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National trends in resection of the distal pancreas

World Journal of Gastroenterology 2012年第32期18卷 4342-4349页

作者： Armando Rosales-Velderrain steven p bowers Ross F Goldberg Tatyan M Clarke Mauricia A Buchanan John A Stauffer Horacio J Asbun Department of General Surgery Mayo Clinic FloridaJacksonvilleFL 32225United States

AIM:To investigate national trends in distal pancreatectomy(Dp) through query of three national patient care ***:From the Nationwide Inpatient Sample(NIS,2003-2009),the National Surgical Quality Improvement project(NSQIp,2005-2010),and the Surveillance Epidemiology and End Results(SEER,2003-2009) databases using appropriate diagnostic and procedural codes we identified all patients with a diagnosis of a benign or malignant lesion of the body and/or tail of the pancreas that had undergone a partial or distal *** of laparoscopy was defined in NIS by the International Classification of Diseases,Ninth Revision correspondent procedure code;and in NSQIp by the exploratory laparoscopy or unlisted procedure current procedural terminology *** SEER,patients were identified by the International Classification of Diseases for Oncology,Third Edition diagnosis codes and the SEER program Code Manual,third edition procedure *** analyzed the databases with respect to trends of inpatient outcome metrics,oncologic outcomes,and hospital volumes in patients with lesions of the neck and body of the pancreas that underwent operative ***:NIS,NSQIp and SEER identified 4242,2681 and 11 082 Dp resections,***,laparoscopy was utilized in 15%(NIS) and 27%(NSQIp).No significant increase was seen over the course of the *** was performed for malignancy in 59%(NIS) and 66%(NSQIp).Neither patient Body mass index nor comorbidities were associated with operative approach(p = 0.95 and p = 0.96,respectively).Mortality(3% vs 2%,p = 0.05) and reoperation(4% vs 4%,p = 1.0) was not different between laparoscopy and open *** complications(10% vs 15%,p pital costs [44 741 dollars,interquartile range(IQR) 28 347-74 114 dollars vs 49 792 dollars,IQR 13 299-73 463,p = 0.02] and hospital length of stay(7 d,IQR 4-11 d vs 7 d,IQR 6-10,p paroscopy was *** and two year sur

关键词：切除术胰腺远端数据库查询教学医院程序代码肿瘤疾病 SEER

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Calcium/calcimimetic via calcium-sensing receptor ameliorates cholera toxin-induced secretory diarrhea in mice

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World Journal of Gastroenterology 2024年第3期30卷 268-279页

作者： Lie-Qi Tang Johnathan Fraebel Shi Jin steven p Winesett Jane Harrell Wen-Han Chang Sam Xianjun Cheng Department of pediatrics University of FloridaGainesvilleFL 32610United States College of Medicine University of FloridaGainesvilleFL 32610United States Applied physiology and Kinesiology University of FloridaGainesvilleFL 32610United States Brain Rehabilitation Research Center Malcom Randall VA Medical CenterGainesvilleFL 32610United States Department of Medicine Endocrine Research UnitVeterans Affairs Medical CenterUniversity of CaliforniaSan FranciscoSan FranciscoCA 94121United States Department of pediatric Gastroenterology Hepatologyand NutritionUniversity of Florida Shands Children’s HospitalGainesvilleFL 32608United States

BACKGROUND Enterotoxins produce diarrhea through direct epithelial action and indirectly by activating the enteric nervous ***-sensing receptor(CaSR)inhibits both *** latter has been well documented in vitro but not in *** hypothesis to be tested was that activating CaSR inhibits diarrhea in *** To determine whether CaSR agonists ameliorate secretory diarrhea evoked by cholera toxin(CTX)in *** CTX was given orally to C57BL/6 mice to induce *** and calci-mimetic R568 were used to activate *** maximize their local intestinal actions,calcium was administered luminally via oral rehydration solution(ORS),whereas R568 was applied serosally using an intraperitoneal *** verify that their actions resulted from the intestine,effects were also examined on Cre-lox intestine-specific CaSR *** outcome was measured biochemically by monitoring changes in fecal Cl-or clinically by assessing stool consistency and weight *** CTX induced secretory diarrhea,as evidenced by increases in fecal Cl-,stool consistency,and weight loss following CTX exposure,but did not alter CaSR,neither in content nor in ***,calcium and R568 were each able to ameliorate diarrhea when applied to diseased *** CaSR involvement is suggested by gene knockout experiments where the anti-diarrheal actions of R568 were lost in intestinal epithelial CaSR knockouts(villinCre/Casrflox/flox)and neuronal CaSR knockouts(nestinCre/Casrflox/flox).CONCLUSION Treatment of acute secretory diarrheas remains a global *** advances in diarrhea research,few have been made in the realm of diarrhea *** therapy has remained the standard of care,although it does not halt the losses of intestinal fluid and ions caused by *** is no cost-effective therapeutic for *** and other studies suggest that adding calcium to ORS or using calcimimetics to activate intestinal CaSR might

