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Nutri.i.nal epi.eneti.s educati.n i.proves di.t and atti.ude of parents of chi.dren wi.h auti.m or attenti.n defi.i./hyperacti.i.y di.order

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World Journal of Psychi.try 2024年第1期14卷 159-178页

作者： Renee J Dufault Katheri.e m Adler Davi. O Carpenter steven G Gi.bert Raquel A Cri.er College of Graduate health Studi.s A.T.Still UniversityKirksvilleMO 63501United States Department of Research Food Ingredient and Health Research InstituteNaalehuHI 96772United States Department of health Sci.nces University of New HavenWest HavenCT 06516United States i.sti.ute for health and the Envi.onment School of Public HealthState University of New YorkAlbanyNY 12222United States Department of Research Institute of Neurotoxicology and Neurological DisordersSeattleWA 98105United States Department of Stati.ti.s Food Ingredient and Health Research InstituteNaalehuHI 96772United States

BACKGROUND Unhealthy maternal di.t leads to heavy metal exposures from the consumpti.n of ultra-processed foods that may i.pact gene behavi.r across generati.ns,creati.g condi.i.ns for the neurodevelopmental di.orders known as auti.m and attenti.n defi.i./hyperacti.i.y di.order(ADhD).Chi.dren wi.h these di.orders have di.fi.ulty metaboli.i.g and excreti.g heavy metals from thei. bloodstream,and the severi.y of thei. symptoms correlates wi.h the heavy metal levels measured i. thei. *** may play a key role i. helpi.g parents reduce thei. ultra-processed food and di.tary heavy metal i.take by provi.i.g access to effecti.e nutri.i.nal epi.eneti.s *** To test the effi.acy of nutri.i.nal epi.eneti.s i.structi.n i. reduci.g parental ultra-processed food *** The study uti.i.ed a semi.randomi.ed test and control group pretest-posttest pi.ot study desi.n wi.h parti.i.ants recrui.ed from parents havi.g a learni.g-di.abled chi.d wi.h auti.m or ***-two parents who met the i.clusi.n cri.eri. were randomly selected to serve i. the test(n=11)or control(n=11)*** test group parti.i.ated i. the si.-week onli.e nutri.i.nal epi.eneti.s tutori.l,whi.e the control group di. *** effi.acy of the nutri.i.nal epi.eneti.s i.structi.n was determi.ed by measuri.g changes i. parent di.t and atti.ude usi.g data deri.ed from an onli.e di.t survey admi.i.tered to the parti.i.ants duri.g the pre and post i.terventi.n *** i.take scores were deri.ed for both ultra-processed and whole/organi. *** sample t-tests were conducted to determi.e any di.ferences i. mean di.t scores wi.hi. each *** There was a si.ni.i.ant di.ference i. the di.t scores of the test group between the pre-and post-i.terventi.n *** parents i. the test group si.ni.i.antly reduced thei. i.take of ultra-processed foods wi.h a prei.terventi.n di.t score of 70(mean=5.385,SD=2.534)and a post-i.terventi.n di.t score of 113(mean=8.692,SD=1.750)and the

关键词： Epi.enomi.s Parenteral nutri.i.n Auti.m Attenti.n defi.i./hyperacti.i.y di.order Ultra-processed foods heavy metals

Fri.ti.n and wear performance of polyether ether ketone(PEEK)polymers i. three lubri.ati.n regi.es

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Fri.ti.n 2024年第4期12卷 670-682页

作者： Davi.e mASSOCChi.Nora LECi. marco LATTUADA Davi.e SCAGLi. steven ChATTERTON Paolo PENNACChi Department of mechani.al Engi.eeri.g Politecnico di MilanoMilan 20156Italy Eni.SpA Downstream product R&DLombardia 20097Italy Eurobeari.gs S.R.L. Lombardia 29016Italy

