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C-terminal tensin-like (CTEN) knockin alleviates cystic kidney defects in Tensin-1 knockout mice

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Genes & Diseases 2023年第3期10卷 643-646页

作者： Chun-Lung Chiu Shiao-Ya Hong Ying Tan Yuh-Ru Julie Lee Yi-Ping Shih Clifford GTepper su hao lo Department of Biochemistry and Molecular Medicine University of California-DavisSacramentoCA 95817USA Department of Plant Biology University of California-DavisDavisCA 95616USA

Tensin-1(TNS1)is a 220 kD focal adhesion protein that binds to actin filaments,integrin receptors,small GTPases,tyrosine-phosphorylated proteins,and lipids.1 These binding activities enable TNS1 to link the actin cytoskeleton to integrins and transduce outside-in and inside-out signals at focal adhesion sites,thereby regulating cell attachment,migration,proliferation,and mechanical sensing.1 Lack of TNS1 in kidney epithelial cells results in multiple lumen,instead of single lumen,phenotypes in the three-dimensional(3D)culture.

关键词： kidney Tensin thereby

Numerical Simulation for the Optimization of Polygonal Pin Profiles in Friction Stir Welding of Aluminum

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Acta Metallurgica Sinica(English Letters) 2021年第8期34卷 1065-1078页

作者： hao su Chuansong Wu MOE Key Lab for Liquid-Solid Structure Evolution and Materials Processing Institute of Materials JoiningShandong UniversityJinan 250061China

The tool with polygonal pin profile has been widely employed in friction stir welding(FSW) of aluminum, but there is hardly an effective optimization methodology existed as the thermomechanical characteristics affected by pins with various flats number have not been understood comprehensively. Therefore, the present work employs a 3-dimensional computational fluid dynamics(CFD) model to have an integrated observation of the FSW process with the effect of polygonal pin profiles. Both the heat generation modes due to contact friction at the tool–workpiece interface and volumetric viscous dissipation in the vicinity of the tool are considered. The model is utilized to give a quantitative analysis of the heat generation, temperature distribution, plastic material flow and welding loads during the FSW process for various tools with polygonal pin profiles, as well as a variety of shoulder diameters, welding speeds and tool rotation speeds. The calculated results of thermal cycles, tool torques and joint cross sections for some typical polygonal pins and welding parameters are all found to be compared well with the experimental ones, which demonstrates the feasibility and applicability of the present numerical model. Particularly, a methodology is developed for the optimization of the flats number by identifying the torque components in both parallel and vertical direction of the pin-side flat region. The results show that the optimized pin flats number increases with increasing tool rotation speed, while the influence of both welding speed and shoulder diameter can be supposed to be insignificant. Moreover, the dependability of the optimized results is also discussed by considering wear tendency and service life of the pin for multiple welding conditions.

关键词： Friction stir welding Polygonal pin Numerical simulation Optimization design Aluminum

Path A∞ algebras of positively graded quivers

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Frontiers of Mathematics in China 2018年第1期13卷 173-185页

作者： hao su School of Mathematical Sciences University of Science and Technology of ChinaHefei 230026 China

Let A be a path A∞-algebra over a positively graded quiver Q. We prove that the derived category of A is triangulated equivalent to the derived category of kQ, which is viewed as a DG algebra with trivial differentia... 详细信息

关键词： A∞-algebras Koszul dual DG-algebras

Probabilistic modeling of scenes using object frames

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Science China(Information Sciences) 2015年第3期58卷 119-131页

作者： su hao YU AdamsWei School of Mathematics Beihang University Department of Computer Science Stanford University Language Technologies Institute Carnegie Mellon University

In this paper,we propose a probabilistic scene model using object frames,each of which is a group of co-occurring objects with fixed spatial *** contrast to standard co-occurrence models,which mostly explore the pairwise co-existence of objects,the proposed model captures the spatial relationship among groups of *** information is closely tied to the semantics of the underlying scenes,which allows us to perform object detection and scene recognition in a unified *** proposed probabilistic model has two major *** first models the dependencies between object frames and objects by adopting the Latent Dirichlet Allocation model for text *** second component characterizes the dependencies between object frames and scenes by establishing a mapping between global image features and object frame *** results show that the induced object frames are both semantically meaningful and spatially *** addition,our model significantly improves the performance of object recognition and scene retrieval.

