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Epidemiology and phenotypes of diabetes in children and adolescents in non-European-origin populations in or from Western Pacific region

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World Journal of Clinical Pediatrics 2022年第2期11卷 173-195页

作者： steven james Jayanthi Maniam Pik-To Cheung Tatsuhiko Urakami Julia von Oettingen Supawadee Likitmaskul Graham Ogle School of Nursing Midwifery and ParamedicineUniversity of the Sunshine CoastPetrie 4502QueenslandAustralia Life for a Child Program Diabetes NSW&ACTGlebe 2017New South WalesAustralia Department of Paediatric Endocrinology Genetics and MetabolismVirtus Medical GroupHong KongChina Department of Pediatrics Nihon University School of MedicineTokyo 173-8610Japan Research Institute McGill University Health CentreMontreal H4A 3JIQuebecCanada Siriraj Diabetes Center Faculty of MedicineSiriraj HospitalMahidol UniversityBangkok 10700Thailand

BACKGROUND Type 1 diabetes(T1D)incidence varies substantially between countries/territories,with most studies indicating increasing *** Western Pacific region(WPR),reported rates are much lower than European-origin *** contrast,there are reports of substantial numbers of young people with type 2 diabetes(T2D).A deeper understanding of T1D and T2D in the WPR may illuminate factors important in pathogenesis of these ***,with varying resources and funding for diabetes treatment in this region,there is a need to more clearly determine the current burden of disease and also any gaps in *** To compile and summarise published epidemiologic and phenotypic data on childhood diabetes in non-European populations in and from *** Research articles were systematically searched from PubMed(MEDLINE),Embase,Cochrane library,and gray *** outcome measures were incidence and prevalence,with secondary measures including phenotypic descriptions of diabetes,including diabetes type categorization,presence of diabetic ketoacidosis(DKA)at onset,autoantibody positivity,Cpeptide levels,and human leucocyte antigen *** data were collected using a customized *** hundred and thirty relevant records were identified from 16 countries/territories,with analysis conducted on 265(80.3%)records published from the year *** T1D incidence ranged from<1-7.3/100000 individuals/year,rates were highest in emigrant/mixed populations and lowest in South-East Asia,with most countries/territories(71.4%)having no data since *** was increasing in all six countries/territories with data(annual increases 0.5%-14.2%,highest in China).Peak age-of-onset was 10-14 years,with a female case *** of DKA at onset varied from 19.3%-70%.Pancreatic autoantibodies at diagnosis were similar to European-origin populations,with glutamic acid decarboxylase-65 autoantibody frequency of 44.1%-64.5%,insulinoma-ass

关键词： Epidemiology Phenotypes Diabetes Children Adolescents Western Pacific

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Choledochoscope with stent placement for treatment of benign duodenal strictures:A case report

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World Journal of Gastrointestinal Endoscopy 2019年第3期11卷 256-261页

作者： Ryan Sung-Eun Cho John Magulick Shelby Madden james steven Burdick Department of Gastroenterology and Hepatology San Antonio Uniformed Services Health Education Consortium Department of Internal Medicine San Antonio Uniformed Services Health Education Consortium Depart of Gastroenterology and Hepatology Baylor University Medical Center

BACKGROUND Endoscopically or fluoroscopically guided dilation is a safe and effective alternative to surgery for patients with benign strictures of the gastric *** SUMMARY We describe two cases where a novel approach with a Spyglass~? choledochoscope in assessing the extent of benign duodenal strictures and aiding in placement of duodenal stents for treatment of the strictures. Choledochoscope-guided wire and stent placement was successful in all cases, leading to symptom resolution related to benign duodenal obstruction. No major adverse events were *** Choledochoscope-guided assessment and endoscopic therapy is a viable approach in relieving duodenal obstruction, if the conventional combined fluoroscopic and endoscopic methods fail.

