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Randomized clinical trial on seven-day-per-week continuous accelerated irradiation for patients with esophageal carcinoma: Preliminary report on tumor response and acute toxicity

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World Journal of Gastroenterology 2006年第43期12卷 7047-7050页

作者： su-Ping sun Ya-Zhou Liu Tao Ye Wen Zhang Wen-Bin Shen Jing-Lei Shi Hai-Ting Xu Wei-Dong Wang Department of Radiation Oncology ChangzhouSecond hospital-The Affiliated Hospital of Nanjing MedicalUniversity Changzhou 213003 Jiangsu Province China Department of Radiation Oncology Xuzhou Cancer Hospital Xuzhou 221005 Jiangsu Province China

AIM: Tumor response and normal tissue toxicity of seven-day-per-week continuous accelerated irradiation (CAIR) for patients with esophageal carcinoma were evaluated and compared to conventional irradiation (CR). METHODS: Sixty patients with squamous cell carcinoma of the esophagus were randomized into two groups: the CAIR group (30 patients) and the CR group (30 pa- tients). Patients in the CAIR group received radiotherapy (RT) with 2 Gy/fraction per day at 7 d/wk with a total dose of 50-70 Gy (average dose 64.2 Gy). The overall time of irradiation was 3.6-5.0 wk (average 4.6 wk). RT in the CR group was 2 Gy/fraction per day at 5 d/wk with a total dose of 40-70 Gy (average dose 61.7 Gy). The overall time of irradiation was 4.0-7.0 wk (average 6.4 wk). REsuLTS: The data showed that the immediate tumor response to RT was better in the CAIR group than in the CR group. Efficiency rates (CR plus PR) were 82.8% (24/29) and 58.6% (17/29), respectively (P = 0.047). In both groups the incidences of esophagitis and tracheitis were insignificant (P = 0.376, 0.959), and no patient re- ceived toxicity that could not be tolerated. CONCLUSION: CAIR shortens overall treatment time and is well tolerated by patients. It may be superior to CR in enhancing the local response of tumor, but its remote effect for esophageal carcinoma awaits further follow-up.

关键词： Esophageal carcinoma Continuous acceler-ated irradiation Conventional irradiation Toxicity Over-all treatment time

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Influence of Low-Energy Ion Irradiation on Plasma Membrane Permeability of Cells

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Chinese Physics Letters 2000年第1期17卷 61-63页

作者： ZHANG Dong-Mei CUI Fu-Zhai sun su-Qin LIN You-Bo TIAN Min-Bo CHEN Guo-Qiang Department of Materials Science and Engineering Tsinghua UniversityBeijing 100084 Analysis Center Tsinghua UniversityBeijing 100084 Department of Biological Science and Biotechnology Tsinghua UniversityBeijing 100084

Effect of low-energy ion irradiation on plasma membrane permeability has been investigated by using electron spin resonance(ESR)spectroscopy of spin probe *** investigated system is plumule cells of wheat(Triticum aestivum L.)seeds implanted by 30 keV N^(+) *** spectra indicated that plasmalemma permeability is sensitive to low-energy ion *** irradiations with increasing Huences up to semi-lethal dose lead to gradual increase in plasmalemma permeability of the plumule *** possible factors relevant to the changes in membrane permeability are discussed in relation to the changes in the physical state and chemical nature of membranes.

关键词： technique. permeability irradiation

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CircR-ZC3HC1 mediates MiR-384-5p/SIRT1 axis to promote neuronal autophagy and relieves ischemic stroke

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BIOCELL 2024年第3期48卷 491-499页

作者： MIN SHEN XIAOMAN XU GUANGLING sun LIANGZHU WANG TAO YING HANG su WEI WANG QINGHUA CAO ZHEZHE sun Department of Neurology The First Affiliated Hospital of Ningbo UniversityNingbo315010China School of Medicine Ningbo UniversityNingbo315211China

