Atmospheric Sciences 2016年第2期33卷 221-232页

作者： su Jeong lee Myoung-Hwan AHN Yeonjin lee Department of Atmospheric Science and Engineering Ewha Women’s University

Atmospheric instability information derived from satellites plays an important role in short-term weather forecasting, especially the forecasting of severe convective storms. For the next generation of weather satellites for Korea＇s multi-purpose geostationary satellite program, a new imaging instrument has been developed. Although this imaging instrument is not de- signed to perform full sounding missions and its capability is limited, its multi-spectral infrared channels provide information on vertical sounding. To take full advantage of the observation data from the much improved spatiotemporal resolution of the imager, the feasibility of an artificial neural network approach for the derivation of the atmospheric instability is investigated. The multi-layer perceptron model with a feed-forward and back-propagation training algorithm shows quite a sensitive re- sponse to the selection of the training dataset and model architecture. Through an extensive performance test with a carefully selected training dataset of 7197 independent profiles, the model architectures are selected to be 12, 5000, and 0.3 for the number of hidden nodes, number of epochs, and learning rate, respectively. The selected model gives a mean absolute error, RMSE, and correlation coefficient of 330 J kg-1, 420 J kg-1, and 0.9, respectively. The feasibility is further demonstrated via application of the model to real observation data from a similar instrument that has comparable observation channels with the planned imager.

关键词： CAPE artificial neural network instability geostationary imager

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Monitoring of non-point source pollutants load from a mixed forest land use

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Journal of Environmental Sciences 2010年第6期22卷 801-805页

作者： sung Wan Yoon Se woong Chung Dong Geun Oh Jae Woon lee Department of Environmental Engineering Chungbuk National University Geum River Environmental Research Center National Institute of Environmental Research

The aim of this study was to determine the unit load of NPS （non-point source） pollutants including organic variables such as BOD （biochemical oxygen demand）, COD （chemical oxygen demand） and DOC （dissolved organic carbon）, nitrogen and phosphorus constituents, and suspended solids （SS） and their event mean concentration （EMC） of runoff flows from a water-shed of mixed forest land use by intensive field experiments. Field monitoring for continuous measurements of rainfall, flow, and water quality was conducted over 12 storm events during 2008-2009 using automated and manual sampling methods. The EMCs of individual runoff event were estimated for each water quality constituent based on the flow rate and concentration data of runoff discharge. The average EMCs of BOD, COD, DOC, SS, TN （total nitrogen）, NH4^＋-N, NO3^--N, TP （total phosphorus）, PO4^3-P from the mixed forest land were 1.794, 3.498, 1.462, 10.269, 0.862, 0.044, 0.634, 0.034, and 0.005 mg/L, respectively. The annual unit loads of BOD, COD, DOC, SS, TN, NH4^＋-N, NO3^--N, TP and PO4^3--P were estimated as 66.9, 133.2, 55.5, 429.8, 36.5, 1.6, 26.9, 1.3 and 0.1 kg/（ha·yr）, respectively. In addition, affecting parameters on the EMCs were investigated by statistic analysis of the field data. As a result, significant correlations with precipitation, rainfall intensity, and total runoff flows were found in most constituents.

关键词： event mean concentration mixed forest land use non-point source pollutant load unit load

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Network Traffic Obfuscation System for IIoT-Cloud Control Systems

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Computers, Materials & Continua 2022年第9期72卷 4911-4929页

作者： Yangjae lee sung Hoon Baek Jung Taek Seo Ki-woong Park SysCore Lab. Sejong UniversitySeoul05006Korea Department of Computer System Engineering Jungwon UniversityChungcheongbuk-do28024Korea Department of Computer Engineering Gachon UniversityGyeonggi-do13120Korea

One of the latest technologies enabling remote control,operational efficiency upgrades,and real-time big-data monitoring in an industrial control system(ICS)is the IIoT-Cloud ICS,which integrates the Industrial Internet of Things(IIoT)and the cloud into the *** an ICS benefits from the application of IIoT and the cloud in terms of cost reduction,efficiency improvement,and real-time monitoring,the application of this technology to an ICS poses an unprecedented security risk by exposing its terminal devices to the outside *** adversary can collect information regarding senders,recipients,and prime-time slots through traffic analysis and use it as a linchpin for the next attack,posing a potential threat to the *** address this problem,we designed a network traffic obfuscation system(NTOS)for the IIoT-Cloud ICS,based on the requirements derived from the ICS characteristics and limitations of existing NTOS *** a strategy to solve this problem wherein a decrease in the traffic volume facilitates traffic analysis or reduces the packet transmission speed,we proposed an NTOS based on packet scrambling,wherein a packet is split into multiple pieces before transmission,thus obfuscating network *** minimize the ICS modification and downtime,the proposed NTOS was designed using an agentbased *** addition,for the ICS network traffic analyzer to operate normally in an environment wherein the NTOS is applied,a rule-based NTOS was adopted such that the actual traffic flow is known only to the device that is aware of the rule and is blocked for *** experimental results verified that the same time requested for response and level of difficulty of analysis were maintained by the application of an NTOS based on packet scrambling,even when the number of requests received by the server per second was *** network traffic analyzer of the ICS can capture the packet flow by using the pre-communicated NTOS *** addition,by designing an N

关键词： Cloud computing system moving-target defense container orchestration

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