关键词： Choledochoscope Duodenal stricture Intraluminal stent Case report

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“我永远不懂我的妻子”

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英语学习 2004年第5期 30-31页

作者： steven james 馨儿

Teacher,tender comrade,wife,A fellow-farer true through llfe.—Robert Louis stevenson I'll never understand my *** day she moved in with me,she started opening and closingmy kitchen cabinets,gasping,"Youdon't have any shelf paper!We'regoing to have to get some shelfpaper in here before I move mydishes in.""But why?"I asked innocently.

关键词： when 永远妻子

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Methodology to locate and quantify radial winding deformation in power transformers

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High Voltage 2017年第1期2卷 17-24页

作者： steven D.Mitche james S.Wesh School of Electrical and Computer Engineering University of NewcastleCallaghanN.S.W 2308Australia

Frequency response analysis(FRA)is a tool that can be used to detect changes within the structural geometry of a *** application of FRA is to detect winding displacement after the transformer experiences an overcurrent *** paper proposes a methodology which will facilitate both locating and quantifying winding *** procedure is based on the fitting of a Gray Box transformer model to FRA measurements which were recorded both before and after the *** variation in key parameters of the model can then be used to quantify winding deformation *** research will demonstrate the applicability of this approach to a wide range of transformer applications by using FRA from a modified 1.3 MVA distribution transformer,and assessing the change in key parameters relative to the emulated buckling introduced to the *** authors propose that this approach is ideally suited for use within an automated diagnostic system which will locate,diagnose and quantify winding deformation within power transformers.

关键词： winding deformation power

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Observer-based fault detection scheme for a class of discrete time-delay systems

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Journal of Systems Engineering and Electronics 2004年第3期15卷 288-294页

作者：钟麦英张承慧 Ding steven X Lain james ControlScienceandEngineeringSchool ShandongUniversityJinan250061P.R.China Gerhard-Mercator-UniversityDuisburg Germany DepartmentofMechanicalEngineering TheUniversityofHongKongP.R.China

In this contribution, robust fault detection problems for discrete time-delay systems with l2-norm bounded unknown inputs are studied. The basic idea of our study is first to introduce a state-memoryless observer-based fault detection filter (FDF) as the residual generator and then to formulate such a FDF design problem as an Hen optimization problem in the sense of increasing the sensitivity of residual to the faults, while simultaneously enhancing the robustness of residual to unknown input as well as plant input. The main results consist of the formulation of such a residual generation optimization problem, solvability conditions and the derivation of an analytic solution. The residual evaluation problem is also considered, which includes the determination of residual evaluation function and threshold. A numerical example is used to demonstrate the proposed fault detection scheme.

关键词： residual generator robustness unknown input time-delay system post-filter.

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NADPH oxidase-1 deficiency offers little protection in Salmonella typhimurium-induced typhlitis in mice

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World Journal of Gastroenterology 2016年第46期22卷 10158-10165页

作者： Fong-Fong Chu R steven Esworthy james H Doroshow Binghui Shen Department of Gastroenterology and Hepatology The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology Department of Cancer Genetics and Epigenetics Beckman Research Institute of City of Hope Center for Cancer Research and Division of Cancer Treatment and Diagnosis National Cancer Institute