关键词： Bayes network scene understanding object frame probabilistic model

Bullous pemphigoid associated with acquired hemophilia A: A case report

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World Journal of Clinical Cases 2025年第4期13卷 28-33页

作者： su-Ye Hu Meng-Can Li Zi-Jia hao Xu-Ya Chai Pei-Sai Li Yang Liu Li-Xia Liu Ying Xu Pan-Pan Yang Ling-E Li Department of Dermatology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina Graduate School Hebei University of Traditional Chinese MedicineShijiazhuang 050051Hebei ProvinceChina Department of Pathology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Acquired hemophilia A (AHA) is a rare and potentially severe bleeding disordercaused by circulating autoantibodies against factor Ⅷ (FⅧ). In approximately50% of the patients, the condition is associated with autoimmune diseases,cancers, medication use, pregnancy, and the post-partum period. Bullous pemphigoid(BP) is a chronic autoimmune subepidermal blistering disease associatedwith tissue-bound and circulating autoantibodies against BP antigens 180 (BP180)and 230 (BP230). AHA-associated BP has a high mortality rate;hence, the understandingof this disease must *** suMMARY A 69-year-old man presented with erythema, blisters, blood blisters, and crustsaccompanied by severe pruritus for more than 20 days, and ecchymosis andswelling on his left upper arm for 3 days. Pathological examination revealed asubepidermal blister that contained eosinophils. Laboratory tests showed that theBP180 autoantibody levels had increased, isolated activated partial thromboplastintime was notably prolonged (115.6 s), and coagulation FⅧ activity wasextremely low (lometasone cream, and transferred to a higher-level hospitalfor effective treatment;however, he died after 2 *** AHA associated BP is rare, dangerous, and has a high mortality rate. Therefore, its timely diagnosis and effectivetreatment are necessary.

关键词： Bullous pemphigoid Acquired hemophilia A Acquired hemophilia A FactorⅧ Case report

Numerical simulation for the comparison of thermal and plastic material flow behavior between symmetrical and asymmetrical boundary conditions during friction stir welding

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Advances in Manufacturing 2023年第1期11卷 143-157页

作者： hao su Chuan-Song Wu MOE Key Lab for Liquid-Solid Structure Evolution and Materials Processing Institute of Materials JoiningShandong UniversityJinan250061People’s Republic of China

An accurate description of the contact condition between the tool and the workpiece material is one of the most important issues for expounding the underlying multi-physics coupled mechanism during friction stir welding(FSW)*** the present study,a novel asymmetrical boundary condition around the tool-workpiece contact interface is proposed for the FSW of AA2024-T4 alloy.A three-dimensional computational fluid dynamics model is employed for the comparison of the coupled thermal and plastic material flow behavior between asymmetrical and symmetrical boundary *** results of heat generation,temperature distribution,tunnel defect formation and material flow streamline during the welding process are quantitatively ***,various experimental measuring methods are utilized to obtain information about temperature,thermal cycle,tool torque and horizontal cross-section around the exiting *** is revealed that the modeling results of heat flux density and temperature distribution around the pin,as well as material flow characteristics all change significantly for the two models with different boundary ***,the asymmetrical boundary condition is more capable of predicting temperature fluctuation,plastic material flow along the vertical direction,as well as tunnel defect formation during ***,the superiority of the model with asymmetrical boundary condition over the symmetrical one during the numerical simulation of FSW is elucidated.