Thi. experi.ental study i.vesti.ates the fri.ti.n and wear of three coati.gs commonly used i. i.dustri.l appli.ati.ns,parti.ularly i. hydrodynami. *** three materi.ls under i.vesti.ati.n were Babbi.t,polyether ether ketone(PEEK)rei.forced wi.h 15%carbon fi.ers,and PEEK rei.forced wi.h 20%carbon *** fi.st polymer materi.l was extruded,whi.e the other was produced by fused deposi.i.n modelli.g(FDm).The materi.ls were subjected to sli.i.g tests i. a pi.-on-di.c confi.urati.n,wi.h a steel ball servi.g as the counter *** tests were conducted at room temperature,wi.h a load of 10 N and under three di.ferent lubri.ati.n condi.i.ns:dry,grease,and *** li.ear speed was set at 0.3 m/s for the dry and semi.soli. lubri.ati.n tests,whi.e for the oi. tests,the speed was set at 0.25 m/*** greases used had consi.tency grades of NGLi.000 and NGLi.*** i.O VG 68 ci.culati.n oi. was used for the oi. lubri.ati.n ***,thermodynami. analyses were performed under the most severe condi.i.ns(i.e.,dry)to i.vesti.ate the steel-Babbi.t and steel-PEEK contact.

关键词： hydrodynami. beari.gs polyether ether ketone(PEEK)polymers addi.i.e manufacturi.g grease lubri.ati.n sli.i.g oi. lubri.ati.n ball-on-di.k tri.ology

Thi.teen years to get from b to a:one of the neglected i.oforms of i.-37 enters the stage

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Cellular & molecular i.munology 2024年第2期21卷 201-202页

作者： steven X.Cho i.a Rudloff Andrew m.Elli.don Claudi. A.Nold-Petry marcel F.Nold Ri.chi. Centre Hudson Institute of Medical ResearchMelbourneVICAustralia Department of Pedi.tri.s Monash UniversityMelbourneVICAustralia Cancer Program Biomedicine Discovery InstituteMonash UniversityMelbourneVICAustralia monash Newborn Monash Children’s HospitalMelbourneVICAustralia

i.terleuki.(i.)-37 i. one of the few anti.i.flammatory members of the predomi.antly pro-i.flammatory i.-1 cytoki.e ***-37 possesses alarmi.-li.e properti.s[1]and exerts i.s acti.i.i.s vi. i.tracellular[2]as well as cell surface receptor-dependent mechani.ms,and the latter i.volves i.-1R8 and i.-18Rα[3].Because of i.s powerful and broad-spectrum“peacemaki.g”[4]functi.ns,consi.erable efforts have been i.vested i. developi.g i.-37-based anti.i.flammatory therapeuti.s[5,6].

关键词： i.terleuki. neglected cytoki.e

Associ.ti.ns of accelerometry-measured and self-reported physi.al acti.i.y and sedentary behavi.r wi.h skeletal muscle energeti.s:The Study of muscle,mobi.i.y and Agi.g(SOmmA)

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Journal of Sport and health Sci.nce 2024年第5期13卷 621-630页

作者： Yuji.(Susanna)Qi.o Terri.L.Blackwell Peggy m.Cawthon Paul m.Coen steven R.Cummi.gs Gi.vanna Di.tefano Samaneh Farsi.ani.Dani.l E.Forman Bret h.Goodpaster Stephen B.Kri.chevsky Theresa mau Frederi.o G.S.Toledo Anne B.Newman Nancy W.Glynn Department of Epi.emi.logy School of Public HealthUniversity of PittsburghPittsburghPA 15261USA San Franci.co Coordi.ati.g Center California Pacific Medical Center Research InstituteSan FranciscoCA 94143USA Department of Epi.emi.logy and Bi.stati.ti.s University of CaliforniaSan FranciscoCA 94143USA Translati.nal Research i.sti.ute AdventHealthOrlandoFL 32804USA Department of medi.i.e(Geri.tri.s and Cardi.logy) University of Pittsburghand GeriatricsResearchEducationand Clinical Center(GRECC)VA Pittsburgh Healthcare SystemPittsburghPA 15261USA Department of i.ternal medi.i.e Section on Gerontology and Geriatric MedicineWake Forest School of MedicineWinston-SalemNC 27109USA Di.i.i.n of Endocri.ology and metaboli.m Department of MedicineUniversity of PittsburghPittsburghPA 15261USA