关键词： Cholera Enteric nervous system Secretory diarrhea Oral rehydration solution Calcium-sensing receptor Gene knockout

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Relational and Euclidean Temporal Space

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Journal of Applied Mathematics and physics 2024年第2期12卷 683-719页

作者： steven D. p. Moore Independent Researcher Milton Canada

In mathematics, space encompasses various structured sets such as Euclidean, metric, or vector space. This article introduces temporal space—a novel concept independent of traditional spatial dimensions and frames of reference, accommodating multiple object-oriented durations in a dynamical system. The novelty of building temporal space using finite geometry is rooted in recent advancements in the theory of relationalism which utilizes Euclidean geometry, set theory, dimensional analysis, and a causal signal system. Multiple independent and co-existing cyclic durations are measurable as a network of finite one-dimensional timelines. The work aligns with Leibniz’s comments on relational measures of duration with the addition of using discrete cyclic relational events that define these finite temporal spaces, applicable to quantum and classical physics. Ancient formulas have symmetry along with divisional and subdivisional orders of operations that create discrete and ordered temporal geometric elements. Elements have cyclically conserved symmetry but unique cyclic dimensional quantities applicable for anchoring temporal equivalence relations in linear time. We present both fixed equivalences and expanded periods of temporal space offering a non-Greek calendar methodology consistent with ancient global timekeeping descriptions. Novel applications of Euclid’s division algorithm and Cantor’s pairing function introduce a novel paired function equation. The mathematical description of finite temporal space within relationalism theory offers an alternative discrete geometric methodology for examining ancient timekeeping with new hypotheses for Egyptian calendars.

关键词： Relationalism pairing Function Equation Discrete Euclidean Timelines Ancient Timekeeping

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Development,validation,and transportability of several machine-learned,non-exercise-based VO_(2max)prediction models for older adults

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Journal of Sport and Health Science 2024年第5期13卷 611-620页

作者： Benjamin T.Schumacher Michael J.LaMonte Andrea Z.LaCroix Eleanor M.Simonsick steven p.Hooker Humberto parada Jr. John Bellettiere Arun Kumar Herbert Wertheim School of public Health and Human Longevity Science University of California San DiegoLa JollaCA 92093USA Department of Epidemiology and Environmental Health School of Public Health and Health ProfessionsUniversity at BuffaloState University of New YorkBuffaloNY 14214USA Translational Gerontology Branch Intramural Research ProgramNational Institute on AgingNational Institutes of HealthBaltimoreMD 21225USA College of Health and Human Services San Diego State UniversitySan DiegoCA 92182USA Division of Epidemiology and Biostatistics School of Public HealthSan Diego State UniversitySan DiegoCA 92182USA University of California San Diego Moores Cancer Center La JollaCA 92093USA Computer Science and Engineering and Halicioglu Data Science Institute University of California San DiegoLa JollaCA 92093USA

