检索结果-南通市图书馆

Validity of continuous-failure-state unloading triaxial tests as a means to estimate the residual strength of rocks

Journal of Rock mechanics and Geotechnical Engineering 2021年第4期13卷 717-726页

作者： Gabriel Walton steven Gaines Leandro R.Alejano Department of Geology and Engineering Geology Colorado School of MinesGoldenCO80401USA Natural Resources Canada CanmetMININGOttawaOntarioK1A 1M1Canada Department of Natural Resources and Environmental Engineering Universidad de VigoVigo36310Spain

The residual strength of rocks and rock masses is an important parameter to be constrained for analysis and design purposes in many rock engineering applications.A residual strength envelope in principal stress space is typically developed using residual strength data obtained from compression tests on many different specimens of the same rock *** this study,we examined the potential for use of the continuous-failure-state testing concept as a means to constrain the residual strength envelope using a limited number of ***,cylindrical specimens of three rock types(granodiorite,diabase,and Stanstead granite)were unloaded at the residual state such that a full residual strength envelope for each individual specimen was *** a residual strength model that introduces a single new strength parameter(the residual strength index,or RSI),the results of the continuous-failurestate unloading tests were compared to conventionally obtained residual strength ***,the continuous-failure-state residual strength data were found to be consistent with the conventional residual strength ***,it was identified that the primary factor limiting an accurate characterization of the residual strength for a given rock type is not the amount of data for a given specimen,but the variety of specimens available to characterize the inherent variability of the rock unit of ***,the use of continuous-failure-state testing for estimation of the residual strength of a rock unit is only recommended when the number of specimens available for testing is very limited(i.e.<5).

关键词： Residual strength Continuous-failure-state testing Compression testing Brittle rock mechanics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

mycophenolate mofetil for maintenance of remission in steroid-dependent autoimmune pancreatitis

引用

World Journal of Gastroenterology 2012年第18期18卷 2287-2290页

作者： Jamie B Sodikoff steven A Keilin Sheila J Bharmal melinda m Lewis Gottumukkala S Raju Field F Willingham Division of Digestive Diseases Department of MedicineEmory University School of MedicineAtlantaGA 30322United States Department of Pathology Emory University School of MedicineAtlantaGA 30322United States Department of Gastroenterology the University of Texas MD Anderson Cancer CenterHoustonTX 77030United States

Systemic corticosteroids represent the standard treatment for autoimmune pancreatitis with IgG4-associated *** steroid-dependent disease,azathioprine has been used for maintenance of *** mofetil has been used for transplant immunosuppression and more recently for autoimmune hepatitis;however,there are no case reports to date on the use of mycophenolate mofetil in adult patients with autoimmune pancreatitis.A patient with IgG4-mediated autoimmune pancreatitis and IgG4-associated cholangitis refractory to steroids and intolerant of azathioprine was treated with mycophenolate mofetil,which inhibits de novo guanosine synthesis and blockade of both B and T lymphocyte *** of mycophenolate mofetil and uptitration to 1000 mg by mouth twice daily over a treatment period of 4 mo was associated with improvement in the patient's energy level and blood glucose control and was not associated with any adverse *** patient was managed without a biliary ***,there was a return of symptoms,jaundice,increase in transaminases,and hyperbilirubinemia when the prednisone dose reached 11 mg per *** the first report of mycophenolate mofetil use in an adult patient with IgG4-associated autoimmune pancreatitis and IgG4-associated cholangitis,the introduction of mycophenolate mofetil was safe and well-tolerated without adverse events,but it did not enable discontinuation of the *** mofetil and other immunomodulatory therapies should continue to be studied for maintenance of remission in the large subset of patients with refractory or recurrent autoimmune pancreatitis.

关键词： Autoimmune diseases Pancreatitis mycophenolate mofetil Recurrence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Wedge and needle liver biopsies show discordant histopathology in morbidly obese patients undergoing Roux-en-Y gastric bypass surgery

引用

Gastroenterology Report 2013年第1期1卷 51-57页

作者： Sekou R.Rawlins Cynthia m.mullen Howard m.Simon Taewan Kim steven K.Landas marguerite S.Walser Robert A.levine Division of Gastroenterology Department of MedicineState University of New York(SUNY)Upstate Medical UniversitySyracuseNYUSA Associates in Gastroenterology RockvilleMDUSA Department of Surgery SUNYUpstate Medical UniversitySyracuseNYUSA Department of Pathology SUNYUpstate Medical UniversitySyracuseNYUSA Section of Gastroenterology Department of MedicineBoston University School of MedicineBostonMAUSA

