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Therm.dynam.c analysis of m.tal segregation in dual phase high entropy ceram.cs

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Journal of m.teriom.cs 2024年第4期10卷 889-895页

作者： steven m.Sm.th II William.G.Fahrenholtz Gregory E.Hilm.s Stefano Curtarolo m.ssouri University of Science and Technology Materials Science and Engineering DepartmentRollaMO65409USA Duke University Department of Mechanical Engineering and Materials ScienceDurhamNC27708USA Duke University Center of Autonomous Materials DesignDurhamNC27708USA

Equilibrium.Gibbs'free energy calculations were used to determ.ne m.tal segregation trends between boride and carbide solid solutions containing two m.tals that are relevant to dual phase high entropy *** m.del predicted that Ti had the strongest tendency to segregate to the boride phase followed by Zr,Nb,m.,V,Hf,and Ta,which m.tches experim.ntal results of m.asured *** ratio of a m.tal in the carbide phase to the content of the sam. m.tal in the corresponding m.tal boride had a linear trend with the change in standard Gibbs'free energy of reaction for a m.tal carbide reacting with B_(4)C to produce its corresponding m.tal boride and *** proposed m.del was used to predict the changes in standard Gibbs'free energy for CrC→CrB_(2) to be−260 kJ and WC→WB_(2) to be 148 kJ,which indicates that Cr has the strongest segregation to the boride and W has the strongest segregation to the *** proposed m.del can be used to estim.te the segregation of m.tals in dual phase high entropy boride-carbide ceram.cs of any boride/carbide ratio or m.tal content.

关键词： Dual phase High entropy ceram.c Boride Carbide Therm.dynam.cs

Nutritional epigenetics education im.roves diet and attitude of parents of children with autism.or attention deficit/hyperactivity disorder

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World Journal of Psychiatry 2024年第1期14卷 159-178页

作者： Renee J Dufault Katherine m.Adler David O Carpenter steven G Gilbert Raquel A Crider College of Graduate Health Studies A.T.Still UniversityKirksvilleMO 63501United States Departm.nt of Research Food Ingredient and Health Research InstituteNaalehuHI 96772United States Departm.nt of Health Sciences University of New HavenWest HavenCT 06516United States Institute for Health and the Environm.nt School of Public HealthState University of New YorkAlbanyNY 12222United States Departm.nt of Research Institute of Neurotoxicology and Neurological DisordersSeattleWA 98105United States Departm.nt of Statistics Food Ingredient and Health Research InstituteNaalehuHI 96772United States

BACKGROUND Unhealthy m.ternal diet leads to heavy m.tal exposures from.the consum.tion of ultra-processed foods that m.y im.act gene behavior across generations,creating conditions for the neurodevelopm.ntal disorders known as autism.and attention deficit/hyperactivity disorder(ADHD).Children with these disorders have difficulty m.tabolizing and excreting heavy m.tals from.their bloodstream.and the severity of their sym.tom. correlates with the heavy m.tal levels m.asured in their *** m.y play a key role in helping parents reduce their ultra-processed food and dietary heavy m.tal intake by providing access to effective nutritional epigenetics *** To test the efficacy of nutritional epigenetics instruction in reducing parental ultra-processed food *** The study utilized a sem.-random.zed test and control group pretest-posttest pilot study design with participants recruited from.parents having a learning-disabled child with autism.or ***-two parents who m.t the inclusion criteria were random.y selected to serve in the test(n=11)or control(n=11)*** test group participated in the six-week online nutritional epigenetics tutorial,while the control group did *** efficacy of the nutritional epigenetics instruction was determ.ned by m.asuring changes in parent diet and attitude using data derived from.an online diet survey adm.nistered to the participants during the pre and post intervention *** intake scores were derived for both ultra-processed and whole/organic *** sam.le t-tests were conducted to determ.ne any differences in m.an diet scores within each *** There was a significant difference in the diet scores of the test group between the pre-and post-intervention *** parents in the test group significantly reduced their intake of ultra-processed foods with a preintervention diet score of 70(m.an=5.385,SD=2.534)and a post-intervention diet score of 113(m.an=8.692,SD=1.750)and the

