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Neural regeneration research 2022年第10期17卷 2208-2210页

作者： Alexandre F.r.stewart Hsiao-Huei Chen Department of Biochemistry Microbiology and ImmunologyUniversity of Ottawaand University of Ottawa Heart InstituteOttawaONCanada Centre for Infection Immunity and InflammationOttawaONCanada Medicine Cellular and Molecular MedicineUniversity of Ottawa Brain and Mind InstituteOttawa Hospital Research InstituteOttawaONCanada

Glutamate is the main exc i tatory neurotransmitter in the brain and binds to two major classes of receptors,theα-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid(AMPA)and the N-methyl-D-aspartate(NMDA)*** AMPA receptors that are immediately activated by glutamate release,NMDA receptors are blocked by magnesium and can only be activated by glutamate after membrane ***,NMDA receptors are only activated after repeated AMPA receptor activation by *** receptors are,for the most part,calcium-permeable *** influx through NMDA receptors modulates synaptic transmission in neurons based on prior history of excitation,and provides a means of scaling the strength of synapses required for Hebbian plasticity.

关键词： PTP1B aspartate NMDA

Design and mathematical analysis of activating transcriptional amplifiers that enable modular temporal control in synthetic juxtacrine circuits

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Synthetic and Systems Biotechnology 2023年第4期8卷 654-672页

作者： Calvin lam Department of Biochemistry and Molecular Biology University of Nebraska Medical CenterOmahaNE68198USA.

The ability to control mammalian cells such that they self-organize or enact therapeutic effects as desired has incredible *** only would it further our understanding of native processes such as development and the immune response,but it would also have powerful applications in medical fields such as regenerative medicine and *** control is typically obtained by synthetic circuits that use synthetic receptors,but control remains *** synthetic juxtacrine receptors(SJrs)are widely used as they are fully modular and enable spatial control,but they have limited gene expression amplification and temporal *** these are integral facets to cell control,I therefore designed transcription factor based amplifiers that amplify gene expression and enable unidirectional temporal control by prolonging duration of target gene *** a validated in silico framework for SJr signaling,I combined these amplifiers with SJrs and show that these SJr amplifier circuits can direct spatiotemporal patterning and improve the quality of self-organization.I then show that these circuits can improve chimeric antigen receptor(CAr)T cell tumor killing against various heterogenous antigen expression *** amplifiers are flexible tools that improve control over SJr based circuits with both basic and therapeutic applications.

关键词： Synthetic biology Synthetic development Synthetic immunotherapy synNotch SNIPr Amplifiers Self-organization Temporal control Spatiotemporal control CAr T cell Synthetic receptors

restriction of Intramolecular Motion(rIM):Investigating AIE Mechanism from Experimental and Theoretical Studies

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Chemical research in Chinese Universities 2021年第1期37卷 1-15页

作者： ZHANG Jianyu ZHANG Haoke lam Jacky w.Y. TANG Ben Zhong Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration and ReconstructionInstitute for Advanced Studyand Department of Chemical and Biological EngineeringThe Hong Kong University of Science&TechnologyClear Water BayKowloonHong KongP.R.China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027P.R.China Center for Aggregation-Induced Emission SCUT-HKUST Joint Research InstituteState Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhou510640P.R.China Guangzhou Development District AIE InstituteGuangzhou510530P.R.China

Mechanistic studies promote scientific development from phenomena to ***-induced emission(AIE),as an unusual photophysical phenomenon,builds the bridge between molecular science and aggregate *** the twenty-year development of AIE,restriction of intramolecular motion(rIM)has been verified as the working mechanism of AIE *** this review,these mechanistic works about rIM are summarized from experimental and theoretical ***,the experimental studies are introduced from three parts:external rigidification,structural modification and structural *** the theoretical part,calculations on the low-frequency motion of AIEgens have been performed to prove the rIM *** virtue of the theoretical calculations,some new mechanisms are proposed to supplement the rIM,such as restriction of access to conical intersection,suppression of Kasha transition,restriction of access to dark state,*** is foreseeable that the rIM mechanism will unify the photophysical theories for both molecules and aggregates,and inspire more progress in aggregate science.

