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Estimation of quality of life in Cypriot patients with inflammatory bowel disease

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World Journal of Gastroenterology 2017年第1期23卷 121-126页

作者： Maria Tsoukka Eleni Jelastopulu Giagkos Lavranos George charalambous Postgraduate Program Health Management Frederick UniversityNicosiaCyprus University General Hospital of Larnaca Department of Public Health School of MedicineUniversity of Patras Department of Health Sciences School of SciencesEuropean University General Hospital of Athens“Hippocratio”

AIM To investigate the health-related quality of life(HRQoL)of patients suffering with idiopathic inflammatory bowel disease(IBD).METHODS The Greek validated version of the Short Inflammatory Bowel Disease Questionnaire was used for evaluating the quality of life of IBD *** questionnaire was distributed to 100 consecutive patients suffering from IBD and presenting for a clinic appointment at the endoscopy unit of Larnaca General Hospital during the period from October to November *** criteria for participating in this study were constituted by the documented diagnosis of either ulcerative colitis(UC)or Crohn’s disease(CD)after endoscopy and histologic examination at least 6 months before the study,adult patients(18 years old or older),the capability of verbal communication and the patient’s written consent for attending this *** majority of the questionnaires were completed by a nurse practitioner who specializesin IBD patient *** Regarding the physical dimension in patients with UC,males scored significantly higher than females(4.2 vs3.4,P=0.023).Higher scores were also observed in UC patients younger than 35 or older than 50 years(4.0 and 4.2 vs 3.2,respectively,P=0.021).The psychological dimension revealed similar results in patients with UC,with males,and older ages scoring higher(5.0 vs 3.0,P=0.01 and 4.7 vs 2.7,P<0.5,respectively),whereas regarding CD higher scores were observed in married compared to unmarried(3.83vs 2.33,P=0.042).No statistical differences in any parameters in the social dimension were *** the treatment of,patients with CD,overall higher scores were observed when treated with biological factors compared to standard therapy in all dimensions but with statistical significant difference in the social dimension(5.00 vs 3.25,P=0.045).CONCLUSION The study reveals a negative impact of IBD on HRQo *** risks are age and gender in patients with UC and family status in patients with CD.

关键词： Crohn’ s 疾病生活的健康相关质量生活的质量短煽动性的肠疾病问询表 Ulcerative 大肠炎

The effects of artificial surface temperature on mechanical properties and player kinematics during landing and acceleration

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Journal of Sport and Health Science 2016年第3期5卷 355-360页

作者： Laura charalambous Hans Christian von Lieres und Wilkau Wolfgang Potthast Gareth Irwin Department of Sport Science and Physical Activity University of Bedfordshire Cardiff School of Sport Cardiff Metropolitan University Institute of Biomechanics and Orthopaedics German Sport University Cologne

Background: Artificial turf is considered a feasible global alternative to natural turf by many sports governing bodies. Consequently, its ability to provide a safe and consistent playing surface regardless of climate becomes essential. The aims of this study were to determine the effects of artificial surface temperature on:(1) mechanical properties of the turf and(2) the kinematics of a turf-sport related ***: Two identical artificial turf pitches were tested: one with a cold surface temperature(1.8°C–2.4°C) and one with a warm surface temperature(14.5°C–15.2°C). Mechanical testing was performed to measure the surface properties. Four amateur soccer players performed a hurdle jump to sprint acceleration movement, with data(contact time, step length and hip, knee and ankle kinematics) collected using CODASport(200 Hz).Results: The temperature difference had a significant influence on the mechanical properties of the artificial turf, including force absorption,energy restitution, rotational resistance, and the height where the head injury criterion was met. Both step length(p = 0.008) and contact time(p = 0.002) of the initial step after the landing were significantly longer on the warm surface. In addition, significant range of motion and joint angular velocity differences were ***: These findings highlight different demands placed on players due to the surface temperature and suggest a need for coaches,practitioners, and sports governing bodies to be aware of these differences.

