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Corneal Wavefront Aberrations in Patients Wearing Multifocal Soft Contact Lenses for Myopia Control

Open Journal of Ophthalmology 2012年第3期2卷 45-53页

作者： Frank Spors Donald J. Egan Jie Shen Lance E. McNaughton stuart mann Neil M. Patel College of Optometry Pomona CA Western University of Health Sciences Pomona CA

Purpose: The purpose of this study was to evaluate the change in corneal wavefront aberrations in young adults who have been fit with multifocal soft contact lenses for myopia progression control. Findings have been analyzed for statistical significance and clinical relevance and compared to reportedly successful Orthokeratology outcomes. Methods: The dominant eye of 40 participants (27 women, 13 men;mean age 27.3 ± 3.2 years;range 23 to 39 years) was fit with Proclear Multifocal center distance lenses (Coopervision, Pleasanton, USA) having a variety of distance powers and reading additions. Refractive errors were limited to a range of –6.00 D up to +1.00 D of sphere, and no greater than –1.00 D of cylinder. Corneal wavefront measurements were performed over 6 mm diameters with a Zeiss Atlas 9000 corneal topographer (Zeiss Meditec, Dublin, USA) prior to, and following lens fitting. Data were converted into rectangular Fourier optics terms M, J0, J45 and RMS values for each reading addition were statistically analyzed. Following evaluation of statistical significance and clinical relevance, results were compared to published data from successful Orthokeratology treatments. Results: Statistically significant changes in higher order aberrations were detected for lenses of all reading additions. Lens groups with higher Add-powers demonstrated stronger changes with increased significance. Final RMS values relating to 2nd, 3rd and 4th Zernike Orders reached clinical significance with a wavefront error of 0.10 μm, the equivalent of 0.25D. Moreover, as Add-powers increased, 3rd and 4th order aberrations likewise showed an increase. Pre-fitting astigmatism values accounted for the highest recorded aberrations and remained predominantly unchanged. Conclusion: Proclear Multifocal center-distance contact lenses were found to increase higher order wavefront aberrations in a manner dependent on their Add-power. In comparison to successful Orthokeratology outcomes, the amounts of

关键词： Multifocal Soft Contact Lenses Wavefront Aberrations Myopia Myopia Progression Control Orthokeratology Zernike Polynomials

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坦德鲁姆步行桥澳大利亚墨尔本

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世界建筑导报 2018年第2期33卷 104-105页

作者： john wardle stefan mee mathew van kooy adam kolsrud james loder paul bickell stuart mann ruairi molloy sharon crabb nader tehrani arthur chang parke macdowell thomas tait nick safley JWA NADAAA事务所

连接比拉容马尔公园（Birrarung Marr）和墨尔本公园体育区的新坦德鲁姆人行天桥，为墨尔本公园建造了一个新的主要到达途径。澳大利亚网球公开赛期间，这座桥是一个主要行人入口。一条经过比拉容马尔公园坡道通向大桥，坡道的布置与已... 详细信息

连接比拉容马尔公园（Birrarung Marr）和墨尔本公园体育区的新坦德鲁姆人行天桥，为墨尔本公园建造了一个新的主要到达途径。澳大利亚网球公开赛期间，这座桥是一个主要行人入口。一条经过比拉容马尔公园坡道通向大桥，坡道的布置与已建桥梁和公园景观地形相得益彰。在我们的设计中，我们把”演讲角”的历史景观同横跨”蝙蝠侠大道”的墨尔本公园的网球场连接起来。这两个现存空间满是平等和民主的价值观--一个空间承载着普通公民可就任何问题自由发言的历史，

关键词：澳大利亚墨尔本步行桥公园景观历史景观人行天桥网球场价值观

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Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy

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World Journal of Gastroenterology 2020年第24期26卷 3458-3471页

作者： stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong University of South Florida College of Medicine TampaFL 33612United States Department of Diagnostic and Interventional Radiology H.Lee Moffitt Cancer Center and Research InstituteTampaFL 33612United States Department of Biostatistics and Bioinformatics H.Lee Moffitt Cancer Center and Research InstituteTampaFL 33612United States Department of Anatomic Pathology H.Lee Moffitt Cancer Center and Research InstituteTampaFL 33612United States Department of Cancer Physiology H.Lee Moffitt Cancer Center and Research InstituteTampaFL 33612United States Department of Clinical Science H.Lee Moffitt Cancer Center and Research InstituteTampaFL 33612United States Department of Radiology University of FloridaGainesvilleFL 32610United States Department of Cancer Epidemiology H.Lee Moffitt Cancer Center and Research InstituteTampaFL 33612United States

BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal ***,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)*** using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of *** hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN *** To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus *** Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective *** lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast *** analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic *** quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and mann Whitney U(continuous)*** Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the"malignant"cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the"benign"*** analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features

关键词： Radiomics Intraductal papillary mucinous neoplasm Multiphase computed tomography Pancreas Oncology Pancreatic cancer

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利拉鲁肽对糖尿病的影响和作用:心血管预后结果的评估(LEADER(?))试验的原理与研究设计

利拉鲁肽对糖尿病的影响和作用:心血管预后结果的评估(LEADER(?))...

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中华医学会糖尿病学分会第十六次全国学术会议

作者：罗小夫 Richard Bergenstal Gilbert Daniels Johannes mann Steven Nissen stuart Pocock Bernard Zinman John Buse Alan Moses Marcin Zychma Steven Marso University of Toronto International Diabetes Center MinneapolisMNUSA Massachusetts General Hospital BostonMAUSA Friedrich Alexander University of Erlangen MunichGermany Cleveland Clinic Foundation ClevelandOHUSA London School of Hygiene and Tropical Medicine LondonUK University of North Carolina at Chapel Hill School of Medicine Chapel HillNCUSA Novo Nordisk Inc PrincetonNJUSA Novo Nordisk CopenhagenDenmark Saint Luke’s Mid America Heart and Vascular Institute Kansas CityMOUSA

目的利拉鲁肽是1 d1次注射的人胰高糖素样肽-1类似物,已被批准用于治疗T2DM患者。尽管利拉鲁肽能显著降低空腹血糖、HbA1c、体重和收缩压,但其对心血管(CV)预后的影响尚未明确。LEADER是一项国际化、多中心、随机、双盲、安慰剂对照试验...

目的利拉鲁肽是1 d1次注射的人胰高糖素样肽-1类似物,已被批准用于治疗T2DM患者。尽管利拉鲁肽能显著降低空腹血糖、HbA1c、体重和收缩压,但其对心血管(CV)预后的影响尚未明确。LEADER是一项国际化、多中心、随机、双盲、安慰剂对照试验,旨在探讨以下假设:在T2DM患者中,利拉鲁肽联合标准治疗非劣于安慰剂与联合标准治疗,以主要不良CV事件为复合终点。

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