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Forecasting of in situ electron energy loss spectroscopy

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npj.Computational Materials 2022年第1期8卷 2400-2408页

作者： Nicholas R.Lewis Yicheng j.n Xiuyu Tang Vidit Shah Christina Doty Bethany E.Matthews Sarah Akers steven R.Spurgeon Department of Chemical Engineering University of WashingtonSeattleWA98195USA National Security Directorate Pacific Northwest National LaboratoryRichlandWA99352USA Energy and Environment Directorate Pacific Northwest National LaboratoryRichlandWA99352USA Department of Physics University of WashingtonSeattleWA98195USA

Forecasting models are a central part of many control systems,where high-consequence decisions must be made on long latency control *** models are particularly relevant for emerging artificial intelligence(AI)-guided instrumentation,in which prescriptive knowledge is needed to guide autonomous *** we describe the implementation of a long short-term memory model(LSTM)for forecasting in situ electron energy loss spectroscopy(EELS)data,one of the richest analytical probes of materials and chemical *** describe key considerations for data collection,preprocessing,training,validation,and benchmarking,showing how this approach can yield powerful predictive insight into order-disorder phase ***,we comment on how such a model may integrate with emerging AI-guided instrumentation for powerful high-speed experimentation.

关键词： consequence autonomous transitions

The j.suits II: Cultures, Sciences, and the Arts, 1540–1773

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Pharmacologic inhibition of mTORC1 mimics dietary protein restriction in a mouse model of lactation

2006年

作者： j.hn W. O'Malley Gauvin Alexander Bailey steven j. Harris T. Frank Kennedy (eds.)

ISBN: (纸本)0802038611

Recent years have seen scholars in a wide range of disciplines re-evaluate the history of the Society of j.sus. In 1997, a group of scholars convened a maj.r international conference to discuss the world of the j.suits between 1540 and 1773 (the year of its suppression by papal edict). This meeting led to the creation of the first volume in this series, The j.suits, which examined the worldwide j.suit undertaking in such fields as music, art, architecture, devotional writing, mathematics, physics, astronomy, natural history, public performance, and education, with special attention to the j.suits''interaction with non-European *** second volume, following a second conference in 2002, continues in a similar path as its predecessor, complementing the regional coverage with contributions on the Flemish and Iberian provinces, on the missions in j.pan, and in post-Suppression Russia and the United States. The performing arts, like theatre and music, are broadly treated, and, in addition to continued attention to painting and architecture, the volume contains essays on a range of obj.ts d''art, including statuary, reliquaries, and alter pieces - as well as on gardens, mechanical clocks, and related automata. Other themes include finances, natural theology, censorship within the j.suit order, and the Society''s relationship to *** most important, the volume gives particular attention to the eighteenth century, the''age of disasters''for the j.suits - the negative papal ruling on Chinese Rites, the destruction the of Paraguay Reductions, and the suppressions of the order that began in Portugal and that culminated in the general Suppression of 1773. With contributions from distinguished scholars from a dozen different countries, The j.suits, II continues in the illustrious tradition of its predecessor to make an important contribution to religious memory.

关键词： j.suits

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j.urnal of Animal Science and Biotechnology 2021年第2期12卷 729-738页

作者： Virginia L.Pszczolkowski steven j.Halderson Emma j.Meyer Amy Lin Sebastian I.Arriola Apelo Department of Animal and Dairy Sciences University of Wisconsin-MadisonMadisonWIUSA Endocrinology and Reproductive Physiology Graduate Training Program University of Wisconsin-MadisonMadisonWIUSA

Background:Understanding the mechanisms of N utilization for lactation can lead to improved requirement estimates and increased efficiency,which modern dairy diets currently fail to *** mechanistic target of rapamycin complex 1(mTORC1)is a central hub of translation regulation,processing extra-and intra-cellular signals of nutrient availability and physiological state,such as amino acids and *** hypothesized that dietary amino acids regulate lactation through mTORC1,such that inhibition of mTORC1 will lead to decreased lactation performance when amino acids are not *** obj.ctives were to assess lactation performance in lactating mice undergoing dietary and pharmacologic interventions designed to alter mTORC1 ***:First lactation mice(N=18;n=6/treatment)were fed an adequate protein diet(18%crude protein),or an isocaloric protein-restricted diet(9%crude protein)from the day after parturition until lactation day 13.A third group of mice was fed an adequate protein diet and treated with the mTORC1 inhibitor rapamycin(4 mg/kg every other day)intraperitoneally,with the first two groups treated with vehicle as *** and pups were weighed daily,and feed intake was recorded every other *** production was measured every other day beginning on lactation day 4 by the weigh-suckle-weigh *** were collected after fasting and ***:Milk production and pup weight were similarly decreased by both protein restriction and rapamycin treatment,with final production at 50%of control(P=0.008)and final pup weight at 85%of control(P<0.001).Mammary phosphorylation of mTORC1’s downstream targets were decreased by protein restriction and rapamycin treatment(P<0.05),while very little effect was observed in the liver of rapamycin treated mice,and none by protein ***:Overall,sufficient supply of dietary amino acids was unable to maintain lactation performance status in mice with pharmacologically reduced mam

