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RNAi screen in Drosophila yields a fat catch of Hedgehog

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Protein & Cell 2010年第3期1卷 205-206页

作者： steven Y Cheng Center for Regenerative Medicine and Department of Developmental Genetics Nanjing Medical UniversityNanjing 210029China

Obesity,the scrooge of technological advances of the human society,just had its genetic makings revealed once again.A large international team led by Josef *** and Harald Esterbauer from the Austrian Academy of Sciences and Medical University of Vienna have conducted a systemic hunt for obesity genes in adult Drosophila using an ingenious design of RNAi-based screening strategy(Pospisilik et al.,2010).This study covered 78%of Drosophila genome,including 30%of genes that would otherwise cause embryonic lethality if inactivated by conventional *** findings included~500 obesity genes that have their functions linked to control of differentiation along neuronal,muscle,and oenocyte lineages,but components of the Hedgehog(Hh)signaling distinguished themselves as the top-scoring hits。

关键词： Hedgehog otherwise finding

Androgen receptor functions in prostate cancer development and progression

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Asian Journal of Andrology 2014年第4期16卷 561-564页

作者： steven P Balk Division of Hematology-Oncology Beth Israel Deaconess Medical Center Harvard Medical School Boston MA USA.

The androgen receptor （AR） is critical for the normal development ofprostate and for its differentiated functions. The consistent expression of AR in prostate cancer （PCa）, and its continued activity in PCa that relapse after androgen deprivation therapy （castration-resistant prostate cancer （CRPC））, indicate that at least a subset of these genes are also critical for PCa development and progression. This review addressed AR regulated genes that may be critical for PCa, and how AR may acquire new functions during PCa development and progression.

关键词： BETA-CATENIN NUCLEAR RECEPTOR TRANSCRIPTIONAL ACTIVITY PTEN LOSS COREPRESSOR SOX9 GENE INHIBITION CELLS PROLIFERATION

Effects of ply orientation and material on the ballistic impact behavior of multilayer plain-weave aramid fabric targets

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Defence Technology（防务技术） 2018年第3期14卷 165-178页

作者： Gaurav Nilakantan steven Nutt Mork Family Department of Chemical Engineering and Materials Science M.C.Gill Composites CenterUniversity of Southern CaliforniaLos AngelesCA Currently at Teledyne Scientific&Imaging 1049 Camino Dos RiosThousand OaksCA91360USA.

Virtual testing of fabric armor provides an efficient and inexpensive means of systematically studying the influence of various architectural and material parameters on the ballistic impact behavior of woven fabrics, before actual laboratory prototypes are woven and destructively tested. In this finite element study, the combined effects of individual ply orientations and material properties on the impact performance of multi-layered, non-stitched woven aramid fabrics are studied using 2-and 4-sided clamping configurations. Individual ply orientations of 0°, ±15°, ±30°, and ±45° are considered along with three levels of inter-yarn friction coefficient. Functionally graded fabric targets are also considered wherein the yarn stiffness progressively increases or decreases through the target thickness while keeping the yarn strain energy density constant and with all other material and architectural parameters unchanged for consistency. For each target configuration, one non-penetrating and one penetrating impact velocity is chosen. The impact performance is evaluated by the time taken to arrest the projectile and the backface deformation for the non-penetrating impacts, and by the residual velocity for the penetrating impact tests. All deterministic impact simulations are performed using LS-DYNA. 2-sided clamped targets and lower inter-yarn frictional levels generally resulted in better impact *** functionally graded targets generally showed either similar or inferior impact performance than the baseline fabric target configurations for the non-penetrating shots. Some performance improvements were observed for the penetrating shots when the yarn stiffness was progressively decreased through the layers in a direction away from the strike face, with additional performance enhancements achieved by simultaneously reducing the inter-yarn friction.

关键词：材料参数线织物芳香族厚度编织取向行为弹道

FRACTAL NATURE OF LIGHT SCATTERING IN TISSUES

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Journal of Innovative Optical Health Sciences 2011年第1期4卷 1-7页

作者： steven L.JACQUES Dermatology and Biomedical Engineering Oregon Health and Science University 3303 SW Bond Ave Portland OR97239USA

Light scattering by a tissue has a wavelength dependence that depends on the size distribution of scatterers in the *** measuring the wavelength dependence of scattering,one can deduce changes in the nanoscale architecture of cells and *** report discusses the connection between nanoscale architecture and measurable light *** significance of this work is to develop label-free optical imaging that describes tissue structure,to complement the absorption,fluorescence,and Raman scattering spectra that describe the chemical constituents of a tissue.

关键词： Optical scattering fractal biomedical optics

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文化数字化变革:赋能中国软实力提升

国际人才交流 2024年第9期 51-56页

作者：贝思文沈婧(译) 匈牙利国家博物馆匈牙利国家美术馆佰路得信息技术(上海)有限公司不详

我与中国的相遇,可以说是恰逢其时。在中国这场文化发展、数字化与遗产保护的变革中,我是见证者,也是参与者。我的工作主要是走访历史遗址、博物馆、美术馆和历史名人纪念馆,创新其传播方式,拉近它们与公众的距离,深化其宣传教育的力量... 详细信息

我与中国的相遇,可以说是恰逢其时。在中国这场文化发展、数字化与遗产保护的变革中,我是见证者,也是参与者。我的工作主要是走访历史遗址、博物馆、美术馆和历史名人纪念馆,创新其传播方式,拉近它们与公众的距离,深化其宣传教育的力量。我们精心策划、设计并推出各式互动展览,力求让每一位访客获得触动心灵深处的难忘体验。在中国的时光里,我有幸踏访了千余座博物馆与科技中心,亲眼见证了中国在文化领域里建设与现代化发展的显著成果。文化场馆的蓬勃兴起,是中国人民文化自信日益增强的生动写照。