Background:Skeletal muscle energeti.s decli.e wi.h age,and physi.al acti.i.y(PA)has been shown to offset these decli.es i. older ***,many studi.s reporti.g these effects were based on self-reported PA or structured exerci.e ***,we exami.ed the associ.ti.ns of accelerometry-measured and self-reported PA and sedentary behavi.r(SB)wi.h skeletal muscle energeti.s and explored the extent to whi.h PA and sedentary behavi.r would attenuate the associ.ti.ns of age wi.h muscle ***:As part of the Study of muscle,mobi.i.y and Agi.g,enrolled older adults(n=879),810(age=76.4±5.0 years old,mean±SD;58%women)had maxi.al muscle oxi.ati.e capaci.y measured ex vi.o vi. hi.h-resoluti.n re spi.ometry of permeabi.i.ed myofi.ers(maxi.al oxi.ati.e phosphorylati.n(maxOXPhOS))and i. vi.o by ^(31)phosphorus magneti. resonance spectroscopy(maxi.al adenosi.e tri.hosphate(ATP_(max))).Accelerometry-measured sedentary behavi.r,li.ht acti.i.y,and moderate-to-vi.orous PA(mVPA)were assessed usi.g a wri.t-worn Acti.raph GT9X over 7 ***-reported sedentary behavi.r,mVPA,and all PA were assessed wi.h the Communi.y healthy Acti.i.i.s model Program for Seni.rs(ChAmPS)*** regressi.n models wi.h progressi.e covari.te adjustments evaluated the associ.ti.ns of sedentary behavi.r and PA wi.h muscle energeti.s,as well as the attenuati.n of the age/muscle energeti.s associ.ti.n by mVP A and sedentary *** a sensi.i.i.y analysi.,we also exami.ed acti.PAL-measured dai.y step count and ti.e spent i. sedentary behavi.r and thei. associ.ti.ns wi.h muscle ***:Every 30 mi./day more of Acti.raph-measured mVPA was associ.ted wi.h 0.65 pmol/(s×mg)hi.her maxOXPhOS and 0.012 mm/s hi.her ATP_(max)after adjusti.g for age,si.e/techni.i.n,and sex(pi.ht acti.i.y was not associ.ted wi.h maxOXPhOS or ATP_(max).meanwhi.e,every 30 mi./day spent i. Acti.raph-measured sedentary behavi.r was associ.ted wi.h 0.39 pmol/s×mg lower maxOXPhOS and0.

关键词： Agi.g Exerci.e mi.ochondri.

Development,vali.ati.n,and transportabi.i.y of several machi.e-learned,non-exerci.e-based VO_(2max)predi.ti.n models for older adults

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Journal of Sport and health Sci.nce 2024年第5期13卷 611-620页

作者： Benjami. T.Schumacher mi.hael J.Lamonte Andrea Z.LaCroi. Eleanor m.Si.onsi.k steven P.hooker humberto Parada Jr. John Belletti.re Arun Kumar herbert Werthei. School of Publi. health and human Longevi.y Sci.nce University of California San DiegoLa JollaCA 92093USA Department of Epi.emi.logy and Envi.onmental health School of Public Health and Health ProfessionsUniversity at BuffaloState University of New YorkBuffaloNY 14214USA Translati.nal Gerontology Branch Intramural Research ProgramNational Institute on AgingNational Institutes of HealthBaltimoreMD 21225USA College of health and human Servi.es San Diego State UniversitySan DiegoCA 92182USA Di.i.i.n of Epi.emi.logy and Bi.stati.ti.s School of Public HealthSan Diego State UniversitySan DiegoCA 92182USA Uni.ersi.y of Cali.orni. San Di.go moores Cancer Center La JollaCA 92093USA Computer Sci.nce and Engi.eeri.g and hali.i.glu Data Sci.nce i.sti.ute University of California San DiegoLa JollaCA 92093USA

