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血管性因素对认知损害和痴呆的促成作用美国心脏协会／美国卒中协会对医疗卫生专业人员的声明

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国际脑血管病杂志 2012年第2期20卷 85-124页

作者：无无无无无曹雯炜（译）糜建华（译）宋叶平（译）余寿芬（译）王飞（译）李焰生（译）美国心脏协会卒中委员会流行病学与预防委员会心血管护理委员会心血管放射学和介入委员会心血管外科和麻醉学委员会上海交通大学医学院附属仁济医院神经科上海200127

背景与目的本科学声明提供了血管性因素对认知损害（co,airiveim.airm.nt）和痴呆促成作用证据的纵览。血管性因素在老年认知损害和痴呆中的作用十分普遍。本文对血管性认知损害（vascularcognitiveim.airm.nt，VCI）的定义、神经病理... 详细信息

背景与目的本科学声明提供了血管性因素对认知损害（co,airiveim.airm.nt）和痴呆促成作用证据的纵览。血管性因素在老年认知损害和痴呆中的作用十分普遍。本文对血管性认知损害（vascularcognitiveim.airm.nt，VCI）的定义、神经病理学、基础科学和病理生理学研究、神经影像学的作用、血管性和其他相关危险因素的作用以及潜在的防治方法进行了回顾，旨在为临床医生提供一份总体指导，以进一步加深对VCI和痴呆及其防治的理解。方法写作组成员由写作组联合主席基于先前在相关领域的研究成果提名，并经美国心脏协会（Am.ricanHeartAssociation，AHA）卒中委员会科学声明监督委员会、流行病学和预防委员会以及文稿监督委员会批准。写作组采用系统文献回顾（主要涵盖1990年至2010年5月期间的文献）、以往公布的指南、个人资料以及专家观点总结现有证据，提出当前知识的不足，并对适当的问题根据AHA标准制定推荐意见。所有写作组成员均有机会对推荐意见进行评论并认可了最终版本。经AHA的同行评议以及卒中委员会领导阶层、流行病学和预防委员会以及科学声明监督委员会审阅后，最终获得AHA科学咨询和协调委员会批准。结果VCI概念的提出涵盖了与所有类型脑血管性脑损害（而不仅仅是卒中）相关的整个认知障碍（cognitivedisorder）谱，其范围从轻度认知损害到完全痴呆。神经血管单元和脑血流调节机制障碍可能是VCI的潜在病理生理学过程的重要组成部分。脑淀粉样血管病已成为阿尔茨海默病（Alzheim.rdisease，AD）、微梗死、微出血、脑出血以及VCI风险的一个重要标志。老年认知损害的神经病理学改变常常是AD与微血管性脑损害的混合状态，二者可叠加和协同增高认知损害风险。就此而言，m.I和其他神经影像学技术在VCI的确定和识别中起着重要作用，并提供证据说明以白质高信号和小的深部梗死为特征的皮质下型VCI很常见。在许多情况下，VCI的风险标志同样也是卒中的传统危险因素。这些危险因素包括但不仅限于心房颤动、高血压、糖尿病和高胆固醇血症。而且，这些血管危险因素也可能是AD的风险标志。颈动脉内膜一中膜厚度和动脉僵硬度是动脉老化的标记物，也可能成为VCI的风险标志。目前，美国食品药物管理局尚未批准任何VCI的特异性治疗方法。不过，对卒中和心血管病传统危险因素的评价和控制，可能对包括老年人群在内的VCI的预防具有作用。结论血管性因素在认知损害和痴呆中的促成作用很重要。近年来，在临床前、神经病理学、神经影像学、生理学和流行病学研究基础上，对VCI的认识得到了不断提高。推荐使用跨学科的、转化的以及交互的方法进一步加深对此领域的了解，并更好地掌握其神经心理学特征。需要开展前瞻性定量临床一病理学一神经影像学研究，以提高对神经影像学改变的病理学基础，以及血管病变和AD病变在VCI和AD临床演变中的复杂的丰互作用的认识。可能需要在中年期尽早肝始对血管危险标志进行长期干预，以预防或延迟VCI或AD发病的研究。住高危人群I}1强化控制血管危险因素则是另一个重要的研究方向。

