检索结果-南通市图书馆

Osteoclasts:New Insights

在线全文

学校读者我要写书评

暂无评论

Bone Research 2013年第1期1卷 11-26页

作者： Xu Feng steven l.Teitelbaum Department of Pathology The University of Alabama at BirminghamBirminghamAlabama 35294USA Department of Pathology and Immunology Washington University School of MedicineSt.LouisMissouri 63110USA

Osteoclasts, the bone-resorbing cells, play a pivotal role in skeletal development and adult bone remodeling. They also participate in the pathogenesis of various bone disorders. Osteoclasts differentiate from cells of the monocyte/macrophage lineage upon stimulation of two essential factors, the monocyte/ macrophage colony stimulating factor （M-CSF） and receptor activation of NF-κB ligand （RANKl）. M-CSF binds to its receptor c-Fms to activate distinct signaling pathways to stimulate the proliferation and survival of osteoclast precursors and the mature cell. RANKl, however, is the primary osteoclast differentiation factor, and promotes osteoclast differentiation mainly through controlling gene expression by activating its receptor, RANK. Osteoclast function depends on polarization of the cell, induced by integrin avβ3, to form the resorptive machinery characterized by the attachment to the bone matrix and the formation of the bone-apposed ruffled border. Recent studies have provided new insights into the mechanism of osteoclast differentiation and bone resorption. In particular, c-Fms and RANK signaling have been shown to regulate bone resorption by cross-talking with those activated by integrin avβ3. This review discusses new advances in the understanding of the mechanisms of osteoclast differentiation and function.

关键词： osteoclast bone remodeling M-CSF RANKl integrin avβ3

Effect of forest disturbance on myxomycete assemblages in the southwestern Peruvian Amazon

在线全文

学校读者我要写书评

暂无评论

Fungal Diversity 2013年第2期59卷 45-53页

作者： Carlos Rojas steven l.Stephenson Instituto de Investigaciones en Ingeniería and Escuela de Biología Universidad de Costa RicaSan Pedro de Montes de Oca 11501-2060Costa Rica Department of Biological Sciences University of ArkansasFayettevilleAR 72701-1201USA

Although the effects of microenvironmental factors on distribution patterns in myxomycetes have been investigated,studies of the responses of this group of organisms to different regimes of forest disturbance are relatively few in *** an effort to understand the implications of forest fragmentation and habitat loss on myxomycetes,the project described herein was carried out at the los Amigos Biological Station in southeastern *** structure and composition of assemblages of myxomycetes were investigated in relation to three different forest types and climatic periods in the area of *** analysis of the most commonly recorded substrates was carried out as *** results suggested that habitat loss,through differences in forest structure,was the factor determining most of the differences in fruiting body abundance of myxomycetes among forest *** addition,a switch in the ecological strategy of dispersal seemed to be an important factor accounting for differences in the fruiting body abundance and structure of assemblages of myxomycetes between collecting *** study provides evidence indicating that for microbial assemblages to maintain the balance of functional interactions within a particular forest ecosystem,the conservation of the forests themselves should be considered.

关键词： Biogeography Microbial ecology Mycetozoans Myxogastrids Restoration ecology

NUMERICAl SIMUlATION OF THE XZ TAURI SUPERSONIC ASTROPHYSICAl JET

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematica Scientia 2009年第6期29卷 1677-1683页

作者： Carl l. Gardner steven J. Dwyer School of Mathematical and Statistical Sciences Arizona State University Tempe AZ 85287 USA

Computational gas dynamical simulations using the WENO-lF method are applied to modeling the high Mach number astrophysical jet XZ Tauri, including the effects of radiative cooling. Mach 55 simulations of the pulsed proto-jet are presented and analyzed in terms of interacting nonlinear waves： terminal Mach disks, bow shocks, and Meshkov-Richtmyer instabilities of the leading jet contact boundary.

