检索结果-南通市图书馆

Ambient Ozone Exposure, Semen Plasma Metabolites, and Sperm Quality Decline among Adult Men in Wuhan China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Environment & Health 2024年第10期2卷 729-738页

作者： Yangchang Zhang Shi Zhao Wangnan Cao TREE study team Shengzhi Sun Qiang Zeng Peng Luo School of Public Health Capital Medical UniversityBeijing 100069P.R.China School of Public Health Tianjin Medical UniversityTianjin 300070P.R.China Tianjin Key Laboratory of Environment Nutrition and Public HealthTianjin Medical UniversityTianjin 300070P.R.China Department of Social Medicine and Health Education School of Public HealthPeking UniversityBeijing 100191P.R.China 不详 School of Public Health and Beijing Municipal Key Laboratory of Clinical Epidemiology Capital Medical UniversityBeijing 100069P.R.China Department of Occupational and Environmental Health School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074P.R.China Key Laboratory of Environment and Health Ministry of Education&Ministry of Environmental ProtectionState Key Laboratory of Environmental Health(incubating)School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074 HubeiP.R.China School of Public Health The Key Laboratory of Environmental Pollution Monitoring and Disease ControlMinistry of EducationGuizhou Medical UniversityGuiyang 550025P.R.China

Ambient ozone(O3)exposure may be associated with a reduction of semen quality,yet the potential biological mechanisms remain *** investigated the effects of certain seminal plasma metabolites on mediating the links between O3 exposure and the deterioration of semen *** untargeted metabolomics analysis was performed on semen samples of 200 Chinese adult men to determine candidate metabolites associated with characteristics of semen *** analysis was adopted to examine whether these metabolites modulated the links between O3 exposure and semen *** found a significant reduction in sperm concentration by−28.1%(95%CI:−41.7%,−11.3%),and sperm count by−29.2%(95%CI:−43.7%,−11.0%)associated with each 10μg/m3 increase in ambient O3 concentration during the period of sperm *** delineated 7 metabolites in seminal fluid that substantially mediated the links between O3 exposure and declined semen quality,including myristoleic acid,aspartyl-isoleucine,phenylethyl primeveroside,ACar(18:2),ACar(18:1),FAHFA(22:6/22:3),and LPS(22:5).Among these,myristoleic acid exhibited the most pronounced mediation effects,with its indirect effect of which accounts for 46.4%of the overall *** findings suggested that exposure to ozone decreased sperm quality by disrupting fatty acid metabolism,particularly myristoleic acid.

关键词： ozone exposure sperm quality adult men metabolomics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

改革水电前期工作经费筹措及管理办法的研究

水力发电 1995年第9期22卷 1-6页

作者： (Project study team, China Electric Power Enterprise Association)

从计划经济沿袭下来的水电前期经费投入与产出分离的两条线运行机制，已严重影响水电前期工作的开展，从而制约了水电建设的发展。因此，水电前期工作的改革，首先要解决经费严重不足的问题。水电前期工作经费筹措办法的改革，要明确责... 详细信息

从计划经济沿袭下来的水电前期经费投入与产出分离的两条线运行机制，已严重影响水电前期工作的开展，从而制约了水电建设的发展。因此，水电前期工作的改革，首先要解决经费严重不足的问题。水电前期工作经费筹措办法的改革，要明确责任者，要实行勘测设计成果商品化，走资源勘探与开发一体化的路子，建立和完善资金管理的制度。

关键词：水电建设经费筹措管理

Developing Whole-Process People’s Democracy and Ensuring the People Run the Country

在线全文

学校读者我要写书评

暂无评论

Qiu Shi 2023年第4期15卷 62-69页

作者： Core Theoretical study team of the CPC Leadership Group for the Working Bodies of the National People's Congress Standing Committee Core Theoretical study team of the CPC Leadership Group for the Working Bodies of the National People's Congress Standing Committee

Since the 18th National Congress of the Communist Party of China (CPC) held in 2012, President Xi Jinping has comprehensively reviewed achievements and experiences in building China’s socialist democracy, deepened understanding of the laws governing the development of democracy, and put forward a key concept of whole-process people’s democracy. This concept has further enriched Marxist democratic theory and represents a historic achievement and landmark in the development of democracy in China in the new era.

