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Pemetrexed in Previously Treated Non-small Cell Lung Cancer Patients with Poor Performance Status

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中国肺癌杂志 2011年第1期14卷 33-38页

作者： sun Young JUNG su jin yoo Ji Young SHIN Ji Won PARK Jeong Eun LEE Hee sun PARK Ju Ock KIM sun Young KIM Department of Internal Medicine Chungnam National University Hospital

Background and objective Pemetrexed have been approved for the treatment of patients affected by advanced non-small cell lung cancner(NSCLC) in progression after first-line *** evaluated the activity and feasibility of pemetrexed in previously treated *** Patients with histologically or cytologically confirmed NSCLC were evaluated from April 2007 to March *** patients had relapsed or progressed after prior chemotherapy ***(500 mg/m2) was administered intravenously once every 3 weeks after progression to prior *** tumor response was evaluated according to RECIST criteria by chest CT at every 2 cycles of *** A total 61 patients were eligible for *** status of them(100%) was over *** response rate and disease control rate were 14.7% and 37.7% ***-squamous cell carcinoma histology was significantly associated with a superior response rate(P=0.045) and disease control rate(P=0.008).The median survival time and the median progression free survival(PFS) time were 6.11 months and 2.17 months,*** the efficacy of pemetrexed in these two settings [second-line versus(12/61) more than third(49/61)],there was no significant difference in regard to median survival(11.18 months vs 11.46 months,P=0.922,5),but PFS was more longer in third-or further-line groups than second-line group(1.39 months vs 2.25 months,P=0.015,3).Conclusion Pemetrexed is a feasible regimen in previously treated NSCLC with poor performance status.

关键词：肺癌症状化学疗法临床治疗

计算机视觉技术赋能大学英语课堂展示中的学习投入研究

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新疆师范大学学报（哲学社会科学版） 2025年第2期46卷 144-151页

作者：谭苏燕王晋军广州大学外国语学院广东广州510010

学习投入是预测学习者学习效果的重要指标,学术界对其与课堂展示间的相关性研究鲜有涉猎。文本以某综合性大学303名非英语专业本科生为研究对象,采用人工智能与计算机视觉技术模型YOLOv7对大学英语课堂中的课堂展示实录进行学习投入多... 详细信息

学习投入是预测学习者学习效果的重要指标,学术界对其与课堂展示间的相关性研究鲜有涉猎。文本以某综合性大学303名非英语专业本科生为研究对象,采用人工智能与计算机视觉技术模型YOLOv7对大学英语课堂中的课堂展示实录进行学习投入多模态数据分析,并辅以问卷调查,形成双向印证。研究发现,学生课堂展示中的行为投入、认知投入和情感投入值均等于或高于3.78,投入结果均值达4.01,说明学生在课堂展示中的学习投入情况良好。此外,不同时段课堂展示对学生行为投入的影响显著,学生专注度及参与度在课堂前10分钟的课堂展示中效果最佳。文本为课堂展示的有效性提供了智能化、多模态、多维度的实证支持,为课堂教学的数智技术应用提供了新视角。

关键词：大学英语课堂展示学习投入计算机视觉技术展示时段

Infrageneric relationships of Korean Viola based on eight chloroplast markers

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Journal of Systematics and Evolution 2010年第6期48卷 474-481页

作者： Ki-Oug yoo su-Kil JANG Department of Biological Sciences Kangwon National University

Phylogeny and infrageneric relationships were reconstructed for Korean Viola(Violaceae) using eight chloroplast sequences:the atpB-rbcL intergenic spacer,the atpF-H intergenic spacer,the matK gene,the psbA-trnH intergenic spacer,the psbK-I intergenic spacer,the rpl16 intron,the rpoC1 exon 2,and the trnL-trnF *** combined analyses of the eight chloroplast regions suggest that sections Dischidium and Chamaemelanium are monophyletic,whereas section Nomimium is paraphyletic;sections Dischidium and Chamaemelanium form a clade with subsections Hypocarpae and Trigonocarpae of section Nomimium,but unresolved within the clade;two subsections(*** and Vaginatae) of section Nomimium form a clade and are placed between the stem and stemless species group;and subsection Patellares of section Nomimium is monophyletic,and Viola dissecta is diverged first in the clade with high support(BS = 100,PP = 100).Our present results support the subsectional grouping based on morphological characteristics,although discordance remained at the series level.

关键词： chloroplast DNA infrageneric relationships phylogeny series subsection Viola.