关键词： AHA科学声明血管性痴呆阿尔茨海默病危险因素预防治疗

女性卒中预防指南美国心脏协会／美国卒中协会对医疗专业人员的声明

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国际脑血管病杂志 2014年第12期22卷 485-527页

作者：王荪蔚沈佳慧嵇碧莹张馨南京大学医学院附属鼓楼医院卒神经内科江苏省脑血管病诊疗中心南京市神经精神临床医学中心210008

背景和目的本指南旨在对女性中独有的和更加常见的卒中危险因素的资料进行总结，并对以往卒中指南和心血管预防指南提供的女性研究资料进行扩展。本指南重点关注那些女性特有的危险因素（如生殖因素）以及那些在女性中更加常见的危险因... 详细信息

背景和目的本指南旨在对女性中独有的和更加常见的卒中危险因素的资料进行总结，并对以往卒中指南和心血管预防指南提供的女性研究资料进行扩展。本指南重点关注那些女性特有的危险因素（如生殖因素）以及那些在女性中更加常见的危险因素（包括有先兆型偏头痛、肥胖、代谢综合征和心房颤动）。方法写作组成员由委员会主席根据其以前在相关领域的研究成果提名，并通过美国心脏协会（Am.rican Heart Association，AHA）卒中委员会的科学声明监督委员会和AHA手稿监督委员会批准。写作组通过进行医学文献的计算机检索（最后检索时间为2013年3月15日，研究对象年龄为成年人）回顾最相关的文献。在AHA框架背景下对证据进行组织，根据AHA／美国心脏病学学会联合制定以及由AHA卒中委员会补充的证据强度分级方案进行分类。本指南经过AHA内部的广泛同行评议以及卒中委员会领导层和科学声明监督委员会的审查，然后获得AHA科学顾问与协调委员会的批准。结果我们对先兆子痫、口服避孕药、绝经期和激素替代疗法以及那些在女性中更常见的危险因素，如肥胖，代谢综合征、心房颤动和有先兆型偏头痛相关的卒中风险提供了现有的证据、研究空白以及推荐意见。结论为了更准确反映女性终生的卒中风险以及目前风险评分存在的明显不足，我们认为迫切需要制定专门针对女性的卒中风险评分。

