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Orbital-Ordering Driven Simultaneous Tunability of Magnetism and Electric Polarization in Strained Monolayer VCl_(3)

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Chinese Physics Letters 2024年第4期41卷 126-131页

作者：郭的坪王聪王侣锦陆赟豪吴骅张妍宁季威 Beijing Key Laboratory of Optoelectronic Functional Materials&Micro-Nano Devices Department of PhysicsRenmin University of ChinaBeijing 100872China Key Laboratory of Quantum State Construction and Manipulation(Ministry of Education) Renmin University of ChinaBeijing 100872China Zhejiang Province Key Laboratory of Quantum Technology and Device State Key Laboratory of Silicon MaterialsDepartment of PhysicsZhejiang UniversityHangzhou 310027China Laboratory for Computational Physical Sciences(MOE) State Key Laboratory of Surface Physicsand Department of PhysicsFudan UniversityShanghai 200433China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China

Two-dimensional(2D)van der Waals magnetic materials have promising and versatile electronic and magnetic properties in the 2D limit,indicating a considerable potential to advance spintronic *** predictions thus far have not ascertained whether monolayer VCl_(3) is a ferromagnetic(FM)or anti-FM monolayer;this also remains to be experimentally *** theoretically investigate the influence of potential factors,including C_(3) symmetry breaking,orbital ordering,epitaxial strain,and charge doping,on the magnetic ground *** first-principles calculations,we predict a collinear type-Ⅲ FM ground state in monolayer VCl_(3) with a broken C_(3) symmetry,wherein only the former two of three t_(2g)orbitals(a_(1g),e_(g2)^(π)and e_(g1)^(π))are *** atomic layer thickness and bond angles of monolayer VCl_(3) undergo abrupt changes driven by an orbital ordering switch,resulting in concomitant structural and magnetic phase *** doping to the underlying Cl atoms of monolayer VCl_(3) without C_(3) symmetry simultaneously induces in-and out-of-plane *** can achieve a multiferroic phase transition if combined with the discovered adjustments of magnetic ground state and polarization magnitude under *** establishment of an orbital-ordering driven regulatory mechanism can facilitate deeper exploration and comprehension of magnetic properties of strongly correlated systems in monolayer VCl_(3).

关键词： monolayer symmetry orbital

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环洞庭湖土壤抗生素抗性基因分布和潜在风险

中国环境科学 2024年第3期44卷 1575-1583页

作者：武晨黄凤莲刘新刚范青青陆海楠李启武郭倩李莹彭勇春李峰湘潭大学环境与资源学院湖南湘潭411105 长沙环境保护职业技术学院湖南长沙410004 国家环境保护城市土壤污染控制与修复工程技术中心上海市环境科学研究院上海200233 环境生态健康湖南省普通高校重点实验室湖南湘潭411105 湖南省长沙生态环境监测中心湖南长沙410001 湖南省生态环境监测中心湖南长沙410027 湖南省湘西生态环境监测中心湖南吉首416000 国家环境保护重金属污染监测重点实验室湖南长沙410014

本研究通过实时荧光定量PCR和基于Monte Carlo模拟的概率健康风险评估模型,分析了环洞庭湖流域52个表层土壤点位中8类典型抗生素抗性基因(ARGs,16种ARGs亚型)的分布特征和潜在健康风险.结果表明,环洞庭湖流域周边表层土壤中ARGs总丰度... 详细信息

本研究通过实时荧光定量PCR和基于Monte Carlo模拟的概率健康风险评估模型,分析了环洞庭湖流域52个表层土壤点位中8类典型抗生素抗性基因(ARGs,16种ARGs亚型)的分布特征和潜在健康风险.结果表明,环洞庭湖流域周边表层土壤中ARGs总丰度范围为3.29×10^(7)~3.73×109copies/g,远高于土壤ARGs背景值(1.80×10^(5)~1.35×10^(7)copies/g,平均值为3.03×106copies/g).南洞庭湖流域表层土壤中ARGs丰度高于东、西洞庭湖流域.磺胺类、四环素类和氨基糖苷类ARGs是高丰度的ARGs类型,平均丰度分别为1.51×10^(8)、1.50×10^(7)和2.64×10^(7)copies/g,主要ARGs亚型是sul1和dfrA14,均属于磺胺类ARGs.I类整合子基因(intl1)的平均丰度为6.94×10^(8)copies/g,高于总ARGs平均丰度.相关性分析表明intl1丰度与dfrA14、tetR和kan基因丰度呈显著正相关(P<0.05),表明intl1通过水平基因转移促进了研究区域表层土壤中ARGs的传播.Monte Carlo模拟表明,研究区域存在64.92%~98.68%概率的ARGs人体暴露剂量高于风险背景值(成人12.56copies/(g·d),儿童38.11copies/(g·d)),表明研究区域土壤ARGs造成的潜在健康风险不可忽视,皮肤接触是ARGs主要暴露途径,磺胺类ARGs是潜在健康风险的主要来源.

