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Liver Research 2018年第4期2卷 186-199页

作者： helen h.Wang piero portincasa Min Liu patrick Tso David Q.-h.Wang Department of Medicine Division of Gastroenterology and Liver DiseasesMarion Bessin Liver Research CenterAlbert Einstein College of MedicineBronxNYUSA Department of Biomedical Sciences and human Oncology Clinica Medica“A.Murri”University of Bari“Aldo Moro”Medical SchoolBariItaly Department of pathology and Laboratory Medicine University of Cincinnati College of MedicineCincinnatiOHUSA

The terms biliary sludge and cholesterol microlithiasis(hereafter referred to as microlithiasis)were originated from different diagnostic techniques and may represent different stages of cholesterol gall-stone *** the pathogenesis of biliary sludge and microlithiasis may be similar,micro-lithiasis could be preceded by biliary sludge,followed by persistent precipitation and aggregation of solid cholesterol crystals,and eventually,gallstone *** clinical conditions are clearly associated with the formation of biliary sludge and microlithiasis,including total parenteral nutrition,rapid weight loss,pregnancy,organ transplantation,administration of certain medications,and a variety of acute and chronic *** studies have demonstrated complete resolution of biliary sludge in approximately 40%of patients,a cyclic pattern of disappearing and reappearing in about 40%,and progression to gallstones in nearly 20%.Although only a minority of patients with ultrasonographic demonstration of biliary sludge develop gallstones,it is still a matter of controversy whether micro-lithiasis could eventually evolve to cholesterol *** sludge and microlithiasis are asymp-tomatic in the vast majority of patients;however,they can cause biliary colic,acute cholecystitis,and acute *** sludge and microlithiasis are most often diagnosed ultrasonographically and bile microscopy is considered the gold standard for their *** measures to prevent the development of biliary sludge are not practical or cost-effective in the general *** cholecystectomy offers the most definitive therapy on biliary *** sphincterotomy or surgical intervention is effective for microlithiasis-induced *** acid can effectively prevent the recurrence of solid cholesterol crystals and significantly reduce the risk of recurrent pancreatitis.

关键词： Biliary sludge Cholesterol microlithiasis Acute cholecystitis Acute pancreatitis Biliary colic Cholesterol monohydrate crystals Lithogenic bile

Windows 3.1、NT和OS/2内的pnp

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个人电脑 1995年第7期1卷 72-73页

作者： M.David stone 伍颖文

如果你正在运行Windows 95,那么安装即插即用外设保证是轻而易举的,并且安装传统卡好象比你过去更容易些。但是Windows

关键词： OS/2 Windows 即插即用 h心人工指段距定数适配卡 O口成象

preparation process and properties of porous Ecological Concrete

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武汉理工大学学报 2010年第17期32卷 256-260页

作者： LIANG L M YU h F pAN Z F Department of Civil Engineering Nanjing University of Aeronautics &AstronauticsNanjing 210016China

By using waste bricks as aggregate,a kind of porous ecological concrete was prepared and the mixing technique and its properties were studied. Effects of the cement paste fluidity on workability of the porous ecological concrete were investigated,and influences of the water-cement ratio,the aggregate-cement ratio and the aggregate size on compressive strength and porosity of the porous ecological concrete were also discussed. Results show that for preparation of the porous ecological concrete,the aggregates should be enveloped with neat cement paste,and recommended fluidity of the cement paste is 200～235 mm. With the increasing of the aggregate-cement ratio,porosity of the porous ecological concrete increases while the 28 d compressive strength decreases. With increasing of the water-cement ratio,porosity of the porous ecological concrete decreases. And relationship between compressive strength and water-cement ratio of the porous ecological concrete does not follow Bolomey's formula. As a result of this study the porous ecological concrete is prepared,its porosity is 38.93%,the water absorption is 11.39% and the compressive strength is 1.14 Mpa.

