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Assessment of refractive astigmatism and simulated therapeutic refractive surgery strategies in coma-like-aberrations- dominant corneal optics

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Eye and Vision 2016年第1期3卷 97-107页

作者： Wen Zhou aleksandar stojanovic Tor Paaske Utheim SynsLaser Kirurgi AS TromsøTromsNorway School of Ophthalmology and Optometry Wenzhou Medical UniversityWenzhouChina Eye Department University Hospital North NorwayTromsøNorway Department of Ophthalmology Vestre Viken Hospital TrustDrammenNorway Department of Medical Biochemistry Oslo University HospitalOsloNorway Department of Oral Biology Faculty of DentistryUniversity of OsloOsloNorway

Background:The aim of the study is to raise the awareness of the influence of coma-like higher-order aberrations(HOAs)on power and orientation of refractive astigmatism(RA)and to explore how to account for that influence in the planning of topography-guided refractive surgery in eyes with coma-like-aberrations-dominant corneal ***:Eleven eyes with coma-like-aberrations-dominant corneal optics and with low lenticular astigmatism(LA)were selected for astigmatism analysis and for treatment simulations with topography-guided custom *** analysis was used to evaluate the contribution of coma-like corneal HOAs to *** different strategies were used for simulated treatments aiming to regularize irregular corneal optics:With both strategies correction of anterior corneal surface irregularities(corneal HOAs)were *** of total corneal astigmatism(TCA)and RA was intended as well with strategies 1 and 2,***:Axis of discrepant astigmatism(RA minus TCA minus LA)correlated strongly with axis of *** coma influenced RA by canceling the effect of the with-the-rule astigmatism and increasing the effect of the against-the-rule *** simulated correction of anterior corneal HOAs along with TCA and RA(strategies 1 and 2),only a small amount of anterior corneal astigmatism(ACA)and no TCA remained after strategy 1,while considerable amount of ACA and TCA remained after strategy ***:Coma-like corneal aberrations seem to contribute a considerable astigmatic component to RA in eyes with coma-like-aberrations dominant corneal *** topography-guided ablation is programmed to correct the corneal HOAs and RA,the astigmatic component caused by the coma-like corneal HOAs will be treated twice and will result in induced *** RA and treating TCA along with the corneal HOAs is recommended instead.

关键词： Coma Higher-order-aberrations Corneal irregular astigmatism Topography-guided ablation

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Corneal collagen cross-linking(CXL)in thin corneas

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Eye and Vision 2015年第1期2卷 130-136页

作者： Xiangjun Chen aleksandar stojanovic Jon Roger Eidet Tor Paaske Utheim SynsLaser Kirurgi Oslo and TromsøNorway Faculty of Medicine University of OsloOsloNorway Eye Department University Hospital North NorwayTromsøNorway Department of Medical Biochemistry Oslo University HospitalOsloNorway Department of Oral Biology Faculty of DentistryUniversity of OsloOsloNorway.

Corneal collagen cross-linking(CXL)is a therapeutic procedure aiming at increasing the corneal stiffness in the keratoconus eyes by induction of cross-links within the extracellular *** is achieved by ultraviolet-A(370 nm)irradiation of the cornea after saturation with the photosensitizer *** the conventional CXL protocol,a minimum de-epithelialized corneal thickness of 400μm is recommended to avoid potential irradiation damage to the corneal *** advanced keratoconus,however,stromal thickness is often lower than 400μm,which limits the application of CXL in that *** have been undertaken to modify the conventional CXL procedure to be applicable in thin *** current review discusses different techniques employed to achieve this end and their *** overall safety and efficacy of the modified CXL protocols are good,as most of them managed to halt the progression of keratectasia without postoperative ***,the evidence of safety and efficacy in the use of modified CXL protocols is still limited to few studies with few patients *** studies with long-term follow-up are required to confirm the safety and efficacy of the modified protocols.

关键词： Collagen cross-linking Keratoconus Thin cornea

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Central corneal regularization (CCR): an alternative approach in keratoconus treatment

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Eye and Vision 2019年第1期6卷 338-344页

作者： Giulio Mulè Shihao Chen Jia Zhang Wen Zhou Vasileios Selimis aleksandar stojanovic Ioannis M.Aslanides iVis Trento Center San Camillo HospitalTrentoItaly Eye Hospital Wenzhou Medical UniversityWenzhouChina SynsLaser Kirurgi AS Skippergata 7TromsoNorway Emmetropia Mediterranean Eye Institute Plateia Eleftherias 44Heraklion71201 CreteGreece