Background:There exist few maximal oxygen uptake(VO_(2max))non-exercise-based prediction equations,fewer using machine learning(ML),and none specifically for older *** direct measurement of VO_(2max)is infeasible in large epidemiologic cohort studies,we sought to develop,validate,compare,and assess the transportability of several ML VO_(2max)prediction ***:The Baltimore Longitudinal Study of Aging(BLSA)participants with valid VO2_(max)tests were included(n=1080).Least absolute shrinkage and selection operator,linear-and tree-boosted extreme gradient boosting,random forest,and support vector machine(SVM)algorithms were trained to predict VO_(2max)*** developed these algorithms for:(a)the overall BLSA,(b)by sex,(c)using all BLSA variables,and(d)variables common in aging ***,we quantified the associations between measured and predicted VO_(2max)and ***:The age was 69.0±10.4 years(mean±SD)and the measured VO_(2max)was 21.6±5.9 mL/kg/*** absolute shrinkage and selection operator,linear-and tree-boosted extreme gradient boosting,random forest,and support vector machine yielded root mean squared errors of 3.4 mL/kg/min,3.6 mL/kg/min,3.4 mL/kg/min,3.6 mL/kg/min,and 3.5 mL/kg/min,*** quartiles of measured VO_(2max)showed an inverse gradient in mortality *** VO_(2max)variables yielded similar effect estimates but were not robust to ***:Measured VO_(2max)is a strong predictor of *** ML can improve the accuracy of prediction as compared to simpler approaches but estimates of association with mortality remain sensitive to *** studies should seek to reproduce these results so that VO_(2max),an important vital sign,can be more broadly studied as a modifiable target for promoting functional resiliency and healthy aging.

关键词： Cardiorespiratory fitness prediction algorithms Epidemiology Mortality

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Multiple interface coupling on natural tourmaline enables high-efficiency removal of antibiotic:Superior property and mechanism

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Journal of Environmental Sciences 2024年第6期140卷 242-254页

作者： Jingjing Cui Xiangyu Liu Feifan Qie Chengzhe Xie Qingdong He Jian Liu steven L.Suib Wenbo Wang College of Chemistry and Chemical Engineering Inner Mongolia UniversityHohhot 010021China Department of Chemistry University of ConnecticutStorrsCT 06269-3060United States

Reasonably designing highly active,environmentally friendly,and cost-effective catalysts for efficient elimination of pollutants from water is desirable but ***,an efficient heterogeneous photo-Fenton catalyst tourmaline(TM)/tungsten oxide(WO_(3-x))(named TW10)containing tungsten/boron/iron(W/B/Fe)synergistic active centers and 90%of cheap natural tourmaline(TM)mineral rich in Fe and B *** TW10 catalyst can quickly activate peroxymonosulfate(pMS)to generate massive active free radicals,which may induce the rapid and efficient degradation of tetracycline(TC).The TW10/pMS/Visible light system can effectively degrade up to 98.7%of tetracycline(TC)in actual waters(***,Yellow River,and Yangtze River water),and the catalytic degradation rates reach 1.65,5.569,and 2.38 times higher than those of TM,WO_(3-x),and commercial p25(Degussa,Germany),*** addition,the catalyst can be recycled and reused multiple *** spin resonance spectroscopy(EpR),X-ray photoelectron spectroscopy(XpS),and liquid chromatograph-mass spectrometer(LC-MS)analyses confirm that the synergistic catalytic effect of W/B/Fe sites on the TW10 catalyst accelerates the electron transfer between Fe(Ⅱ)and Fe(Ⅲ),as well as between W(Ⅴ)and W(Ⅵ),and thus promotes the rapid degradation of *** catalytic reaction mechanism and degradation pathway of TC were *** work provides a feasible route for the design and development of new eco-friendly and efficient catalyst.

关键词： Tourmaline(TM) Fenton-like catalyst Tungsten oxide peroxymonosulfate Antibiotic

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Development and application of photocatalytic coating for roadside NO_(x) mitigation in Hong Kong

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Chinese Chemical Letters 2024年第3期35卷 153-157页

作者： Xinwei Li pengge Wang Shuwen Han Yu Huang Wingkei Ho steven Sai Hang Ho Shun-cheng Lee Meng Wang Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong KongChina State Key Laboratory of Loess and Quaternary Geology(SKLLQG)and Key Laboratory of Aerosol Chemistry and physics Institute of Earth EnvironmentChinese Academy of SciencesXi'an 710061China Department of Science and Environmental Studies The Education University of Hong KongHong KongChina Division of Atmospheric Sciences Desert Research InstituteRenoNV 89512United States