关键词：环洞庭湖土壤抗生素抗性基因分布特征潜在风险

Protease inhibitor in scorpion (Mesobuthus eupeus) venom prolongs the biological activities of the crude venom

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Chinese Journal of Natural Medicines 2016年第8期14卷 607-614页

作者： Hakim MA Tang Xiao-peng ,YANG Shi-Long lu Qiu-Min LAI Ren Key Laboratory of Animal Models and Human Disease Mechanisms Kunming Institute of Zoology Chinese Academy of sciences Kunming 650223 China Graduate University of Chinese Academy of Sciences Beijing 100009 China Joint Laboratory of Natural peptide University of Science and Technology of China and Kunming Institute of Zoology Chinese Academy of Sciences Kunming 650223 China

It is hypothesized that protease inhibitors play an essential role in survival of venomous animals through protecting peptide/protein toxins from degradation by proteases in their prey or predators. However, the biological function of protease inhibitors in scorpion venoms remains unknown. In the present study, a trypsin inhibitor was purified and characterized from the venom of scorpion Mesobuthus eupeus, which enhanced the biological activities of crude venom components in mice when injected in combination with crude venom. This protease inhibitor, named Me KTT-1, belonged to Kunitz-type toxins subfamily. Native Me KTT-1 selectively inhibited trypsin with a K_i value of 130 nmol×L^(–1). Furthermore, Me KTT-1 was shown to be a thermo-stable peptide. In animal behavioral tests, Me KTT-1 prolonged the pain behavior induced by scorpion crude venom, suggesting that protease inhibitors in scorpion venom inhibited proteases and protect the functionally important peptide/protein toxins from degradation, consequently keeping them active longer. In conclusion, this was the first experimental evidence about the natural existence of serine protease inhibitor in the venom of scorpion Mesobuthus eupeus, which preserved the activity of venom components, suggests that scorpions may use protease inhibitors for survival.

关键词： Scorpion Mesobuthus eupeus Venom Protease inhibitor Me KTT-1

Calculus bovis inhibits M2 tumor-associated macrophage polarization via Wnt/β-catenin pathway modulation to suppress liver cancer

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World Journal of Gastroenterology 2024年第29期30卷 3511-3533页

作者： Zhen Huang Fan-Ying Meng Lin-Zhu lu Qian-Qian Guo Chang-Jun Lv Nian-Hua Tan Zhe Deng Jun-Yi Chen Zi-Shu Zhang Bo Zou Hong-Ping Long Qing Zhou Sha Tian Si Mei Xue-Fei Tian College of Integrated Chinese and Western Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Hunan Key Laboratory of Translational Research in Formulas and Zheng of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Key Laboratory of Traditional Chinese Medicine for Mechanism of Tumor Prevention and Treatment Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina The First Clinical College of Traditional Chinese Medicine Hunan University of Traditional Chinese MedicineChangsha 410007Hunan ProvinceChina Department of Hepatology Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina The First Hospital of Hunan University of Chinese Medicine Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina Faculty of Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina

BACKGROUND Calculus bovis(CB),used in traditional Chinese medicine,exhibits anti-tumor effects in various cancer *** also constitutes an integral component of a compound formulation known as Pien Tze Huang,which is indicated for the treatment of liver ***,its impact on the liver cancer tumor microenvironment,particularly on tumor-associated macrophages(TAMs),is not well *** To elucidate the anti-liver cancer effect of CB by inhibiting M2-TAM polarization via Wnt/β-catenin pathway *** This study identified the active components of CB using UPLC-Q-TOF-MS,evaluated its anti-neoplastic effects in a nude mouse model,and elucidated the underlying mechanisms via network pharmacology,transcriptomics,and molecular *** vitro assays were used to investigate the effects of CB-containing serum on HepG2 cells and M2-TAMs,and Wnt pathway modulation was validated by real-time reverse transcriptase-polymerase chain reaction and Western blot *** This study identified 22 active components in CB,11 of which were detected in the *** investigations have demonstrated the ability of CB to effectively inhibit liver tumor *** integrated approach employing network pharmacology,transcriptomics,and molecular docking implicated the Wnt signaling pathway as a target of the antineoplastic activity of CB by suppressing M2-TAM *** vitro and in vivo experiments further confirmed that CB significantly hinders M2-TAM polarization and suppresses Wnt/β-catenin pathway *** inhibitory effect of CB on M2-TAMs was reversed when treated with the Wnt agonist SKL2001,confirming its pathway *** This study demonstrated that CB mediates inhibition of M2-TAM polarization through the Wnt/β-catenin pathway,contributing to the suppression of liver cancer growth.

