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Efficacy and safety of the long-acting fusion inhibitor albuvirtide in antiretroviral-experienced adults with human immunodeficiency virus-1:interim analysis of the randomized,controlled,phase 3,non-inferiority TALENT study

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Chinese Medical Journal 2020年第24期133卷 2919-2927页

作者： Bin Su Cheng Yao Qing-Xia Zhao Wei-Ping Cai Min Wang Hong-Zhou Lu Yuan-Yuan Chen Li Liu Hui Wang Yun He Yu-Huang Zheng Ling-Hua Li Jin-Feng Chen Jian-Hua Yu Biao Zhu Min Zhao Yong-Tao Sun Wen-Hui Lun Wei Xia Li-Jun Sun Li-Li Dai Tai-Yi Jiang Mei-Xia Wang Qing-Shan Zheng Hai-Yan Peng Yao Wang Rong-Jian Lu Jian-Hua Hu Hui Xing Yi-Ming Shao Dong Xie Tong Zhang Fu-Jie Zhang Hao Wu TALENT study team Center for Infectious Diseases Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Frontier Biotechnologies Inc. NanjingJiangsu 211122China Department of Infectious Diseases Infectious Disease Hospital of Henan ProvinceZhengzhouHenan 450061China Infectious Disease Center Guangzhou Eighth People’s HospitalGuangzhou Medical UniversityGuangzhouGuangdong 510060China Institute of HIV/AIDS The First Hospital of ChangshaChangshaHunan 410005China Department of Infectious Diseases Shanghai Public Health Clinical CenterFudan UniversityShanghai 201508China Department of Infectious Diseases National Clinical Center for Infectious DiseasesShenzhen Third People’s HospitalShenzhenGuangdong 518112China Department of Infectious Diseases The Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China Department of Infectious Diseases Xixi Hospital of HangzhouHangzhouZhejiang 310023China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesThe First Affiliated HospitalZhejiang UniversityHangzhouZhejiang 310003China National Clinical Research Center for Infectious Diseases the Fifth Medical Center of PLA General HospitalBeijing 100039China Department of Infectious Diseases Tangdu HospitalThe Fourth Military Medical UniversityXi’anShaanxi 710038China Clinical and Research Center of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Center for Drug Clinical Research Shanghai University of Traditional Chinese MedicineShanghai 201203China Beijing Co-CRO Medical Development Co. Ltd.Beijing 100711China State Key Laboratory for Infectious Disease Prevention and Control National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China 不详

Background:Albuvirtide is a once-weekly injectable human immunodeficiency virus(HIV)-1 fusion *** present interim data for a phase 3 trial assessing the safety and efficacy of albuvirtide plus lopinavir-ritonavir in HIV-1-infected adults already treated with antiretroviral ***:We carried out a 48-week,randomized,controlled,open-label non-inferiority trial at 12 sites in *** on the World Health Organization(WHO)-recommended first-line treatment for>6 months with a plasma viral load>1000 copies/mL were enrolled and randomly assigned(1:1)to receive albuvirtide(once weekly)plus ritonavir-boosted lopinavir(ABT group)or the WHO-recommended second-line treatment(NRTI group).The primary endpoint was the proportion of patients with a plasma viral load below 50 copies/mL at 48 ***-inferiority was prespecified with a margin of 12%.Results:At the time of analysis,week 24 data were available for 83 and 92 patients,and week 48 data were available for 46 and 50 patients in the albuvirtide and NRTI groups,*** 48 weeks,80.4%of patients in the ABT group and 66.0%of those in the NRTI group had HIV-1 RNA levels below 50 copies/mL,meeting the criteria for *** the per-protocol population,the superiority of albuvirtide over NRTI was *** frequency of grade 3 to 4 adverse events was similar in the two groups;the most common adverse events were diarrhea,upper respiratory tract infections,and grade 3 to 4 increases in triglyceride *** function was significantly more impaired at 12 weeks in the patients of the NRTI group who received tenofovir disoproxil fumarate than in those of the ABT ***:The TALENT study is the first phase 3 trial of an injectable long-acting HIV *** interim analysis indicates that once-weekly albuvirtide in combination with ritonavir-boosted lopinavir is well tolerated and non-inferior to the WHO-recommended second-line regimen in patients with first-line treatme