A facile chemical method for the development of photocatalytic coating products was proposed based on practical application perspective for the Hong Kong roadside nitrogen oxides(NO_(x))***_(2)-based photocatalytic coating pC-C film with crystallized size of around 5–6 nm was synthesized with the peptization of H_(2)O_(2).The pC-C coating possesses a super-hydrophilicity surface and is proven to have a NO_(x)degradation rate of 46.8%with an optimum pH level of *** addition,the pC-C coating presents a promising photocatalytic NO_(x)degradation compared with other commercially available coating products and p25 when applied on two building materials of poly-methyl methacrylate(pMMA)and concrete surface.A weather resistance simulation and a 180-day on-site field trial were carried out the attenuation effects of photocatalytic coating applied in outdoor *** on epidemiological estimation and field investigation,hospital admissions for respiratory diseases(HARD)and mortality cases(MC)could be reduced with the application of pC-C coating along the street *** work demonstrates the feasibility of air pollution control measures for the local roadside NO_(x)using photocatalytic technology,offering promising health benefits with environmental remediation.

关键词： photocatalysis Coating NO_(x) mitigation Hong Kong Roadside

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Updates on management of gliomas in the molecular age

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World Journal of Clinical Oncology 2024年第2期15卷 178-194页

作者： Ali Ahmed Mohamed Rakan Alshaibi steven Faragalla Youssef Mohamed Brandon Lucke-Wold Charles E.Schmidt College of Medicine Florida Atlantic UniversityBoca RatonFL 33431United States Herbert Wertheim College of Medicine Florida International UniversityMiamiFL 33199United States College of Osteopathic Medicine Kansas City UniversityJoplinMO 64804United States Department of Neurosurgery University of FloridaGainesvilleFL 32611United States

Gliomas are primary brain tumors derived from glial cells of the central nervous system,afflicting both adults and children with distinct characteristics and therapeutic *** developments have ushered in novel clinical and molecular prognostic factors,reshaping treatment paradigms based on classi-fication and grading,determined by histological attributes and cellular *** review article delves into the diverse treatment modalities tailored to the specific grades and molecular classifications of gliomas that are currently being discussed and used clinically in the year *** adults,the therapeutic triad typically consists of surgical resection,chemotherapy,and *** contrast,pediatric gliomas,due to their diversity,require a more tailored *** complete tumor excision can be curative based on the location and grade of the glioma,certain non-resectable cases demand a chemotherapy approach usually involving,vincristine and ***-tionally,if surgery or chemotherapy strategies are unsuccessful,Vinblastine can be *** recent advancements in treatment methodologies,there remains a need of exploration in the literature,particularly concerning the efficacy of treatment regimens for isocitrate dehydrogenase type mutant astrocytomas and fine-tuned therapeutic approaches tailored for pediatric *** review article explores into the therapeutic modalities employed for both adult and pediatric gliomas in the context of their molecular classification.

关键词： Gliomas Chemotherapy Radiotherapy Isocitrate dehydrogenase type mutant pediatric gliomas Astrocytoma Oligodendroglioma 1p/19q-codeleted

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Adding Value to Crop production Systems by Integrating Forage Cover Crop Grazing

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American Journal of plant Sciences 2024年第3期15卷 180-192页

作者： Robert B. Mitchell Daren D. Redfearn Kenneth p. Vogel Terry J. Klopfenstein Galen Erickson p. Stephen Baenziger Bruce E. Anderson Mary E. Drewnoski Jay parsons steven D. Masterson Marty R. Schmer Virginia L. Jin USDA-ARS Wheat Sorghum and Forage Research Unit University of Nebraska-Lincoln Lincoln NE USA Department of Agronomy and Horticulture University of Nebraska-Lincoln Lincoln NE USA Department of Animal Science University of Nebraska-Lincoln Lincoln NE USA Department of Agricultural Economics University of Nebraska-Lincoln Lincoln NE USA USDA-ARS Agroecosystem Management Research Unit University of Nebraska-Lincoln Lincoln NE USA