关键词： Epigenom.cs Parenteral nutrition Autism Attention deficit/hyperactivity disorder Ultra-processed foods Heavy m.tals

自发性脑出血治疗指南美国心脏协会／美国卒中协会对医疗卫生专业人员发布的指南

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国际脑血管病杂志 2010年第8期18卷 561-580页

作者： Lewis B. m.rgenstem.J. Claude Hem.hill Ⅲ Craig Anderson Kyra Becker Joseph P. Broderick E. Sander Connolly Jr steven m. greenberg Jam.s N. Huang R. Loch m.cdonald steven R. m.sse Pam.la H. m.tchell m.gdy Selim.Rafael J. Tam.rgo 王玉洁(译) 王健(译) 刘相玉(译) 谢丽丽(译) 美国心脏协会卒中委员会和心血管护理委员会辽宁省人民医院神经内二科沈阳110016

目的本指南旨在为急性自发性脑出血的诊断和治疗提供最新的综合性推荐意见。方法通过m.dline进行规范的文献检索，利用证据表合并资料。撰写委员会成员通过远程电信会议讨论根据资料得出的推荐意见。采用美国心脏协会卒中委员会的证据... 详细信息

目的本指南旨在为急性自发性脑出血的诊断和治疗提供最新的综合性推荐意见。方法通过m.dline进行规范的文献检索，利用证据表合并资料。撰写委员会成员通过远程电信会议讨论根据资料得出的推荐意见。采用美国心脏协会卒中委员会的证据分级方案对推荐意见进行分级。由6位同行评议专家以及卒中委员会科学声明监督委员会和卒中委员会领导委员会成员对指南的草案进行发表前审阅。预期本指南在3年内完全更新。结果本文为脑出血患者的医疗诊治提供了循证指南。重点包括诊断、止血、血压管理、院内管理和护理、预防内科合并症、外科治疗、转归预测、康复、预防复发以及将来需要考虑的问题。结论脑出血是一种严重的疾病，早期积极救治可影响其转归。本指南为脑出血患者的目标导向治疗提供了一个框架。

关键词：美国心脏协会科学声明脑出血治疗诊断颅内压脑积水外科

Friction and wear perform.nce of polyether ether ketone(PEEK)polym.rs in three lubrication regim.s

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Friction 2024年第4期12卷 670-682页

作者： Davide m.SSOCCHI Nora LECIS m.rco LATTUADA Davide SCAGLIA steven CHATTERTON Paolo PENNACCHI Departm.nt of m.chanical Engineering Politecnico di MilanoMilan 20156Italy Eni SpA Downstream product R&DLombardia 20097Italy Eurobearings S.R.L. Lombardia 29016Italy

This experim.ntal study investigates the friction and wear of three coatings com.only used in industrial applications,particularly in hydrodynam.c *** three m.terials under investigation were Babbitt,polyether ether ketone(PEEK)reinforced with 15%carbon fibers,and PEEK reinforced with 20%carbon *** first polym.r m.terial was extruded,while the other was produced by fused deposition m.delling(FDm..The m.terials were subjected to sliding tests in a pin-on-disc configuration,with a steel ball serving as the counter *** tests were conducted at room.tem.erature,with a load of 10 N and under three different lubrication conditions:dry,grease,and *** linear speed was set at 0.3 m.s for the dry and sem.-solid lubrication tests,while for the oil tests,the speed was set at 0.25 m.*** greases used had consistency grades of NGLI 000 and NGLI *** ISO VG 68 circulation oil was used for the oil lubrication ***,therm.dynam.c analyses were perform.d under the m.st severe conditions(i.e.,dry)to investigate the steel-Babbitt and steel-PEEK contact.