AIM To test whether Nox1 plays a role in typhlitis induced by Salmonella enterica serovar Typhimurium(S. Tm) in a mouse *** Eight-week-old male wild-type(WT) and Nox1 knockout(KO) C57BL6/J(B6) mice were administered metronidazole water for 4 d to make them susceptible to S. Tm infection by the oral route. The mice were given plain water and administered with 4 different doses of S. Tm by oral gavage. The mice were followed for another 4 d. From the time of the metronidazole application, the mice were observed twice daily and weighed daily. The ileum, cecum and colon were removed for sampling at the fourth day post-inoculation. Portions of all three tissues were fixed for histology and placed in RNAlater for m RNA/c DNA preparation and quantitative real-time PCR. The contents of the cecum were recovered for estimation of S. Tm *** We found Nox1-knockout(Nox1-KO) mice were not more sensitive to S. Tm colonization and infection than WT B6 mice. This conclusion is based on the following observations:(1) S. Tm-infection induced similar weight loss in Nox1-KO mice compared to WT mice;(2) the same S. Tm CFU was recovered from the cecal content of Nox1-KO and WT mice regardless of the inoculation dose, except the lowest inoculation dose(2 × 106 CFU) for which the Nox1-KO had one-log lower CFU than WT mice;(3) there is no difference in cecal pathology between WT and Nox1-KO groups; and(4) there are no S. Tm infection-induced changes in gene expression levels(IL-1b, TNF-α, and Duox2) between WT and Nox1-KO groups. The Alpi gene expression was more suppressed by S. Tm treatment in WT than the Nox1-KO cecum. CONCLUSION Nox1 does not protect mice from S. Tm colonization. Nox1-KO provides a very minor protective effect against S. Tm infection. Using NOX1-specific inhibitors for colitis therapy should not increase risks in bacterial infection.

关键词： Knockout mouse NADPH Oxidase-1 Salmonella typhimurium Goblet cells Reactive oxygen species

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Optimization of operational strategies for rich gas enhanced oil recovery based on a pilot test in the Bakken tight oil reservoir

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Petroleum Science 2023年第5期20卷 2921-2938页

作者： Xincheng Wan Lu Jin Nicholas A.Azzolina Jin Zhao Xue Yu steven A.Smith james A.Sorensen Energy&Environmental Research Center University of North Dakota15 North 23rd StreetStop 9018Grand ForksND58202-9018USA

Horizontal well drilling and multistage hydraulic fracturing have been demonstrated as effective approaches for stimulating oil production in the Bakken tight oil ***,after multiple years of production,primary oil recovery in the Bakken is generally less than 10%of the estimated original oil in *** huff‘n’puff(HnP)has been tested in the Bakken Formation as an enhanced oil recovery(EOR)method;however,most field pilot test results showed no significant incremental oil *** of the factors affecting HnP EOR performance is premature gas breakthrough,which is one of the most critical issues observed in the field because of the presence of interwell ***,injected gas rapidly reaches adjacent production wells without contacting reservoir rock and increasing oil *** conformance control is therefore needed to avoid early gas breakthrough and improve EOR *** this study,a rich gas EOR pilot in the Bakken was carefully analyzed to collect the essential reservoir and operational data.A simulation model with 16 wells was then developed to reproduce the production history and predict the EOR performance with and without conformance *** operational strategies,including single-and multiple-well HnP,with different gas injection constraints were *** simulation results of single-well HnP without conformance control showed that a rich gas injection rate of at least 10 MMscfd was needed to yield meaningful incremental oil *** strategy of conformance control via water injection could significantly improve oil production in the HnP well,but injecting an excessive amount of water also leads to water breakthrough and loss of oil production in the offset *** analyzing the production performance of the wells individually,the arrangement of wells was optimized for multiple-well HnP *** multiwell results showed that rich gas EOR could improve oil production up to 7.4%by employing confor

关键词： Rich gas injection Bakken tight oil reservoir EOR strategies Conformance control Embedded discrete fracture model

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Dual enzyme activated fluorescein based fluorescent probe

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Frontiers of Chemical Science and Engineering 2020年第1期14卷 117-121页

作者： Maria L.Odyniec Jordan E.Gardiner Adam C.Sedgwick Xiao-Peng He steven D.Bull Tony D.james Department of Chemistry University of BathBathBA27AYUK Department of Chemistry University of Texas at AustinAustinTX 78712-1224USA Key Laboratory for Advanced Materials&Feringa Nobel Prize Scientist Joint Research Center East China University of Science and TechnologyShanghai 200237China

A simple dual analyte fluorescein-based probe(PF3-Glc)was synthesised containingβ-glucosidase(β-glc)and hydrogen peroxide(H2O2)trigger *** presence ofβ-glc,resulted in fragmentation of the parent molecule releasing glucose and the slightly fluorescent mono-boronate fluorescein(PF3).Subsequently,in the presence of glucose oxidase(GOx),the released glucose was catalytically converted to D-glucono-δ-lactone,which produced H2O2 as a *** GOx-produced H2O2,resulted in classic H2O2-mediated boronate oxidation and the release of the highly emissive fluorophore,*** unique cascade reaction lead to an 80-fold increase in fluorescence intensity.