Objective:Circular RNAs(circRNAs)have been shown to involve in pathological processes of ischemic stroke(IS),including *** study was designed to explore the effect of circR-ZC3HC1 on neuronal autophagy in IS and the related ***:Expression of circR-ZC3HC1 in blood samples of IS patients and healthy controls was *** neurons were treated with oxygen and glucose deprivation(OGD)to establish IS in vitro *** expression of LC3 and p62 and the number of autophagosomes were examined to evaluate the autophagy level of OGD induced neurons using western blotting and transmission electron *** apoptosis rate and the expression of cleaved caspase-3,Bax,and Bcl-2 were assessed byﬂow cytometry and western *** binding relationships among circR-ZC3HC1,miR-384-5p,and SIRT1 were predicted and veriﬁ***:Low expression of circR-ZC3HC1 was found in blood samples of IS patients and OGD-treated *** circR-ZC3HC1 or inhibited miR-384-5p expression promoted autophagy and inhibited apoptosis of OGD-treated neurons,which could be reversed by further 3-MA ***,circR-ZC3HC1 targeted miR-384-5p to mediate SIRT1 ***-384-5p overexpression or SIRT1 knockdown in the presence of circR-ZC3HC1 overexpression in OGD-treated neurons lead to reduced autophagy and enhanced ***:Collectively,circR-ZC3HC1 promoted neuronal autophagy to attenuate IS via miR-384-5p/SIRT1 axis.

关键词： Ischemic stroke circR-ZC3HC1 miR-384-5p SIRT1 Autophagy

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Studying the variable energy band structure for energy storage materials in charge/discharge process

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Chinese Chemical Letters 2024年第2期35卷 584-589页

作者： Xuancheng Chen Yu Huan Ningqiang sun Yuanhui su Xuesong Shen Guoqing Li Jiaqi Zhang Tao Wei University of Jinan Ji'nan 250022China Weichai Power Co. Ltd.Weifang 261061China

So far,a clear understanding about the relationship of variable energy band structure with the corresponding charge-discharge process of energy storage materials is still ***,using optical spectroscopy(red-green-blue(RGB)value,reflectivity,transmittance,UV-vis,XPS,UPS)to studyα-Co(OH)_(2) electrode working in KOH electrolyte as the research object,we provide direct experimental evidence that:(1)The intercalation of OH-ions will reduce the valence/conduction band(VB and CB)and band gap energy(Eg)values;(2)The deintercalation of OH-ions corresponds with the reversion of VB,CB and E_(g) to the initial values;(3)The color of Co(OH)_(2) electrode also exhibit regular variations in RGB value during the charge-discharge process.

关键词： Variable energy band structure Energy storage materials Charge-discharge process Optical spectroscopy supercapacitors

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Increased glacier melt enhances future extreme floods in the southern Tibetan Plateau

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Advances in Climate Change Research 2024年第3期15卷 431-441页

作者： He sun Tan-Dong YAO Feng-Ge su Tinghai Ou Zhihua HE Guoqiang TANG Deliang CHEN State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China Regional Climate Group Department of Earth SciencesUniversity of GothenburgGothenburg 40530Sweden Centre for Hydrology University of SaskatchewanSaskatoon S7N 1K2Canada Climate and Global Dynamics National Center for Atmospheric ResearchBoulder CO 80307USA

Mountainous areas are of special hydrological concern because topography and atmospheric conditions can result in large and sudden floods,posing serious risks to water-related safety in neighbouring *** Yarlung Zangbo(YZ)River basin is the largest river basin on the Tibetan Plateau(TP),but how floods will discharge in this basin and how the role of glacier melt in floods will change throughout the 21st-century under shared socioeconomic pathways scenarios(SSP2-4.5 and SSP5-8.5)remain ***,we comprehensively address this scientific question based on a well-validated large-scale glacier-hydrology *** results indicate that extreme floods was projected to increase in the YZ basin,and was mainly reflected in increased duration(4–10 d per decade)and intensity(153–985 m^(3)s^(−1)per decade).Glacier runoff was projected to increase(2–30 mm per decade)throughout the 21st-century,but there was also a noticeable decrease or deceleration in glacier runoff growth in the late first half of the century under the SSP2-4.5,and in the latter half of the century under the *** melt was projected to enhance the duration(12%–23%)and intensity(15%–21%)of extreme floods under both SSPs,which would aggravate the impact of future floods on the socioeconomics of the YZ *** effect was gradually overwhelmed by precipitation-induced floods from glacier areas to YZ *** study takes the YZ basin as a projection framework example to help enrich the understanding of future flood hazards in basins affected by rainfall-or meltwater across the TP,and to help policy-makers and water managers develop future plans.