关键词： Amino acids Lactation Mammary Mouse model mTORC1 Rapamycin

Encapsulating peritoneal sclerosis

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World j.urnal of Gastroenterology 2018年第28期24卷 3101-3111页

作者： Christopher j.Danford steven C Lin Martin P Smith j.cqueline L Wolf Division of Gastroenterology and Hepatology Beth Israel Deaconess Medical Center Harvard Medical School Department of Radiology Beth Israel Deaconess Medical Center Harvard Medical School

Encapsulating peritoneal sclerosis(EPS) is a debilitating condition characterized by a fibrocollagenous membrane encasing the small intestine, resulting in recurrent small bowel obstructions. EPS is most commonly associated with long-term peritoneal dialysis, though medications, peritoneal infection, and systemic inflammatory disorders have been implicated. Many cases remain idiopathic. Diagnosis is often delayed given the rarity of the disorder combined with non-specific symptoms and laboratory findings. Although cross-sectional imaging with computed tomography of the abdomen can be suggestive of the disorder, many patients undergo exploratory laparotomy for diagnosis. Mortality approaches 50% one year after diagnosis. Treatment for EPS involves treating the underlying condition or eliminating possible inciting agents(i.e. peritoneal dialysis, medications, infections) and nutritional support, frequently with total parenteral nutrition. EPSspecific treatment depends on the disease stage. In the inflammatory stage, corticosteroids are the treatment of choice, while in the fibrotic stage, tamoxifen may be beneficial. In practice, distinguishing between stages may be difficult and both may be used. Surgical intervention, consisting of peritonectomy and enterolysis, is timeconsuming and high-risk and is reserved for situations in which conservative medical therapy fails in institutions with surgical expertise in this area. Herein we review the available literature of the etiology, pathogenesis, diagnosis, and treatment of this rare, but potentially devastating disease.

关键词： Abdominal cocoon Sclerosing encapsulating peritonitis Peritoneal sclerosis Peritonectomy Enterolysis Peritoneal dialysis Tamoxifen Corticosteroids

Challenges in Managing Hospitalized HIV Infected Persons with Low Absolute CD4 and Preserved CD4 Percentage

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World j.urnal of AIDS 2012年第3期2卷 237-244页

作者： steven M. Bobula Carl j. Fichtenbaum Division of Infectious Diseases Department of Internal Medicine University of Cincinnati College of Medicine Cincinnati USA

Background: HIV infected persons are at risk for opportunistic illnesses based upon severity of immune deficiency. Management is generally based upon the most recent absolute CD4 count. We hypothesized there is a group of patients with a low absolute CD4 count and preserved CD4 percentage that are at low risk of AIDS-related opportunistic illnesses (OI). Methods: A retrospective review of medical records in HIV-infected persons hospitalized from 2004-2006. Individuals without CD4 counts available within 180 days of admission and during hospitalization were excluded. Patients with a decrease in the absolute CD4 count during hospitalization and stable CD4 percentage were compared to the rest of the cohort. Appropriate management was defined using DHHS guidelines for the prevention and treatment of opportunistic illnesses in HIV infection. Results: 464 patients had 978 hospitalizations. In 221 hospitalizations (N = 161 patients) inpatient and outpatient CD4 counts were available. In 35 hospitalizations (N = 25 patients) the absolute CD4 count declined with stable CD4 percent (cases). Cases had an average decline in CD4 of –197 cells/mm3 compared to –5 cells/mm3 in the comparator group. 30% of comparators had AIDS defining OI's compared to none in the case group (p = 0.01). Management outside of DHHS guidelines was more common in cases compared to the comparator group (49% vs 30%, p = 0.048). The median length of stay was prolonged in cases with management outside guidelines compared to appropriately managed persons in the comparator group (7 days vs 3.5 days, p = 0.03). Conclusion: In persons on potent antiretroviral therapy, abrupt declines in absolute CD4 counts without an accompanying change in CD4 percentage are associated with a low risk of AIDS related opportunistic infection, a higher rate of in-patient management outside DHHS guidelines, and a more prolonged length of stay.