关键词： Friction stir welding(FSW) Numerical simulation Heat generation Plastic material flow Asymmetrical boundary condition

Single 5-nm quantum dot detection via microtoroid optical resonator photothermal microscopy

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Light(Science & Applications) 2024年第10期13卷 2145-2155页

作者： Shuang hao Sartanee suebka Judith su Wyant College of Optical Sciences University of ArizonaTucsonAZ 85721USA Wyant College of Optical Sciences and Department of Biomedical Engineering University of ArizonaTucsonAZ 85721USA

Label-free detection techniques for single particles and molecules play an important role in basic science,disease diagnostics,and nanomaterial *** fluorescence-based methods are tools for single molecule detection and imaging,they are limited by available molecular probes and photoblinking and *** microscopy has emerged as a label-free imaging technique capable of detecting individual nanoabsorbers with high *** gallery mode(WGM)microresonators can confine light in a small volume for enhanced light-matter interaction and thus are a promising ultra-sensitive photothermal microscopy ***,microtoroid optical resonators were combined with photothermal microscopy to detect 250 nm iong gold nanorods and 100 nm long ***,we combine microtoroids with photothermal microscopy to spatially detect single 5 nm diameter quantum dots(QDs)with a signal-to-noise ratio exceeding 10*.Photothermal images were generated by point-by-point scanning of the pump *** particle detection was confrmed for 18 nm QDs by high sensitivity fluorescence imaging and for 5 nm QDs via comparison with *** system demonstrates the capability to detect a minimum heat dissipation of o.75 *** achieve this,we integrated our microtoroid based photothermal microscopy setup with a low amplitude modulated pump laser and utilized the proportional-integral-derivative controller output as the photothermal signal source to reduce noise and enhance signal *** heat dissipation of these QDs is below that from single dye *** anticipate that our work will have application in a wide variety of fields,including the biological sciences,nanotechnology,materials science,chemistry and medicine.

关键词： pump resonator quantum

H_(∞)/Passive Synchronization of Semi-Markov Jump Neural Networks subject to Hybrid Attacks via an Activation Function Division Approach

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Journal of Systems Science & Complexity 2024年第3期37卷 1023-1036页

作者： ZHANG Ziwei SHEN hao su Lei School of Electrical and Information Engineering Anhui University of TechnologyMa'anshan 243002China Anhui Province Key Laboratory of Special Heavy load Robot and School of Electrical and Information Engineering Anhui University of TechnologyMa'anshan243002China

In this work,an H_(∞)/passive-based secure synchronization control problem is investigated for continuous-time semi-Markov neural networks subject to hybrid attacks,in which hybrid attacks are the combinations of denial-of-service attacks and deception attacks,and they are described by two groups of independent Bernoulli *** this foundation,via the Lyapunov stability theory and linear matrix inequality technology,the H_(∞)/passive-based performance criteria for semi-Markov jump neural networks are ***,an activation function division approach for neural networks is adopted to further reduce the conservatism of the ***,a simulation example is provided to verify the validity and feasibility of the proposed method.

关键词： Activation function division approach deception attacks denial-of-service attacks H_(∞)/passive synchronization semi-Markov jump neural networks

Excitation Current and Vibration Characteristics of DC Biased Transformer

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CSEE Journal of Power and Energy Systems 2021年第3期7卷 604-613页

作者： Chao Pan Chengjian Wang hao su Key Laboratory of Modem Power System Simulation and Control&Renewable Energy Technology Ministry of Education(Northeast Electric Power University)Jilin 132012China

In practical engineering,DC disturbance will lead to excitation saturation and vibration intensification on transformer core,as well as affecting the normal operation of equipment and power *** to the problem,a new idea is proposed in this *** on the electromagnetic characteristics of DC biased transformer,excitation saturation and core vibration are studied by using excitation-vibration harmonic response analysis *** current is identified through electromagnetic coupling to characterize the excitation saturation ***,vibration harmonic response model is established to analyze core *** characteristics of DC biased Y/△transformer are *** variation of excitation current and core vibration at different DC levels are ***-vibration characteristics of three-phase group transformer and three-phase three-limb transformer are compared and *** experimental platform built,the correctness of simulation results is verified by experimental data,and the effectiveness of the proposed method can be proved.

关键词： DC disturbance excitation-vibration harmonic response Y/△transformer