关键词： Aggregation-induced emission(AIE) restriction of intramolecular motion Photophysical mechanism Aggregate science

Scalable Ir‑Doped NiFe_(2)O_(4)/TiO_(2)Heterojunction Anode for Decentralized Saline wastewater Treatment and H_(2)Production

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Nano-Micro Letters 2025年第3期17卷 1-18页

作者： Sukhwa Hong Jiseon Kim Jaebeom Park Sunmi Im Michael r.Hoffmann Kangwoo Cho Division of Environmental Science and Engineering Pohang University of Science and Technology(POSTECH)Pohang 790−784Korea Linde Laboratory California Institute of TechnologyPasadenaCA 91125USA Institute for Convergence research and Education in Advanced Technology(I‑CrEATE) Yonsei University International CampusIncheon 21983Republic of Korea

wastewater electrolysis cells(wECs)for decentralized wastewater treatment/reuse coupled with H_(2)production can reduce the carbon footprint associated with transportation of water,waste,and energy *** study reports Ir-doped NiFe_(2)O_(4)(NFI,~5 at%Ir)spinel layer with TiO_(2)overlayer(NFI/TiO_(2)),as a scalable heterojunction anode for direct electrolysis of wastewater with circumneutral pH in a single-compartment *** dilute(0.1 M)NaCl solutions,the NFI/TiO_(2)marks superior activity and selectivity for chlorine evolution reaction,outperforming the benchmark IrO_(2).robust operation in near-neutral pH was *** including operando X-ray absorption spectroscopy unveiled crucial roles of TiO_(2) which serves both as the primary site for Cl−chemisorption and a protective layer for NFI as an ohmic *** electrolysis of NH4+-laden synthetic wastewater demonstrated that NFI/TiO_(2)not only achieves quasi-stoichiometric NH_(4)^(+)-to-N_(2)conversion,but also enhances H_(2)generation efficiency with minimal competing reactions such as reduction of dissolved oxygen and reactive *** scaled-up wEC with NFI/TiO_(2)was demonstrated for electrolysis of toilet wastewater.

关键词： wastewater electrolysis cell Ir-doped NiFe_(2)O_(4) reactive chlorine species Decentralized H_(2)production On-site wastewater treatment

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单核细胞增多性李斯特氏菌的分离

广东畜牧兽医科技 1987年第2期 44-46页

作者： JACOB w.lam 何美联美国Lowell大学健康职业学院 Ph.D

在牛奶的调查研究中发现,用选择性肉汤标明Stuart转移培养基在阳性牛奶样品中没有统计学显著差异。同样,当阳性牛奶样品用于两种倒平板的培养基时,也没有统计

关键词：李斯特氏菌食物牛肉琼脂 LEB 肉类李斯特氏菌病单核细胞增多

CArBAZOLE-CONTAINING HYPErBrANCHED POLY(ArYLENEETHYNYLENE)S:SYNTHESIS,CHArACTErIZATION,ANDPrOPErTIES

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Chinese Journal of Polymer Science 2007年第6期25卷 641-649页

作者： Han Peng Xiu-wen Zheng Jacky w. Y. lam Ben-zhong Tang Institute of Material Science and Engineering South China University of Technology Guangzhou 510640 China Department of Chemistry Hong Kong University of Science ＆ Technology Clear Water Bay Kowloon Hong Kong China

New hyperbranched poly（aryleneethynylene）s containing carbazole moieties are synthesized in high yields （up to 87%） by polycyclotrimerization of 3,6-bis（4-ethynylphenyl）-9-octylcarbazole and its copolymerization with 1-octyne catalyzed by CpCo（CO）2 in THF. The structures and properties of the polymers are characterized and evaluated by Ir, NMr, TGA, UV, photoluminescence, and cyclic voltammetry analyses. All the polymers are soluble in common organic solvents and show outstanding thermal stability （≥ 430℃）. They graphitize in high yields （up to 79%） when pyrolyzed at 800℃. Upon photoexcitation, the polymers emit a strong deep blue light of ca. 400 nm with quantum yields larger than 60%.

关键词： Acetylenes Carbazole Cyclopolymerization Hyperbranched Luminescence.

Human induced pluripotent stem cell-derived therapies for regeneration after central nervous system injury

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Neural regeneration research 2025年第11期20卷 3063-3075页

作者： Stephen Vidman Yee Hang Ethan Ma Nolan Fullenkamp Giles w.Plant Department of Neuroscience Ohio State UniversityColumbusOHUSA