关键词： Calculus bovis M2 tumor-associated macrophage polarization Liver cancer Wnt/β-catenin pathway Tumor microenvironment

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老旧社区包容性设计的理论逻辑及实施路径

北京社会科学 2024年第9期 72-85页

作者：刘晨澍吕莉东华大学服装与艺术设计学院

老旧社区改造面临着来自城市快速变迁的综合挑战，除基础设施老化、环境恶化等问题外，多样化的人群需求与当地文化的融合也是一个突出的问题。包容性设计中“以人为本”的原则可以用来尝试解决上述困境。通过归纳老旧社区的包容性案例... 详细信息

老旧社区改造面临着来自城市快速变迁的综合挑战，除基础设施老化、环境恶化等问题外，多样化的人群需求与当地文化的融合也是一个突出的问题。包容性设计中“以人为本”的原则可以用来尝试解决上述困境。通过归纳老旧社区的包容性案例、政策及专家访谈文本，运用扎根理论方法分析发现，包容性的老旧社区立足人群认同、物理设施适宜、社会服务完善等七个关键要素。其中，物理环境适宜和维持经济平衡为物质条件，社会服务完善和机会平等为服务条件，人群认同和文化共存则为情感条件。三种条件以创建信任联结的管理条件为纽带，构建起“物质包容，社会包容，情感包容”三重包容性社区的呈现层级。在此基础上，从设计视角介入，结合利益相关者及组织架构，构建弹性组织网络的路径，以确保包容性设计实践中的连续性。

关键词：老旧社区包容性设计扎根理论社区更新

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区域绿色创新能力的驱动模式及其内在机制:基于绿色创新生态系统视角

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改革 2024年第4期 93-107页

作者：李璐张怀英吉首大学学报编辑部吉首大学商学院

以中国30个省份为研究样本,采用组态思维和模糊集定性比较分析方法,基于绿色创新生态系统视角,探讨环境、资源、主体对区域绿色创新能力的联动效应以及互动匹配模式所蕴含的运行机制。研究发现:绿色创新主体是促进区域高水平绿色创新能... 详细信息

以中国30个省份为研究样本,采用组态思维和模糊集定性比较分析方法,基于绿色创新生态系统视角,探讨环境、资源、主体对区域绿色创新能力的联动效应以及互动匹配模式所蕴含的运行机制。研究发现:绿色创新主体是促进区域高水平绿色创新能力提升的必要条件;区域高绿色创新能力的背后逻辑是由多重因素并发且协同匹配形成的多种不同路径,主要包括政府支持下的主体双轮驱动型、金融环境缺失下的技术主体弥补型、环境规制下的产学研促进型三种驱动模式。促进区域绿色创新均衡化稳步发展,应持续推进企业主体、市场导向、政府支持的绿色创新体系建设,大力培育以绿色技术、绿色项目、绿色产业为目标的政产研学战略联盟,加大绿色创新体制机制的精准化创设和协同化推进力度。

关键词：绿色创新绿色创新生态系统驱动模式联动效应

Numerical analysis on mechanical difference of sandstone under in-situ stress,pore pressure preserved environment at depth

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International Journal of Mining Science and Technology 2023年第11期33卷 1339-1350页

作者： Hongwei Zhou Mingyuan lu Heping Xie Wenhao Jia Ruidong peng Yimeng Wang Bocen Chen pengfei Jing School of Energy and Mining Engineering China University of Mining and Technology-BeijingBeijing 100083China State Key Laboratory of Coal Resources and Safe Mining China University of Mining and Technology-BeijingBeijing 100083China State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource and HydropowerSichuan UniversityChengdu 610065China Guangdong Provincial Key Laboratory of Deep Earth Sciences and Geothermal Energy Exploitation and Utilization Institute of Deep Earth Sciences and Green EnergyCollege of Civil and Transportation EngineeringShenzhen UniversityShenzhen 518060China Shenzhen Key Laboratory of Deep Underground Engineering Sciences and Green Energy Shenzhen UniversityShenzhen 518060China School of Mechanics and Civil Engineering China University of Mining and Technology-BeijingBeijing 100083China