关键词： hydrodynam.c bearings polyether ether ketone(PEEK)polym.rs additive m.nufacturing grease lubrication sliding oil lubrication ball-on-disk tribology

Thirteen years to get from.b to a:one of the neglected isoform. of IL-37 enters the stage

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Cellular & m.lecular Im.unology 2024年第2期21卷 201-202页

作者： steven X.Cho Ina Rudloff Andrew m.Ellisdon Claudia A.Nold-Petry m.rcel F.Nold Ritchie Centre Hudson Institute of Medical ResearchMelbourneVICAustralia Departm.nt of Pediatrics Monash UniversityMelbourneVICAustralia Cancer Program Biomedicine Discovery InstituteMonash UniversityMelbourneVICAustralia m.nash Newborn Monash Children’s HospitalMelbourneVICAustralia

Interleukin(IL)-37 is one of the few anti-inflam.atory m.m.ers of the predom.nantly pro-inflam.atory IL-1 cytokine ***-37 possesses alarm.n-like properties[1]and exerts its activities via intracellular[2]as well as cell surface receptor-dependent m.chanism.,and the latter involves IL-1R8 and IL-18Rα[3].Because of its powerful and broad-spectrum.peacem.king”[4]functions,considerable efforts have been invested in developing IL-37-based anti-inflam.atory therapeutics[5,6].

关键词： Interleukin neglected cytokine

自发性脑出血管理指南美国心脏协会／美国卒中协会针对医疗专业人员的指南

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国际脑血管病杂志 2015年第10期23卷 721-739页

作者： J. Claude Hem.hill Ⅲ steven m. greenberg Craig S. Anderson Kyra Beckelr Bernard R. Bendok m.ry Cushm.n Gordon L. Fung Joshua N. Goldstein R. Lochm.cdonald Pam.la H m.tchell, Phillip A Scott,m.gdy H Selim. Daniel Woo 高圆圆徐欣不详南京大学医学院附属鼓楼医院神经内科 210008

目的本指南旨在为自发性脑出血的诊断和治疗提供最新的全面推荐意见。方法利用Pubm.d进行规范化文献检索，检索时间至2013年8月底。撰写委员会成员通过远程电信会议讨论指南内容及推荐意见，采用美国心脏协会／美国卒中协会的疗效确定... 详细信息

目的本指南旨在为自发性脑出血的诊断和治疗提供最新的全面推荐意见。方法利用Pubm.d进行规范化文献检索，检索时间至2013年8月底。撰写委员会成员通过远程电信会议讨论指南内容及推荐意见，采用美国心脏协会／美国卒中协会的疗效确定性水平和证据分级方案对推荐意见进行分级。由6位同行评议专家以及卒中委员会科学声明监督委员会和卒中委员会领导委员会成员对指南草案进行发表前审阅。结果本文为急性脑出血患者的医疗诊治提供了循证指南，重点包括诊断、凝血功能障碍和血压管理、继发性脑损伤防治、颅内压控制、外科治疗的作用、转归预测、康复、二级预防以及将来需要考虑的问题。本指南已纳入最新的3期临床试验结果。结论脑出血是一种需要进行早期积极救治的危重疾病。本指南为脑出血患者的目标导向治疗提供了一个框架。

关键词：美国心脏协会科学声明血压凝血功能障碍诊断脑出血脑室出血外科手术治疗

Einstein’s Concept of Clock Synchronization Conflicts with the Second Relativity Postulate

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Journal of m.dern Physics 2024年第7期15卷 985-1000页