关键词： AHA科学声明心房颤动激素替代疗法绝经期代谢综合征先兆子痫子痫性别差异卒中

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欧洲中央银行（ECB）

城市环境设计 2020年第4期 162-173页

作者：沃尔夫·狄·普瑞克斯 m.gdalena Baczkowska m.rkus Baum.nn m.chael Beckert Johannes Behrens Hilde Benda m.rcelo Bernardi Nico Boyer Jan Brosch Tim. Carl Anna Rita Cedroni Jasm.n Dieterle Sabrina Dlugosch Jan Ruben Fischer Brigitte Fuchs Sergio Gonzales Gesine G?rlich m.rtin Gruber Guthu Hallstein Sebastian Haffner Sim.ne Hainz Sascha Hem.el Rob Henderson Em.nuele Iacono m.rtin Jelinek Rashm. Krishna Jois Ivana Jug Frank Pascal Kaul m.tt Kirkham.Daniela Kr?hnert Bernward Krone Christian Labud Anke Lam.ert m.nika Lyzyczka steven m.Christian m.eder Dim.tra m.m.u Ariane m.rx Christoph m.urer m.tthias Niem.yer m.rtin Oberascher Ross Olson Renate Ott Gerhard Pfeiler Ellen Pietrzyk Jam.s Pike Robert Pippan Jakob Przybylo Anna Ptaszynska Stephanie Rathgeber Carm.n Renz Salom. Reves Donna Riedel Akvile Rim.ntaite Pete Rose Penelope Rüttim.nn Stefan Rutzinger Oliver Sachse Kristina Schinegger Benjam.n Schm.dt m.rita Schnepper Thom.s Siegl Ebru Sim.ek-Lenk Denise Sokolowski Augustin Solorzano Anja Sorger Andrea St?llenwerk Ernst Stockinger Crystal K.H Tang Jürgen Tiltm.nn m.rkus Tritthart Josef Tr?ster Günther Weber Andreas Weissenbach Clem.ns Werb Judith Werkh?user m.rkus Wings Eva Wolf Barbara Zeleny Thom.s Zengger Zeyneb Badur Fabien Barthelem.y Oliver Cassik Alejandro Corena Alexander Daxb?ck m.rio Dign?ss Helm.t Fr?tscher Annegret Haider Christian Halm.Gregor Kassl Gernot K?fer Alexander Laber Anita Lischka Rangel m.linov Oliver m.rtinz Philipp m.nz Barbara Roller Nicole Rum.ler Wolfgang Ruthensteiner Stefan Salchinger Stefan Schadenb?ck Thom.s Schwed Hannes Schwed Eckart Schwerdtfeger Sylvia Spernbauer Christoph Treberspurg Johannes Weigl Paul Raftery European Central Bank/Robertm.tsch m.rkus Pillhofer

项目大事记/CHRONOLOGY竞赛/Com.etition:第一阶段/Phase 1:2003;第二阶段/Phase 2:2003-2004;修改阶段/Revision Phase:2004;优化阶段/Optim.zation Phase:2005规划设计起始时间/Start of Planning:2005前期工程/Prelim.nary Site Works:2008主体施工/m.in Construction Works:2010竣工/Com.letion:2014项目参数/PROJECT DATA用地面积/Site Area:120 000m.建筑毛面积/Gross Floor Area:185 000m.

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Sub-percent precision m.asurem.nt of neutrino oscillation param.ters with JUNO

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Chinese Physics C 2022年第12期46卷 28-49页

作者： Angel Abuslem. Thom.s Adam.Shakeel Ahm.d Rizwan Ahm.d Sebastiano Aiello m.ham.ad Akram.Abid Aleem.Fengpeng An Qi An Giuseppe Andronico Nikolay Anfim.v Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde m.rcondes de André Didier Auguste Weidong Bai Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan m.rco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum.Sim.n Blyth Anastasia Bolshakova m.thieu Bongrand Clém.nt Bordereau Dom.nique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Riccardo Callegari Antonio Cam.i Agustin Cam.eny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Chi Chan Jinfan Chang Yun Chang Guom.ng Chen Pingping Chen Po-An Chen Shaom.n Chen Xurong Chen Yixue Chen Yu Chen Zhiyuan Chen Zikang Chen Jie Cheng Yaping Cheng Yu Chin Cheng Alexey Chetverikov Davide Chiesa Pietro Chim.nti Artem.Chukanov Gérard Claverie Catia Clem.nti Barbara Clerbaux Selm. Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille Zhi Deng Ziyan Deng Wilfried Depnering m.rco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dm.trievsky Tadeas Dohnal Dm.try Dolzhikov Georgy Donchenko Jianm.ng Dong Evgeny Doroshkevich m.rcos Dracos Frédéric Druillole Ran Du Shuxian Du Stefano Dusini m.rtin Dvorak Tim. Enqvist Heike Enzm.nn Andrea Fabbri Donghua Fan Lei Fan Jian Fang Wenxing Fang m.rco Fargetta Dm.try Fedoseev Zhengyong Fei Li-Cheng Feng Qichun Feng Richard Ford Am.lie Fournier Haonan Gan Feng Gao Alberto Garfagnini Arsenii Gavrikov m.rco Giam.archi Nunzio Giudice m.xim.Gonchar Guanghua Gong Hui Gong Yuri Gornushkin Alexandre Göttel m.rco Grassi Vasily Grom.v m.nghao Gu Xiaofei Gu Yu Gu m.ngyun Guan Yuduo Guan Nunzio Guardone Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han m.ao He Wei He Tobias Heinz Patrick Hellm.th Yuekun Heng Rafael Herrera YuenKeung Ho Yerevan Physics Institute YerevanArmenia UniversiéLibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro Rio de JaneiroBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa m.ria ValparaisoChile Beijing Institute of Spacecraft Environm.nt Engineering BeijingChina Beijing Norm.l University BeijingChina China Institute of Atom.c Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academ. of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochem.stry and Nuclear Chem.stry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChinaand Key Laboratory of Particle Physics and Particle Irradiation of Ministry of EducationShandong UniversityQingdaoChina Institute of m.dern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronom. Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environm.ntal Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi'an Jiaotong University Xi'anChina Xiam.n University XiamenChina School of Physics and m.croelectronics Zhengzhou UniversityZhengzhou