关键词： floods glacier Tibetan

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foxl2l is a germ cell-intrinsic gatekeeper of oogenesis in zebrafish

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Zoological Research 2024年第5期45卷 1116-1130页

作者： Zhiqin Ren Ding Ye Naike su Chaofan Wang Lijia He Houpeng Wang Mudan He Yonghua sun Key Laboratory of Breeding Biotechnology and sustainable Aquaculture Hubei Hongshan LaboratoryInstitute of HydrobiologyInnovation Academy for Seed DesignChinese Academy of SciencesWuhanHubei 430072China School of Marine Biology and Fisheries Hainan UniversityHaikouHainan 570228China College of Advanced Agricultural Sciences University of Chinese Academy of SciencesBeijing 100049China College of Fisheries and Life Science Dalian Ocean UniversityDalianLiaoning 116023China

Zebrafish serve as a valuable model organism for studying germ cell biology and reproductive *** AB strain of zebrafish is proposed to exhibit a polygenic sex determination system,where most males initially develop juvenile ovaries before committing to male *** species with chromosomal sex determination,gonadal somatic cells are recognized as key determinants of germ cell ***,the loss of germ cells in zebrafish leads to masculinization,implying that germ cells harbor an intrinsic feminization ***,the specific signal triggering oogenesis in zebrafish remains *** the present study,we identified foxl2l as an oocyte progenitor-specific gene essential for initiating oogenesis in germ *** showed that foxl2l-knockout zebrafish bypassed the juvenile ovary stage and exclusively developed into fertile *** analysis revealed that loss of foxl2l hindered the initiation of oocyte-specific meiosis and prevented entry into oogenesis,leading to premature spermatogenesis during early gonadal ***,while mutation of the pro-male gene dmrt1 led to fertile female differentiation,simultaneous disruption of foxl2l in dmrt1 mutants completely blocked oogenesis,with a large proportion of germ cells arrested as germline stem cells,highlighting the crucial role of foxl2l in ***,this study highlights the unique function of foxl2l as a germ cell-intrinsic gatekeeper of oogenesis in zebrafish.

关键词： foxl2l dmrt1 Oogenesis Sex determination Meiosis

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Host-induced gene silencing of the Verticillium dahliae thiamine transporter protein gene(VdThit)confers resistance to Verticillium wilt in cotton

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Journal of Integrative Agriculture 2024年第10期23卷 3358-3369页

作者： Qi Wang Guoqiang Pan Xingfen Wang Zhengwen sun Huiming Guo Xiaofeng su Hongmei Cheng National Key Laboratory of Agricultural Microbiology/Biotechnology Research Institute Chinese Academy of Agricultural SciencesBeijing100081China Xinjiang Jinfengyuan Seeds Co. Ltd.Aksu 843100China College of Agronomy Hebei Agricultural UniversityBaoding 071001China Institute of Microbiology Applications Xinjiang Academy of Agricultural SciencesUrumqi 830091China

Verticillium wilt(VW),induced by the soil-borne fungus Verticillium dahliae(Vd),poses a substantial threat to a diverse array of plant *** molecular breeding technology for the development of cotton varieties with heightened resistance to VW stands out as one of the most efficacious protective *** this study,we successfully generated two stable transgenic lines of cotton(Gossypium hirsutum L.),VdThitRNAi-1 and VdThit-RNAi-2,using host-induced gene silencing(HIGS)technology to introduce double-stranded RNA(dsRNA)targeting the thiamine transporter protein gene(VdThit).Southern blot analysis confirmed the presence of a single-copy insertion in each *** examination showed marked reductions in the colonization and spread of Vd-mCherry in the roots of VdThit-RNAi cotton compared to wild type(WT).The corresponding disease index and fungal biomass of VdThit-RNAi-1/2 also exhibited significant ***-time quantitative PCR(qRT-PCR)analysis demonstrated a substantial inhibition of VdThit expression following prolonged inoculation of VdThit-RNAi *** RNA sequencing(sRNA-Seq)analysis revealed the generation of a substantial number of VdThit-specific siRNAs in the VdThit-RNAi transgenic ***,the silencing of VdThit by the siVdThit produced by VdThit-RNAi-1/2 resulted in the elevated expression of multiple genes involved in the thiamine biosynthesis pathway in *** field conditions,VdThit-RNAi transgenic cotton exhibited significantly enhanced disease resistance and yield compared with *** summary,our findings underscore the efficacy of HIGS targeting VdThit in restraining the infection and spread of Vd in cotton,thereby potentially enabling the development of cotton breeding as a promising strategy for managing VW.