In recent years,the progression of stem cell therapies has shown great promise in advancing the nascent field of regenerative *** the non-regenerative nature of the mature central nervous system,the concept that“blank”cells could be reprogrammed and functionally integrated into host neural networks remained *** work has also demonstrated the ability of such cells to stimulate intrinsic growth programs in post-mitotic cells,such as *** embryonic stem cells demonstrated great potential in treating central nervous system pathologies,ethical and technical concerns *** barriers,along with the clear necessity for this type of treatment,ultimately prompted the advent of induced pluripotent stem *** advantage of pluripotent cells in central nervous system regeneration is multifaceted,permitting differentiation into neural stem cells,neural progenitor cells,glia,and various neuronal *** precise spatiotemporal application of extrinsic growth factors in vitro,in addition to microenvironmental signaling in vivo,influences the efficiency of this directed *** the pluri-or multipotency of these cells is appealing,it also poses the risk of unregulated differentiation and teratoma *** of the neuroectodermal lineage,such as neuronal subpopulations and glia,have been explored with varying degrees of *** the risk of cancer or teratoma formation is greatly reduced,each subpopulation varies in effectiveness and is influenced by a myriad of factors,such as the timing of the transplant,pathology type,and the ratio of accompanying progenitor ***,successful transplantation requires innovative approaches to develop delivery vectors that can mitigate cell death and support ***,host immune responses to allogeneic grafts must be thoroughly characterized and further developed to reduce the need for *** to a clinical setting wi

关键词： axon regeneration central nervous system regeneration induced pluripotent stem cells neurotrauma regenerative medicine spinal cord injury stem cell therapy

Activation of tyrosine phosphatases in the progression of Alzheimer’s disease

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Neural regeneration research 2020年第12期15卷 2245-2246页

作者： Alexandre F.r.stewart Hsiao-Huei Chen University of Ottawa Heart Institute OttawaCanada Ottawa Hospital research Institute OttawaCanada

Patients with Alzheimer’s disease(AD)have progressive memory loss,inability to reason,and display anxiety that accelerates disease *** points to two deficits:1)the brain fails to respond to insulin that regulates the formation of neuron connections required to store memories,and 2)deficits arise in the brain’s endogenous cannabinoid signaling that regulates mood and prevents anxiety(Aso and Ferrer,2014).In addition,leptin signaling,important in regulating hypothalamic synaptic plasticity and cognitive function is also affected in AD(McGregor and Harvey,2018).

关键词： Alzheimer endogenous arise

Interferon regulatory factor 2 binding protein 2:a new player of the innate immune response for stroke recovery

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Neural regeneration research 2017年第11期12卷 1762-1764页

作者： Hsiao-Huei Chen Alexandre E r.stewart Ottawa Hospital research Institute OttawaCanada University of Ottawa Heart Institute OttawaCanada

Ischemic brain injury triggers an inflammatory response. tissue but can also exacerbate brain injury. Microglia are This response is necessary to clear damaged brain the innate immune cells of the brain that execute this critical function. In healthy brain, microglia perform a housekeeping function, pruning unused syn- apses between neurons. However, microglia become activated to an inflammatory phenotype upon brain injury. Interferon regulatory factors modulate microglial activation and their production of inflammatory cytokines. This review briefly discusses recent findings pertaining to these regulatory mechanisms in the context of stroke recovery.

关键词： interferon regulatory factors interferon beta protein 2 stroke inflammation synaptie pruning anxiety microglia interferon regulatory factor 2 binding

Accelerating phase-field-based microstructure evolution predictions via surrogate models trained by machine learning methods

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npj Computational Materials 2021年第1期7卷 9-19页

作者： David Montes de Oca Zapiain James A.stewart rémi Dingreville Center for Integrated Nanotechnologies Sandia National LaboratoriesAlbuquerqueNM 87185USA Energetic Materials Dynamic and reactive Science Sandia National LaboratoriesAlbuquerqueNM 87185USA

The phase-field method is a powerful and versatile computational approach for modeling the evolution of microstructures and associated properties for a wide variety of physical,chemical,and biological ***,existing high-fidelity phase-field models are inherently computa fonally expensive,requiring high-performance computing resources and sophisticated numefical integration schemes to achieve a useful degree of *** this paper,we present a computationally inexpensive,accurate,data-driven surmogate model that directly learns the microstructural evolution of targeted systems by combining phase-field and history-dependent machine-learning *** integrate a statisti cally representative,low-dimensianal description of the micrastructure,obtained direcdy from phase-field simulations,with either a time-series multivariate adaptive regression splines autoregressive al garithm or a lang short-term memory neural *** neural-network-trained surrogate model shows the bestperformance and accurately predicts the nanlinear microstructure evolutian of a two-phase mixture during spinodal decomposition in seconds,without the need for"on-the-fly"solutions of the phase-field equations of *** also show that the predictions from our machine learned surrogate model can be fed directly as an input into a classical high-fideli ty phase-field model in order to accelerate the high-fidelity phase field simulations by leaping in *** machine-learned phase-field framework opens a promising path forward to use accelerated phase field simulations for discovering,understanding,and predicting processing-microstructure-performance relationships.

关键词： phase versatile statist