Background:There exi.t few maxi.al oxygen uptake(VO_(2max))non-exerci.e-based predi.ti.n equati.ns,fewer usi.g machi.e learni.g(mL),and none speci.i.ally for older *** di.ect measurement of VO_(2max)i. i.feasi.le i. large epi.emi.logi. cohort studi.s,we sought to develop,vali.ate,compare,and assess the transportabi.i.y of several mL VO_(2max)predi.ti.n ***:The Balti.ore Longi.udi.al Study of Agi.g(BLSA)parti.i.ants wi.h vali. VO2_(max)tests were i.cluded(n=1080).Least absolute shri.kage and selecti.n operator,li.ear-and tree-boosted extreme gradi.nt boosti.g,random forest,and support vector machi.e(SVm)algori.hms were trai.ed to predi.t VO_(2max)*** developed these algori.hms for:(a)the overall BLSA,(b)by sex,(c)usi.g all BLSA vari.bles,and(d)vari.bles common i. agi.g ***,we quanti.i.d the associ.ti.ns between measured and predi.ted VO_(2max)and ***:The age was 69.0±10.4 years(mean±SD)and the measured VO_(2max)was 21.6±5.9 mL/kg/*** absolute shri.kage and selecti.n operator,li.ear-and tree-boosted extreme gradi.nt boosti.g,random forest,and support vector machi.e yi.lded root mean squared errors of 3.4 mL/kg/mi.,3.6 mL/kg/mi.,3.4 mL/kg/mi.,3.6 mL/kg/mi.,and 3.5 mL/kg/mi.,*** quarti.es of measured VO_(2max)showed an i.verse gradi.nt i. mortali.y *** VO_(2max)vari.bles yi.lded si.i.ar effect esti.ates but were not robust to ***:measured VO_(2max)i. a strong predi.tor of *** mL can i.prove the accuracy of predi.ti.n as compared to si.pler approaches but esti.ates of associ.ti.n wi.h mortali.y remai. sensi.i.e to *** studi.s should seek to reproduce these results so that VO_(2max),an i.portant vi.al si.n,can be more broadly studi.d as a modi.i.ble target for promoti.g functi.nal resi.i.ncy and healthy agi.g.

关键词： Cardi.respi.atory fi.ness Predi.ti.n algori.hms Epi.emi.logy mortali.y

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电子皮肤与高效率会议

空中英语教室（高级版．彭蒙惠英语） 2024年第1期 34-36,49,50页

作者： Li.a m.Kri.ger steven i.Wei.s 不详

29斯坦福大学团队研发出具有触觉的电子皮肤斯坦福大学的科学家研发出了一种柔软又可伸展的电子皮肤,而且能够模仿真实皮肤的感觉反馈,并直接传送给大脑。这项发明所用的技术如果进一步改善,有可能为数百万装义肢的人士带来希望.

关键词：斯坦福大学电子皮肤直接传送高效率

Ei.stei.’s Concept of Clock Synchroni.ati.n Confli.ts wi.h the Second Relati.i.y Postulate

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Journal of modern Physi.s 2024年第7期15卷 985-1000页

作者： steven D. Dei.es Donatech Corporati.n Inc. Fairfield Iowa USA

Ei.stei. defi.ed clock synchroni.ati.n whenever photon pulses wi.h ti.etags traverse a fi.ed di.tance between two clocks wi.h equal ti.e spans i.ei.her di.ecti.n. Usi.g the second relati.i.y postulate, he found clocksmounted on a rod uni.ormly movi.g parallel wi.h the rod’s length cannot besynchroni.ed, but clocks attached to a stati.nary rod can. he di.0}ssed thi.di.crepancy by clai.i.g si.ultanei.y and clock synchroni.ati.n were not commonbetween i.erti.l frames, but thi. paper proves wi.h both Gali.ean and Lorentztransformati.ns that si.ultanei.y and clock synchroni.ati.n are preservedbetween i.erti.l frames. hi. deri.ati.n means movi.g clocks can never besynchroni.ed i. a “resti.g” i.erti.l frame. Ultrapreci.e atomi. clocks i.ti.ekeepi.g labs dai.y contradi.t hi. results. No algebrai. error occurred i.Ei.stei.’s deri.ati.ns. The two cases of clocksattached to a rod reveal three major confli.ts wi.h the currentsecond postulate. The net veloci.y between a photon source and detector plusthe “uni.ersal” veloci.y c i. mathemati.ally equi.alent toEi.stei.’s clock synchroni.ati.n method. As the ultrapreci.e ti.ekeepi.gcommuni.y dai.y synchroni.es atomi. clocks on the movi.g Earth wi.hultrapreci.e ti.e uncertai.ty well below Ei.stei.’s lowest li.i. ofsynchroni.ati.n, the theoreti.al resoluti.n of the apparent confli.t i.accompli.hed by expandi.g the second relati.i.y postulate to i.corporate thenet veloci.y between the photon source and detector wi.h the emi.ted veloci.y c as components of the total veloci.y c. Thi. means the magni.udeof the total photon veloci.y can exceed the speed li.i. (299792458 m/s) set by the standard veloci.y c. .

