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The Trend of Smoking-Related Cognition and Its Association with Smoking Behaviors Among Junior High School Students—China,2013–2021

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China CDC weekly 2024年第22期6卷 503-508页

作者： Wenzhao Liu Xinying Zeng qi su Lin Xiao Shiwei Liu Tobacco Control Office Chinese Center for Disease Control and PreventionBeijingChina

What is already known about this topic?In 2013,31.61%of students perceived quitting smoking as difficult,61.73%considered smoking less attractive,and 73.89%believed that secondhand smoke is definitely harmful to *** is added by this report?The percentage of students who perceived quitting smoking as difficult increased from 31.61%in 2013 to 38.83%in 2021,while the percentage of students who found smoking less attractive rose from 61.73%to 69.40%.Conversely,there was a decrease in the percentage of students who perceived secondhand smoke as harmful,from 73.89%to 68.46%.An increased awareness of the hazards of secondhand smoke was associated with a reduction in smoking *** are the implications for public health practice?It is imperative to enhance health education efforts that aim to raise awareness of the hazards of secondhand smoke.

关键词： smoke attractive Junior

dECM restores macrophage immune homeostasis and alleviates iron overload to promote DTPI healing

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Regenerative Biomaterials 2024年第2期3卷 100-113页

作者： Ju Zhang Ruijuan Si Yu Gao Hui Shan qi su Zujian Feng Pingsheng Huang Deling Kong Weiwei Wang Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical EngineeringChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin300192China School of Nursing Qingdao UniversityNingde RoadShinan DistrictQingdaoShandong266071China Cancer Hospital of Tianjin Medical University North Huanhu West RoadTianjinChina The Affliated Hospital of qingdao University 16 Jjiangsu RoadShinan DistrictQingdaoChina 5NankaiUniver aniin300071.China

Due to its highly insidious and rapid progression,deep tissue pressure injury(DTPI)is a clinical *** previous study found that DTPI may be a skeletal muscle injury dominated by macrophage immune dysfunction due to excessive iron *** extracellular matrix(dECM)hydrogel promotes skeletal muscle injury ***,its role in po-larizing macrophages and regulating iron metabolism in DTPI remains ***,porcine dECM hydrogel was prepared,and its therapeutic function and mechanism in repairing DTPI were *** stimulus of dECM hydrogel toward RAW264.7 cells resulted in a significantly higher percentage of CD2o6+macrophages and notably decreased intracellular divalent iron *** mice DTPI model,dECM hydrogel treatment promoted M1 to M2 macrophage conversion,improved iron metabolism and reduced oxidative stress in the early stage of *** the remodeling phase,the dECM hydrogel remarkably enhanced revascularization and accelerated skeletal muscle ***,the immunomodulation of dEcM hydrogels in vivo was mainly involved in the P13k/Akt signaling pathway,as revealed by GO and KEGG pathway analysis,which may ameliorate the iron deposition and promote the healing of *** findings indicate that dECM hydrogel is promising in skeletal muscle repair,inflammation resolution and tissue injury healing by effectively restoring macrophage immune homeostasis and normalizing iron metabolism.

关键词： Deep tissue pressure injury hydrogel immunomodulation tissue repair

Optimization Design of the Multi-Layer Cross-Sectional Layout of An Umbilical Based on the GA-GLM

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China Ocean Engineering 2024年第2期38卷 247-254页

作者： YANG Zhi-xun YIN Xu FAN Zhi-rui YAN Jun LU Yu-cheng su qi MAO Yandong WANG Hua-lin Institute of marine machinery College of Mechanical and Electrical EngineeringHarbin Engineering UniversityHarbin 150001China State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentDepartment of Engineering MechanicsDalian University of TechnologyDalian 116024China Ningbo Institube of Dalian University of Technology Ningbo 315040China

Marine umbilical is one of the key equipment for subsea oil and gas exploitation,which is usually integrated by a great number of different functional components with *** layout of these components directly affects manufacturing,operation and storage performances of the *** the multi-layer cross-sectional layout design of the umbilical,a quantifiable multi-objective optimization model is established according to the operation and storage *** the manufacturing factors,the multi-layering strategy based on contact point identification is introduced for a great number of functional ***,the GA-GLM global optimization algorithm is proposed combining the genetic algorithm and the generalized multiplier method,and the selection operator of the genetic algorithm is improved based on the steepest descent *** algorithm is used to find the optimal solution in the global space,which can converge from any initial layout to the feasible layout *** feasible layout solution is taken as the initial value of the generalized multiplier method for fast and accurate ***,taking umbilicals with a great number of components as examples,the results show that the cross-sectional performance of the umbilical obtained by optimization algorithm is better and the solution efficiency is ***,the multi-layering strategy is effective and *** design method proposed in this paper can quickly obtain the optimal multi-layer cross-sectional layout,which replaces the manual design,and provides useful reference and guidance for the umbilical industry.