Background:Controversy exists over whether or not single-needle liver biopsies are sufficient to compare histological parameters in patients with non-alcoholic fatty liver ***:To identify sampling variability,we biopsied four liver specimens per patient,based on biopsy size(needle vs wedge)and location(left vs right lobe),immediately prior to bariatric Roux-en-Y gastric bypass ***:Ten prospectively enrolled,morbidly obese patients underwent 40 laparoscopy-guided biopsies;two needle and two wedge from each of 16 left and 16 right liver *** Kappa coefficient for concordance compared histological parameters from left and right lobe needle-and wedge *** biopsies were considered our‘Gold Standard’.Results:Each patient had two wedge-and two needle liver *** concordance between all needle and wedge biopsies from right and left lobes showed ***-and needle liver biopsies from contralateral lobes had higher concordance with each other,compared to ipsilateral needle/wedge biopsy *** wedge pairs had higher concordance than contralateral needle/needle *** were no biopsy ***:Wedge biopsy pairs had the best Kappa concordance but contralateral needle/needle biopsy pairs had good Kappa *** were no complications from the 40 needle-and wedge liver biopsies,confirming the safety of laporoscopic multi-biopsy in both liver lobes.

关键词： gastric bypass liver biopsy steatosis fibrosis image analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Osteoclasts:New Insights

引用

Bone Research 2013年第1期1卷 11-26页

作者： Xu Feng steven L.Teitelbaum Department of Pathology The University of Alabama at BirminghamBirminghamAlabama 35294USA Department of Pathology and Immunology Washington University School of MedicineSt.LouisMissouri 63110USA

Osteoclasts, the bone-resorbing cells, play a pivotal role in skeletal development and adult bone remodeling. They also participate in the pathogenesis of various bone disorders. Osteoclasts differentiate from cells of the monocyte/macrophage lineage upon stimulation of two essential factors, the monocyte/ macrophage colony stimulating factor （m-CSF） and receptor activation of NF-κB ligand （RANKL）. m-CSF binds to its receptor c-Fms to activate distinct signaling pathways to stimulate the proliferation and survival of osteoclast precursors and the mature cell. RANKL, however, is the primary osteoclast differentiation factor, and promotes osteoclast differentiation mainly through controlling gene expression by activating its receptor, RANK. Osteoclast function depends on polarization of the cell, induced by integrin avβ3, to form the resorptive machinery characterized by the attachment to the bone matrix and the formation of the bone-apposed ruffled border. Recent studies have provided new insights into the mechanism of osteoclast differentiation and bone resorption. In particular, c-Fms and RANK signaling have been shown to regulate bone resorption by cross-talking with those activated by integrin avβ3. This review discusses new advances in the understanding of the mechanisms of osteoclast differentiation and function.

关键词： osteoclast bone remodeling m-CSF RANKL integrin avβ3

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Business statistics /.4th ed 4th ed.

引用

丛书名：工商管理经典教材·核心课系列= Business administration classics

2006年

作者： levine David m.

本书涵盖了应用统计学在当代商务经济领域中几乎所有的重要应用，并且将统计软件（包括Excel，SPSS，minitab）的使用贯穿全书始终。书中提供了大量的实例。

ISBN: (数字)7300061249

ISBN: (纸本)7300061249

关键词： Industrial management

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

Nutritional epigenetics education improves diet and attitude of parents of children with autism or attention deficit/hyperactivity disorder

引用

World Journal of Psychiatry 2024年第1期14卷 159-178页

作者： Renee J Dufault Katherine m Adler David O Carpenter steven G Gilbert Raquel A Crider College of Graduate Health Studies A.T.Still UniversityKirksvilleMO 63501United States Department of Research Food Ingredient and Health Research InstituteNaalehuHI 96772United States Department of Health Sciences University of New HavenWest HavenCT 06516United States Institute for Health and the Environment School of Public HealthState University of New YorkAlbanyNY 12222United States Department of Research Institute of Neurotoxicology and Neurological DisordersSeattleWA 98105United States Department of Statistics Food Ingredient and Health Research InstituteNaalehuHI 96772United States