关键词： Speci.l Relati.i.y Si.ultanei.y Clock Synchroni.ati.n Photon Speed Lorentz Transformati.n Gali.ean Transformati.n

Growth of ni.rate contri.uti.n to aerosol polluti.n duri.g wi.terti.e i. Xi.an,northwest Chi.a:Formati.n mechani.m and effects of Nh_(3)

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Parti.uology 2024年第4期87卷 303-315页

作者： hui.Su Ti.g Zhang Sui.i. Li. Yao Qu huan Li.Ji.mao Zhou Zhuzi.Zhao Qi.uan Wang Lu Li.mi.xi. Shen Shuoyuan Chen steven Sai.hang ho Junji.Cao State Key Laboratory of Loess and Quaternary Geology.Key Laboratory ofAerosol Chemi.try and Plhysi.s Institute of Earth EnvironmentChinese Acadery of SciencesXi'an 710061China Xi.an i.sti.ute for i.novati.e Earth Envi.onment Research Xi'an 710061China Nati.nal pbservati.n and Research Stati.n of Regi.nal Ecologi.al Envi.onment Change and Cornprehensi.e management i. the Guanzhong Plai. Xi'an 710061China Shaanxi.Key Laboratory of Atmospheri. and haze fog Polluti.n Preventi.n Institute of Earth EnvironmentChinese Academy of SciencesXi'an 710061China Uni.ersi.y of Chi.ese Academy of Sci.nces Beijing 100049China School of Chemi.al and Envi.onmental Engi.eeri.g Jiangsu University of TechnologyChangzhou 213001China Di.i.i.n of Atmospheri. Sci.nces Desert Research InstituteReno NV89512United States i.sti.ute of Atmospheri. Physi.s Chinese Academy of SciencesBeijing 100029China

Wi.h the strengthened controls on SO2 emi.si.ns and extensi.e i.creases i. motor vehi.les'exhaust,aerosol polluti.n shi.ts from sulfate-ri.h to ni.rate-ri.h i. recent years i. Xi.an,*** further gai. i.si.hts i.to the factors on ni.rate formati.n and effi.i.ntly mi.i.ate ai. polluti.n,hi.hly ti.e-resolved observati.ns of water-soluble i.organi. i.ns(WSi.s)i. Pm_(2.5) were measured i. a suburban area of Xi.an,Chi.a duri.g *** concentrati.n of total WSi.s i. 39.8μg m-3 on average,accounti.g for 50.3%of Pm_(2.5) *** contrast to a sli.ht decrease i. the mass fracti.n of SO_(4)^(2-),NO_(3)-shows a si.-ni.i.ant i.crease of the Pm_(2.5) contri.uti.n wi.h the aggravati.n of aerosol *** suggests the i.portance of NO_(3)-formati.n to haze ***,homogeneous reacti.ns govern the formati.n of NO_(3)-,whi.e alkali.metals such as calci.m and sodi.m play an addi.i.nal role i. retai.i.g NO_(3)-i. Pm_(2.5) duri.g clean ***,the heterogeneous hydrolysi. reacti.n contri.uted more to NO_(3)-formati.n duri.g the polluti.n peri.ds under hi.h relati.e *** i.vesti.ati.n reveals that temperature,relati.e humi.i.y,oxi.ant,and ammoni. emi.si.ns faci.i.ate rapi. NO_(3)-*** the random forest(RF)model,NO_(3)-concentrati.ns were successfully si.ulated wi.h measured vari.bles for the trai.i.g and testi.g datasets(R2>0.95).Among these vari.bles,CO,Nh_(3),and NO_(2) were found to be the mai. factors affecti.g the NO_(3)-*** wi.h the peri.d wi.hout vehi.le re-stri.ti.n,the contri.uti.ns of NO_(3)-and Nh4+to Pm_(2.5) mass decreased by 5.3%and 3.4%i. traffi. re-stri.ti.n peri.ds,*** vehi.le restri.ti.n leads to the decreases of precursor gases of NO_(2),SO_(2),and Nh_(3) by 12.8%,5.9%,and 27.6%,*** results demonstrate collaborati.e emi.si.n reducti.n of NO_(x) and Nh_(3) by vehi.le restri.ti.ns,and usi.g new energy vehi.les(or electri. vehi.les)can effecti.ely allevi.te parti.ul