关键词： umbilical cross-sectional layout multi-layers GA-GLM optimization

High-performance 0.75Li3V2（PO4）3·0.25Li3PO4/C composite cathode for lithium-ion batteries

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Rare Metals 2024年第11期 6081-6087页

作者： Rui-qi su Jing-Jing Zhu qing-Rong Kong Xiang Yao Department of Chemistry Faculty of ScienceNational University of Singapore College of Chemistry and Chemical Engineering Xinjiang Key Laboratory of Energy Storage and Photoelectrocatalytic MaterialsXinjiang Normal University

A composite cathode material,denoted as 0.75Li3V2（-PO4）3·0.25Li3PO4/C,designed for utilization in lithium-ion batteries,has been successfully synthesized utilizing the sol-gel *** resultant analysis revealed that the prepared sample exhibits a monoclinic crystal structure,with a space group denoted as p21/***,an evaluation of the electrochemical performance of these materials was *** to the results of X-ray diffraction analysis,it was confirmed that Li3PO4wasindeed incorporated within the Li3V2（PO4）3.

关键词：

Pyrimethamine upregulates BNIP3 to interfere SNARE-mediated autophagosome-lysosomal fusion in hepatocellular carcinoma

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Journal of Pharmaceutical Analysis 2024年第2期14卷 211-224页

作者： Jingjing Wang qi su Kun Chen qing Wu Jiayan Ren Wenjuan Tang Yu Hu Zeren Zhu Cheng Cheng Kaihui Tu Huaizhen He Yanmin Zhang School of Pharmacy Health Science CenterXi'an Jiaotong UniversityXi'an710061China

Hepatocellular carcinoma (HCC) is one of the most common tumor types and remains a major clinical challenge. Increasing evidence has revealed that mitophagy inhibitors can enhance the effect of chemotherapy on HCC. However, few mitophagy inhibitors have been approved for clinical use in humans. Pyrimethamine (Pyr) is used to treat infections caused by protozoan parasites. Recent studies have reported that Pyr may be beneficial in the treatment of various tumors. However, its mechanism of action is still not clearly defined. Here, we found that blocking mitophagy sensitized cells to Pyr-induced apoptosis. Mechanistically, Pyr potently induced the accumulation of autophagosomes by inhibiting autophagosome-lysosome fusion in human HCC cells. In vitro and in vivo studies revealed that Pyr blocked autophagosome-lysosome fusion by upregulating BNIP3 to inhibit synaptosomal-associated protein 29 (SNAP29)-vesicle-associated membrane protein 8 (VAMP8) interaction. Moreover, Pyr acted synergistically with sorafenib (Sora) to induce apoptosis and inhibit HCC proliferation in vitro and in vivo. Pyr enhances the sensitivity of HCC cells to Sora, a common chemotherapeutic, by inhibiting mitophagy. Thus, these results provide new insights into the mechanism of action of Pyr and imply that Pyr could potentially be further developed as a novel mitophagy inhibitor. Notably, Pyr and Sora combination therapy could be a promising treatment for malignant HCC.

关键词： Pyrimethamine BNIP3 SNARE Autophagosome-lysosome fusion Hepatocellular carcinoma Sorafenib

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大语言模型在二语教学中的应用效能解析

外语界 2024年第3期 35-42页

作者：苏祺北京大学外国语学院外国语言学及应用语言学研究所、人工智能研究院、数字人文研究中心北京100871

本研究聚焦大语言模型在二语教学的语法纠错、语言翻译、智能写作与写作评分、智能语伴与口语评估等重要领域的应用,通过对比大语言模型与其他语言智能系统在特定语言学习场景下的表现,探讨大语言模型的应用前景及其对二语学习成效的影... 详细信息