关键词： HIV CD4 Count Risk Stratification Acute Illness Opportunistic Infections

A CONSERVATIVE VIEW OF RADIAL KERATOTOMY

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眼科学报 1991年第3期7卷 130-139页

作者： steven Olkowski Walter j. Stark j.hn D. Gottsch Gerri Goodman Daniel Goodman A.E. Maumenee Ivan Esente The Wilmer Ophthalmological Institute The Johns Hopkins University School of Medicine Baltimore Maryland 21205 U.S.A.The Wilmer Ophthalmological Institute The Johns Hopkins University School of Medicine Baltimore Maryland 21205 U.S.A.The Wilmer Ophthalmological Institute The Johns Hopkins University School of Medicine Baltimore Maryland 21205 U.S.A.The Wilmer Ophthalmological Institute The Johns Hopkins University School of Medicine Baltimore Maryland 21205 U.S.A.The Wilmer Ophthalmological Institute The Johns Hopkins University School of Medicine Baltimore Maryland 21205 U.S.A.The Wilmer Ophthalmological Institute The Johns Hopkins University School of Medicine Baltimore Maryland 21205 U.S.A.The Wilmer Ophthalmological Institute The Johns Hopkins University School of Medicine Baltimore Maryland 21205 U.S.A.

It has been known for almost a century that radial keratotomy (RK) will flatten the cornea and reduce myopia. Since the introduction of radial keratotomy (RK) in the United States by Bores in 1978, there have been many published studies documenting the effects of this procedure. The questions. about radial keratotomy today are not only quantitative but also qualitative in nature. We know this technique can flatten the cornea, but how reliably can the results be predicted? Does the patient benefit suffic...

关键词： RK A CONSERVATIVE VIEW OF RADIAL KERATOTOMY

Improving detection of cerebral small vessel disease aetiology in patients with isolated lobar intracerebral haemorrhage

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Stroke & Vascular Neurology 2023年第1期8卷 26-33页

作者： Alvin S Das Elif Gokcal Robert W Regenhardt Mitchell j.Horn Kristin Schwab Nader Daoud Anand Viswanathan W Taylor Kimberly j.shua N Goldstein Alessandro Biffi Natalia Rost j.nathan Rosand Lee H Schwamm steven M Greenberg M Edip Gurol Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMassachusettsUSA Department of Neurology Massachusetts General HospitalHarvard Medical SchoolBostonMassachusettsUSA Department of Neurosurgery Massachusetts General HospitalHarvard Medical SchoolBostonMassachusettsUSA Department of Emergency Medicine Massachusetts General HospitalHarvard Medical SchoolBostonMassachusettsUSA

Background and purpose We evaluate whether non-haemorrhagic imaging markers(NHIM)(white matter hyperintensity patterns,lacunes and enlarged perivascular spaces(EPVS))can discriminate cerebral amyloid angiopathy(CAA)from hypertensive cerebral small vessel disease(HTN-cSVD)among patients with isolated lobar intracerebral haemorrhage(isolated-LICH).Methods In patients with isolated-LICH,four cSVD aetiologic groups were created by incorporating the presence/distribution of NHIM:HTN-cSVD pattern,CAA pattern,mixed NHIM and no *** pattern consisted of patients with any combination of severe centrum semiovale EPVS,lobar lacunes or multiple subcortical spots ***-cSVD pattern consisted of any HTN-cSVD markers:severe basal ganglia PVS,deep lacunes or peribasal ganglia white matter hyperintensity *** NHIM consisted of at least one imaging marker from either *** hypothesis was that patients with HTN-cSVD pattern/mixed NHIM would have a higher frequency of left ventricular hypertrophy(LVH),which is associated with *** In 261 patients with isolated-LICH,CAA pattern was diagnosed in 93 patients,HTN-cSVD pattern in 53 patients,mixed NHIM in 19 patients and no NHIM in 96 *** frequency of LVH was similar among those with HTN-cSVD pattern and mixed NHIM(50%vs 39%,p=0.418)but was more frequent in HTN-cSVD pattern compared with CAA pattern(50%vs 20%,p<0.001).In a regression model,HTN-cSVD pattern(OR:7.38;95%CI 2.84 to 19.20)and mixed NHIM(OR:4.45;95%CI 1.25 to 15.90)were found to be independently associated with *** Among patients with isolated-LICH,NHIM may help differentiate HTN-cSVD from CAA,using LVH as a marker for HTN-cSVD.