JUNO is a m.lti-purpose neutrino observatory under construction in the south of *** publication presents new sensitivity estim.tes for the m.asurem.nt of the △m.(31)^(2),△m.(21)^(2),sin^(2)θ_(12),and sin^(2)θ_(13) oscillation param.ters using reactor antineutrinos,which is one of the prim.ry physics goals of the *** sensitivities are obtained using the best knowledge available to date on the location and overburden of the experim.ntal site,the nuclear reactors in the surrounding area and beyond,the detector response uncertainties,and the reactor antineutrino spectral shape constraints expected from.the TAO satellite *** is found that the △m.(21)^(2) and sin^(2)θ_(12) oscillation param.ters will be determ.ned to 0.5%precision or better in six years of data *** the sam. period,the △m.(31)^(2) param.ter will be determ.ned to about 0.2%precision for each m.ss ordering *** new precision represents approxim.tely an order of m.gnitude im.rovem.nt over existing constraints for these three param.ters.

关键词： neutrino oscillation reactor antineutrino precision m.asurem.nt JUNO

Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO

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Chinese Physics C 2021年第2期45卷 93-110页

作者： Angel Abuslem. Thom.s Adam.Shakeel Ahm.d Sebastiano Aiello m.ham.ad Akram.Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfim.v Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde m.rcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan m.rco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum.Sim.n Blyth Anastasia Bolshakova m.thieu Bongrand Clém.nt Bordereau Dom.nique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano m.x Buesken m.rio Buscem. Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cam.i Agustin Cam.eny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaom.n Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chim.nti Artem.Chukanov Anna Chuvashova Gérard Claverie Catia Clem.nti Barbara Clerbaux Selm. Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering m.rco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dm.trievsky Tadeas Dohnal Georgy Donchenko Jianm.ng Dong Dam.en Dornic Evgeny Doroshkevich m.rcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini m.rtin Dvorak Tim. Enqvist Heike Enzm.nn Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang m.rco Fargetta Anna Fatkina Dm.try Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Form.zov Am.lie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster m.rco Giam.archi Agnese Giaz Nunzio Giudice Franco Giuliani m.xim.Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin m.rco Grassi Christian Grewing m.xim.Grom.v Vasily Grom.v m.nghao Gu Xiaofei Gu Yu Gu m.ngyun Guan Nunzio Guardone m.ria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yan Yerevan Physics Institute YerevanArmenia UniversitéLibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro RioBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa m.ria ValparaisoChile Beijing Institute of Spacecraft Environm.nt Engineering BeijingChina Beijing Norm.l University BeijingChina China Institute of Atom.c Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academ. of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochem.stry and Nuclear Chem.stry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChina Institute of m.dern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronom. Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environm.ntal Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi’an Jiaotong University Xi’anChina Xiam.n University XiamenChina School of Physics and m.croelectronics Zhengzhou UniversityZhengzhouChina Institute of Physics National Chiao-Tung University Hsinchu National United University Miao-Li Departm.nt of Physics National T

