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Chinese Journal of Chemistry 2019年第4期37卷 378-404页

作者： Ebenezer Baa Gary m.watkins Rui.W.Krause Derek.N.Tantohb Department of Chemistry Rhodes UniversityPO Box 94Grahamstown6140South Africa Department of Applied Chemistry University of JohannesburgPO Box 524Auckland Park2006South Africa

Since the early reports of mOFs and their interesting properties,research involving these materials has grown wide in scope and *** synthetic approaches have ensued in view of obtaining materials with optimised properties,the extensive scope of application spanning from energy,gas sorption,catalysis biological applications has meant exponentially evolved over the *** far-reaching synthetic and PSm approaches and porosity control possibilities have continued to serve as a motivation for research on these *** respect to the biological applications,mOFs have shown promise as good candidates in applicati ons involving drug delivery,BiomOFs,sensing,imaging amongst *** being a while away from successful entry into the market,observed results in sensing,drug delivery,and imaging put these materials on the spot light as candidates poised to usher in a revolution in *** this regard,this review article focuses current approaches in synthesis,post functionalization and biological applications of these materials with particular attention on drug delivery,imaging,sensing and BiomOFs.

关键词： Current Trend Post-Synthetic modifications Nanometal-Organic Frameworks(NmOFs)

骨髓造血细胞来源的半乳糖苷凝集素导致细胞和系统胰岛素抵抗

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科学新闻 2017年第4期 40-40页

作者：李平平 Shuainan Liu min Lu Gautum Bandyopadhyay Dayoung Oh Takeshi Imamura Andrew m.F.Johnson Dorothy Sears Zhufang Shen Bing Cui Lijuan Kong Shaocong Hou Xiao Liang Salvatore Iovino steven m.watkins Wei Ying Olivia Osborn Joshua Wollam martin Brenner Jerrold m.Olefsky 中国医学科学院药物研究所

文章简介肥胖时巨噬细胞与其他免疫细胞在胰岛素靶组织大量聚集,构成一种慢性炎症状态和胰岛素抵抗。半乳糖苷凝集素Galectin-3(Gal3)主要来源于巨噬细胞。无论在肥胖小鼠或者肥胖病人,Gal3水平明显增加。Gal3给药可让正常小鼠诱发胰岛... 详细信息

文章简介肥胖时巨噬细胞与其他免疫细胞在胰岛素靶组织大量聚集,构成一种慢性炎症状态和胰岛素抵抗。半乳糖苷凝集素Galectin-3(Gal3)主要来源于巨噬细胞。无论在肥胖小鼠或者肥胖病人,Gal3水平明显增加。Gal3给药可让正常小鼠诱发胰岛素抵抗和糖耐量异

关键词：胰岛素抵抗炎症病理凝集素细胞

Transport model for shale gas well leakage through the surrounding fractured zones of a longwall mine

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International Journal of mining Science and Technology 2020年第5期30卷 635-641页

作者： Kayode m.Ajayi steven J.Schatzel Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthPittsburghPA 15236USA

The environmental risks associated with casing deformation in unconventional(shale)gas wells positioned in abutment pillars of longwall mines is a concern to many in the mining and gas well *** the recent interest in shale exploration and the proximity to longwall mining in Southwestern Pennsylvania,the risk to mine workers could be catastrophic as fractures in surrounding strata create pathways for transport of leaked ***,this research by the National Institute for Occupational Safety and Health(NIOSH)presents an analytical model of the gas transport through fractures in a low permeable *** derived equations are used to conduct parametric studies of specific transport conditions to understand the influence of stratum geology,fracture lengths,and the leaked gas properties on subsurface *** results indicated that the prediction that the subsurface gas flux decreases with an increase in fracture length is specifically for a non-gassy *** sub-transport trend could be significantly impacted by the stratum gas generation rate within specific fracture lengths,which emphasized the importance of the stratum *** findings provide new insights for improved understanding of subsurface gas transport to ensure mine safety.