Microstructure and mechanical properties of 2219 aluminum alloy VPTIG welds during cyclic thermal treatment

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Rare Metals 2022年第10期41卷 3539-3545页

作者： Di-Yao su Hui-jin jin su-Jun Wu School of Materials Scienceand Engineering Beihang UniversityBeijing 100191China

In this study,the effect of the cyclic thermal treatment(CTT) on the microstructure and mechanical properties of the 2219 Al alloy welds fabricated using variable polarity tungsten inert gas(VPTIG) arc welding method were investigated by optical microscope(OM),transmission electron microscope(TEM),and low-temperature tensile tests,with emphasis on precipitation evolution and property variation in different areas of the *** of the microhardness profile across the weld reveals that there are maximum and minimum hardness values in the heat-affected zone(HAZ) adjacent to the fusion boundary(FB).It is found that the maximum hardness value increases with the temperature cycles of the cyclic thermal treatment due to the formation of GuinierPreston(GP) zones,while the microhardness at other positions remains *** results show that the CCT results in an increase in the yield strength,but a decrease in the ductility of the weld joint.

关键词： 2219 aluminum alloy VPTIG weld Microstructure Microhardness

Inverse correlation between gastroesophageal reflux disease and atrophic gastritis assessed by endoscopy and serology

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World Journal of Gastroenterology 2022年第8期28卷 853-867页

作者： yoo Min Han su jin Chung Seokha yoo Jong In Yang Ji Min Choi Jooyoung Lee Joo sung Kim Department of Internal Medicine and Healthcare Research Institute Seoul National University Hospital Healthcare System Gangnam CenterSeoul 06236South Korea Department of Anesthesiology and Pain Medicine Seoul National University College of MedicineSeoul 03080South Korea Department of Internal Medicine and Liver Research Institute Seoul National University College of MedicineSeoul 03080South Korea

BACKGROUND Helicobacter pylori(***)infection is known to prevent the occurrence of gastroesophageal reflux disease(GERD)by inducing gastric mucosal ***,little is known about the relationship between atrophic gastritis(AG)and *** To confirm the inverse correlation between AG and the occurrence and severity of *** Individuals receiving health checkups who underwent upper gastrointestinal endoscopy at Seoul National University Healthcare System Gangnam Center were *** grade of reflux esophagitis was evaluated according to the Los Angeles *** AG(EAG)was categorized into six *** AG(SAG)was defined as pepsinogen I≤70 ng/m L and pepsinogen I/II ratio≤*** association between the extent of EAG and SAG and the occurrence and severity of GERD was evaluated using multivariate logistic regression *** In total,4684 individuals with GERD were compared with 21901 healthy *** multivariate logistic regression analysis,advanced age,male sex,body mass index>23 kg/m2,presence of metabolic syndrome,current smoking,and alcohol consumption were associated with an increased risk of *** for *** immunoglobulin G antibodies was associated with a decreased risk of *** was an inverse correlation between the extent of EAG and occurrence of GERD:Odds ratio(OR),1.01[95%confidence interval(CI):0.90-1.14]in C1,0.87(0.78-0.97)in C2,0.71(0.62-0.80)in C3,0.52(0.44-0.61)in O1,0.37(0.29-0.48)in O2,and 0.28(0.18-0.43)in ***,the extent of EAG showed an inverse correlation with the severity of *** presence of SAG was correlated with a reduced risk of GERD(OR=0.49,95%CI:0.28-0.87,P=0.014).CONCLUSION The extent of EAG and SAG exhibited strong inverse relationships with the occurrence and severity of *** followed by *** infection may be independently protect against GERD.

关键词： Gastroesophageal reflux disease Reflux esophagitis Helicobacter pylori Atrophic gastritis Pepsinogen

APPLICATION OF VIDEO ANAGLYPH MAKER FOR 3-D FLOW SIMULATION

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Journal of Hydrodynamics 2010年第2期22卷 289-294页

作者： KANG su-hai jin Sheng State Key Laboratory of Coastal and Offshore Engineering Dalian University of Technology Dalian 116024China Key Laboratory of Engineering Sediment of Ministry of Communications Tianjin Research Institute for WaterTransport Engineering Tianjin 300456 China

In this article,the anaglyph video maker is employed for generating realistic 3-D flows and the software FlowAnimator is developed using that *** on Microsoft Windows Presentation Foundation（WPF）,the real 3-D scene is set up and marker particles are distributed in it randomly in order to create a more natural flow *** trajectory of the particle motion is calculated with Lagrangian description in 3-D *** the simulation,the viewport can be changed in order to focus on different parts of the model by panning,zooming,rotating and inclination variation *** particles may appear in different shapes：spheres,tracking-balls,cylinders and ribbons in order to fit different *** is the first time that the video anaglyph technology is employed in the 3-D hydrodynamic simulation,which removes the obstacles for 3-D scenes to be rendered on a flat-panel display.

