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Calcium channels caught in peripheral glia’s tug-of-war on axon regeneration in drosophila

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Neural Regeneration Research 2025年第2期20卷 475-476页

作者： jackson Powell Tobias Steinschaden Rose Horowitz Yuanquan Song Raymond G.Perelman Center for Cellular and Molecular Therapeutics The Children’s Hospital of PhiladelphiaPhiladelphiaPAUSA The Neuroscience Graduate Group University of PennsylvaniaPhiladelphiaPAUSA department of Pathology and Laboratory Medicine University of PennsylvaniaPhiladelphiaPAUSA Medical University of Vienna Center for Brain ResearchDepartment of NeuroimmunologyViennaAustria

Neural damage or degeneration is at the crux of many diseases,and treatment of these diseases will require the development of therapeutics to enhance and guide neural *** intrinsic and extrinsic factors dictate a neuron’s ability to regenerate,and the combination of these factors results in the great regenerative capacity of the peripheral nervous system(PNS)and the poor regenerative capacity of the central nervous system(CNS)following *** the core of a neuron’s function is its ability to relay electrochemical signals,and a neuron’s excitability is a key factor in its ability to *** works have focused on the changes in neuronal electrophysiological properties,firing patterns,and ion flux after injury,which differentially activate signaling pathways at the core of *** role of glia in neuron regeneration has long been studied.

关键词： degeneration firing system

Leading Approaches to Vascularize Kidney Constructs in Tissue Engineering

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Engineering 2022年第12期19卷 117-127页

作者： diana S.Lim John d.jackson Anthony Atala James J.Yoo Wake Forest Institute for Regenerative Medicine Wake Forest University School of MedicineMedical Center BoulevardNC 27157USA

There is an unprecedented need for new treatments for renal failure,as the incidence of this disease is increasing disproportionately to advancements in *** treatments are limited by the availability of viable organs,for which there is a worldwide *** treatment modalities also require a substantial amount of infrastructure,significantly limiting the access to care in most *** tissue engineering approaches promise to develop alternative solutions that address many of the inadequacies in current *** many advancements have been made—primarily in the past decade—in biofabrication and whole-organ tissue engineering,many challenges *** major hindrance to the progress of current tissue engineering approaches is establishing successful vascularization of developed engineered tissue *** review focuses on the recent advancements that address the vascular challenge,including the biofabrication of vasculature,whole-organ engineering through decellularization and recellularization approaches,microscale organogenesis,and vascularization using organoids in the context of kidney tissue *** also highlight the specific challenges that remain in developing successful strategies capable of clinical translation.

关键词： Kidney Vascularization Tissue engineering Biofabrication Organoids

Postpartum meloxicam administration alters plasma haptoglobin, polyunsaturated fatty acid, and oxylipid concentrations in postpartum ewes

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Journal of Animal Science and Biotechnology 2020年第4期11卷 1047-1060页

作者： Katie EOlagaray Barry J.Bradford Lorraine M.Sordillo Jeffery C.Gandy Laman K.Mamedova Turner H.Swartz Trey d.jackson Emma K.Persoon Caitlin S.Shugart Curtis R.Youngs department of Animal Sciences and Industry Kansas State UniversityManhattan 66506USA College of Veterinary Medicine Michigan State University2265K Anthony HallEast LansingMI 48824-1225USA department of Animal Science Iowa State UniversityAmesIAUSA.

Background: Postpartum inflammation is a natural and necessary response;however, a dysfunctional inflammatory response can be detrimental to animal productivity. The objective of this study was to determine the effects of a non-steroidal anti-inflammatory drug(meloxicam) on ewe postpartum inflammatory response, ewe plasma polyunsaturated fatty acid and oxylipid concentrations, and lamb ***: After lambing, 36 Hampshire and Hampshire × Suffolk ewes were sequentially assigned within type of birth to control(n = 17) or meloxicam orally administered on d 1 and 4 of lactation(MEL;90 mg, n = 19). Milk and blood samples were collected on d 1(prior to treatment) and d 4. Milk glucose-6-phosphate was not affected by MEL. Plasma haptoglobin(Hp) concentrations were less for MEL ewes;control ewes with greater d 1 Hp concentrations had elevated Hp on d 4, but this was not the case for MEL-treated ewes. Treatment with MEL increased plasma arachidonic acid concentration by more than 4-fold in ewes rearing singles but decreased concentrations of 9,10-dihydroxyoctadecenoic acid, prostaglandin F2α, 8-iso-prostaglandin E2, and 8,9-dihydroxyeicosatetraenoic acid. Nine oxylipids in plasma had interactions of treatment with d 1 Hp concentration,all of which revealed positive associations between d 1 Hp and d 4 oxylipid concentrations for CON, but neutral or negative relationships for MEL. MEL decreased 13-hydroxyoctadecadienoic acid:13-oxooctadecadienoic acid ratio and tended to increase 9-hydroxyoctadecadienoic acid:9-oxooctadecadienoic acid ratio(both dependent on d 1 values), indicating progressive metabolism of linoleic acid-derived oxylipids occurred by enzymatic oxidation after MEL treatment. Meloxicam reduced oxylipids generated across oxygenation pathways, potentially due to an improved redox ***: Postpartum MEL treatment of ewes decreased plasma concentrations of Hp and several oxylipids,with the greatest impact in ewes with biomarkers reflecting a greate

