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Extraintestinal heterotopic gastric tissue simulating acute appendicitis

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World Journal of Gastroenterology 2008年第14期14卷 2268-2269页

作者： Elizabeth Bender steven P Schmidt Department of Surgery and Division of Surgical Research Summa Health System Akron Ohio 44304 United States

We describe the case of a 68-year-old otherwise healthy male who presented to our emergency room with signs and symptoms of acute appendicitis. Exploratory surgery revealed a normal appendix. Further examination revealed an enlarged lymph node-like mass of tissue near the appendix, in the ileocecal mesentery. This mass was removed and was found to be inflamed heterotopic gastric tissue. Although reports of heterotopic gastric tissue in the literature are common, we believe that this case represents the first report of inflamed heterotopic gastric tissue simulating appendicitis.

关键词： Heterotopic gastric mucosa Acute appendicitis

DNA alkylation promoted by an electron-rich quinone methide intermediate

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Frontiers of Chemical Science and Engineering 2016年第2期10卷 213-221页

作者： Chengyun Huang steven E. Rokita Department of Chemistry and Biochemistry University of Maryland College Park MD 20742 USA Sichuan Institute of Geological Engineering Investigation Chengdu 610072 China Department of Chemistry Johns Hopkins University Baltimore MD 21218 USA

Biological application of conjugates derived from oligonucleotides and quinone methides have pre- viously been limited by the slow exchange of their covalent self-adducts and subsequent alkylation of target nucleic acids. To enhance the rates of these processes, a new quinone methide precursor with an electron donating substituent has been prepared. Additionally, this substi- tuent has been placed para to the nascent exo-methylene group of the quinone methide for maximum effect. A conjugate made from this precursor and a 5＇-aminohex- yloligonucleotide accelerates formation of its reversible self-adduct and alkylation of its complementary DNA as predicted from prior model studies.

关键词： quione methide DNA alkylation reversible covalent reaction bioconjugation target-directed modification of nucleic acids

Assessing the reproductive health of men with occupational exposures

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Asian Journal of Andrology 2014年第1期16卷 23-30页

作者： steven M Schrader Katherine L Marlow Centers for Disease Control and Prevention National Institute for Occupational Safety and Health Division of Applied Research and Technology Cincinnati OH USA.

The earliest report linking environmental （occupational） exposure to adverse human male reproductive effects dates back to1775 when an English physician, Percival Pott, reported a high incidence of scrotal cancer in chimney sweeps. This observation led to safety regulations in the form of bathing requirements for these workers. The fact that male-mediated reproductive harm in humans may be a result of toxicant exposures did not become firmly established until relatively recently, when Lancranjan studied lead-exposed workers in Romania in 1975, and later in 1977, when Whorton examined the effects of dibromochloropropane （DBCP） on male workers in California. Since these discoveries, several additional human reproductive toxicants have been identified through the convergence of laboratory and observational findings. Many research gaps remain, as the pool of potential human exposures with undetermined effects on male reproduction is vast. This review provides an overview of methods used to study the effects of exposures on male reproduction and their reproductive health, with a primary emphasis on the implementation and interpretation of human studies. Emphasis will be on occupational exposures, although much of the information is also useful in assessing environmental studies, occupational exposures are usually much higher and better defined.

关键词： accessory glands endocrine epidemiology semen sexual function sperm testis toxicology

Quantum Yang-Baxter equation and constant R-matrix over Grassmann algebra

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2005年第10期6卷 1065-1079页

作者： DUPLIJ steven KOTULSKA Olga SADOVNIKOV Alexander Department of Physics and Technology V.N. Karazin Kharkov National University Svoboda Sq. 4 Kharkov 61077 UkraineDepartment of Physics and Technology V.N. Karazin Kharkov National University Svoboda Sq. 4 Kharkov 61077 UkraineDepartment of Physics and Technology V.N. Karazin Kharkov National University Svoboda Sq. 4 Kharkov 61077 Ukraine

Constant solutions to Yang-Baxter equation are investigated over Grassmann algebra for the case of 6-vertex R-matrix. The general classification of all possible solutions over Grassmann algebra and particular cases with 2,3,4 generators are studied. As distinct from the standard case, when R-matrix over number field can have a maximum 5 nonvanishing elements, we obtain over Grassmann algebra a set of new full 6-vertex solutions. The solutions leading to regular R-matrices which appear in weak Hopf algebras are considered.

关键词： Constant solution Grassmann algebra Regularity R-matrix

The Importance of Active Surveillance in the Assessment of Vaccine Safety

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China CDC weekly 2019年第2期1卷 26-27页

作者： steven Black Global Vaccine Data Network USA Cincinnati Children’s Hospital USA

Vaccines are among the most effective public health interventions(1).However,vaccines can potentially cause *** minimize risk,proactive regulation of drugs and vaccines was implemented globally beginning in the *** ne... 详细信息

关键词： routine globally drugs

Surveillance of patients following surgery with curative intent for colorectal cancer

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World Journal of Gastroenterology 2007年第28期13卷 3816-3823页

作者： steven Gan Katherine Wilson Paul Hollington Department of Surgery St George HospitalGray StreetKogarahNSW 2217Australia Department of Surgery Flinders Medical CentreFlinders DriveBedford Park 5042AdelaideAustralia

Surveillance after resection of colorectal cancer with curative intent is an important component of post- operative care. Clinical review, imaging, colonoscopy, and cost to the community are among significant issues to consider in planning a surveillance regime. This review aims to identify the available evidence for the use of surveillance and its individual components. The literature pertaining to follow-up of patients following potentially curative surgery for colorectal cancer was reviewed in order to formulate a summary of the wide range of clinical practice. There is evidence of improved survival of patients undergoing more intense follow-up compared with those having minimal surveillance, with an estimated overall 5-year gain of up to 10%. The efficacy of individual components of follow-up regimes remains unclear, but an overall package of 'intensive' follow-up including clinical review, liver imaging, and colonoscopy appears to be of benefit. It is cost-effective and can be specialist or community-based.