关键词： aggregate-cement ratio water-cement ratio aggregate size on fluidity of cement paste porous ecological concrete process of paste encapsulated stone porosity compressive strength

Stents for malignant ureteral obstruction

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Asian Journal of Urology 2016年第3期3卷 142-149页

作者： Kristina pavlovic Dirk Lange Ben h.Chew Department of Urologic Sciences The Stone Centre at Vancouver General HospitalUniversity of British ColumbiaVancouverCanada

Malignant ureteral obstruction can result in renal dysfunction or urosepsis and can limit the physician’s ability to treat the underlying *** are multiple methods to deal with ureteral obstruction including regular polymeric double J stents(DJS),tandem DJS,nephrostomy tubes,and then more specialized products such as solid metal stents(e.g.,Resonance Stent,Cook Medical)and polyurethane stents reinforced with nickel-titanium(e.g.,UVENTA stents,TaeWoong Medical).In patients who require long-term stenting,a nephrostomy tube could be transformed subcutaneously into an extra-anatomic stent that is then inserted into the bladder *** outline the most recent developments published since 2012 and report on identifiable risk factors that predict for failure of urinary *** failures are typically a sign of cancer progression and the natural history of the disease rather than the individual type of drainage *** that were identified to predict drainage failure included low serum albumin,bilateral hydronephrosis,elevated C-reactive protein,and the presence of pleural ***-to-head studies show that metal stents are superior to polymeric DJS in terms of maintaining *** with the patient should take into consideration the frequency that exchanges will be needed,the need for externalized hardware(with nephrostomy tubes),or severe urinary symptoms in the case of internal *** review will highlight the current state of diversions in the setting of malignant ureteral obstruction.

关键词： Malignant ureteral obstruction Ureteral stent hydronephrosis

院内获得性血小板减少症对因急性心肌梗死行直接血管成形术的患者的影响

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世界核心医学期刊文摘（心脏病学分册） 2006年第1期2卷 35-36页

作者： Nikolsky E. Sadeghi h. M. Effron M. B. G. W. stone 王亭忠 Dr. Columbia University Medical Center Cardiovascular Research Foundation New York NY United States

Thrombocytopenia that develops after percutaneous coronary intervention(pCI) may result in hemorrhagic complications, requirement for blood product transfusions, and potentially thrombotic or ischemic complications. The incidence and prognostic significance of thrombocytopenia, in patients with acute myocardial infarction(AMI) who undergo primary pCI have not been evaluated. In the CADILLAC trial 2,082 patients who had AMI within 12 hours of onset without shock were prospectively randomized to receive balloon angioplasty with or without abciximab versus stenting with or without abciximab. Acquired thrombocytopenia, defined as a nadir platelet countpatients who did not have baseline thrombocytopenia, developed in 50 of 1,975 qualifying patients(2.5%) after primary pCI. By multivariate analysis, acquired thrombocytopenia developed more frequently in patients who had non-insulin-requiring diabetes mellitus(odds ratio 3.88[OR], p=0.0002), previous statin administration(OR 3.28, p=0.002), and use of abciximab(OR 2.06, p=0.02) and less frequently in patients who had previous aspirin use(OR 0.26, p=0.002), a higher baseline platelet count(OR 1.20, pp=0.006). patients who developed thrombocytopenia versus those who did not had higher in-hospital rates of major hemorrhagic complications(10.0%vs 2.7%, p=0.01), greater requirement for blood transfusions(10.0%vs 3.9%, p=0.05), longer hospital stay(median 4.8 vs 3.6 days, p=0.008), and increased costs(median ＄14,466 vs ＄11,629, p=0.001). All-cause mortality was markedly increased at 30 days(8.0%vs 1.6%, p=0.0008) and at 1 year(10.0%vs 3.9%, p=0.03) in patients who developed thrombocytopenia. In conclusion, thrombocytopenia that develops after primary pCI for AMI, although uncommon, is associated with increased hemorrhagic complications and decreased survival.