关键词： HIV Fusion inhibitor Albuvirtide LPV/r Phase 3 clinical trial

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大学生网络借贷的失范与法律规制实证研究

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贵州师范学院学报 2017年第7期33卷 31-36页

作者：云南大学法学院“挑战杯”培育课题项目组肖艺邓剑星云南大学法学院云南昆明650091

大学生网络借贷是具有门槛低、贷款利率高、坏账率高等特点的新型民间借贷。大学生特殊的消费心理、经济状况和生活环境,促使其成为网络借贷的主力军。由于网络借贷缺乏具体法律规制,其对大学生存在诸多风险。但其吸收了民间借贷的长处... 详细信息

大学生网络借贷是具有门槛低、贷款利率高、坏账率高等特点的新型民间借贷。大学生特殊的消费心理、经济状况和生活环境,促使其成为网络借贷的主力军。由于网络借贷缺乏具体法律规制,其对大学生存在诸多风险。但其吸收了民间借贷的长处,弥补了传统金融机构的缺陷,为其发展提供了必要性条件。为了使网络借贷健康发展,应从大学生和网贷平台两方面进行规制和引导,净化其发展环境。

关键词：大学生网络借贷网贷平台

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住院分娩早产儿呼吸窘迫综合征：中国13家医院的回顾性调查

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中华围产医学杂志 2016年第10期19卷 743-754页

作者：中国城市多中心早产儿呼吸窘迫综合征调查协作组中国城市多中心早产儿呼吸窘迫综合征调查协作组

目的了解我国住院分娩早产儿呼吸窘迫综合征（respiratory distress syndrome，RDS）的发病率、病死率、并发症特点和发病高危因素，以及产前应用地塞米松对早产儿RDS的发病率及预后的影响。方法收集国内13家医院2013年1月1日至12月31... 详细信息

目的了解我国住院分娩早产儿呼吸窘迫综合征（respiratory distress syndrome，RDS）的发病率、病死率、并发症特点和发病高危因素，以及产前应用地塞米松对早产儿RDS的发病率及预后的影响。方法收集国内13家医院2013年1月1日至12月31日住院分娩的、胎龄≥24-〈37周的全部早产儿。分析这些早产儿的一般情况、围产期因素、主要并发症发生情况和死亡情况等。根据是否发生RDS，将研究对象分为RDS组和非RDS组；根据产前是否应用地塞米松，又将研究对象分为地塞米松组和非地塞米松组，分别分析RDS发病率、病死率、主要并发症、发病高危因素及产前应用地塞米松的效果。采用两独立样本t检验、单因素方差分析、秩和检验、χ^2检验或Fisher精确概率法以及二项分布检验对数据进行统计学分析。多因素分析时，采用Logistic回归分析。结果（1）研究期间，活产新生儿共62 880例，其中早产儿6 017例，早产儿发生率为9.6%。6 017例早产儿平均胎龄为（34.4±2.2）周，平均出生体重为（2 258.3±584.5）g。其中≥28-〈32周的极早产儿747例（12.4%），〈28周的超早产儿56例（0.9%）。（2）6 017例早产儿中，969例（16.1%）发生RDS。早产儿胎龄越小，RDS发病率越高（χ^2=1 532.619，P=0.000）。RDS早产儿病死率为6.4%（62/969），高于非RDS早产儿的0.4%（22/5 048），差异有统计学意义（χ^2=209.957，P=0.000）。早产儿出生体重越低，RDS发病率越高（χ^2=882.979，P=0.000）。出生体重≥1 000 g的早产儿中，RDS早产儿的病死率明显高于非RDS早产儿（P值均〈0.05）。（3）6 017例早产儿中，入院早产儿4 409例（73.3%）。未入院早产儿1 608例，其中胎龄≥32-〈37周者1 424例（88.6%）。入院患儿中，RDS患儿主要并发症发病率明显高于非RDS早产儿（P值均〈0.01）。（4）Logistic回归分析显示，男性、胎龄〈33周、出生体重〈2 500 g、身长〈40 cm、新生儿窒息、孕母产前发热是早产儿RDS发病的危险因素。在胎龄〈33周的早产儿中，男性、胎龄〈28周、身长〈40 cm、新生儿窒息和产次≥2次是RDS发病的高危因素，产前应用地塞米松是保护因素；在胎龄≥33周的早产儿中，身长〈40 cm、胎次≥2次、新生儿窒息、剖宫产、胎盘早剥、前置胎盘、母体外周血白细胞计数≥10×109/L是RDS发病的高危因素，辅助生殖技术妊娠为保护因素。（5）6 017例早产儿中，共2 606例（43.3%）应用了地塞米松；其中，在803例胎龄〈32周早产儿中，共438例（54.5%）应用了地塞米松。胎龄≥29-〈33周时，应用地塞米松的早产儿的RDS发病率均低于相应胎龄未应用者（P值均〈0.05）。住院治疗的862例RDS患儿中，应用地塞米松者共414例，其生后1和5 min的Apgar评分≤7分的比例均低于未用地塞米松者（共448例）；应用地塞米松者剖宫产、母亲妊娠期糖尿病、前置胎盘和妊娠期高血压疾病的比例均高于未用地塞米松者（P值均〈0.05）。胎龄〈33周时，应用地塞米松的早产儿的RDS发病率、重度RDS发病率、需要使用2剂以上肺表面活性物质的比例低于未应用地塞米松者；总住院时间、总吸氧时间长于未应用地塞米松组者。胎龄≥33周的早产儿中，应用地塞米松者的RDS发病率高于未应用地塞米松者，总住院时间长于未应用地塞米松者（P值均〈0.05）。结论本研究早产儿发生率与既往报道大致相同，存活率明显提高。RDS患儿病死率及并发症发生率较高。胎龄〈33周的早产儿RDS发病高危因素多为自身因素，产前地塞米松能有效减少RDS的发病率，并可改善预后；胎龄≥33周的早产儿RDS发病高危因素则多为围产期病理因素，产前地塞米松预防RDS作用不明显。