关键词： Colorectal cancer Colorectal carcinoma Follow-up Surveillance Post-operative review Post-operative imaging Post-operative colonoscopy Surveillance cost benefit

Pathophysiology and treatment of Barrett's esophagus

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World Journal of Gastroenterology 2010年第30期16卷 3762-3772页

作者： Daniel S Oh steven R DeMeester Department of Surgery The University of Southern CaliforniaKeck School of MedicineLos AngelesCA 90033United States

Gastroesophageal reflux disease (GERD) affects an estimated 20% of the population in the United States. About 10%-15% of patients with GERD develop Barrett’s esophagus, which can progress to adenocarcinoma, currently the most prevalent type of esophageal cancer. The esophagus is normally lined by squamous mucosa, therefore, it is clear that for adenocarcinoma to develop, there must be a sequence of events that result in transformation of the normal squamous mucosa into columnar epithelium. This sequence begins with gastroesophageal reflux, and with continued injury metaplastic columnar epithelium develops. This article reviews the pathophysiology of Barrett’s esophagus and implications for its treatment. The effect of medical and surgical therapy of Barrett’s esophagus is compared.

关键词： Gastroesophageal reflux disease Barrett’s esophagus Lower esophageal sphincter Esophageal motility Proton pump inhibitors Antireflux surgery

Acupuncture Points Used in the Prophylaxis against Recurrent Uncomplicated Cystitis, Patterns Identified and Their Possible Relationship to Physiological Measurements

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Chinese Journal of Integrative Medicine 2016年第7期22卷 510-517页

作者： Terje Alraek Anders Baerheim steven Birch The National Research Center in Complementary and Alternative Medicine Department of Community Medicine Faculty of Health Science UiT The Arctic University of Norway University College of Health Sciences Institute of Acupuncture Faculty of Medicine and Dentistry Department of Global Health and Primary Care University of Bergen

Objective： To explore the correlation between single acupoints used and the recurrence rate of cystitis among cystitis-prone women receiving acupuncture as a prophylactic treatment. Methods： In all, 58 cystitis-prone women were included in the analysis. Customised acupuncture treatments were given twice a week, over 4 weeks. The main effect parameter was the number of cystitis episodes during the 6-month observation time. Residual urine was measured at baseline, 2, 4 and 6 months using portable ultrasound equipment. Sympathetic and vagotone nerve activities were measured by using skin conductance and respiratory sinus arrhythmia, respectively. Results： The main acupoints used for patients with Kidney （Shen） qi/yang deficiency were Shenshu （BL23）, Taixi （KI3）, Zhongji （CV3）, Sanyinjiao （SP6） and Pangguangshu （BL2.8）, compared with Taichong （LR3）, CV3, BL28, Yinlingquan （SP9） and SP6 for Liver （Gan） qi stagnation, and SP6, CV3, BL28, Zusanli （ST36） and SP9 for Spleen （Pi） qi/yang deficiency patients. The combination BL23 and KI3 were used in 16 women, 13 of which were Kidney pattern related patients. When used, the number of symptomatic episodes were reduced to a third compared with what occurred in the 42 women where this combination was not used （3/16 vs. 28/42, P〈0.05）. BL23 application correlated to a significant reduction in residual urine measured a few days after treatment. Patients with the pattern of Spleen qi/yang deficiency had an initial increase in residual urine after treatments. Conclusion： Treating Kidney pattern related patients with the combination of BL23 and KI3 resulted in far better outcome than other points/combination of points for other Chinese medicine diagnoses. The acupoint SP6 may be less indicated than previously assumed when treating cvstitis-Drone women DroDhvlacticalIv.

关键词： acupuncture point recurrent urinary tract infection Chinese medicine pattern identification,syndrome differentiation women

Deriving the magnetopause position from wide field-of-view soft X-ray imager simulation

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Science China Earth Sciences 2022年第8期65卷 1601-1611页

作者： Yihong GUO Tianran SUN Chi WANG steven SEMBAY Aerospace Information Research Institute Chinese Academy of SciencesBeijing100094China National Space Science Center Chinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100049China School of Physics and Astronomy University of LeicesterLeicesterLE17RHUK

Imaging techniques provide essential information in astronomical and space physics *** Soft X-ray Imager(SXI)will obtain images of the Earth’s magnetosphere via the solar wind charge exchange process in a global ***,it is a challenge to reconstruct its 3-D structures from the observed 2-D image(s).In this paper,a recently proposed method,Tangent Fitting Approach(TFA),is validated to reconstruct the large-scale magnetopause from a single X-ray image obtained by instrument *** is revealed that the large-scale magnetopause under a medium solar wind number density can be well reconstructed,although the locations of maximum X-ray photon counts are scattered in the image due to instrumental effects and diffusive sky *** solar wind number density leads to stronger signals and further leads to better reconstruction *** lower solar wind density,the X-ray maximum photon counts may not be identified from the SXI simulations,preprocessing of the images shall be considered before applying ***,the subsolar magnetopause can be well derived when the satellite is on the dayside orbits.

关键词： Soft X-ray Imager Magnetosphere SMILE TFA