关键词： Pm_(2.5) Water-soluble i.organi. i.ns Ni.rate formati.n Excess ammoni.m Vehi.le restri.ti.ns

mDGA2 Constrai.s Glutamatergi. i.puts Selecti.ely onto CA1 Pyrami.al Neurons to Opti.i.e Neural Ci.cui.s for Plasti.i.y,memory,and Soci.l Behavi.r

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Neurosci.nce Bulleti. 2024年第7期40卷 887-904页

作者： Xuehui.Wang Donghui.Li. Ji. Ji.ng Yuhua Li. Xi.yan Dong Ji.nchen Fan Li.en Gong Wei.a Shen Li.ghui.Zeng Tonghui.Xu Kewen Ji.ng steven A.Connor Yi.heng Xi. School of Li.e Sci.nces Nanchang UniversityNanchang330031China Department of Neurology Children's HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Bi.logy York University4700 Keele StreetTorontoON M3J 1P3Canada Key Laboratory of Novel Targets and Drug Study for Neural Repai. of Zheji.ng Provi.ce School of MedicineHangzhou City UniversityHangzhou 310015China

Synapse organi.ers are essenti.l for the development,transmissi.n,and plasti.i.y of *** as rare synapse suppressors,the mAm domai. contai.i.g glycosylphosphati.yli.osi.ol anchor(mDGA)protei.s contri.utes to synapse organi.ati.n by i.hi.i.i.g the formati.n of the synaptogeni. neuroli.i.-neurexi. complex.A previ.us analysi. of mDGA2 mi.e lacki.g a si.gle copy of mdga2 revealed upregulated glutamatergi. synapses and behavi.rs consi.tent wi.h ***,mDGA2 i. expressed i. di.erse cell types and i. locali.ed to both exci.atory and i.hi.i.ory *** the network versus cell-speci.i. effects of mDGA2 loss-of-functi.n requi.es a cell-type and brai. regi.n-selecti.e *** address thi.,we generated mi.e harbori.g a condi.i.nal knockout of mdga2 restri.ted to CA1 pyrami.al *** we report that mDGA2 suppresses the densi.y and functi.n of exci.atory synapses selecti.ely on pyrami.al neurons i. the mature *** deleti.n of mdga2 i. CA1 pyrami.al neurons of adult mi.e upregulated mi.i.ture and spontaneous exci.atory postsynapti. potenti.ls,vesi.ular glutamate transporter 1 i.tensi.y,and neuronal *** effects were li.i.ed to glutamatergi. synapses as no changes were detected i. mi.i.ture and spontaneous i.hi.i.ory postsynapti. potenti.l properti.s or vesi.ular GABA transporter ***,evoked basal synapti. transmissi.n and AmPAR receptor currents were enhanced at glutamatergi. *** a behavi.ral level,memory appeared to be compromi.ed i. mdga2 cKO mi.e as both novel object recogni.i.n and contextual fear condi.i.ni.g performance were i.pai.ed,consi.tent wi.h defi.i.s i. long-term potenti.ti.n i. the CA3-CA1 *** affi.i.ti.n,a behavi.ral analog of soci.l defi.i.s i. auti.m,was si.i.arly *** results demonstrate that mDGA2 confi.es the properti.s of exci.atory synapses to CA1 neurons i. mature hi.pocampal ci.cui.s,thereby opti.i.i.g thi. network for plasti.i.y,c

关键词： mDGA2 CA1 pyrami.al neurons Glutamatergi. i.puts Synapti. plasti.i.y memory Soci.l behavi.rs Auti.m Synapse organi.ers