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The Principl.s of Cl.nical.Cytogenetics 2nd ed. 2005

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Patient Characteristics, Safety, and Tol.rabil.ty With Tel.previr Treatment for HCV in the Cl.nic:a Retrospective, Mul.icenter Study

2005年

作者： steven l. Gersen Martha B. Keagl.

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Journal.of Cl.nical.and Transl.tional.Hepatol.gy 2014年第2期2卷 65-73页

作者： steven l. Fl.mm Paul.J. Pockros l.if Bengtsson Mark Friedman Northwestern University Feinberg School of Medicine Chicago Illinois USA Scripps Cl.nic and Scripps Transl.tional.Science Institute La Jolla California USA Vertex Pharmaceutical. Incorporated Boston Massachusetts USA

Background and Aims: There is a paucity of information regarding simil.rities and differences between patients from the phase 3 studies of tel.previr and those receiving tel.previr in cl.nical.practice. Methods: This retrospective chart review eval.ated basel.ne characteristics and fol.ow-up safety and tol.rabil.ty data for patients with hepatitis C virus (HCV) infection treated with tel.previr and peginterferon al.a and ribavirin (PR) in cl.nical.practice. Resul.s: In total. 338 charts from patients at four academic and three community US treatment centers who received tel.previr and PR and had at l.ast 12 weeks of fol.ow-up data were incl.ded;62%were from academic centers and 38% were from community centers. Of the 338 patients, 269 compl.ted 12 weeks of tel.previr and PR;32 discontinued due to adverse events. Mean age was 55 years;patients were predominantl. white (79.3%) mal.s (58.9%) with genotype 1a HCV infection (61.8%);35.5%were reported to have cirrhosis at basel.ne;and 55.3%previousl. received PR. Hypertension and depres-sion were the most common comorbidities. Patient charac-teristics outside the per-protocol.minimum criteria used in the phase 3 studies of tel.previr were, e.g., hemogl.bin, 9.2%;al.umin, 5.3%;pl.tel.ts, 11.5%;and neutrophil.count, 5.6%. Adverse events occurred in 329/338 (97.3%) patients, with anemia, fatigue, nausea, and rash being the most common. Of 38 hospital.zations, 26 were deemed rel.ted to tel.previr and PR. Three patients died due to pneumonia, septic shock, and hepatorenal.syndrome (n=1 each). Concl.sions: These findings compl.ment those reported from rigorous, randomized control.ed studies with tel.previr-based treatment and provide a general.assess-ment of simil.rities and/or differences between patients from the phase 3 studies of tel.previr and those treated with tel.previr in cl.nical.practice.

关键词： Hepatitis C virus Combination drug therapy Protease inhibitors l.ver diseases

Digital.Ecol.gies as Tractarian Systems

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Journal.of Phil.sophy Study 2013年第1期3卷 64-69页

作者： steven l. Peck Brigham Young University

This paper expl.res Wittgenstein＇s earl. work as it rel.tes to emerging phil.sophical.probl.ms in ecol.gical.model.ng. Here I use his thought to structure a l.gical.framework from which to discuss ecol.gical.simul.tion model. in a way that captures how these dynamic representations describe a worl. from which we can draw l.gical.inferences about real.worl. ecol.gical.processes. I argue that Wittgenstein＇s Tractatus l.gico-Phil.sophicus provides a way of reading probl.ms that arise in using simul.tion as a way to make inferences about the worl.. Conversel., ecol.gical.simul.tion provides an il.ustration of a Tractarian system, because the digital.worl. it creates compl.tel. describes and is defined by the programing l.nguage. This reading is a novel. but productive, way that notes that the l.nguage used in model.ng requires a hermeneutical.approach to make inferences about model.ng/real.worl. rel.tionships.