Deep in-situ rock mechanics considers the influence of the in-situ environment on mechanical properties,differentiating it from traditional rock *** investigate the effect of in-situ stress,pore pressure preserved environment on the mechanical difference of sandstone,four tests are numerically modeled by COMSOL:conventional triaxial test,conventional pore pressure test,in-situ stress restoration and reconstruction test,and in-situ pore pressure-preserved test(not yet realized in the laboratory).The in-situ stress restoration parameter is introduced to characterize the recovery effect of in-situ stress on elastic modulus and heterogeneous distribution of sandstone at different depths.A random function and nonuniform pore pressure coefficient are employed to describe the non-uniform distribution of pore pressure in the in-situ *** results are compared with existing experimental data to validate the models and calibrate the numerical *** extracting mechanical parameters from numerical cores,the stress-strain curves of the four tests under different depths,in-situ stress and pore pressure are *** influence of non-uniform pore pressure coefficient and depth on the peak strength of sandstone is *** results show a strong linear relationship between the in-situ stress restoration parameter and depth,effectively characterizing the enhanced effect of stress restoration and reconstruction methods on the elastic modulus of conventional cores at different *** in-situ pore pressurepreserved test exhibits lower peak stress and peak strain compared to the other three tests,and sandstone subjected to non-uniform pore pressure is more prone to plastic damage and ***,the influence of non-uniform pore pressure on peak strength gradually diminished with increasing depth.

关键词： In-situ pore pressure-preserved environment Numerical simulation approach Deep in-situ rock mechanics In-situ stress restoration and reconstruction

Characteristic Investigation of Nano-Crystal Hydrogen Storage Alloys

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Journal of Rare Earths 2004年第Z1期22卷 232-234页

作者： Xiao Fangming Huang Lili Tang Renheng lu Qiyun peng Neng Wang Ying Rare Earth Materials Research Center Guangzhou Research Institute of Nonferrous Metals Guangzhou 510651 China

A Ml (NiCoMnA1)5 hydrogen storage alloys was prepared by double-roller rapid *** microstructure, electrochemically and kinetic characteristic were studied.A uniform crystal phase with CaCu5 structure could be detected by XRD analyses, whose average grain size is 30 ~ 50 nm and the ratio of c/a of nano-crystal hydrogen storage alloy is *** hydrogen absorption/desertion p - C isotherms of alloy show that its fiat-performance is perfect and the magnetic stagnant effect is very *** simulate cell is used for electrochemical *** is 10C, the capacity decreasing rate via the 450 cycles at 7C is less than 20%.

关键词： nano-crystal hydrogen storage alloys electrochemically characteristic

Melting Temperature of Individual Electrospun Poly(vinylidene fluoride) Fibers Studied by AFM-based Local Thermal Analysis

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Chinese Journal of Polymer Science 2021年第2期39卷 219-227,I0007页

作者： Ze-Qian Wang Zhen-Xing Zhong Yu-Ying Ma Xiao-Feng lu Ce Wang Zhao-Hui su State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China University of Science and Technology of China Hefei 230026China Alan G.MacDiarmid Institute Jilin UniversityChangchun 130012China

Thermal properties such as melting temperature can well reflect the microstructure of the polymer material, and have practical implications in the application of nanofibers. In this work, we investigated the melting temperature of individual electrospun poly(vinylidene fluoride)(PVDF) nanofibers with diameters ranging from smaller than 200 nm to greater than 2 μm by the local thermal analysis technique. The PVDF fibers obtained under four different conditions were found to crystallize into α and β phases, and the fiber mats showed typical values in the crystallinity and Tm with no significant difference among the four. However, analyses at single fiber level revealed broad distribution in diameter and Tm for the fibers produced under identical electrospinning condition. The Tm of individual nanofibers was found to remain constant at large diameters and increase quickly when reducing the fiber diameter toward the nanoscale, and Tm values of 220-230 ℃ were observed for the thinnest nanofibers, much higher than the typical values reported for bulk PVDF. The Tm and molecular orientation at different positions along a beaded fiber were analyzed, showing a similar distribution pattern with a minimum at the bead center and higher values when moving toward both directions. The results indicate that molecular orientation is the driving mechanism for the observed correlation between the Tm and the diameter of the nanofibers.

关键词： Electrospun fibers PVDF Local thermal analysis Melting temperature