Background:To evaluate the safety and efficacy of an approach that combines corneal customized transepithelial therapeutic ablation to treat irregular corneal optics and accelerated corneal collagen cross-linking(CXL)to strengthen the corneal tissue and stop the progression of *** transepithelial therapeutic ablation applied a novel concept named central corneal regularization(CCR)which could correct the corneal morphological irregularities and the eye’s spherocylindrical refractive error with minimal stromal tissue ***:Retrospective *** that underwent CCR combined with CXL were evaluated preoperatively and up to 12 months postoperatively for visual acuity,subjective refraction,corneal haze,pachymetry and maximum keratometry(Kmax).Results:Twenty four eyes of 24 patients with a mean age of 28.92±9.88 years were *** mean spherical equivalent(SE)refractive error changed from−0.74±1.17 D preoperatively to−1.05±1.52 D at 12 months *** mean uncorrected distance visual acuity(UDVA)and corrected distance visual acuity(CDVA)*** eye lost lines of CDVA,21 had a mean improvement of 3.21 *** mean cylinder error and Kmax value dropped from−3.06±1.83 D and 51.38±3.29 D to−1.04±0.80 D and 48.70±2.58 D,*** mean haze score at 3,6 and 12 months was 0.56,0.19 and 0.06,***:CCR combined with CXL offers promising results as a safe and effective treatment in keratoconic patients.

关键词： Central corneal regularization Corneal collagen cross-linking Transepithelial Excimer laser Keratoconus

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波阵面最优化切削与Q值调整的个体化切削治疗近视的对比研究

波阵面最优化切削与Q值调整的个体化切削治疗近视的对比研究

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中华医学会第十二届全国眼科学术大会

作者：汪凌王勤美 aleksandar stojanovic 陈世豪温州医学院附属眼视光医院

目的：通过对比分析波阵面最优化切削与 Q 值调整的个体化切削两种准分子激光切削模式术前与术后的 Q 值、总高阶像差均方根值、球差、三阶像差均方根值、低对比度视力以及安全性、有效性和预测性,评价两者治疗近视的临床疗

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经上皮个性化表面切削术与器械法去上皮准分子激光角膜表面切削术在患者术后早期恢复情况的比较

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中华眼视光学与视觉科学杂志 2011年第4期13卷 290-294页

作者：周雯陈湘君 aleksandar stojanovic 王勤关美温州医学院附属眼视光医院浙江温州325027 9008 SynsLaser Kirurgi AS TromssNorway

目的比较经上皮个性化表面切削术与器械法去上皮准分子激光角膜表面切削术（PRK）的术后疼痛感、上皮愈合时间和早期视力恢复情况。方法非随机前瞻性临床对照研究。连续收集2009年3月18日至2009年10月28期间接受iVIS-Suite 100 Hz激光... 详细信息

目的比较经上皮个性化表面切削术与器械法去上皮准分子激光角膜表面切削术（PRK）的术后疼痛感、上皮愈合时间和早期视力恢复情况。方法非随机前瞻性临床对照研究。连续收集2009年3月18日至2009年10月28期间接受iVIS-Suite 100 Hz激光机切削的经上皮个性化表面切削手术患者15例（30眼，组1），接受Amoils刷器械法去上皮并由Wavelight Allegretto 400 Hz激光机切削的器械法去上皮PRK手术患者15例（30眼，组2）。术后每24小时评估患者上皮愈合情况及主观疼痛感直至上皮愈合。术后1、2、3、4周测量患者术后屈光度，裸眼视力以及最佳眼镜矫正视力。采用独立样本Wilcoxon秩和检验来比较两组患者主观疼痛程度的差别，其他数据比较使用独立样本t检验。结果组1和组2患者的平均上皮愈合时间分别为（2．6±0．5）d和（2．9±0．6）d，差异具有统计学意义（t=2．039，P=0．046）。术后第2天，组1患者疼痛感评分小于组2（Z=-3．535，P〈0．01），且组1患者在术后3d内的最强烈疼痛感评分和平均疼痛感评分均低于组2，差异均有统计学意义（Z=-2．261，P=0．024；Z=-2．982，P=0．003）。术后3周，组1患者平均裸眼视力为-0．068±0．088（10gMAR），组2为-0．024±0．069（10gMAR），差异有统计学意义（t=2．236，P=-0．030）。两组患者术后1至4周的最佳矫正视力和平均等效球镜度经分析差异均无统计学意义。结论单一步骤的经上皮个性化表面切削术与器械法去上皮PRK相比，上皮愈合时间更短，裸眼视力恢复更快，术后疼痛感更轻。两种手术的术后最佳眼镜矫正视力和屈光值无明显差异。

关键词：屈光性角膜切削术上皮角膜疼痛治疗结果恢复期

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地形图引导的经上皮准分子激光屈光性角膜切削术治疗穿透性角膜移植术后散光

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中华眼视光学与视觉科学杂志 2013年第7期15卷 414-417页

作者：金男刘旭陈湘君 stojanovic aleksandar 许跃张婷吕帆温州医科大学附属眼视光医院 325027 9008挪威特罗姆瑟 Syns Laser Kirurgi AS 226001南通大学附属医院眼科中心