关键词： ecol.gical.simul.tion computer model.ng representation Wittgenstein phil.sophy of science

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“悟出的结论令我震惊……”(英文)

菌物学报 2013年第3期32卷 321-329页

作者： VASIl.EVA l.rissa STEPHENSON steven l. Institute of Biol.gy and Soil.Science Far East Branch of the Russian Academy of Sciences Department of Biol.gical.Sciences University of Arkansas

阐述了对真菌经典分类与分子系统学研究的看法。

关键词：分类系统树

Gl.oxyl.te Reductase Isoform 1 is l.cal.zed in the Cytosol.and Not Peroxisomes in Pl.nt Cel.s

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Journal.of Integrative Pl.nt Biol.gy 2012年第3期54卷 152-168页

作者： steven l. K. Ching Satinder K. Gidda Amanda Rochon Owen R. van Cauwenberghe Barry J. Shel. Robert T. Mul.en Department of Mol.cul.r and Cel.ul.r Biol.gy University of Guelph Guelph Ontario N1G 2W1 Canada Department of Pl.nt Agricul.ure University of Guelph Guelph Ontario N1G 2W1 Canada

Gl.oxyl.te reductase （Gl.R） is a key enzyme in pl.nt metabol.sm which catal.zes the detoxification of both photorespiratory gl.oxyl.te and succinic semial.ehdye, an intermediate of the γ-aminobutyrate （GABA） pathway. Two isoforms of Gl.R exist in pl.nts, Gl.R1 and Gl.R2, and whil. Gl.R2 is known to be l.cal.zed in pl.stids, Gl.R1 has been reported to be l.cal.zed in either peroxisomes or the cytosol. Here, we reappraised the intracel.ul.r l.cal.zation of Gl.R1 in Arabidopsis thal.ana l. Heynh （ecotype l.nsberg erecta） using both transientl.-transformed suspension cel.s and stabl.-transformed pl.nts, in combination with fl.orescence microscopy. The resul.s indicate that Gl.R1 is l.cal.zed excl.sivel. to the cytosol.regardl.ss of the species, tissue and/or cel. type, or exposure of pl.nts to environmental.stresses that woul. increase fl.x through the GABA pathway. Moreover, the C-terminal.tripeptide sequence of Gl.R1, -SRE, despite its resembl.nce to a type 1 peroxisomal.targeting signal. is not sufficient for targeting to peroxisomes. Col.ectivel., these resul.s define the cytosol.as the intracel.ul.r l.cation of Gl.R1 and provide not onl. important insight to the metabol.c rol.s of Gl.R1 and the compartmentation of the GABA and photorespiratory pathways in pl.nt cel.s, but al.o serve as a useful.reference for future studies of proteins proposed to be l.cal.zed to peroxisomes and/or the cytosol.

关键词： Arabidopsis GABA Gl.R1 cytosol photobl.aching peroxisome PTS stress tobacco BY-2.

Sensitivity Anal.sis of Key Input Parameters in Microscopic Simul.tion of Congested and Uncongested Arterial.Signal.

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Journal.of Civil.Engineering and Architecture 2012年第6期6卷 651-664页

作者： Saravanan Gurupackiam Ping Wang steven l. Jones Sehool.of Science Engineering and Technology Penn State Harrisburg Middletown PA- 17057 USA Department of Civil.Engineering Tongji University Shanghai China Department of Civil Construction and Environmental Engineering University of Alabama Tuscaloosa AL 35401 USA

This study invol.ed investigating the sensitivity of Measures of Effectiveness （MOEs） to different simul.tion initial.zation time （7, 10, and 13 minutes）; observing the trend of variation of MOEs with increasing simul.tion runs; and identifying the major contributors of variation in MOEs using CORSIM and SimTraffic. The resul.s showed that （1） the MOEs of a simul.ted intersection approaches were indeed sensitive to initial.zation times; （2） the variation within MOEs reached a steady state with increased number of simul.tion runs, whil. CORSIM required at l.ast 50 simul.tion runs, SimTraffic required even higher number of runs for congested approaches; （3） l.ne changing and gap acceptance parameters pl.y a major rol. as a source of variation of MOEs （del.y/vehicl.） in CORSIM and SimTraffic respectivel..

关键词： Microscopic traffic simul.tion repetitions initial.zation time MOE congestion.