关键词： Eicosanoid Inflammation Lactation Nonsteroidal anti-inflammatory drug Sheep

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南加州概率性地震危险性分析

世界地震译丛 1996年第6期27卷 74-79页

作者： M.Mahdyiar A.Cornell d.jackson K.Aki 赵军河北省地震局

引言概率性地震危险性分析(PSHA)是一种涉及多学科的工作,它需要诸如区域地震构造学、地震特征和重复性、地震动形成、地震波传播以及局部场地效应的多种知识。这些资料组成概率模型,可提供任一场地的地震动参数的年超越概率。

关键词：地震危险性概率性分析南加州

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过程控制状态信息的显示

电子技术应用 1978年第6期 52-53+28页

作者： d.jackson 翁瑞琪

在微处理机系统中,显示数据的方法有许多种。本文叙述了作控制应用的一个例行程序。在用微处理机进行过程控制的大多数情况中,微处理机都是运算来自传感器测得的各物理参数的数据。通常的情况是,当系统没有故障时,各个物理参数都在规定... 详细信息

在微处理机系统中,显示数据的方法有许多种。本文叙述了作控制应用的一个例行程序。在用微处理机进行过程控制的大多数情况中,微处理机都是运算来自传感器测得的各物理参数的数据。通常的情况是,当系统没有故障时,各个物理参数都在规定值范围内,即在上限和下限之间。若传感器输出超过上限或低于下限,即指示出系统故障。在这种系统中,在实现任何下一步处理之前,最好检查传感器输出是否在合适的范围内,发现超出范围时即给出直观指示。本文叙述TMS9900的一个例行程序,它可使八个传感器中每一个的输出状态都以经济而直观有效的方式显示出来。

关键词：变址寄存器传感器上限换能器电子技术发光二极管结型发光器件主循环指示器例行程序软件

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证据学的现代趋势:一切都生机盎然?

证据学论坛

证据学论坛 2010年 15卷 253-262页

作者： John d.jackson 王进喜爱尔兰Belfast女王大学中国政法大学证据科学研究院

一、导言当证据学思想史的老前辈William Twining处于其探索的较早阶段时,他得出了这样的结论,即尽管正统的证据文献有诸多优点,仍可以对其提出许多指摘。第一,它过于狭隘,关注的几乎完全是可采性规则。第二,它是非理论性的,因为许多讨...

一、导言当证据学思想史的老前辈William Twining处于其探索的较早阶段时,他得出了这样的结论,即尽管正统的证据文献有诸多优点,仍可以对其提出许多指摘。第一,它过于狭隘,关注的几乎完全是可采性规则。第二,它是非理论性的,因为许多讨论都是在假定的常识性的经验主义范围内进行的。第三,它是非连贯性的,因为法律理论的概念框架没有为建立与其他论域的联系提供足够的基础。第四,它导

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An enhanced functional ability questionnaire(faVIQ) to measure the impact of rehabilitation services on the visually impaired

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International Journal of Ophthalmology(English edition) 2014年第1期7卷 77-85页

作者： James stuart Wolffsohn Jonathan jackson Olivia Anne Hunt Charles Cottriall Jennifer Lindsay Richard Gilmour Anne Sinclair Robert Harper Aston University Life and Health SciencesOphthalmic Research Group Australian College of Optometry Royal Victoria Hospital Oxford Eye Hospital Royal Victoria Hospital Belfast Altnagelvin Area Hospital Low Vision Clinic Fife Low Vision Centre for the Blind Manchester Royal Eye Hospital and Manchester Academic and Health Science Centre Central Manchester University Hospitals NHS Foundation Trust