关键词：呼吸窘迫综合征新生儿婴儿早产发病率回顾性研究

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Results obtained by geodetic instruments of SELENE (KAGUYA)

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Science China(Physics,Mechanics & Astronomy) 2010年第12期53卷 2188-2193页

作者： KAWANO Nobuyuki VRAD/RSAT team LALT team Shanghai Astronomical Observatory

Japanese lunar explorer SELENE (KAGUYA) was equipped with 14 instruments for various measurements of the Moon. Three of these instruments took geodetic measurements of the Moon. These were two sub-satellites and a laser altimeter. The main results obtained by the instruments are: (1) precise orbit determination with an accuracy of ten meters by Doppler and same-beam VLBI; (2) the first precise gravity fields on the lunar far side by 4-way Doppler measurements; (3) the first topography in latitudes higher than 86 degrees; (4) a global map of the gravity anomaly by using the global topography and the global gravity fields; (5) a global map of the lunar crustal thickness and (6) an illumination rate map in the north and south polar regions.

关键词： SELENE gravity field lunar far side topography gravity anomaly crustal thickness illumination rate

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Sawtooth Control Experiments on HT-7 and EAST Tokamak

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Plasma Science and Technology 2012年第4期14卷 278-284页

作者：刘子奚高翔揭银先丁伯江杨曜 HT-7 team EAST team Institute of Plasma Physics Chinese Academy of Sciences

Sawtooth control experiments were performed on HT-7 with a limiter configuration and on the Experimental Advanced Superconducting Tokamak （EAST） with a double null con- figuration. The sawtooth period can be modified by lower hybrid wave （LHW） and ion cyclotron resonance frequency （ICRF）. Different sawtooth behavior was observed with the same plasma density, LHW power but different plasma currents on HT-7. There was a dwell time between LHW added and the sawtooth stabilization on HT-7 while the sawtooth stabilization immediately happened when LHW power was injected on EAST. The possible mechanism of the sawtooth control is discussed in this paper. All the experimental results have proved that power deposition of the radio frequency （RF） should be the key factor for sawtooth control.

关键词： LHW ICRF sawtooth control

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Energy Confinement of both Ohmic and LHW Plasma on EAST

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Plasma Science and Technology 2011年第3期13卷 312-315页

作者：杨曜高翔 EAST team Institute of Plasma Physics Chinese Academy of Sciences Hefei 230031 China

study on the characters of energy confinement in both Ohmic and lower hybrid wave （LHW） discharges on EAST is conducted and the linear Ohmic confinement （LOC）, saturated ohmic confinement （SOC） and improved Ohmic confinement （IOC） regimes are investigated in this paper. It is observed that an improved confinement mode characterized by both a drop of IDa line intensity and an increase in line average density can be triggered by a gas puffing pulse.