BACKGROUND Unhealthy maternal diet leads to heavy metal exposures from the consumption of ultra-processed foods that may impact gene behavior across generations,creating conditions for the neurodevelopmental disorders known as autism and attention deficit/hyperactivity disorder(ADHD).Children with these disorders have difficulty metabolizing and excreting heavy metals from their bloodstream,and the severity of their symptoms correlates with the heavy metal levels measured in their *** may play a key role in helping parents reduce their ultra-processed food and dietary heavy metal intake by providing access to effective nutritional epigenetics *** To test the efficacy of nutritional epigenetics instruction in reducing parental ultra-processed food *** The study utilized a semi-randomized test and control group pretest-posttest pilot study design with participants recruited from parents having a learning-disabled child with autism or ***-two parents who met the inclusion criteria were randomly selected to serve in the test(n=11)or control(n=11)*** test group participated in the six-week online nutritional epigenetics tutorial,while the control group did *** efficacy of the nutritional epigenetics instruction was determined by measuring changes in parent diet and attitude using data derived from an online diet survey administered to the participants during the pre and post intervention *** intake scores were derived for both ultra-processed and whole/organic *** sample t-tests were conducted to determine any differences in mean diet scores within each *** There was a significant difference in the diet scores of the test group between the pre-and post-intervention *** parents in the test group significantly reduced their intake of ultra-processed foods with a preintervention diet score of 70(mean=5.385,SD=2.534)and a post-intervention diet score of 113(mean=8.692,SD=1.750)and the

关键词： Epigenomics Parenteral nutrition Autism Attention deficit/hyperactivity disorder Ultra-processed foods Heavy metals

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Comparative effectiveness of Biobrane^(■),RECELL^(■)Autologous skin Cell suspension and Silver dressings in partial thickness paediatric burns:BRACS randomised trial protocol

引用

Burns & Trauma 2019年第1期7卷 309-320页

作者： Anjana Bairagi Bronwyn Griffin Zephanie Tyack Dimitrios Vagenas steven m.mcPhail Roy Kimble Centre for Children’s Burns and Trauma Research Centre for Children’s Health ResearchBrisbaneQueenslandAustralia Pegg Leditschke Children’s Burns Centre Queensland Children’s HospitalBrisbaneQueenslandAustralia School of Nursing Institute of Health and Biomedical InnovationQueensland University of TechnologyBrisbaneQueenslandAustralia Australian Centre for Health Services Innovation Institute of Health and Biomedical InnovationSchool of Public Health and Social WorkQueensland University of TechnologyBrisbaneQueenslandAustralia Research methods Group Institute of Health and Biomedical InnovationQueensland University of TechnologyBrisbaneQueenslandAustralia The University of Queensland BrisbaneQueenslandAustralia Centre for Functioning and Health Research Metro South Hospital and Health ServiceBrisbaneQueenslandAustralia

Background:mixed partial thickness burns are the most common depth of burn injury managed at a large Australian paediatric hospital specialty burns *** time until re-epithelialisation is associated with increased burn depth and scar *** current wound management approaches have benefits such as anti-microbial cover,these are not without inherent limitations including multiple dressing *** Biobrane^(■)RECELL^(■)Autologous skin Cell suspension and Silver dressings(BRACS)trial aims to identify the most effective wound management approach for mixed partial thickness injuries in ***:All children presenting with an acute burn injury to the study site will be screened for *** is a single-centre,three-arm,parallel group,randomised *** younger than 16 years,with burns≥5%total body surface area involving any anatomical location,up to 48 h after the burn injury,and of a superficial partial to mid-dermal depth,will be included.A sample size of 84 participants will be randomised to standard silver dressing or a Regenerative Epithelial Suspension(RES^(Tm))with Biobrane^(■)or Biobrane^(■)*** first dressing will be applied under general anaesthesia and subsequent dressings will be changed every 3 to 5 days until the wound is≥95%re-epithelialised,with re-epithelialisation time the primary *** outcomes of acute pain,acute itch,scar severity,health-related quality of life,treatment satisfaction,dressing application ease and healthcare resource use will be assessed at each dressing change and 3,6 and 12 months post-burn ***:The findings of this study can potentially change the wound management approach for superficial partial to mid-dermal burns in children locally and *** registration:The Australian New Zealand Clinical Trials Registry(ACTRN12618000245291)approved prospective registration on 15 February *** details can be viewed at https://***/T

关键词： Partial thickness burns Children Regenerative epidermal suspension Re-epithelialisation Wound healing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plant photosystem Ⅱ assembly:TROL2 to the rescue

引用

molecular Plant 2023年第11期16卷 1719-1721页

作者： Sujith Puthiyaveetil steven D.mcKenzie Department of Biochemistry and Center for Plant Biology Purdue UniversityWest LatayetteIN 47907USA

In one of the most consequential biochemical reactions on earth,a pigment-protein complex known as photosystem Ⅱ(PSⅡ)in photosynthesis extracts electrons,protons,and oxygen from water using energy from ***Ⅱ thereby sustains life on earth by harnessing the potential of two nearly inexhaustible raw materials:sunlight and *** plant PSllis a membrane-embedded *** monomer consists of around 28 unique protein subunits,157 chlorophylls,44 carotenoids,2 pheophytins,a heme,a non-heme iron,two quinones,and a mn_(4)CaO_(5) cluster(Su et al.,2017;Cao et al.,2018).Within each monomeric complex,20 protein subunits constitute a core(Figure 1A).