关键词： astrophysical jets ENO. method gas dynamics

Schwann cell extracellular vesicles:judging a book by its cover

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第2期18卷 325-326页

作者： steven l.Gonias Wendy M.Campana Department of Pathology University of CaliforniaSan DiegoCAUSA Department of Anesthesiology Program in NeurosciencesUniversity of California The Veterans Administration San Diego Healthcare System San DiegoCAUSA

Schwann cells(SCs)are essential in the development of the peripheral nervous system(PNS),in PNS inj ury,and the aging *** comprise greater than 90%of the nucleated cells in peripheral nerves(Campana,2007).Myelinating SCs insulate large-diameter axons,forming a 1:1relationship and promoting saltatory conduction of axonal action ***-myelinating SCs ensheathe clusters of smaller diameter axons in Remak *** types of SCs provide essential metabolic and trophic support to axons,which is essential for maintaining axon integrity in healthy peripheral nerves.

关键词： nerves conduction Schwann

Entropy and enthalpy for triggering cutaneous erythema

在线全文

学校读者我要写书评

暂无评论

Journal of Innovative Optical Health Sciences 2015年第4期8卷 54-57页

作者： steven l.Jacques Joseph T.Walsh Wellman laboratories Massachusetts General Hospital BostonMAUSA Harvard Medical School-M.I.T. CambridgeMAUSA Oregon Health&Science University 3303 SW Bond Ave.PortlandORUSA 97239

The molar entropy(OS)and molar enthalpy(△H)for the denaturation event that triggers cutaneous erythema was determined to be △S=190J/(mole K)and△H=146.9×10^(3) J/*** experiment involved placing heated water against the skin of the forearm,for a range of termperatures and exposure *** the skin to 45℃ for 22 s was at the threshold for producing erythema,which was similar to the threshold for a slight degree of pain.

关键词： Skin erythema thermal entropy enthalpy

The Chikungunya virus: An emerging US pathogen

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Emergency Medicine 2016年第1期7卷 65-67页

作者： Thomas M.Nappe Craig M.Chuhran steven A.johnson Department of Emergency Medicine Lehigh Valley Hospital USF Morsani College of Medicine Department of Medicine Lehigh Valley Hospital USF Morsani College of Medicine

BACKGROUND:The Chikungunya(CHIK)virus was recently reported by the CDC to have spread to the United *** report an early documented case of CHIK from the state of Pennsylvania after a patient recently returned from Haiti in June of ***:A 39-year-old man presented to the emergency department complaining of fever,fatigue,polyarthralgias and a diffuse rash for two *** days before,he returned from a mission trip to Haiti and reported that four of his accompanying friends had also become ill.A CHIK antibody titer was obtained and it was found to be *** his hospital stay,he responded well to supportive care,including anti-inflammatories,intravenous hydration and ***:His condition improved within two days and he was ultimately discharged ***:Manifestations of CHIK can be similar to Dengue fever,which is transmitted by the same species of mosquito,and occasionally as a *** should include Chikungunya virus in their differential diagnosis of patients who present with fever,polyarthralgia and rash with a recent history of travel to endemic areas,including those within the United States.

关键词： Chikungunya virus Arbovirus Mosquito-borne disease Polyarthralgia

Differential Splicing of Skipped Exons Predicts Drug Response in Cancer Cell lines

在线全文

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2021年第6期19卷 901-912页

作者： Edward Simpson steven Chen Jill l.Reiter Yunlong liu Center for Computational Biology and Bioinformatics Indiana University School of MedicineIndianapolisIN 46202USA Department of BioHealth Informatics School of Informatics and ComputingIndiana University-Purdue University IndianapolisIndianapolisIN 46202USA Department of Medical and Molecular Genetics Indiana University School of MedicineIndianapolisIN 46202USA