关键词： Whole comprehensive Communist

The efficacy and safety of pramipexole ER versus IR in Chinese patients with Parkinson’s disease: a randomized, double-blind, double-dummy, parallel-group study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Translational Neurodegeneration 2014年第1期3卷 80-88页

作者： Ying Wang Shenggang Sun Suiqiang Zhu Chunfeng Liu Yiming Liu Qing Di Huifang Shang Yan Ren Changhong Lu Mark Forrest Gordon Nolwenn Juhel Shengdi Chen for the Pramipexole ER study team Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine ShanghaiChina Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology WuhanChina Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology WuhanChina The Second Affiliated Hospital of Soochow University SuzhouChina Qilu Hospital affiliated to Shandong University JinanChina Nanjing Brain Hospital NanjingChina West China Hospital affiliated to Sichuan University ChengduChina First Affiliated Hospital of China Medical University ShenyangChina Boehringer Ingelheim International Trading(Shanghai)Co LtdShanghaiChina Boehringer Ingelheim Pharmaceuticals IncRidgefieldCTUSA Boehringer Ingelheim France S.A.S ReimsFrance Department of Neurology Ruijin Hospital affiliated to Shanghai Jiaotong University School of MedicineShanghaiChina 不详

Objective:To evaluate the non-inferiority of pramipexole extended-release(ER)versus immediate-release(IR)in Chinese patients with Parkinson’s disease(PD)in a double-blind,randomized,parallel-group ***:Subjects were Chinese patients with idiopathic PD with diagnosis≥2 years prior to trial,age≥30 years old at diagnosis,and Modified Hoehn and Yahr score 2-4 during‘on’-*** received treatment with pramipexole ER(n=234)or IR(n=239).Non-inferiority was based on the primary endpoint,the change from baseline to end of maintenance(week 18)in the UPDRS(Parts II+III)total ***:For the primary endpoint,the adjusted mean changes(standard error)of UPDRS Parts II+III at week 18 were−13.81(0.655)and−13.05(0.643)for ER and IR formulations,respectively,using ANCOVA adjusted for treatment and centre(fixed effect)and baseline(covariate).The adjusted mean between group difference was 0.8 for the 2-sided 95%CI(−1.047,2.566).Since the lower limit of the 2-sided 95%CI(−1.047)for treatment difference was higher than the non-inferiority margin of−4,non-inferiority between pramipexole ER and IR was *** incidence of adverse events(AEs)was 68.8%in the ER arm and 73.6%in the IR arm with few severe AEs(ER:2.1%;IR:3.8%).Conclusion:Based on the UPDRS II+III score,pramipexole ER was non-inferior to pramipexole *** safety profiles of pramipexole ER and IR were *** results were based on comparable mean daily doses and durations of treatment for both formulations.

关键词： Parkinson’s disease Pramipexole ER Pramipexole IR Non-inferiority Unified Parkinson’s Disease Rating Scale(UPDRS) Safety

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

乡镇集体企业产权制度改革的基本思路

洛阳理工学院学报（社会科学版） 1998年第3期13卷 16-18页

作者： study team (Department of Economic Management)

就乡镇集体企业产权制度改革过程中遇到的难点，即思想认识的非一致性、资产评估与股权设置。

关键词：乡镇集体企业产权制度改革难点思路

在线全文

学校读者我要写书评

暂无评论

我国农村现行组织制度运行障碍及理论设计

河北职业技术学院学报 2006年第1期6卷 72-74页

作者：刘莉河北职业技术学院河北廊坊065000

由于我国农村经济体制改革和农村经济的发展,村集体经济组织企业化程度不断加深,不发达地区的农村组织形式要逐渐转换为发达地区农村的组织形式。本文在分析我国农村现行组织制度运行障碍的基础上,进一步探讨我国农村治理基本方式的选... 详细信息

由于我国农村经济体制改革和农村经济的发展,村集体经济组织企业化程度不断加深,不发达地区的农村组织形式要逐渐转换为发达地区农村的组织形式。本文在分析我国农村现行组织制度运行障碍的基础上,进一步探讨我国农村治理基本方式的选择和农村组织制度理论设计的基本原则。

