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Plant photosystem Ⅱ assembly:TROL2 to the rescue

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Molecular Plant 2023年第11期16卷 1719-1721页

作者： Sujith Puthiyaveetil steven D.McKenzie Department of Biochemistry and Center for Plant Biology Purdue UniversityWest LatayetteIN 47907USA

In one of the most consequential biochemical reactions on earth,a pigment-protein complex known as photosystem Ⅱ(PSⅡ)in photosynthesis extracts electrons,protons,and oxygen from water using energy from ***Ⅱ thereby sustains life on earth by harnessing the potential of two nearly inexhaustible raw materials:sunlight and *** plant PSllis a membrane-embedded *** monomer consists of around 28 unique protein subunits,157 chlorophylls,44 carotenoids,2 pheophytins,a heme,a non-heme iron,two quinones,and a Mn_(4)CaO_(5) cluster(Su et al.,2017;Cao et al.,2018).Within each monomeric complex,20 protein subunits constitute a core(Figure 1A).

关键词： Figure earth thereby

High Strength Low Alloy (HSLA) Steels in Building Construction

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Journal of Iron and Steel Research International 2011年第S1期18卷 773-778页

作者： Sivakumaran Ken Siva Jansto steven G Department of Civil Engineering McMaster UniversityHamilton Reference Metals Company-CBMM 1000 Old Pond RoadBridgevillePA 15017USA

Majority of the buildings,including industrial buildings,are constructed using either structural steel (plates and structural shapes) or deformed bar steel reinforced *** buildings,however,must be designed to be safe and serviceable during construction and during use and *** objectives can be easily achieved by the use of steels having superior mechanical properties,ductility,weldability,fire resistance,*** the years,the steel industry has made improvements in steel making technologies resulting in high strength low alloy (HSLA) steels with superior steel properties well suited for building *** part of this paper presents the structural design considerations,and the constructional considerations associated with the building structures in general,and steel structures in *** second part of the paper looks at the acceptance criteria for HSLA steels for North American building codes and *** third part of the paper presents the structural properties of currently available HSLA steels for building *** discussion focuses on hot-rolled structural steel shapes as well as deformed steel bars for concrete *** paper argues that Niobium microalloying is the key to achieving superior properties in such steels.

关键词： HSLA steels building construction structural shapes deformed bars structural performance niobium

Non-genetic contributions of the sperm nucleus to embryonic development

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Asian Journal of Andrology 2011年第1期13卷 31-35页

作者： Yasuhiro Yamauchi Jeffrey A Shaman W steven Ward Department Anatomy and Reproductive Biology Institute for Biogenesis Research John A. Burns School of Medicine University of Hawaii at Manoa Honolulu HI USA GLP Services GENEWlZ Inc. 115 Corporate Blvd. South Plainfield NJ 07080 USA

Recent data from several laboratories have provided evidence that the newly fertilized oocyte inherits epigenetic signals from the sperm chromatin that are required for proper embryonic development. For the purposes of this review, the term epigenetic is used to describe all types of molecular information that are transmitted from the sperm cell to the embryo. There are at least six different forms of epigenetic information that have already been established as being required for proper embryogenesis in mammals or for which there is evidence that it may do so. These are （i） DNA methylation; （ii） sperm-specific histones, （iii） other chromatin-associated proteins; （iv） the perinuclear theca proteins; （v） sperm-born RNAs and, the focus of this review; and （vi） the DNA loop domain organization by the sperm nuclear matrix. These epigenetic signals should he considered when designing protocols for the manipulation and cryopreservation of spermatozoa for assisted reproductive technology as necessary components for effective fertilization and subsequent embryo development.

关键词： embryogenesis epigenetics sperm DNA sperm nuclear matrix DNA loop domain organization

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Asian Journal of Andrology 2012年第1期14卷 136-137页

作者： Andrea A Chan steven E Canfield Run Wang Division of Urology University of Texas Medical School at Houston Houston TX 77030 USA Department of Urology University of Texas MD Anderson Cancer Center Houston TX 77030 USA

The Scandinavian Prostate Cancer Group- 4 recently reported the long-term survival benefit in men who were randomized to radical prostatectomy versus men watchful waiting for localized prostate cancer.1 The authors have now presented the companion article that updates the long-term quality of life evaluation in these men.2 Given the excellent prognosis of patients with early stage prostate cancer, the impact of therapy on patient＇s quality of life is a significant factor in the optimal management of this disease.