关键词： Subsurface gas transport Longwall mining Shale gas well Analytical modeling Environmental risk Shale gas casing failure

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Amtrak铁路客运机车交流传动技术的应用

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国外内燃机车 1995年第12期 16-20页

作者： Kenneth m.watkins 符志钦

1983年，美国Amtrak客运铁路公司开始在电传动内燃机车和电力机车上应用大型直流牵引电动机。因此，Amtrak铁路官员决定要获得当时正被推荐作为解决牵引电动机存在的许多问题方案的交流牵引技术的第一手经验。文中介绍了由ABB公司和EmD... 详细信息

1983年，美国Amtrak客运铁路公司开始在电传动内燃机车和电力机车上应用大型直流牵引电动机。因此，Amtrak铁路官员决定要获得当时正被推荐作为解决牵引电动机存在的许多问题方案的交流牵引技术的第一手经验。文中介绍了由ABB公司和EmD／西门子公司为Amtrak铁路提供的交流传动机车的历史和运用经验；讨论了交流传动系统的效果和为了改进客车集中供电的可靠性而采用的冗余技术；描述了包括目前可供利用的诊断故障数据的维修体系的改进以及预期的高速内燃机车、电力机车和动车组未来的性能。

关键词：内燃机车交流传动可靠性维修铁路旅客运输

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Assessing the reproductive health of men with occupational exposures

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Asian Journal of Andrology 2014年第1期16卷 23-30页

作者： steven m Schrader Katherine L marlow Centers for Disease Control and Prevention National Institute for Occupational Safety and Health Division of Applied Research and Technology Cincinnati OH USA.

The earliest report linking environmental （occupational） exposure to adverse human male reproductive effects dates back to1775 when an English physician, Percival Pott, reported a high incidence of scrotal cancer in chimney sweeps. This observation led to safety regulations in the form of bathing requirements for these workers. The fact that male-mediated reproductive harm in humans may be a result of toxicant exposures did not become firmly established until relatively recently, when Lancranjan studied lead-exposed workers in Romania in 1975, and later in 1977, when Whorton examined the effects of dibromochloropropane （DBCP） on male workers in California. Since these discoveries, several additional human reproductive toxicants have been identified through the convergence of laboratory and observational findings. many research gaps remain, as the pool of potential human exposures with undetermined effects on male reproduction is vast. This review provides an overview of methods used to study the effects of exposures on male reproduction and their reproductive health, with a primary emphasis on the implementation and interpretation of human studies. Emphasis will be on occupational exposures, although much of the information is also useful in assessing environmental studies, occupational exposures are usually much higher and better defined.

关键词： accessory glands endocrine epidemiology semen sexual function sperm testis toxicology

Strigolactones redefine plant hormones

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Science China(Life Sciences) 2016年第10期59卷 1083-1085页

作者： Lu Wang steven m.Smith School of Biological Sciences University of Tasmania Institute of Genetics and Developmental Biology Chinese Academy of sciences

A commonly accepted view of plant growth hormones is that their interaction with the cognate receptor protein is reversible, so that each hormone molecule can potentially interact multiple times with a receptor and so either amplify the hormone signal or maintain it over an extended period of time. The signal can be ＇cancelled＇ by degrading the hormone. Strigolactones present us with a potentially new paradigm. The receptor is a serine hydrolase-type protein which attacks the strigolactone resulting in covalent modi- fication of the receptor, while at the same time destroying the hormone. Strigolactone is apparently a one-use ＇dispos- able＇ hormone.

关键词：植物激素受体蛋白定义植物生长激素相互作用激素信号酸水解

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IT-Software SmEs in China, Technology Transfer from Universities and Entrepreneurship, a Successful Nexus？

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Frontiers of Business Research in China 2014年第1期8卷 18-48页

作者： Jianghong Cao m. John Foster Lorraine watkins-mathys Kingston-Business School Kingston University Kingston Upon Thames KT2 7LB UK