关键词： energy confinement LHW plasma Ohmic heating EAST

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Development of Powerful RF Plasma Sources for Present and Future NBI Systems

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Plasma Science and Technology 2004年第1期6卷 2135-2140页

作者： E.Speth NBI-team Max-Planck-Institut fiir Plasmaphysik 85748 Garching Germany EURATOM-AssociationMax-Planck-Institut fiir Plasmaphysik 85748 Garching Germany EURATOM-Association

This paper deals with the topic of RF plasma sources and their application inhigh-power neutral beam heating systems for nuclear fusion devices. RF sources represent aninteresting alternative to the conventional arc discharge sources. Due to the absence of hotfilaments they exhibit an inherent simplicity both in mechanical and electrical aspects andconsequently offer advantages in terms of cost savings, gain in availability and reliability andreduced maintenance. This renders the RF plasma source attractive for any long pulse (> 10 sec) NBIsystem and in particular for the ITER NBI system. The latter, however, requires that the RF plasmasource is also capable of delivering negative rather than positive hydrogen ions. In the first partof the paper the types, characteristics and operation experience of RF plasma sources for positiveions in operation are described. The second part is devoted to the development for ITER NBI: thebasic requirements, physics and technology issues and the present status are discussed.

关键词： neutral beam injection negative ions RF plasma source

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Results and Future Plan of JT-60U towards Steady-State Tokamak Reactor

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Plasma Science and Technology 2004年第1期6卷 2151-2158页

作者： S.Sakurai the JT-60 team Japan Atomic Energy Research Institute Naka Ibaraki 311-0193 JapanJapan Atomic Energy Research Institute Naka Ibaraki 311-0193 Japan

Recent results of JT-60U towards establishment of physics basis for ITER andadvanced tokamak operation are presented. Progress in high integrated performance is achieved withimprovement of N-NB and ECRF heating systems. In the next experimental campaign 2003～2004,discharge duration with 17 MW heating will be extended up to 30s for sustaining high-beta plasmalonger than the current diffusion time. Superconducting modification of JT-60 is planned todemonstrate high-beta plasma sustainment exceeding ideal MHD instability limit without wallstabilization.

关键词： JT-60U confinement study steady-state operation high confinement plasma plan and future plan

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Error field penetration in J-TEXT tokamak based on two-fluid drift-MHD model

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Chinese Physics B 2024年第4期33卷 545-551页

作者：王文徐涛张仪 the J-TEXT team State Key Laboratory of Advanced Electromagnetic Technology International Joint Research Laboratory of Magnetic Confinement Fusion and Plasma PhysicsSchool of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074China

An externally generated resonant magnetic perturbation can induce complex non-ideal MHD responses in their resonant *** have studied the plasma responses using Fitzpatrick's improved two-fluid model and program *** calculated the error field penetration threshold for *** addition,we find that the island width increases slightly as the error field amplitude increases when the error field amplitude is below the critical penetration ***,the island width suddenly jumps to a large value because the shielding effect of the plasma against the error field disappears after the *** scanning the natural mode frequency,we find that the shielding effect of the plasma decreases as the natural mode frequency ***,we obtain the m/n=2/1 penetration threshold scaling on density and temperature.

关键词： plasma responses drift-MHD model error field penetration

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SST-1 Refurbishment Progress: an Update

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Plasma Science and Technology 2013年第2期15卷 137-141页

作者： Subrata PRADHAN SST-1 Mission team Institute for Plasma Research Bhat Gandhinagar-382 428 India

Refurbishment of steady state tokamak （SST-1） primarily focused at addressing the issues and bottle-necks involving various subsystems of SST-1 as observed during earlier commis- sioning attempts, have progressed significantly. Under the refurbishment spectrum, all joints in the superconducting magnet system have been re-fabricated as low DC leak tight joint resistances, all toroidal field （TF） magnets have been equipped with 5 K radiation shields on the inner side and successfully tested for their rated parameters in cold under nominal currents, all vessel sectors and modules have been baked and tested under representative conditions, supporting helium and ni- trogen cryogenic facilities have been made 〉 99% reliable in various envisaged operating scenarios of SST-1. The reassemblies of the critical subsystems of the SST-1 machine shell have progressed aggressively and are nearing completion. Auxiliaries such as the baking facility for the vacuum vessel and first wall components, current leads assembly distributions, synchronized timing sys- tem, reliable data acquisition and plasma control systems as well as essential diagnostics have also been readied towards the first plasma. A detailed engineering validation of the assembled SST-1 machine shell including field error measurements has been planned prior to first plasma attempts.

关键词： cryogenic system field error magnet system SST-1 vacuum system

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