关键词： Artificial turf Biomechanics Rugby Soccer Temperature

Stochastic Modeling and Power Control of Time-Varying Wireless Communication Networks

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Communications and Network 2014年第3期6卷 155-164页

作者： Mohammed M. Olama Seddik M. Djouadi Charalambos D. charalambous Computational Sciences and Engineering Division Oak Ridge National Laboratory Oak Ridge USA Department of Electrical and Computer Engineering University of Cyprus Nicosia Cyprus Department of Electrical Engineering and Computer Science University of Tennessee Knoxville USA

Wireless networks are characterized by nodes mobility, which makes the propagation environment time-varying and subject to fading. As a consequence, the statistical characteristics of the received signal vary continuously, giving rise to a Doppler power spectral density (DPSD) that varies from one observation instant to the next. This paper is concerned with dynamical modeling of time-varying wireless fading channels, their estimation and parameter identification, and optimal power control from received signal measurement data. The wireless channel is characterized using a stochastic state-space form and derived by approximating the time-varying DPSD of the channel. The expected maximization and Kalman filter are employed to recursively identify and estimate the channel parameters and states, respectively, from online received signal strength measured data. Moreover, we investigate a centralized optimal power control algorithm based on predictable strategies and employing the estimated channel parameters and states. The proposed models together with the estimation and power control algorithms are tested using experimental measurement data and the results are presented.

关键词： Wireless Networks Time-Varying Wireless Fading Channel Impulse Response Doppler Power Spectral Density Stochastic State-Space Model Stochastic Modeling Optimal Power Control Expectation Maximization Kalman Filter

Bioengineering bacterial encapsulin nanocompartments as targeted drug delivery system

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Synthetic and Systems Biotechnology 2021年第3期6卷 231-241页

作者： Alexander Van de Steen Rana Khalife Noelle Colant Hasan Mustafa Khan Matas Deveikis Saverio charalambous Clare M.Robinson Rupali Dabas Sofia Esteban Serna Diana A.Catana Konstantin Pildish Vladimir Kalinovskiy Kenth Gustafsson Stefanie Frank Department of Biochemical Engineering University College LondonUK Natural Sciences University College LondonUK Division of Biosciences University College LondonUK UCL iGEM Student Team 2019 UK

The development of Drug Delivery Systems(DDS)has led to increasingly efficient therapies for the treatment and detection of various *** use a range of nanoscale delivery platforms produced from polymeric of inorganic materials,such as micelles,and metal and polymeric nanoparticles,but their variant chemical composition make alterations to their size,shape,or structures inherently *** encoded protein nanocages are highly promising DDS candidates because of their modular composition,ease of recombinant production in a range of hosts,control over assembly and loading of cargo molecules and *** example of naturally occurring nanocompartments are encapsulins,recently discovered bacterial organelles that have been shown to be reprogrammable as nanobioreactors and vaccine *** we report the design and application of a targeted DDS platform based on the Thermotoga maritima encapsulin reprogrammed to display an antibody mimic protein called Designed Ankyrin repeat protein(DARPin)on the outer surface and to encapsulate a cytotoxic *** DARPin9.29 chosen in this study specifically binds to human epidermal growth factor receptor 2(HER2)on breast cancer cells,as demonstrated in an in vitro cell culture *** encapsulin-based DDS is assembled in one step in vivo by co-expressing the encapsulin-DARPin9.29 fusion protein with an engineered flavin-binding protein mini-singlet oxygen generator(MiniSOG),from a single plasmid in Escherichia *** encapsulin-DARPin_miniSOG nanocompartments bind specifically to HER2 positive breast cancer cells and trigger apoptosis,indicating that the system is functional and *** DDS is modular and has the potential to form the basis of a multi-receptor targeted system by utilising the DARPin screening libraries,allowing use of new DARPins of known specificities,and through the proven flexibility of the encapsulin cargo loading mechanism,allowing selection of cargo proteins

关键词： Encapsulin Drug delivery system Cytotoxic protein DARPin

Stochastic Control Over Finite Capacity Channels: Causality,Feedback and Uncertainty

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Stochastic Control Over Finite Capacity Channels: Causality,...