Drawing on the empirical work of a broader study, this paper examines whether technology is being successfully transferred from universities to the IT-sottware SmEs present in China, and the effectiveness of entrepreneurship in effecting such transfers. A conceptual framework was generated to guide the investigation. Data were elicited using a detailed questionnaire which generated 53 usable responses; follow-up interviews with 17 of the 53 respondents; and four interviews with relevant government officials （civil servants from the ministry of Science and Technology and state-owned banks）. There were three main fmdings. Chinese software SmEs tend to be reluctant to adopt new technologies from local tmiversities; there is a lack of common purpose between the parties; and entrepreneurs who did undertake such technology transfer felt the process was badly impeded by the lack of available finance, and expressed fears about poor protection of intellectual property rights in China. The majority of the sample firms acted opportunistically, taking advantage of the benefits offered under government schemes to earn rapid returns mainly using extant technologies. These conclusions suggest that the Chinese government＇s policies in this area of technology transfer have had only limited success.

关键词： entrepreneurship technology transfer universities IT-software,SmE China

Determinants of the Specif icity of Protein Targeting to Chloroplasts or mitochondria

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molecular Plant 2019年第7期12卷 893-895页

作者： Lucas mcKinnon steven m.Theg Department of Plant Biology University of California Davis Davis CA USA

Chloroplasts and mitochondria are both thought to have arisen through primary endosymbiosis (Kutschera and Niklas, 2005). As each organelle evolved, most of its genome was transferred to the host nucleus resulting in the vast majority of its proteome being nuclear encoded and synthesized on cytosolic ribosomes (Shi and Theg, 2013).

关键词： Chloroplasts mitochondria

Surgical solutions to the problem of massive weight loss

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World Journal of Gastroenterology 2006年第41期12卷 6602-6607页

作者： Jason A Spector steven m Levine Nolan S Karp Division of Plastic Surgery Weill medicine College of Cornell University New YorkNY 10021United States Institute of Reconstructive and Plastic Surgery Division of Plastic SurgeryNew York University School of MedicineNew YorkNY 10016United States

In response to the global rise in obesity, bariatric surgery has become increasingly more popular and successful As a result, the demand for body contouring following massive weight loss is rapidly growing. Although bariatric procedures may produce impressive weight loss, people who achieve massive weight loss are often unhappy with the hanging folds of skin and subcutaneous tissue that remain. This review examines the nature of the post-bariatric deformity in each body region and briefly reviews common approaches to their treatment.

关键词： Weight loss Bariatric surgery Body contour surgery

KAI2-and mAX2-mediated Responses to Karrikins and Strigolactones Are Largely Independent of HY5 in Arabidopsis Seedlings

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molecular Plant 2013年第1期6卷 63-75页

作者： mark T. Waters steven m. Smitht Plant Energy Biology University of Western Australia Crawley Western Australia 6009 Australia School of Chemistry and Biochemistry University of Western Australia Crawley Western Australia 6009 Australia

Karrikins are butenolide compounds released from burning vegetation that stimulate seed germination and enhance seedling photomorphogenesis. Strigolactones are structurally similar plant hormones that regulate shoot and root development, and promote the germination of parasitic weed seeds. In Arabidopsis, the F-box protein mAX2 is required for responses to karrikins and strigolactones, and the a/~ hydrolase KAI2 is necessary for responses to karrikins. Both mAX2 and KAI2 are essential for normal light-dependent seedling development. The bZIP transcription factor HY5 acts downstream of multiple photoreceptors and promotes photomorphogenesis, but its relationship with mAX2 and KAI2 in terms of seedling development and responses to karrikins and strigolactones is poorly defined. Here, we dem- onstrate that HY5 action is genetically separable from that of mAX2 and KAI2. While by5 mutants have weak hypoco- tyl elongation responses to karrikins and the artificial strigolactone GR24, they have normal transcriptional responses, suggesting that HY5 is not involved in perception or action of karrikins or strigolactones. Furthermore, we show that overexpression of KAI2 is sufficient to enhance responses to both karrikins and GR24 in wild-type seedlings, and that KAI2 overexpression partially suppresses the hy5 long hypocotyl phenotype. These results suggest that KAI2 and mAX2 define a regulatory pathway that largely operates independently of HY5 to mediate seedling responses to abiotic signals such as smoke and light.

关键词： smoke karrikin strigolactone KAI2 HY5 photomorphogenesis.