关键词：文化自信触动心灵遗产保护博物馆美术馆数字化变革文化场馆传播方式

DNA sequence representation by trianders and determinative degree of nucleotides

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2005年第8期6卷 743-755页

作者： DUPLIJ Diana DUPLIJ steven Institute of Molecular Biology and Genetics Kiev 03143 UkraineTheory Group Nuclear Physics LaboratoryKharkov National UniversityKharkov 61077 Ukraine

A new version of DNA walks, where nucleotides are regarded unequal in their contribution to a walk is introduced, which allows us to study thoroughly the “fine structure” of nucleotide sequences. The approach is based on the assumption that nucleotides have an inner abstract characteristic, the determinative degree, which reflects genetic code phenomenological prop-erties and is adjusted to nucleotides physical properties. We consider each codon position independently, which gives three separate walks characterized by different angles and lengths, and that such an object is called triander which reflects the “strength” of branch. A general method for identifying DNA sequence “by triander” which can be treated as a unique “genogram” (or “gene passport”) is proposed. The two- and three-dimensional trianders are considered. The difference of sequences fine structure in genes and the intergenic space is shown. A clear triplet signal in coding sequences was found which is absent in the intergenic space and is independent from the sequence length. This paper presents the topological classification of trianders which can allow us to provide a detailed working out signatures of functionally different genomic regions.

关键词： DNA walk Triander Determinative degree Analysis DNA sequences Dystrophin Nucleotide

SPECTRAL IMAGING AND ANALYSIS TO YIELD TISSUE OPTICAL PROPERTIES

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Journal of Innovative Optical Health Sciences 2009年第2期2卷 123-129页

作者： steven L.JACQUES Departments of Dermatology and Biomedical Engineering Oregon Health&Science University PortlandOregonUSA

An introduction to the basics of spectral imaging as applied to biological tissues is *** example of a spectral image of a face is used to demonstrate the data and spectral analysis that specify the melanin content(M),blood content(B),tissue oxygen saturation(S),water content(W),fraction of scattering due to Rayleigh scattering(f)and due to Mie scattering(1−f),and the reduced scattering coefficient at 500-nm wavelength(µs 500 nm).The sensitivity of reflectance spectra to variation in the various parameters is illustrated.

关键词： Spectroscopy spectral imaging tissue optical properties optical diagnostics.

21^(st) Century Niobium-Bearing Structural Steels

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Journal of Iron and Steel Research International 2011年第S1期18卷 803-807页

作者： Jansto steven CBMM-Reference Metals Company 1000 Old Pond Road Bridgeville PA USA

Value-added applications of niobium (Nb) microalloyed steels continue to be developed for commercial implementation to meet increased material demands and improved properties for 21st century structural applications. These applications demand Nb-bearing steels that deliver improved toughness, fracture and fire resistance and weldability. Such applications include medium and jumbo beam, boiler, bridge, container, heavy equipment, long product, pressure vessel, ship, storage tank and windtower applications. Steel producers are challenged to develop microalloyed steel grades that cost effectively meet end user demands for higher strength at thinner cross sections, better low temperature toughness to resist brittle fracture in building, pressure vessel and ship structures, sustain higher loads per unit area in earthquake and hurricane zone product applications, demonstrate improved fire-resistance in buildings, bridges and tunnels and provide overall improved weldability. Niobium is often a key element to achieve these results. This paper will discuss Nb market opportunities and key operational practices required to successfully melt, cast and roll these high strength steel grades. Niobium process metallurgy is important to leverage the ability of niobium to obtain ultra-fine grain, homogeneous structural steel microstructures with superior mechanical properties. The process metallurgy, physical metallurgy and resultant properties are significantly determined by mill capabilities, mill practices, operational understanding and the culture of the steel mill. The optimal combination and implementation aspects that are unique to each mill we call metallurgical operational integration (MOI) . MOI is the bridge that links the product requirements to mill capability and process implementation.

关键词： Century Niobium-Bearing Structural Steels st

The Contribution of Niobium Bearing Steels and Enhanced Sustainability

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Journal of Iron and Steel Research International 2011年第S1期18卷 966-970页

作者： Jansto steven CBMM-Reference Metals Company 1000 Old Pond RoadBridgevillePAUSA

With the growing concern for the environmental impact of greenhouse gases and the rapid depletion of important resources,the use of Nb-bearing steels for advanced high strength steel applications can reduce raw material usage and the carbon *** conservation and more efficient use of ironmaking and steelmaking raw materials is an urgent issue for steel producers ***-developed Nb-microalloyed steel applications provide a more effective product design and reduce CO 2 emissions and energy consumption per tonne of steel.A sustainability structural steelstudy presents the positive cost and reduced environmental impact of Nb-microalloyed *** analysis compares the CO 2 emission reduction and energy savings in the steelmaking process melted in both the Basic Oxygen Furnace (BOF) and the Electric Arc Furnace (EAF).Nb-microalloyed structural steels offer the opportunity to reduce the total weight of a given structure compared to a non-microalloyed steel ***,one considers the savings associated with less material and lower construction *** addition,there is an environmental benefit in the reduction in emissions (kilograms of CO 2) and less energy consumption (GJ) due to the fact that less steel is ***,there are lighter sections and less material weight in the final end user design which reduces transportation and fabrication costs.A forecasted trend is presented which introduces an increased usage of microalloyed steel grades to replace traditional commodity-type non-alloyed higher carbon-manganese grades for environmental benefits and significant cost reduction.

关键词： In HSLA The Contribution of Niobium Bearing Steels and Enhanced Sustainability