In addition to their value as cereal grains, wheat (Triticum aestivum L.) and triticale (× Triticosecale Wittmack) are important cool-season annual forages and cover crops. Yearling steer (Bos taurus) performance was compared in the spring following autumn establishment as for age cover crops after soybean [Glycine max (L.) Merr.] grain harvest. Replicated pastures (0.4 ha) were no-till seeded in three consecutive years into soybean stubble in autumn, fertilized, and grazed the following spring near Ithaca, NE, USA. Each pasture (n = 3) was continuously stocked in spring with four yearling steers (380 ± 38 kg) for 17, 32, and 28 d in 2005, 2006, and 2007, respectively. In 2005, average daily gain (ADG) for steers grazing triticale exceeded the ADG for wheat by 0.31 kghdp>-1p>dp>-1p>. In 2006, wheat ADG exceeded that for triticale by 0.12 kghdp>-1p>dp>-1p>. In 2007, steers grazing wheat lost weight, while steers grazing triticale gained 0.20 kghdp>-1p>dp>-1p>. Based on the 3-year average animal gains valued at $1.32 kgp>-1p>, mean net return ($ hap>-1p> yrp>-1p>) was $62.15 for triticale and $22.55 for wheat. Since these grazed cover crops provide ecosystem services in addition to forage, grazing could be viewed as a mechanism for recovering costs and adds additional value to the system. Based on this 3-year grazing trial, triticale was superior to wheat and likely will provide the most stable beef yearling performance across years with variable weather for the western Cornbelt USA.

关键词： Cover crops Soybean Triticale Wheat

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Associations of accelerometry-measured and self-reported physical activity and sedentary behavior with skeletal muscle energetics:The Study of Muscle,Mobility and Aging(SOMMA)

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Journal of Sport and Health Science 2024年第5期13卷 621-630页

作者： Yujia(Susanna)Qiao Terri L.Blackwell peggy M.Cawthon paul M.Coen steven R.Cummings Giovanna Distefano Samaneh Farsijani Daniel E.Forman Bret H.Goodpaster Stephen B.Kritchevsky Theresa Mau Frederico G.S.Toledo Anne B.Newman Nancy W.Glynn Department of Epidemiology School of Public HealthUniversity of PittsburghPittsburghPA 15261USA San Francisco Coordinating Center California Pacific Medical Center Research InstituteSan FranciscoCA 94143USA Department of Epidemiology and Biostatistics University of CaliforniaSan FranciscoCA 94143USA Translational Research Institute AdventHealthOrlandoFL 32804USA Department of Medicine(Geriatrics and Cardiology) University of Pittsburghand GeriatricsResearchEducationand Clinical Center(GRECC)VA Pittsburgh Healthcare SystemPittsburghPA 15261USA Department of Internal Medicine Section on Gerontology and Geriatric MedicineWake Forest School of MedicineWinston-SalemNC 27109USA Division of Endocrinology and Metabolism Department of MedicineUniversity of PittsburghPittsburghPA 15261USA

Background:Skeletal muscle energetics decline with age,and physical activity(pA)has been shown to offset these declines in older ***,many studies reporting these effects were based on self-reported pA or structured exercise ***,we examined the associations of accelerometry-measured and self-reported pA and sedentary behavior(SB)with skeletal muscle energetics and explored the extent to which pA and sedentary behavior would attenuate the associations of age with muscle ***:As part of the Study of Muscle,Mobility and Aging,enrolled older adults(n=879),810(age=76.4±5.0 years old,mean±SD;58%women)had maximal muscle oxidative capacity measured ex vivo via high-resolution re spirometry of permeabilized myofibers(maximal oxidative phosphorylation(maxOXpHOS))and in vivo by ^(31)phosphorus magnetic resonance spectroscopy(maximal adenosine triphosphate(ATp_(max))).Accelerometry-measured sedentary behavior,light activity,and moderate-to-vigorous pA(MVpA)were assessed using a wrist-worn ActiGraph GT9X over 7 ***-reported sedentary behavior,MVpA,and all pA were assessed with the Community Healthy Activities Model program for Seniors(CHAMpS)*** regression models with progressive covariate adjustments evaluated the associations of sedentary behavior and pA with muscle energetics,as well as the attenuation of the age/muscle energetics association by MVp A and sedentary *** a sensitivity analysis,we also examined activpAL-measured daily step count and time spent in sedentary behavior and their associations with muscle ***:Every 30 min/day more of ActiGraph-measured MVpA was associated with 0.65 pmol/(s×mg)higher maxOXpHOS and 0.012 mM/s higher ATp_(max)after adjusting for age,site/technician,and sex(ppHOS or ATp_(max).Meanwhile,every 30 min/day spent in ActiGraph-measured sedentary behavior was associated with 0.39 pmol/s×mg lower maxOXpHOS and0.

