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A SPE-HPLC-MS/MS method for the simultaneous determination of pr ior itised pharmaceuticals and EDCs with high environmental risk potential in freshwater

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Journal of Environmental Sciences 2021年第2期33卷 18-27页

作者： Yuan Li MarkATaggart Craig McKenzie Zulin Zhang Yonglong Lu Sabolc Pap stuart wgibb Environmental Research Institute North Highland CollegeUniversity of the Highlands and IslandsCastle StreetThursoCaithnessScotlandKW147JDUK Forensic Drug Research Group Centre for Anatomy and Human IdentificationSchool of Science and EngineeringUK Environm ental and Biochem ical Sciences Group Ja m es Hutton InstituteCraigiebucklerA berdeen AB158QHUK Research Centre for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China University of Novi Sad Faculty of Technical SciencesDepartment of Environmental Engineering and Occupational Safety and H ealthUniversity of Novi Sad21000 NoviSadSerbia 不详

This work describes the development,optimisation and validation of an analytical method for the rapid determination of 17 priority pharmaceutical compounds and endocrine disrupting chemicals(EDCs).Rather than studying compounds from the same therapeutic class,the analyses aimed to determine target compounds with the highest risk potential(with particular regard to Scotland),providing a tool for further monitoring in different water matrices.Prioritisation was based on a systematic environmental risk assessment approach,using consumption data;wastewater treatment removal efficiency;environmental occurrence;toxicological effects;and pre-existing regulatory indicators.This process highlighted 17 compounds across various therapeutic classes,which were then quantified,at environmentally relevant concentrations,by a single analytical methodology.Analytical determination was achieved using a single-step solid phase extraction(SPE)procedure followed by high-performance liquid chromatography with tandem mass spectrometry(HPLC-MS/MS).The fully optimised method performed well for the majority of target compounds,with recoveries>71%for 15 of 17 analytes.The limits of quantification for most target analytes(14 of 17)ranged from 0.07 ng/L to 1.88 ng/L in river waters.The utility of this method was then demonstrated using real water samples associated with a rural hospital/setting.Eight compounds were targeted and detected,with the highest levels found for the analgesic,paracetamol(at up to 105,910 ng/L in the hospital discharge).This method offers a robust tool to monitor high priority pharmaceutical and EDC levels in various aqueous sample matrices.

关键词： Pharmaceuticals prioritisation Risk assessment trace level determination Water quality

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