关键词： 3-D simulation flow simulation anaglyph stereoscopy Windows Presentation Foundation(WPF)

Review on Tidal Energy Technologies and Research subjects

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China Ocean Engineering 2020年第1期34卷 137-150页

作者： Chul Hee JO su jin HWANG Department of Naval Architecture and Ocean Engineering Inha University

Tidal current power is one of the promising and reliable renewable energies with the advantage of continuous and predictable resource. It can make stable electricity regardless of weather conditions or seasons all year around. The required technologies for tidal current power in the ocean have been developed for years and now recognized that it could be commercialized after intensive field tests and successful demonstrations. There are several tidal farm development projects in the world, such as the MeyGen project in UK with its commercialization at hand. However, various research subjects in the tidal current energy field are seeking improvements and industrialization of tidal current power in terms of economy and technical reliability. This paper introduces the resource assessment procedure of tidal energy that has been applied in Korea coastal regions. The key research subjects for tidal current power together with the interaction effect of multi-arrangement is described. Also, this paper is to introduce the research output of each subject such as turbine design, experimental validation, turbine interaction and wake, multi-array module, FSI (fluid-structure interaction), and duct application.

关键词： tidal current power resource assessment turbine design experimental validation turbine interaction multi arrangement FSI(fluid-structure interaction)

Effects of thinning on the understory light environment of different stands and the photosynthetic performance and growth of the reforestation species Phoebe bournei

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Journal of Forestry Research 2024年第1期35卷 12-28页

作者： Shicheng su Nianqing jin Xiaoli Wei College of Forestry Guizhou UniversityGuiyang 550025People’s Republic of China Institute for Forest Resources and Environment of Guizhou Guizhou UniversityGuiyang 550025People’s Republic of China

Light levels determine regeneration in stands and a key concern is how to regulate the light environment of different stand types to the requirements of the *** this study,we selected three stands typical in south China(a Cryptomeria japonica plantation,a Quercus acutissima plantation,and a mixed stand of both)and three thinning intensities to determine the best understory light environ-ment for 3-year-old Phoebe bournei *** canopy structure,understory light environment,and photosynthe-sis and growth indicators were assessed following *** improved canopy structure and understory light availability of each stand;species composition was the reason for differences in the understory light *** the same thinning intensity,the mixed stand had the greatest light radiation and most balanced spectral *** photosynthesis and growth were closely related to the light environment;all three stands required heavy thinning to create an effective and sustained understory light *** a suitable understory light environment,the efficiency of light interception,absorption,and use by seedlings was enhanced,resulting in a higher carbon assimilation the main limiting factor was stomatal *** a shade-avoidance signal,red/far-red radia-tion is a critical factor driving changes in photosynthesis and growth of *** seedlings,and a reduction increased light absorption and use capacity and height:diameter *** growth advantage transformed from diameter to height,enabling seedlings to access more *** findings suggest that the regeneration of shade-tolerant species such as *** could be enhanced if a targeted approach to thinning based on stand type was adopted.

关键词： Thinning Understory light environment Phoebe bournei Photosynthetic performance Growth performance

PPP models and performances from single-to quad-frequency BDS observations

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Satellite Navigation 2020年第1期1卷 179-191页

作者： Shuanggen jin Ke su Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China School of Remote Sensing and Geomatics Engineering Nanjing University of Information Science and TechnologyNanjing 210044China Jiangsu Engineering Center for Collaborative Navigation/Positioning and Smart Applications Nanjing 210044China University of Chinese Academy of Sciences Beijing 100049China

Nowadays,China BeiDou Navigation Satellite System(BDS)has been developed well and provided global services with highly precise positioning,navigation and timing(PNT)as well as unique short-message communication,particularly global system(BDS-3)with higher precision multi-frequency *** precise point positioning(PPP)can provide the precise position,receiver clock,and zenith tropospheric delay(ZTD)with a stand-alone receiver compared to the traditional double differenced relative positioning mode,which has been widely used in PNT,geodesy,meteorology and so ***,it has a lot of challenges for multi-frequency BDS PPP with different strategies and more unknown *** this paper,the detailed PPP models using the single-,dual-,triple-,and quad-frequency BDS observations are presented and ***,BDS system and PPP method are ***,the stochastic models of time delay bias in BDS-2/BDS-3 PPP including the neglection,random constant,random walk and white noise are ***,three single-frequency,four dual-frequency,four triple-frequency and four quad-frequency BDS PPP models are ***,the BDS PPP models progress and performances including theoretical comparison of the models,positioning performances,precise time and frequency transfer,ZTD,inter-frequency bias(IFB)and differential code bias(DCB)are presented and evaluated as well as future *** results show that the multi-frequency BDS observations will greatly improve the PPP performances.

关键词： BDS GNSS PPP IFB ZTD DCB