AIM: To develop a short,enhanced functional ability Quality of Vision(faVIQ) instrument based on previous questionnaires employing comprehensive modern statistical techniques to ensure the use of an appropriate response scale,items and scoring of the visual related difficulties experienced by patients with visual impairment. · METHOdS: Items in current quality-of-life questionnaires for the visually impaired were refined by a multi-professional group and visually impaired focus groups. The resulting 76 items were completed by 293 visually impaired patients with stable vision on two occasions separated by a month. The faVIQ scores of 75 patients with no ocular pathology were compared to 75 age and gender matched patients with visual impairment. ·RESULTS: Rasch analysis reduced the faVIQ items to 27. Correlation to standard visual metrics was moderate(r =0.32-0.46) and to the NEI-VFQ was 0.48. The faVIQ was able to clearly discriminate between age and gender matched populations with no ocular pathology and visual impairment with an index of 0.983 and 95% sensitivity and 95% specificity using a cut off of 29.·CONCLUSION: The faVIQ allows sensitive assessment of quality-of-life in the visually impaired and should support studies which evaluate the effectiveness of low vision rehabilitation services.

关键词： quality of life visual impairment low vision functional ability sensitivity specificity

Ron receptor-dependent gene regulation of Kupffer cells during endotoxemia

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Hepatobiliary & Pancreatic diseases International 2014年第3期13卷 281-292页

作者： Rishikesh M Kulkarni William d stuart Susan E Waltz department of Cancer Biology University of Cincinnati department of Research Cincinnati Veterans Affairs Medical Center

BACKGROUNd: Ron receptor tyrosine kinase signaling in macrophages, including Kupffer cells and alveolar macrophages,suppresses endotoxin-induced proinflammatory cytokine/chemokine production. Further, we have also identified genes from Ron replete and Ron deplete livers that were differentially expressed during the progression of liver inflammation associated with acute liver failure in mice by microarray *** important genes and signaling pathways have been identified downstream of Ron signaling during progression of inflammation by this approach, the precise role that Ron receptor plays in regulating the transcriptional landscape in macrophages, and particular in isolated Kupffer cells, has still not been ***: Kupffer cells were isolated from wild-type(TK+/+)and Ron tyrosine kinase deficient(TK-/-) mice. Ex vivo, the cells were treated with lipopolysaccharide(LPS) in the presence or absence of the Ron ligand, hepatocyte growth factor-like protein(HGFL). Microarray and qRT-PCR analyses were utilized to identify alterations in gene expression between ***: Microarray analyses identified genes expressed differentially in TK+/+ and TK-/- Kupffer cells basally as well as after HGFL and LPS treatment. Interestingly, our studies identified Mefv, a gene that codes for the anti-inflammatory protein pyrin, as an HGFL-stimulated Ron-dependent ***, lipocalin 2, a proinflammatory gene, which is induced by LPS, was significantly suppressed by HGFL *** results were validated by qRT-PCR studies on Kupffer cells treated with LPS and ***: The studies herein suggest a novel mechanism whereby HGFL-induced Ron receptor activation promotes the expression of anti-inflammatory genes while inhibiting genes involved in inflammation with a net effect of diminished inflammation in macrophages.

关键词： Mst1R Mefv Lcn2 Met receptor Kupffer cells macrophages

A numerical investigation into key factors controlling hard rock excavation via electropulse stimulation

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Journal of Rock Mechanics and Geotechnical Engineering 2020年第4期12卷 793-801页

作者： daniel Vogler stuart dCWalsh Martin OSaar Geothermal Energy and Geofluids Institute of GeophysicsETH ZurichZurichSwitzerland department of Civil Engineering Monash UniversityMelbourneAustralia department of Earth and Environmental Sciences University of MinnesotaMinneapolisUSA

Electropulse stimulation provides an energy-efficient means of excavating hard rocks through repeated application of high voltage pulses to the rock *** such,it has the potential to confer significant advantages to mining and drilling operations for mineral and energy ***,before these benefits can be realized,a better understanding of these processes is required to improve their deployment in the *** this paper,we employ a recently developed model of the grain-scale processes involved in electropulse stimulation to examine excavation of hard rock under realistic operating *** that end,we investigate the maximum applied voltage within ranges of 120e600 kV,to observe the onset of rock *** further study the effect of grain size on rock breakage,by comparing fine(granodiorite)and coarse grained(granite)***,the pore fluid salinity is investigated,since the electric conductivity of the pore fluid is shown to be a governing factor for the electrical conductivity of the modeled *** study demonstrates that all investigated factors are crucial to the efficiency of rock fragmentation by electropulsing.

关键词： Electropulse stimulation High voltage breakdown Numerical modeling drilling Thermo-mechanics