本研究聚焦大语言模型在二语教学的语法纠错、语言翻译、智能写作与写作评分、智能语伴与口语评估等重要领域的应用,通过对比大语言模型与其他语言智能系统在特定语言学习场景下的表现,探讨大语言模型的应用前景及其对二语学习成效的影响。文章强调了大语言模型在提供实时反馈、个性化学习体验、多语言支持等方面的优势,也指出了其在语境理解等方面的缺陷,以期明确大语言模型在二语教学中的适用性与局限性,为二语教学中的人工智能工具选择应用和教育技术发展提供有益参考。

关键词：大语言模型语言智能二语教学应用效能

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融合实体信息的古汉语关系分类研究

数据分析与知识发现 2024年第1期8卷 114-124页

作者：唐雪梅苏祺王军北京大学信息管理系北京100871 北京大学数字人文研究中心北京100871 北京大学外国语学院北京100871

【目的】将实体信息与预训练语言模型结合应用到古汉语关系分类任务中,构建古汉语关系分类模型。【方法】首先,在预训练模型输入层中使用特殊标记标出实体对的位置,同时在原关系句之后拼接实体类型描述句;其次,在预练语言模型的输出中... 详细信息

【目的】将实体信息与预训练语言模型结合应用到古汉语关系分类任务中,构建古汉语关系分类模型。【方法】首先,在预训练模型输入层中使用特殊标记标出实体对的位置,同时在原关系句之后拼接实体类型描述句;其次,在预练语言模型的输出中进一步提取实体语义信息;然后,通过CNN将每个字符相对于首尾实体的位置信息融入模型中;最后,将句表示、实体语义表示以及CNN输出拼接经过分类器得到关系标签。【结果】相较于仅使用预训练语言模型,本文模型在Macro F1指标上平均有3.5个百分点的提升。【局限】通过分析混淆矩阵发现本文模型在有相同实体类型组合的关系上容易出现预测错误。【结论】在预训练语言模型中结合实体信息能够提高古汉语关系分类的效果,且实验结果证明本文融合实体信息的方法是有效的。

关键词：古汉语关系抽取关系分类预训练语言模型实体信息

随机误差对光伏组件安装设备行星轮系影响机理研究

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太阳能学报 2024年第3期45卷 542-548页

作者：苏祺王海波钱华政西南交通大学机械工程学院成都610031 轨道交通运维技术与装备四川省重点实验室成都610031 通威股份有限公司成都610014

光伏组件安装设备作为新型特种设备,为减小系统振动、保证光伏组件稳定精确安装,针对动力传动系统中行星轮系双功率输入的微调工况,采用集中质量法,考虑时变啮合刚度、齿侧间隙等非线性因素,建立平移-扭转非线性动力学模型,在此基础上... 详细信息

光伏组件安装设备作为新型特种设备,为减小系统振动、保证光伏组件稳定精确安装,针对动力传动系统中行星轮系双功率输入的微调工况,采用集中质量法,考虑时变啮合刚度、齿侧间隙等非线性因素,建立平移-扭转非线性动力学模型,在此基础上研究各轮齿的制造、安装误差对轮系的振动及均载特性影响。研究表明:当存在制造安装误差时,太阳轮浮动可自动定心适应误差影响,在行星架误差下太阳轮偏离理论原点最远;行星轮误差对系统响应影响最为显著,相较于其他部件误差产生的振动位移存在量级差异;所有行星轮均产生相同误差时系统的均载特性优于仅有单一行星轮误差。

关键词：光伏组件误差数学模型行星轮系均载特性

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论人类遗传资源提供者同意撤回权的行使

中国医学伦理学 2024年第8期37卷 896-902页

作者：苏琦张静王萍北京中医药大学人文学院北京102488

为充分尊重人类遗传资源提供者的真实意思与自主决定,《人类遗传资源管理条例》赋予了提供者随时无条件退出的权利,即同意撤回权。“随时无条件退出”意味着提供者有权在任何阶段撤回其同意并无需因此承担任何不利后果。为确保人类遗传... 详细信息

为充分尊重人类遗传资源提供者的真实意思与自主决定,《人类遗传资源管理条例》赋予了提供者随时无条件退出的权利,即同意撤回权。“随时无条件退出”意味着提供者有权在任何阶段撤回其同意并无需因此承担任何不利后果。为确保人类遗传资源提供者同意撤回权得到法治实现,应充分告知以保障提供者的知情权,同时建立机构管理体系与撤回机制,并加强伦理审查,最终形成提供者终止参与、遗传资源销毁或删除及不再利用等法律效果。

关键词：同意撤回权自主决定遗传资源知情同意