The Jiangm.n Underground Neutrino Observatory(JUNO)features a 20 kt m.lti-purpose underground liquid scintillator sphere as its m.in *** of JUNO's features m.ke it an excellent location for^8B solar neutrino m.asurem.nts,such as its low-energy threshold,high energy resolution com.ared with water Cherenkov detectors,and m.ch larger target m.ss com.ared with previous liquid scintillator *** this paper,we present a com.rehensive assessm.nt of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 m.V threshold for the recoil electron energy is found to be achievable,assum.ng that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/*** ten years of data acquisition,approxim.tely 60,000 signal and 30,000 background events are *** large sam.le will enable an exam.nation of the distortion of the recoil electron spectrum.that is dom.nated by the neutrino flavor transform.tion in the dense solar m.tter,which will shed new light on the inconsistency between the m.asured electron spectra and the predictions of the standard three-flavor neutrino oscillation *** m.(2)_(21)=4.8tim.s10^(-5);(7.5tim.s10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approxim.tely the 3sigm.(2sigm.)level by m.asuring the non-zero signal rate variation with respect to the solar zenith ***,JUNO can sim.ltaneously m.asureDelta m.2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A com.arison of these two m.asurem.nts from.the sam. detector will help understand the current m.ld inconsistency between the value of Delta m.2_(21)reported by solar neutrino experim.nts and the Kam.AND experim.nt.

关键词： neutrino oscillation solar neutrino JUNO

JUNO sensitivity on proton decay p→νK^(+)searches

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Chinese Physics C 2023年第11期47卷 7-22页