关键词：村级组织制度运行障碍理论设计

在线全文

学校读者我要写书评

暂无评论

目前我国农民思想状况的分析

洛阳理工学院学报（社会科学版） 1998年第3期13卷 23-25页

作者： study team (Luoyang Inst of Technology,Luoyang University)

我国农民经过近２０年的改革开放，对文化价值的评价与现实的矛盾，对农村发展的信心与个人能力之间的矛盾、对村领导人评价的心态矛盾等正在经过分化和消融，从而使现代化思想观念日益增强。

关键词：农民现代思想观念基层民主制度建设

Prevalence of Autism Spectrum Disorder in China:A Nationwide Multi-center Population-based study Among Children Aged 6 to 12 Years

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2020年第9期36卷 961-971页

作者： Hao Zhou Xiu Xu Weili Yan Xiaobing Zou Lijie Wu Xuerong Luo Tingyu Li Yi Huang Hongyan Guan Xiang Chen Meng Mao Kun Xia Lan Zhang Erzhen Li Xiaoling Ge Lili Zhang Chunpei Li Xudong Zhang Yuanfeng Zhou Ding Ding Andy Shih Eric Fombonne Yi Zheng Jisheng Han Zhongsheng Sun Yong-hui Jiang Yi Wang LATENT-NHC study team Department of Neurology Children’s Hospital of Fudan UniversityShanghai 201102China Child Health Care Children’s Hospital of Fudan UniversityShanghai 201102China Department of Clinical Epidemiology Children’s Hospital of Fudan UniversityShanghai 201102China Child Development Behavior Center The Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510630China Department of Children and Adolescent Health School of Public HealthHarbin Medical UniversityHarbin 150081China Department of Psychiatry The Second Xiangya Hospital of Central South UniversityChangsha 410011China Child Health Care Children’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Psychiatry West China Hospital of Sichuan UniversityChengdu 610041China Capital Institute of Pediatrics Beijing 100020China The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University Wenzhou 325027China Child Health Care Chengdu Women and Children’s HospitalChengdu 610091China Center for Medical Genetics School of Life SciencesCentral South UniversityChangsha 410013China Children’s Hospital of Fudan University Shanghai 201102China Huashan Hospital of Fudan University Shanghai 200040China Autism Speaks 1 East 33rd StreetNew YorkNY 10016USA Oregon Health and Science University PortlandOR 97239USA Beijing Anding Hospital Capital Medical UniversityBeijing 10008&China Neuroscience Research Institute Peking UniversityBeijing 100191China Beijing Institutes of Life Science Chinese Academy of SciencesBeijing 100021China Department of Genetics and Pediatrics Yale School of MedicineNew HavenCT 06520USA

This study aimed to obtain the first national estimate of the prevalence of autism spectrum disorder(ASD) in Chinese *** targeted the population of 6 to 12-year-old children for this prevalence study by multistage convenient cluster *** Modified Chinese Autism Spectrum Rating Scale was used for the screening *** the target population of 142,086 children,88.5%(n=125,806) participated in the study.A total of 363 children were confirmed as having *** observed ASD prevalence rate was 0.29%(95% CI:0.26%-0.32%) for the overall *** adjustment for response rates,the estimated number of ASD cases was867 in the target population sample,thereby achieving an estimated prevalence of 0.70%(95% CI:0.64%-0.74%).The prevalence was significantly higher in boys than in girls(0.95%;95% CI:0.87%-1.02% versus 0.30%;95%CI:0.26%-0.34%;P <0.001).Of the 363 confirmed ASD cases,43.3% were newly diagnosed,and most of those(90.4%) were attending regular schools,and 68.8% of the children with ASD had at least one neuropsychiatric *** findings provide reliable data on the estimated ASD prevalence and comorbidities in Chinese children.

关键词： Autism spectrum disorder Prevalence Comorbidity Autism Spectrum Rating Scale China

在线全文

学校读者我要写书评

暂无评论

上海交通高职集团化办学初探

中国职业技术教育 2007年第11期23卷 25-27页

作者：课题组陈嵩鲍贤俊吴国伟上海交通职业技术学院上海200032 不详上海市教科院职成教研究所

本文以上海交通高职集团化办学的发展为例，从高职教育管理体制创新研究这一视角，在分析集团化办学主要特点的基础上，总结了集团化办学的成效和体会。

关键词：交通高职集团化办学管理体制