关键词： patients cerebral hypertensive

Black locust coppice stands homogenize soil diazotrophic communities by reducing soil net nitrogen mineralization

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Forest Ecosystems 2022年第3期9卷 289-300页

作者： Kun Li Huimei Tian W.Keith Moser steven T.Overby L.Scott Baggett Ruiqiang Ni Chuanrong Li Weixing Shen Mountain Tai Forest Ecosystem Research Station of State Forestry Administration Key Laboratory of State Forestry Administration for Silviculture of the Lower Yellow RiverForestry College of Shandong Agricultural UniversityTai'an271018ShandongChina Rocky Mountain Research Station United States Forest Service2500 S.Pine Knoll Dr.FlagstaffAZ86001USA Rocky Mountain Research Station United States Forest Service240 West Prospect Fort CollinsCO80526USA Mount Tai Scenic Spot Management Committee Tai'an271000ShandongChina

Background:Black locust(BL,Robinia pseudoacacia)is considered a promising tree species for reforestation due to its great ability to fix ***,after two or three coppice-harvesting rotations,the productivity of BL *** soil microbial communities are affected and how these groups correlate with the nitrogen mineralization process across multi-generation stands remains ***:We investigated the composition and structure of free-living nitrogen-fixing microorganisms(diazotrophs)by sequencing the marker gene nifH and compared these results to levels of soil nitrogen mineralization in the bulk soil and rhizosphere in black locust plantations on Mount Tai,***:The results showed multi-generation BL coppice plantations decreased the total soil nitrogen(N),soil phosphorus(P),soil microbial biomass N(MBN),soil microbial biomass C(MBC),soil nitrification rate(Rn),soil ammonification rate(Ra),and net soil N mineralization rate(Rm),but significantly increased the concentration of soil NH_(4þ)-N to maintain sufficient NO_(3)^(-)*** dominant species in bulk soil and rhizosphere changed from Rhodopseudomonas(22.62%and 15.76%),unclassified_c_Alphaproteobacteria(22.37%and 29.28%),unclassified_o_Rhizobiales(15.40%and 13.31%),Bradyrhizobium(12.00%and 11.74%)in seedling plantations to Bradyrhizobium(45.95%and 47.86%)and Rhodopseudomonas(43.56%and 41.84%)in coppice plantations,*** test and Redundancy analysis(RDA)revealed that Rn,Ra,and Rm were the most important factors shaping the diazotrophic ***:Our results suggest that the multi-generation BL coppice plantation can homogenize soil diazotrophic communities,which is mainly regulated by the available N loss caused by nitrogen *** the management technology of coppice plantations will provide more beneficial external consumption.

关键词： Black locust plantation nifH gene Nitrogen mineralization Coppice Soil nutrient

Ground-based hyperspectral remote sensing for weed management in crop production

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International j.urnal of Agricultural and Biological Engineering 2016年第2期9卷 98-109页

作者： Yanbo Huang Matthew A.Lee steven j.Thomson Krishna N.Reddy United States Department of Agriculture Agricultural Research ServiceCrop Production Systems Research UnitPO Box 350Stoneville MS 38776USA Department of Electrical and Computer Engineering Mississippi State UniversityMississippi State MS 39762USA United States Department of Agriculture National Institute of Food and AgricultureWashington DC 20024USA

Agricultural remote sensing has been developed and applied in monitoring soil,crop growth,weed infestation,insects,diseases and water status in farm fields to provide data and information to guide agricultural management *** agriculture has been implemented through prescription mapping of crop fields at different scales with the data remotely sensed from space-borne,airborne and ground-based ***-based remote sensing techniques offer portability,flexibility and controllability in applications for precision *** weed management,crop inj.ry from off-target herbicide spray drift and herbicide resistance in weeds are two important *** precision weed management,ground-based hyperspectral remote sensing techniques were developed for detection of crop inj.ry from dicamba and differentiation between glyphosate resistant and sensitive *** research presents the techniques for ground-based hyperspectral remote sensing for these two *** illustrate the advantages of ground-based hyperspectral remote sensing for precision weed management.

关键词： ground-based remote sensing hyperspectral crop inj.ry herbicide resistance precision agriculture