关键词：急性心肌梗死(AMI) 血小板减少症直接血管成形术院内获得性患者经皮冠状动脉介入术球囊血管成形术对因单抗治疗阿昔单抗

The physical presence of gallstone modulates ex vivo cholesterol crystallization pathways of human bile

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Gastroenterology Report 2019年第1期7卷 32-41,I0002页

作者： piero portincasa Karel Jvan Erpecum Agostino Di Ciaula David Q-h.Wang Division of Internal Medicine Department of Biomedical Sciences and Human OncologyUniversity Medical SchoolBariItaly Department of Gastroenterology University Medical CenterUtrechtThe Netherlands Division of Internal Medicine Hospital of BisceglieASL BATBisceglieItaly Department of Medicine Division of Gastroenterology and Liver DiseasesMarion Bessin Liver Research CenterAlbert Einstein College of MedicineBronxNYUSA

Background:Cholesterol crystallization is an essential step toward gallstone *** model bile studies showed that competition occurs between the gallstone surface and the surrounding aqueous phase for cholesterol molecules available for crystallization,this has not been investigated in human ***:Fresh gallbladder bile was obtained during laparoscopic cholecystectomy from 13 patients with cholesterol(n紏10)or pigment(n紏3)*** cholesterol gallstones were collected from another two *** native and ultrafiltered bile with or without added gallstones was analysed by polarized light microscopy for the presence of arc-like and needle-like anhydrous cholesterol crystals and classic cholesterol monohydrate *** of the added stones was evaluated before and after 21 days of bile ***:In unfiltered bile,the presence of stones was associated with a trend towards less anhydrous cholesterol crystals,but significantly more aggregated cholesterol monohydrate *** ultrafiltered bile,the presence of stones tended to inhibit the formation of arc-like or needle-like crystals and was associated with significantly greater amounts of both platelike and aggregated cholesterol monohydrate *** 21 days of the incubation,stone weight was decreased in both unfiltered(–4.561.6%,p紏0.046)and ultrafiltered bile(–6.561.5%,p紏0.002).Bile from pigment-stone patients was clear in the absence of stones,but showed early appearance of plate-like and aggregated cholesterol monohydrate crystals in all samples to which cholesterol gallstones were ***:The physical presence of cholesterol gallstones in both native and filtered bile greatly influences cholesterol crystallization *** cholesterol monohydrate crystals increase,anhydrous cholesterol crystals tend to be *** of solid cholesterol crystals from the gallstone surface may explain these findings.

关键词： Bile cholesterol crystals cholesterol stones pigment stones polarizing light microscopy supersaturated bile

performance of engineered cementitious composite containing stone slurry powder waste

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Journal of Central South University 2021年第7期28卷 1990-2002页

作者： Maninder SINGh Babita SAINI h.D.ChALAK Department of Civil Engineering National Institute of Technology KurukshetraHaryana 136119India

Most of the materials used in engineered cementitious composite are fine in size to achieve ductile *** slurry powder(SSp)is an inert material obtained from stone industries as by-product which may cause hazardous impact on *** this research work,partial replacement of silica sand(SS)and fine sand(FS)by SSp with different contents(25%and 50%each)for making engineered cementitious composite has been *** performance was evaluated on the basis of strength,tensile strain,mid span deflection capacity,ultra-sonic pulse velocity and *** strength was found to be increased at 25%SSp in both replacements;whereas,strength decreased slightly at 50%*** strain,mid span deflection and quality of concrete were enhanced with increase in SSp *** SSp formed denser cementitious composite can help to save the natural resources and contribute in making green cementitious composite.