关键词： Figure earth thereby

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

National trends in resection of the distal pancreas

引用

World Journal of Gastroenterology 2012年第32期18卷 4342-4349页

作者： Armando Rosales-Velderrain steven P Bowers Ross F Goldberg Tatyan m Clarke mauricia A Buchanan John A Stauffer Horacio J Asbun Department of General Surgery Mayo Clinic FloridaJacksonvilleFL 32225United States

AIm:To investigate national trends in distal pancreatectomy(DP) through query of three national patient care ***:From the Nationwide Inpatient Sample(NIS,2003-2009),the National Surgical Quality Improvement Project(NSQIP,2005-2010),and the Surveillance Epidemiology and End Results(SEER,2003-2009) databases using appropriate diagnostic and procedural codes we identified all patients with a diagnosis of a benign or malignant lesion of the body and/or tail of the pancreas that had undergone a partial or distal *** of laparoscopy was defined in NIS by the International Classification of Diseases,Ninth Revision correspondent procedure code;and in NSQIP by the exploratory laparoscopy or unlisted procedure current procedural terminology *** SEER,patients were identified by the International Classification of Diseases for Oncology,Third Edition diagnosis codes and the SEER Program Code manual,third edition procedure *** analyzed the databases with respect to trends of inpatient outcome metrics,oncologic outcomes,and hospital volumes in patients with lesions of the neck and body of the pancreas that underwent operative ***:NIS,NSQIP and SEER identified 4242,2681 and 11 082 DP resections,***,laparoscopy was utilized in 15%(NIS) and 27%(NSQIP).No significant increase was seen over the course of the *** was performed for malignancy in 59%(NIS) and 66%(NSQIP).Neither patient Body mass index nor comorbidities were associated with operative approach(P = 0.95 and P = 0.96,respectively).mortality(3% vs 2%,P = 0.05) and reoperation(4% vs 4%,P = 1.0) was not different between laparoscopy and open *** complications(10% vs 15%,P < 0.001),hospital costs [44 741 dollars,interquartile range(IQR) 28 347-74 114 dollars vs 49 792 dollars,IQR 13 299-73 463,P = 0.02] and hospital length of stay(7 d,IQR 4-11 d vs 7 d,IQR 6-10,P < 0.001) were less when laparoscopy was *** and two year sur

关键词： Laparoscopic distal pancreatectomy Trends Nationwide Inpatient Sample National Surgical Quality Improvement Project Surveillance epidemiology and end results

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Exploring the reasons for the seasons using Google Earth, 3D models, and plots

引用

International Journal of Digital Earth 2017年第6期10卷 582-603页

作者： Declan G.De Paor mladen m.Dordevic Paul Karabinos Stephen Burgin Filis Coba steven J.Whitmeyer Departments of Physics and Ocean Earthand Atmospheric SciencesOld Dominion UniversityNorfolkVAUSA Department of Geology and Environmental Science James Madison UniversityHarrisonburgVAUSA Department of Geosciences Williams CollegeWilliamstownMAUSA Department of Curriculum and Instruction University of ArkansasFayettevilleARUSA Department of Physics Old Dominion UniversityNorfolkVAUSA

Public understanding of climate and climate change is of broad societal ***,misconceptions regarding reasons for the seasons abound amongst students,teachers,and the public,many of whom believe that seasonality is caused by large variations in Earth’s distance from the *** may be reinforced by textbook illustrations that exaggerate eccentricity or show an inclined view of Earth’s near-circular *** explanations that omit multiple factors influencing seasons,that do not mesh with students’experiences,or that are erroneous,hinder scientifically valid *** show that many teachers share their students’misconceptions,and even when they understand basic concepts,teachers may fail to appreciate the range of factors contributing to seasonal change,or their relative *** have therefore developed a learning resource using Google Earth,a virtual globe with other useful,weather-and climate-related visualizations.A classroom test of 27 undergraduates in a public research university showed that 15 improved their test scores after the Google Earth-based laboratory class,whereas 5 *** correct answers rose from 4.7/10 to 6/10,giving a paired t-test value of *** using Google Earth,students are helped to segue to a heliocentric view.

关键词： Visualization geo-spatial science geobrowser earth observation 3-d representation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：