Joint 48th IEEE Conference on Decision and Control and 28th Chinese Control Conference

作者： Charalambos D.charalambous Christos K.Kourtellaris Photios Stavrou Department of Electrical Engineering University of Cyprus

Optimal communication/control analysis and design of dynamical controlled systems,when there are finite capacity communication constraints often involve information and control theoretic *** paper,employees information theoretic concepts to develop a mathematical framework for analysis and design of optimal communication/control system subject to uncertainty,causality and *** theory is developed by generalizing the classical information theoretic theorems of Shannon to their robust *** conditions for stability and reconstruction of uncertain control signals over uncertain channels are presented via the causal rate distortion function for a family of sources and channel capacity for a family of ***,in view of the complexity of the causal rate distortion function,a tight lower bound is introduced which applies to families of ***,using a generalized version of the information transmission theorem and the lower bound on the rate distortion function,the connection between stabilizabilty and reconstruction is related to capacity for a class of channels.

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来源： cnki会议评论

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逆向工程，打造了不起的签名

黑客防线 2010年第2期 133-139页

作者： Nicolaou George charalambous Glafkos hackicer（译）

很多的反病毒和反间谍软件可以通过唯一的签名确定怀有恶意的程序。这些签名存储在一个不断更新的数据库里。本文可以指导你通过一系列的步骤来加密可执行文件的代码段．目的就是使那些反病毒文件的签名确认技术不能有效的确认这些恶意... 详细信息

很多的反病毒和反间谍软件可以通过唯一的签名确定怀有恶意的程序。这些签名存储在一个不断更新的数据库里。本文可以指导你通过一系列的步骤来加密可执行文件的代码段．目的就是使那些反病毒文件的签名确认技术不能有效的确认这些恶意代码。

关键词：破解数字签名反病毒

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一种评价结核病治疗方案抗菌活性的新方法

国际结核病与肺部疾病杂志 2003年第4期 150-154页

作者： S.H.Gillespie B.M.charalambous 张本 Department of Medical Microbiology University College London London United Kingdom

目的:快速评价抗结核化疗临床反应。方法:应用指数衰减模型对以前发表的关于标准方案与含异烟肼、利福平和环丙沙星方案临床试验的痰活菌计数进行重新评价。将研究结果拟合单相或双相指数衰减模型。采用单相指数衰减模型描述活菌计数衰... 详细信息

目的:快速评价抗结核化疗临床反应。方法:应用指数衰减模型对以前发表的关于标准方案与含异烟肼、利福平和环丙沙星方案临床试验的痰活菌计数进行重新评价。将研究结果拟合单相或双相指数衰减模型。采用单相指数衰减模型描述活菌计数衰减曲线。根据这些数据计算出活菌数减少50％所用的时间(vt_(50)),以评价化疗方案的杀菌效果。结果和结论:研究结果表明本方法可用于早期鉴定由于耐药或免疫应答低下对治疗反应不积极的病人,并可比较临床试验中抗结核方案的效果。双相指数衰减曲线的拟合失败提示,或者痰标本中不含有只有灭菌活性药物才能起作用的细菌,或者是这种细菌数量少对活菌总数难以形成重要影响。需要进一步研究以了解痰标本中的细菌生理状态。

关键词：数学模型药物作用临床试验

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塞浦路斯劳动人民进步党选举成功析论

当代世界社会主义问题 2009年第4期 50-71页

作者：吉.哈拉兰博斯张文成英国曼彻斯特大学政府系中央编译局

尽管马列主义在欧洲大陆有各种各样的表现形式，但它是塞浦路斯劳动人民进步党（AKEL）和其他所有西欧共产党的意识形态包袱。这些党自认为是先锋队，肩负着实现所有生产资料国有化及建立社会主义社会的使命。除了个别值得注意的例外（... 详细信息

尽管马列主义在欧洲大陆有各种各样的表现形式，但它是塞浦路斯劳动人民进步党（AKEL）和其他所有西欧共产党的意识形态包袱。这些党自认为是先锋队，肩负着实现所有生产资料国有化及建立社会主义社会的使命。除了个别值得注意的例外（例如20世纪70年代的意大利共产党和主张欧洲共产主义的其他党），

关键词：劳动人民塞浦路斯进步党选举社会主义社会马列主义意识形态生产资料