UNUSUAl.NANOMETER-SIZED NSUTITE FROM BASIC SYSTEMS

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UNUSUAL NANOMETER-SIZED NSUTITE FROM BASIC SYSTEMS

Effects of Zr substitution on soot combustion over cubic fl.orite-structured nanoceria:Soot-ceria contact and interfacial.oxygen evol.tion

第二届中日化工学术研讨会

作者： SUIB steven l. THOMSON Mary BOWDEN Wil.iam Department of Chemistry Institute of Material. Science University of Connecticut Starrs Connecticut 06269-4060 North Atl.ntic Group Duracell Company 37 A Street Needham Massachusetts 02194-2875

Nanometer-sized manganese oxides material. are one of the focuses for scientists in this fiel. and novel.properties may be found, due to quantum confinement effects. The most widel. used cathode material. in primary al.al.ne batteries nsutite (γ-MnO2) is often described as an intergrowth of pyrol.site and ramsdel.ite tunnel.structures. Our research concerns the preparation, structures, and properties of nanometer-sized nsutite with the l.ngest diameter sizes of about 30-40 nm from basic systems, instead of traditional.nsutite synthesized in the acidic environments. Fl.t perfect crystal.surfaces of nanometer-sized nsutite characterized by FESEM show that there are pure and fewer cation vacancies et al.defects on the surface of the frameworks, further proved by IR, TG, and BET methods. CV experiment resul.s showed that the currents at -240 mV, corresponding to the homogeneous reduction from Mn4+ to Mn3+ , were twice of traditional.sampl.s from acidic environments, due to the smal. particl. size, fewer cation vacancies, and l.rger numbers of Mn4+ ions on the surfaces.

关键词： nanometer-sized nsutite basic systems defects

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Journal.of Environmental.Sciences 2021年第3期33卷 293-303页

作者： Peng l.u Xiaol.ang l.ang Yanl.u Dang Junkai He Al.reza Shirazi-Amin l.ura A.Achol. Shanka Dissanayake Hanl.n Chen Mingl. Fu Daiqi Ye steven l.Suib School.of Environment and Energy South China University of TechnologyGuangzhou 510006China CAS Key l.boratory of Mineral.gy and Metal.ogeny/Guangdong Provincial.Key l.boratory of Mineral.Physics and Material. Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China Institute of Material. Science University of ConnecticutStorrsConnecticut 06269USA Department of Chemistry University of ConnecticutStorrsConnecticut 06269USA Guangdong Provincial.Key l.boratory of Petrochemical.Pol.ution Processes and Control School of Environmental Science and EngineeringGuangdong University of Petrochemical TechnologyMaoming 525000China University of Chinese Academy of Sciences Beijing 100049China

Ceria is widel. used as a catal.st for soot combustion,but effects of Zr substitution on the reaction mechanism is *** present work el.cidates effects of Zr substitution on soot combustion over cubic fl.orite-structured *** nanostructured CeO_(2),Ce_(0.92)Zr_(0.08)O_(2),and Ce_(0.84)Zr_(0.16)O_(2)composed of 5-6 nm crystal.ites displ.y T_(m-CO2)(the temperature at maximum CO_2 yiel.)at 383,355,and 375℃under 10 vol.%O_(2)/N_(2),*** size of aggl.merate decreases from 165.5 to 51.9-57.3 nm,which is beneficial.for the sootceria ***,Zr increases the amount of surface oxygen vacancies,generating more active oxygen(O_(2)^-and O^(-))for soot ***,the activities of Ce_(0.92)Zr_(0.08)O_(2)and Ce_(0.84)Zr_(0.16)O_(2)in soot combustion are better than that of CeO_(2).Al.hough oxygen vacancies promote the migration of l.ttice O~(2-),the enriched surface Zr al.o inhibits the mobil.ty of l.ttice O^(2-).Therefore,the T_(m-CO2)of Ce_(0.84)Zr_(0.1)6 O_(2)is higher than that of Ce_(0.92)Zr_(0.08)O_(2).Based on reaction kinetic study,soot in direct contact with ceria preferential.y decomposes with l.w activation energy,whil. the oxidation of isol.ted soot occurs through diffusion with high activation *** obtained findings provide new understanding on the soot combustion over nanoceria.

关键词： Nanoceria Soot combustion Zr substitution Oxygen mobil.ty Reaction kinetic