关键词： chemosensors dual-activation GOx fluorescence β-glucosidase molecular logic

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Liver-specific drug delivery platforms: Applications for the treatment of alcohol-associated liver disease

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World Journal of Gastroenterology 2022年第36期28卷 5280-5299页

作者： Jeffrey Barr Warner steven Corrigan Guenthner Josiah Everett Hardesty Craig james McClain Dennis Ray Warner Irina Andreyevna Kirpich Department of Medicine Division of GastroenterologyHepatology and NutritionUniversity of Louisville School of MedicineLouisvilleKY 40202United States Department of Pharmacology and Toxicology University of Louisville School of MedicineLouisvilleKY 40202United States Alcohol Research Center University of Louisville School of MedicineLouisvilleKY 40202United States Hepatobiology and Toxicology Center University of Louisville School of MedicineLouisvilleKY 40202United States Veterans Health Administration Robley Rex Veterans Medical CenterLouisvilleKY 40206United States Department of Microbiology and Immunology University of Louisville School of MedicineLouisvilleKY 40202United States

Alcohol-associated liver disease(ALD)is a common chronic liver disease and major contributor to liver disease-related deaths *** its prevalence,there are few effective pharmacological options for the severe stages of this *** much pre-clinical research attention is paid to drug development in ALD,many of these experimental therapeutics have limitations such as poor pharmacokinetics,poor efficacy,or off-target side effects due to systemic *** means of addressing these limitations is through liver-targeted drug delivery,which can be accomplished with different platforms including liposomes,polymeric nanoparticles,exosomes,bacteria,and adenoassociated viruses,among *** platforms allow drugs to target the liver passively or actively,thereby reducing systemic circulation and increasing the‘effective dose’in the *** many studies,some clinical,have applied targeted delivery systems to other liver diseases such as viral hepatitis or hepatocellular carcinoma,only few have investigated their efficacy in *** review provides basic information on these liver-targeting drug delivery platforms,including their benefits and limitations,and summarizes the current research efforts to apply them to the treatment of ALD in rodent *** also discuss gaps in knowledge in the field,which when addressed,may help to increase the efficacy of novel therapies and better translate them to humans.

关键词： Liver targeted delivery Nanoparticles Liposomes Polymeric nanoparticles Precision medicine Alcohol associated liver disease

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A simple umbelliferone based fluorescent probe for the detection of nitroreductase

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Frontiers of Chemical Science and Engineering 2018年第2期12卷 311-314页

作者： Adam C. Sedgwick Alex Hayden Barry Hill steven D. Bull Robert B. P. Elmes Tony D. james Department of Chemistry University of Bath Bath BA2 7AY UK Department of Chemistry Maynooth University Maynooth Co. Kildare Ireland

A simple nitrobenzyl-umbelliferone （NCOU1） was synthesised containing a nitroreductase （NTR） trigger moiety. The presence of NTR, resulted in the fragmentation of the parent molecule and release of the highly emissive fluorophore umbelliferone via an NTR-catalyzed reduction of the nitro group. In the presence of the NTR enzyme, NCOU1 gave rise to a 5-fold increase in fluorescence intensity at 455 nm and was selective for NTR over other reductive enzymes. These results indicate that NCOU1 can be used as a simple assay for the detection of NTR.

关键词： fragmentation NCOU1 NTR nitroreductase nitrobenzyl-umbelliferone

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