Alternative splicing of pre-mRNA transcripts is an important regulatory mechanism that increases the diversity of gene products in *** studies have linked specific transcript isoforms to altered drug response in cancer;however,few algorithms have incorporated splicing information into drug response *** this study,we evaluated whether basal-level splicing information could be used to predict drug sensitivity by constructing doxorubicin-sensitivity classification models with splicing and expression *** detailed splicing differences between sensitive and resistant cell lines by implementing quasi-binomial generalized linear modeling(QBGlM)and found altered inclusion of 277 skipped *** additionally conducted RNA-binding protein(RBP)binding motif enrichment and differential ex-pression analysis to characterize cis-and trans-acting elements that potentially influence doxorubicin response-mediating splicing *** results showed that a classification model built with skipped exon data exhibited strong predictive *** discovered an association between differentially spliced events and epithelial-mesenchymal transition(EMT)and observed motif enrichment,as well as differential expression of RBFOX and ElAVl RBP family *** work demonstrates the potential of incorporating splicing data into drug response algorithms and the utility of a QBGlM approach for fast,scalable identification of relevant splicing differences between large groups of samples.

关键词： Alternative splicing Transcript isoform Splicing regulation Drug sensitivity Precision medicine

Myxomycetes associated with grasslands of the western central United States

在线全文

学校读者我要写书评

暂无评论

Fungal Diversity 2013年第2期59卷 147-158页

作者： Adam W.Rollins steven l.Stephenson Department of Biology Lincoln Memorial UniversityHarrogateTN 37752USA Department of Biological Sciences University of ArkansasFayettevilleAR 72701USA

The assemblages of myxomycetes associated with the three types of temperate grasslands(tall grass,mixed grass and short grass)found across the western central United States were examined by collecting samples for isolation of these organisms from nine study *** consisted of two types of ground litter,two types of aerial litter(dead but still attached plant parts)and *** were brought back to the laboratory and used to prepare a series of moist chamber *** cultures yielded 1,301 collections of myxomycetes representing 59 species in 18 *** collections could be identified only to genus and one in particular(lepidoderma sp.)appears to be an undescribed *** spectabile was recorded for the first time in North ***,only eight species(Badhamia melanospora,Didymium anellus,***,***,Perichaena depressa,Physarum cinereum,***,and Stemonitis fusca)were recovered from all nine study sites and thus are considered to represent a core component of the myxomycete biota of temperate grasslands.

关键词： Community ecology Ecological distribution Grasslands Microhabitat Myxogastrids

ASSESSMENT OF OPTICAl ClEARING AGENTS USING REFlECTANCE-MODE CONFOCAl SCANNING lASER MICROSCOPY

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Innovative Optical Health Sciences 2010年第3期3卷 183-188页

作者： RAVIKANT SAMATHAM KEVIN G.PHIllIPS steven l.JACQUES Departments of Dermatology and Biomedical Engineering Oregon Health and Science University 3303 SW Bond Avenue PortlandOR 97239USA

The mechanism of action of clearing agents to improve optical imaging of mouse skin during reflectance-mode confocal microscopy was *** dermal side of excised dorsal mouse skin was exposed for one hour to saline,glycerin,or 80% DMSO,then the clearing agent was removed and the dermis placed against a glass cover slip through which a confocal microscope measured reflectance at 488 nm *** untreated control was also *** axial attenuation of reflectance signal,R(z_(f))versus increasing depth of focus zf behaved as R=ρexp(−μz_(f) 2G),where ρ is tissue reflectivity and μ is attenuation[cm^(−1)].The factor 2G accounts for the in/out path of photons,and the numerical aperture of the *** ρ,μ data were mapped to values of scattering coefficient(μ_(s)[cm^(−1)])and anisotropy of scattering(g).Images showed that glycerin significantly increased the g of dermis from about 0.7 to about 0.99,with little change in the μ_(s) of dermis at about 300cm^(−1).DMSO and saline had only slight and inconsistent effects on g and μ_(s).

关键词： Optical properties skin anisotropy