关键词： Aging Exercise Mitochondria

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互利作用促进了高山树线幼苗的存活

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Journal of plant Ecology 2024年第3期17卷 115-127页

作者： Wensheng Chen Jiangrong Li Jesús Julio Camarero Huihui Ding Fangwei Fu Yueyao Li Xiangyu Zheng Xiaoxia Li Wei Shen Shalik Ram Sigdel steven W.Leavitt Eryuan Liang Institute of Tibet plateau Ecology Tibet Agricultural&Animal Husbandry UniversityNyingchi 860000China Key Laboratory of Forest Ecology in Tibet plateau(Tibet Agricultural&Animal Husbandry University) Ministry of EducationNyingchi 860000China National Forest Ecosystem Observation&Research Station of Nyingchi Tibet Nyingchi 860000China Key Laboratory of Alpine Vegetation Ecological Security in Tibet Nyingchi 860000China Zhejiang Zhoushan Archipelago Observation and Research Station Zhejiang Tiantong Forest Ecosystem National Observation and Research Stationand Shanghai Key Lab for Urban Ecological Processes and Eco-RestorationSchool of Ecological and Environmental SciencesEast China Normal UniversityShanghai 200241China State Key Laboratory of Tibetan plateau Earth System Resources and Environment(TPESRE)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China Instituto pirenaico de Ecología(IpE-CSIC) Zaragoza 50059Spain Anhui province Key Lab of Farmland Ecological Conservation and pollution prevention Key Laboratory of JiangHuai Arable Land Resources Protection and Eco-restorationMinistry of Natural ResourcesCollege of Resources and EnvironmentAnhui Agricultural UniversityHefei 230036China Laboratory of Tree-Ring Research University of ArizonaTucsonAZ 85721USA

高山树线被视为记录气候变化对树木和森林影响的生态监测器。迄今为止,大多数树线研究都集中在气候变化如何驱动树线动态的变化。然而,关于生物相互作用如何调节树线变化,特别是在树木更新这一树线动态的瓶颈方面,人们知之甚少。本研究... 详细信息

高山树线被视为记录气候变化对树木和森林影响的生态监测器。迄今为止,大多数树线研究都集中在气候变化如何驱动树线动态的变化。然而,关于生物相互作用如何调节树线变化,特别是在树木更新这一树线动态的瓶颈方面,人们知之甚少。本研究假设种间和种内促进作用决定了高山树线树苗的定居和存活。为了验证这一假设,我们在青藏高原东南部的色季拉山高山树线交错区(海拔4300–4500 m)的3个生长生境(林冠内、林冠外和草地)中共计移植了630株不同年龄(4–6年、7–9年和10–15年)的急尖长苞冷杉(Abies georgei ***)幼苗,连续3年监测了移植后幼苗的微气候、高度生长、死亡率和叶片功能性状。结果发现,叶片功能性状的变化是由微气候驱动的。移植后,叶片可溶性糖和淀粉浓度以及C:p比增加,而叶面积减小。幼苗的资源利用逐渐转向更保守的策略,其背后机制主要受到了生理性状(非结构性碳水化合物和植物养分)的介导。同时,由结构方程模型发现太阳辐射、温度和水分条件在植物相互作用下,通过介导叶片形态性状的变化最终影响了幼苗的死亡率和年生长。上述研究结果表明,植物间的互利作用通过改变太阳辐射和叶片功能性状,最终在决定幼苗生长和存活上起到至关重要的作用,同时也为理解全球气候变化背景下高山树线动态变化的驱动机制提供了新的见解。

关键词：青藏高原移栽实验叶片功能性状太阳辐射

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