关键词： Health-related quality of life Scandinavian patients radical prostatectomy watchful waiting

Molecular profiles to biology and pathways:a systems biology approach

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Chinese Journal of Cancer 2016年第10期35卷 497-499页

作者： steven Van Laere Luc Dirix Peter Vermeulen Translational Cancer Research Unit Center for Oncological ResearchFaculty of Medicine and Health SciencesUniversity of Antwerp

Interpreting molecular profiles in a biological context requires specialized analysis strategies. Initially, lists of relevant genes were screened to identify enriched concepts associated with pathways or specific molecular processes. However, the shortcoming of interpreting gene lists by using predefined sets of genes has resulted in the development of novel methods that heavily rely on network-based concepts. These algorithms have the advantage that they allow a more holistic view of the signaling properties of the condition under study as well as that they are suitable for integrating different data types like gene expression, gene mutation, and even histological parameters.

关键词：生物学方法分子图谱系统通路相关基因分子过程数据类型基因表达

Determinants of the Specif icity of Protein Targeting to Chloroplasts or Mitochondria

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Molecular Plant 2019年第7期12卷 893-895页

作者： Lucas McKinnon steven M.Theg Department of Plant Biology University of California Davis Davis CA USA

Chloroplasts and mitochondria are both thought to have arisen through primary endosymbiosis (Kutschera and Niklas, 2005). As each organelle evolved, most of its genome was transferred to the host nucleus resulting in the vast majority of its proteome being nuclear encoded and synthesized on cytosolic ribosomes (Shi and Theg, 2013).

关键词： Chloroplasts Mitochondria

Can a science-based definition of acupuncture improve clinical outcomes？

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Journal of Integrative Medicine 2017年第3期15卷 165-171页

作者： Ted Priebe steven H. Stumpf Rod Zalunardo Healthpointe Medical Group La Mirada La Mirada CA 90638 USA Department of Health Administration California State University at Northridge Northridge CA 90638 USA Chief Operations Officer Health Core Possibilities Los Angeles CA 90638 USA

Research on acupuncture has been muddled by attempts to bridge the ancient with the modern. Barriers to effectiveness research are reflected in recurring conflicts that include disagreement on use of the most basic terms, lack of standard intervention controls, and the absence of functional measures for assessing treatment effect. Acupuncture research has stalled at the ＂placebo barrier＇ wherein acupuncture is ＂no better than placebo.＂ The most widely recognized comparative effectiveness research in acupuncture does not compare acupuncture treatment protocols within groups, thereby, mutating large scale effectiveness studies into large scale efficacy trials. Too often research in acupuncture attempts to tie outcomes to traditional belief systems thereby limiting usefulness of the research. The acupuncture research paradigm needs to focus more closely on a scientific definition of treatments and outcomes that compare protocols in terms of prevalent clinical issues such as relative effectiveness for treating pain.

关键词： acupuncture research medicine, traditional Chinese

Methodology to locate and quantify radial winding deformation in power transformers

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High Voltage 2017年第1期2卷 17-24页

作者： steven D.Mitche James S.Wesh School of Electrical and Computer Engineering University of NewcastleCallaghanN.S.W 2308Australia

Frequency response analysis(FRA)is a tool that can be used to detect changes within the structural geometry of a *** application of FRA is to detect winding displacement after the transformer experiences an overcurrent *** paper proposes a methodology which will facilitate both locating and quantifying winding *** procedure is based on the fitting of a Gray Box transformer model to FRA measurements which were recorded both before and after the *** variation in key parameters of the model can then be used to quantify winding deformation *** research will demonstrate the applicability of this approach to a wide range of transformer applications by using FRA from a modified 1.3 MVA distribution transformer,and assessing the change in key parameters relative to the emulated buckling introduced to the *** authors propose that this approach is ideally suited for use within an automated diagnostic system which will locate,diagnose and quantify winding deformation within power transformers.

关键词： winding deformation power

Volterra filter modeling of a nonlinear discrete-time system based on a ranked differential evolution algorithm

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Journal of Zhejiang University-Science C(Computers and Electronics) 2014年第8期15卷 687-696页

作者： De-xuan ZOU Li-qun GAO steven LI School of Electrical Engineering and Automation Jiangsu Normal University School of Information Science and Engineering Northeastern University Graduate School of Business and Law RMIT UniversityGPO Box 2476 Melbourne 3001 Australia

This paper presents a ranked differential evolution(RDE) algorithm for solving the identification problem of nonlinear discrete-time systems based on a Volterra filter model. In the improved method, a scale factor, generated by combining a sine function and randomness, effectively keeps a balance between the global search and the local search. Also, the mutation operation is modified after ranking all candidate solutions of the population to help avoid the occurrence of premature convergence. Finally, two examples including a highly nonlinear discrete-time rational system and a real heat exchanger are used to evaluate the performance of the RDE algorithm and five other approaches. Numerical experiments and comparisons demonstrate that the RDE algorithm performs better than the other approaches in most cases.

关键词： Ranked differential evolution Identification problem Nonlinear discrete-time systems Volterra filter model Premature convergence