关键词： Verticillium dahliae thiamine transporter host-induced gene silencing(HIGS) RNAi

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Protein tyrosine phosphatases:emerging role in cancer therapy resistance

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Cancer Communications 2024年第6期44卷 637-653页

作者： Min Zhao Wen Shuai Zehao su Ping Xu Aoxue Wang Qiu sun Guan Wang Innovation Center of Nursing Research Nursing Key Laboratory of Sichuan ProvinceDepartment of BiotherapyCancer Center and State Key Laboratory of BiotherapyNational Clinical Research Center for GeriatricsWest China HospitalWest China School of NursingSichuan UniversityChengduSichuanP.R.China West China Biomedical Big Data Center Med-X Center for InformaticsSichuan UniversityChengduSichuanP.R.China Emergency Department Zigong Fourth People’s HospitalChengduSichuanP.R.China

Background:Tyrosine phosphorylation of intracellular proteins is a posttranslational modification that plays a regulatory role in signal transduction during cellular *** of signal transduction proteins caused by protein tyrosine phosphatases(PTPs)contributed their role as a convergent node to mediate cross-talk between signaling *** the context of cancer,PTP-mediated pathways have been identified as signaling hubs that enabled cancer cells to mitigate stress induced by clinical *** is achieved by the promotion of constitutive activation of growth-stimulatory signaling pathways or modulation of the immune-suppressive tumor *** evidences suggested that anticancer drugs will release their greatest therapeutic potency when combined with PTP inhibitors,reversing drug resistance that was responsible for clinical failures during cancer *** covered:This review aimed to elaborate recent insights that supported the involvement of PTP-mediated pathways in the development of resistance to targeted therapy and immune-checkpoint *** opinion:This review proposed the notion of PTP inhibition in anticancer combination therapy as a potential strategy in clinic to achieve long-term tumor *** clinical trials are currently underway to assess the safety and efficacy of combination therapy in advanced-stage tumors.

关键词： cancer treatment combination therapy drug resistance protein tyrosine phosphatase

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惰性气体原子间相互作用势比较研究

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物理学报 2015年第14期64卷 122-131页

作者：孙素蓉王海兴北京航空航天大学宇航学院北京100191

原子间相互作用势是预测惰性气体输运性质的必要输入条件.文章对描述惰性气体原子间相互作用的Lennard-Jones势、指数排斥势、Hartree-Fock-Dispersion-B(HFD-B)势和唯象势的形式和特点进行了分析.基于Chapman-Enskog方法,计算得到了惰... 详细信息

原子间相互作用势是预测惰性气体输运性质的必要输入条件.文章对描述惰性气体原子间相互作用的Lennard-Jones势、指数排斥势、Hartree-Fock-Dispersion-B(HFD-B)势和唯象势的形式和特点进行了分析.基于Chapman-Enskog方法,计算得到了惰性气体在300—5000 K温度区间内基于四种原子相互作用势的黏性和热导率,并与文献报道的实验和理论计算结果进行了比较.研究结果表明,基于Hartree-Fock排斥理论与色散理论发展起来的HFD-B势能够合理反映惰性气体原子相互作用的趋势与特征,因而可以较好地预测惰性气体的宏观输运性质.

关键词：原子间作用势惰性气体输运性质

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BL03HB: a Laue microdiffraction beamline for both protein crystallography and materials science at SSRF

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Nuclear Science and Techniques 2024年第7期35卷 68-78页

作者： Zhi-Jun Wang Si-Sheng Wang Zheng-Huang su Li Yu Yu-Zhu Wang Bo sun Wen Wen Xing-Yu Gao Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai201210China University of Chinese Academy of Science Beijing100049China

A Laue microdiffraction beamline(BL03HB) was constructed at the Shanghai Synchrotron Radiation Facility(SSRF).This beamline features two consecutive focusing points in two different sectors within its end station, the first dedicated to protein crystallography and the other tailored to materials science applications. Based on a superbend dipole magnet with a magnetic field of 2.29 T, a two-stage focusing design was implemented with two sets of Kirkpatrick-Baez mirrors to achieve a micro white beam as small as 4.2 μ m ×4.3 μ m at the first sector and 0.9 μ m ×1.3 μ m at the second sector in the standard beamline operation mode at SSRF. The X-ray microbeam in the two sectors can be easily switched between monochromatic and white beams by moving a four-bounce monochromator in or out of the light path, respectively. In the protein crystallography sector, white-beam Laue microdiffraction was demonstrated to successfully determine the structure of protein crystals from only a few images of diffraction data collected by a Pilatus 2 M area detector. In the materials science sector,the white-beam Laue diffraction was collected in a reflection geometry using another Pilatus 2 M area detector, which could map the microstructural distribution on the sample surface by scanning the samples. In general, the BL03HB beamline promotes the application of Laue microdiffraction in both protein crystallography and materials science. This paper presents a comprehensive overview of the BL03HB beamline, end station, and the first commission results.

关键词： Crystallography White-beam Laue microdiffraction Beamline Synchrotron

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