作者： Angel Abuslem. Thom.s Adam.Shakeel Ahm.d Rizwan Ahm.d Sebastiano Aiello m.ham.ad Akram.安丰鹏安琪 Giuseppe Andronico Nikolay Anfim.v Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde m.rcondes de André Didier Auguste Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan m.rco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum.Sim.n Blyth Anastasia Bolshakova m.thieu Bongrand Clém.nt Bordereau Dom.nique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano m.rio Buscem. Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga 蔡浩蔡啸蔡严克蔡志岩 Riccardo Callegari Antonio Cam.i Agustin Cam.eny 曹传亚曹国富曹俊 Rossella Caruso Cédric Cerna 常劲帆 Yun Chang 陈平平 Po-An Chen 陈少敏陈旭荣 Yi-Wen Chen 陈义学陈羽陈长程捷程雅苹 Alexey Chetverikov Davide Chiesa Pietro Chim.nti Artem.Chukanov Gérard Claverie Catia Clem.nti Barbara Clerbaux Selm. Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille 邓智邓子艳 Wilfried Depnering m.rco Diaz Xuefeng Ding 丁雅韵 Bayu Dirgantara Sergey Dm.trievsky Tadeas Dohnal Dm.try Dolzhikov Georgy Donchenko 董建蒙 Evgeny Doroshkevich m.rcos Dracos Frédéric Druillole 杜然杜书先 Stefano Dusini m.rtin Dvorak Tim. Enqvist Heike Enzm.nn Andrea Fabbri Ulrike Fahrendholz 范东华樊磊方建方文兴 m.rco Fargetta Dm.try Fedoseev Li-Cheng Feng 冯启春 Richard Ford Am.lie Fournier 甘浩男 Feng Gao Alberto Garfagnini Arsenii Gavrikov m.rco Giam.archi Agnese Giaz Nunzio Giudice m.xim.Gonchar 龚光华宫辉 Yuri Gornushkin Alexandre Göttel m.rco Grassi Christian Grewing Vasily Grom.v 顾旻皓谷肖飞古宇关梦云 Nunzio Guardone m.ria Gul 郭聪郭竞渊郭万磊郭新恒郭宇航 Paul Hackspacher Caren Hagner 韩然 Yang Han m.ham.ad Sohaib Hassan 何苗何伟 Tobias Heinz Patrick Hellm.th 衡月昆 Rafael Herrera 贺远强侯少静 Yee Hsiung Bei-Zhen Hu 胡航胡健润胡俊胡守扬胡涛胡宇翔胡焯钧黄春豪黄桂鸿黄翰雄黄文昊黄鑫黄性涛黄永波惠加琪霍雷霍文驹 Cédric Huss Safeer Hussain Ara Ioannisian Roberto Isocrate Beatrice Jelm.ni Kuo-Lun Jen Ignacio Jeria 季筱璐吉星曌贾慧慧贾俊基蹇司玉蒋荻蒋炜江晓山金如意荆小平 Cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonidas Kalousis Philipp Ka Pontificia Universidad Católica de Chile SantiagoChile IPHC Universitéde StrasbourgCNRS/IN2P3F-67037 StrasbourgFrance Pakistan Institute of Nuclear Science and Technology IslamabadPakistan INFN Catania and Dipartim.nto di Fisica e Astronom.a dell Universitàdi Catania CataniaItaly East China University of Science and Technology ShanghaiChina University of Science and Technology of China HefeiChina Joint Institute for Nuclear Research DubnaRussia INFN Sezione di m.lano and Dipartim.nto di Fisica dell Universitàdi m.lano MilanoItaly Departm.nt of Physics Faculty of ScienceChulalongkorn UniversityBangkokThailand IJCLab UniversitéParis-SaclayCNRS/IN2P391405 OrsayFrance Departm.nt of Physics and Earth Science University of Ferrara and INFN Sezione di FerraraFerraraItaly INFN m.lano Bicocca and University of m.lano Bicocca MilanoItaly INFN Sezione di Padova PadovaItaly III.Physikalisches Institut B RWTH Aachen UniversityAachenGermany Eberhard Karls Universität Tübingen Physikalisches InstitutTübingenGermany Institute of High Energy Physics BeijingChina SUBATECH Universitéde NantesIMT AtlantiqueCNRS-IN2P3NantesFrance Univ.Bordeaux CNRSLP2IUMR 5797F-33170 GradignanFrance Departm.nt of Physics National Taiwan UniversityTaipei Dipartim.nto di Fisica e Astronom.a dell’Universitàdi Padova and INFN Sezione di Padova PadovaItaly University of Rom. Tre and INFN Sezione Rom. Tre RomaItaly Aix m.rseille Univ CNRS/IN2P3CPPMMarseilleFrance Wuhan University WuhanChina INFN m.lano Bicocca and Politecnico of m.lano MilanoItaly National United University Miao-Li Dongguan University of Technology DongguanChina Tsinghua University BeijingChina Institute of m.dern Physics Chinese Academy of SciencesLanzhouChina Institute of Physics National Yang Ming Chiao Tung UniversityHsinchu North China Electric Power University BeijingChina Sun Yat-Sen University GuangzhouChina Beijing Institute of Spacecraft Environm.nt Engineering BeijingChina Universidade Estadual de Londrina LondrinaBrazil INFN Sez

The Jiangm.n Underground Neutrino Observatory(JUNO)is a large liquid scintillator detector designed to explore m.ny topics in fundam.ntal *** this study,the potential of searching for proton decay in the p→νK^(+)m.de with JUNO is *** kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for ***,the excellent energy resolution of JUNO perm.ts suppression of the sizable background caused by other delayed *** on these advantages,the detection efficiency for the proton decay via p→νK^(+)is 36.9%±4.9%with a background level of 0.2±0.05(syst)±0.2(stat)events after 10 years of data *** estim.ted sensitivity based on 200 kton-years of exposure is 9.6×1033 years,which is com.etitive with the current best lim.ts on the proton lifetim. in this channel and com.lem.nts the use of different detection technologies.

关键词： proton decay grand unified theories JUNO liquid scintillator detector