关键词： stone slurry powder fine sand scanning electron microscopy energy dispersive X-ray spectroscopy ultrasonic pulse velocity

Fibulin5基因错义变异和年龄相关性黄斑变性

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世界核心医学期刊文摘（眼科学分册） 2005年第1期1卷 6-7页

作者：肖颖 stone E.M Braun T.A Russell S.R Center for Macular De -g eneration Univ.of Iowa Carver Col l.of Med.200Hawkins Dr.Iowa CityIA 52242United States.Dr

BACKGROUND:Age-related macular degeneration(AM-D)is the most common cause of irreversible vision loss in the developed *** study of a ra re mendelian form of macular degeneration implicated fibulin genes in the pathogenesis of more common forms of this *** evaluated five fibulin genes in a large series of patients with ***:We studied 402patients with AMD and 429control subjects from the same clinic *** were examined by m eans of indirect ophthalmoscopy,slit-lamp microsc opy,and fundus pho-tography to establish the presence a nd phenotypic pattern of *** samples were screened for sequence vari-ations in five members of the fibulin gene ***-SULTS:Amino acid-altering sequence variations were found in all five fibulin genes,many of which were ob-served only in patients with *** eral of the altered residues have been conserved during *** of the 402patients with AMD had amino ac idaltering se-quence variations in the fibulin 5ge ne,whereas none were observed among 429control subjects(phese seven patients all h ad small,circular drusen,which are commonly referred to as basal laminar or cuticular ***:Missense mutations in the fibulin 5gene were found in 1.7percent of patients with *** variationsin other fibulin genes were also found in these patients,and the evolutionary con-servation of the affected residues s uggests that several of these variations may also be involved in AMD.

关键词： Fibulin5 错义遗传性黄斑变性眼底照相玻璃膜疣间接检眼镜样本研究氨基酸序列孟德尔表现型

Endoscopic retrograde cholangiopancreatography outcome from a single referral center in Iran

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hepatobiliary & pancreatic Diseases International 2010年第4期9卷 428-432页

作者： Amir h Mohammad Alizadeh Esmaeil S Afzali Mirhadi Mousavi Yaghoub Moaddab Mohammad R Zali Shahid Beheshti University of Medical Sciences Taleghani Hospital

BACKGROUND: Endoscopic retrograde cholangiopancreato- graphy (ERCp) is the first choice for diagnostic evaluation of the pancreatic and biliary tree and can be accompanied by a high diagnostic sensitivity and a poor therapeutic outcome. In the current study, we described our experiences in the indications, findings, and technical success of ERCp in a sample of the Iranian population admitted to a referral center in Iran. METhODS: In a retrospective review database-based study, 780 patients (393 males and 387 females; mean age 57.5 years) who had undergone diagnostic and therapeutic ERCp with the primary diagnosis of hepatobiliary disorder between 2006 and 2008 at Taleghani hospital in Tehran were reviewed. The key data were demographic characteristics, clinical information, laboratory parameters, as well as post-ERCp complications. RESULTS: A history of cholecystectomy was found in about one-third (36.3%) of participants and 80 (10.3%) out of 780 patients had a previous history of biliary stone. A minority (1.4%) of the patients suffered from hepatobiliary carcinomas, and 11 patients had cirrhosis. The most common clinical manifestations in the patients undergoing diagnostic ERCp were icterus (47.3%), weight loss (31.2%), and dark urine (26.9%). Selective biliary cannulation was technically successful in 87.0% of the patients; however, cannulation failed in 13.0%. The most frequent final diagnosis of ERCp was common bile duct stone that was detected in 40.1% of the patients. The ERCp results in 11.0% of the patients were normal. Regarding appropriate treatment, successful stenting was performed in 43 patients (15.2%). Among post-ERCp complications, pancreatitis was the most adverse event withan incidence rate of 3.3%. Other complications including local bleeding, cholangitis and gastrointestinal perforation, rarely occurred. post-ERCp pancreatitis was reported in 1.8% of men and 3.6% of women (p=0.120). pancreatitis was more common in women below 70 years than in th

关键词： endoscopy outcome diagnosis complication pancreatitis