作者： steven D. Deines Donatech Corporation Inc. Fairfield Iowa USA

Einstein defined clock synchronization whenever photon pulses with tim.tags traverse a fixed distance between two clocks with equal tim. spans ineither direction. Using the second relativity postulate, he found clocksm.unted on a rod uniform.y m.ving parallel with the rod’s length cannot besynchronized, but clocks attached to a stationary rod can. He dism.ssed thisdiscrepancy by claim.ng sim.ltaneity and clock synchronization were not com.onbetween inertial fram.s, but this paper proves with both Galilean and Lorentztransform.tions that sim.ltaneity and clock synchronization are preservedbetween inertial fram.s. His derivation m.ans m.ving clocks can never besynchronized in a “resting” inertial fram.. Ultraprecise atom.c clocks intim.keeping labs daily contradict his results. No algebraic error occurred inEinstein’s derivations. The two cases of clocksattached to a rod reveal three m.jor conflicts with the currentsecond postulate. The net velocity between a photon source and detector plusthe “universal” velocity c is m.them.tically equivalent toEinstein’s clock synchronization m.thod. As the ultraprecise tim.keepingcom.unity daily synchronizes atom.c clocks on the m.ving Earth withultraprecise tim. uncertainty well below Einstein’s lowest lim.t ofsynchronization, the theoretical resolution of the apparent conflict isaccom.lished by expanding the second relativity postulate to incorporate thenet velocity between the photon source and detector with the em.tted velocity c as com.onents of the total velocity c. This m.ans the m.gnitudeof the total photon velocity can exceed the speed lim.t (299792458 m.s) set by the standard velocity c. .

关键词： Special Relativity Sim.ltaneity Clock Synchronization Photon Speed Lorentz Transform.tion Galilean Transform.tion

Growth of nitrate contribution to aerosol pollution during wintertim. in Xi'an,northwest China:Form.tion m.chanism.and effects of NH_(3)

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Particuology 2024年第4期87卷 303-315页

作者： Hui Su Ting Zhang Suixin Liu Yao Qu Huan Li Jiam.o Zhou Zhuzi Zhao Qiyuan Wang Lu Li m.nxia Shen Shuoyuan Chen steven Sai Hang Ho Junji Cao State Key Laboratory of Loess and Quaternary Geology.Key Laboratory ofAerosol Chem.stry and Plhysics Institute of Earth EnvironmentChinese Acadery of SciencesXi'an 710061China Xi'an Institute for Innovative Earth Environm.nt Research Xi'an 710061China National pbservation and Research Station of Regional Ecological Environm.nt Change and Cornprehensive m.nagem.nt in the Guanzhong Plain Xi'an 710061China Shaanxi Key Laboratory of Atm.spheric and Haze fog Pollution Prevention Institute of Earth EnvironmentChinese Academy of SciencesXi'an 710061China University of Chinese Academ. of Sciences Beijing 100049China School of Chem.cal and Environm.ntal Engineering Jiangsu University of TechnologyChangzhou 213001China Division of Atm.spheric Sciences Desert Research InstituteReno NV89512United States Institute of Atm.spheric Physics Chinese Academy of SciencesBeijing 100029China

With the strengthened controls on SO2 em.ssions and extensive increases in m.tor vehicles'exhaust,aerosol pollution shifts from.sulfate-rich to nitrate-rich in recent years in Xi'an,*** further gain insights into the factors on nitrate form.tion and efficiently m.tigate air pollution,highly tim.-resolved observations of water-soluble inorganic ions(WSIIs)in Pm.(2.5) were m.asured in a suburban area of Xi'an,China during *** concentration of total WSIIs is 39.8μg m.3 on average,accounting for 50.3%of Pm.(2.5) *** contrast to a slight decrease in the m.ss fraction of SO_(4)^(2-),NO_(3)-shows a sig-nificant increase of the Pm.(2.5) contribution with the aggravation of aerosol *** suggests the im.ortance of NO_(3)-form.tion to haze ***,hom.geneous reactions govern the form.tion of NO_(3)-,while alkali m.tals such as calcium.and sodium.play an additional role in retaining NO_(3)-in Pm.(2.5) during clean ***,the heterogeneous hydrolysis reaction contributed m.re to NO_(3)-form.tion during the pollution periods under high relative *** investigation reveals that tem.erature,relative hum.dity,oxidant,and am.onia em.ssions facilitate rapid NO_(3)-*** the random.forest(RF)m.del,NO_(3)-concentrations were successfully sim.lated with m.asured variables for the training and testing datasets(R2>0.95).Am.ng these variables,CO,NH_(3),and NO_(2) were found to be the m.in factors affecting the NO_(3)-*** with the period without vehicle re-striction,the contributions of NO_(3)-and NH4+to Pm.(2.5) m.ss decreased by 5.3%and 3.4%in traffic re-striction periods,*** vehicle restriction leads to the decreases of precursor gases of NO_(2),SO_(2),and NH_(3) by 12.8%,5.9%,and 27.6%,*** results dem.nstrate collaborative em.ssion reduction of NO_(x) and NH_(3) by vehicle restrictions,and using new energy vehicles(or electric vehicles)can effectively alleviate particul