目的评价地形图引导的经上皮准分子激光屈光性角膜切削术（***）治疗穿透性角膜移植（PKP）术后高度散光及不规则散光的安全性和有效性。方法非随机、回顾性研究。收集PKP术后因高度散光或不规则散光而接受地形图引导的T—PRK治疗的患... 详细信息

目的评价地形图引导的经上皮准分子激光屈光性角膜切削术（***）治疗穿透性角膜移植（PKP）术后高度散光及不规则散光的安全性和有效性。方法非随机、回顾性研究。收集PKP术后因高度散光或不规则散光而接受地形图引导的T—PRK治疗的患者18例（20眼）。记录并分析术前及进行本研究时末次随访的裸眼视力（UDVA）、最佳矫正视力（CDVA）、屈光状态、角膜地形图及视觉症状变化等．应用秩和检验对视力、屈光状态、角膜地形图变化进行比较。结果术后平均随访（12．15±2．06）个月。平均logMARUDVA由1．36±0．42提高到0．65±0．40（Z=-3．727，P〈0．01）；平均CDVA由0．34±0．22提高到0．17±0．14（Z=-3．607．P〈0．01），10眼CDVA提高≥2行。术后平均球镜度由（1．48±3．14）D下降到（-0．19±2．11）D（Z=-2．373，P〈0．05）；术后平均柱镜度由（-7．81±3．43）D下降到（-3．06±1．99）D（z=-3．792，P〈0．01）；术后平均等效球镜矫正度（术后实际值与术前目标值之差）为（-1．72±2．55）D，其中3眼在目标值±O．50D范围内，9眼在目标值±1．00D范围内。平均角膜不规则指数由（66．33±22．03）μm降低为（59．11±14．66）μm（Z=-0．831，P〉0．05），而平均角膜正交曲率不对称性由（8．96±4．36）D降低为（7．44±3．56）D（Z=-2．576，P〈0．05）。患者术后视觉症状均不同程度好转，无-症状恶化。结论地形图引导的T-PRK是治疗PKP术后高度散光及不规则散光的一种安全、有效的方法。

关键词：屈光性角膜切削术角膜地形图不规则散光角膜移植术穿透性

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A resilience-based approach in managing the closure and abandonment of large mine tailing ponds

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International Journal of Mining Science and Technology 2020年第5期30卷 737-746页

作者： Dragan Komljenovic Lazar stojanovic Vladimir Malbasic aleksandar Lukic Hydro-Québec Research Institute(IREQ) VarennesQC J3X 1S1Canada Faculty of Mining University of Banja Luka79101 PrijedorBosnia and Herzegovina ArcelorMittal Prijedor d.o.o.Prijedor 79101 PrijedorBosnia and Herzegovina

Mining tailing ponds are large infrastructure objects whose life cycle spans over several *** are indispensable for certain types of mines where technological process produces and rejects *** also have potential to generate risks for human life,property and *** that reason,it is essential to adequately manage them throughout all the stages of their life *** phase of their closure and abandonment is less studied and *** paper proposes a holistic resilience-based approach for analyzing this phase of their life *** proposed methodology is validated through a case study at an actual surface iron ore mine in Bosnia and Herzegovina.

关键词： Mine tailing ponds Closure Abandonment Resilience Risks Uncertainties Complexity

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Malignant schwannoma of the pancreas involving transversal colon treated with en-bloc resection

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World Journal of Gastroenterology 2010年第1期16卷 119-122页

作者： Miroslav P stojanovic Milan Radojkovic Ljiljana M Jeremic aleksandar V Zlatic Goran Z Stanojevic Milan A Jovanovic Milos S Kostov Vuka P Katic Department of Hepato-bilio-pancreatic Surgical ClinicClinical Center Nis

Pancreatic schwannoma is a very uncommon tumor of the pancreas,with only 27 cases *** pancreatic schwannomas are benign,with only four malignant tumors *** describe a case of giant malignant schwannoma of the pancreatic body and tail,which involved the transverse *** tumor was treated successfully with en bloc distal splenopancreatectomy and colon *** is believed to be the first reported radical operation for malignant schwannoma of the pancreatic body,with infiltration of the transverse colon,with excellent longterm *** patient is alive and well 28 mo after the *** authors conclude that pancreatic schwannomas should be considered in the differential diagnosis of cystic neoplasms of the pancreas,although the diagnosis can only be confirmed by microscopic *** the case of the benign tumors,local excision is adequate,but in the case of malignant schwannoma,oncological standards must be fulfilled.

关键词： Pancreatic neoplasms Schwannoma Colonic neoplasms Surgery

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Node.js无服务器应用实战

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作者： (塞尔维亚)斯洛博丹·斯托扬诺维奇(Slobodan stojanovic)，亚历山大·西蒙维奇( aleksandar Simovic)

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