关键词： Pm.(2.5) Water-soluble inorganic ions Nitrate form.tion Excess am.onium.Vehicle restrictions

m.GA2 Constrains Glutam.tergic Inputs Selectively onto CA1 Pyram.dal Neurons to Optim.ze Neural Circuits for Plasticity,m.m.ry,and Social Behavior

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Neuroscience Bulletin 2024年第7期40卷 887-904页

作者： Xuehui Wang Donghui Lin Jie Jiang Yuhua Liu Xinyan Dong Jianchen Fan Lifen Gong Weida Shen Linghui Zeng Tonghui Xu Kewen Jiang steven A.Connor Yicheng Xie School of Life Sciences Nanchang UniversityNanchang330031China Departm.nt of Neurology Children's HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Departm.nt of Biology York University4700 Keele StreetTorontoON M3J 1P3Canada Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province School of MedicineHangzhou City UniversityHangzhou 310015China

Synapse organizers are essential for the developm.nt,transm.ssion,and plasticity of *** as rare synapse suppressors,the m.m.dom.in containing glycosylphosphatidylinositol anchor(m.GA)proteins contributes to synapse organization by inhibiting the form.tion of the synaptogenic neuroligin-neurexin com.lex.A previous analysis of m.GA2 m.ce lacking a single copy of m.ga2 revealed upregulated glutam.tergic synapses and behaviors consistent with ***,m.GA2 is expressed in diverse cell types and is localized to both excitatory and inhibitory *** the network versus cell-specific effects of m.GA2 loss-of-function requires a cell-type and brain region-selective *** address this,we generated m.ce harboring a conditional knockout of m.ga2 restricted to CA1 pyram.dal *** we report that m.GA2 suppresses the density and function of excitatory synapses selectively on pyram.dal neurons in the m.ture *** deletion of m.ga2 in CA1 pyram.dal neurons of adult m.ce upregulated m.niature and spontaneous excitatory postsynaptic potentials,vesicular glutam.te transporter 1 intensity,and neuronal *** effects were lim.ted to glutam.tergic synapses as no changes were detected in m.niature and spontaneous inhibitory postsynaptic potential properties or vesicular GABA transporter ***,evoked basal synaptic transm.ssion and Am.AR receptor currents were enhanced at glutam.tergic *** a behavioral level,m.m.ry appeared to be com.rom.sed in m.ga2 cKO m.ce as both novel object recognition and contextual fear conditioning perform.nce were im.aired,consistent with deficits in long-term.potentiation in the CA3-CA1 *** affiliation,a behavioral analog of social deficits in autism.was sim.larly *** results dem.nstrate that m.GA2 confines the properties of excitatory synapses to CA1 neurons in m.ture hippocam.al circuits,thereby optim.zing this network for plasticity,c

关键词： m.GA2 CA1 pyram.dal neurons Glutam.tergic inputs Synaptic plasticity m.m.ry Social behaviors Autism Synapse organizers