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Community-Based Screening and the Detection of Critical Carotid Artery Stenosis and Abdominal Aortic Aneurysm

Open j.urnal of Preventive Medicine 2015年第2期5卷 38-46页

作者： steven M. Weisman Nathalie I. Garbani Andrew j. Manganaro Innovative Science Solutions Morristown USA Life Line Screening (LLS) Independence USA

Background: Community-based cardiovascular screening has the opportunity to detect critical cardiovascular disease and positively affect public health outcomes. Disease deemed to be critical or severe at detection requires appropriate medical follow-up. This article examined the self-reported outcomes of individuals who had undergone community-based cardiovascular screening and had critical findings for abdominal aortic aneurysm (AAA) or carotid artery stenosis (CAS). Methods: Over 390,000 screening records for AAA and over 490,000 screening records for CAS were reviewed to identify individuals with critical screening findings. A critical AAA is defined as an aneurysm ≥ 5cm and critical CAS is defined as a hemodynamically significant stenosis with recorded peak systolic velocities of ≥300 cm/s, in this population. Identified individuals were then contacted via phone and surveyed about the medical care they received after their screening. Results: Review of the screening records found a prevalence of critical AAA findings of 0.037% (146 participants) and critical CAS findings of 0.12% (579 participants). 61% of participants with critical findings were reached for follow-up from both groups. Over 96% of participants with critical AAA and over 92% of participants with critical CAS had some forms of medical follow-up. Conclusions: Community-based cardiovascular screening has the ability to detect critical levels of disease. Findings of critical disease in the reviewed population are similar to the findings from previously published studies. Importantly, medical treatment received by those who seek follow-up appears to be consistent with recommended treatment guidelines. Identification and management of critical disease represent meaningful public and individual health benefits and the possibility of cost-savings.

关键词： Cardiovascular Screening Carotid Artery Stenosis Abdominal Aortic Aneursym

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A cross-analysis framework formulti-source volunteered, crowdsourced, and authoritative geographic information: The case study of volunteered personal traces analysis against transport network data

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Geo-Spatial Information Science 2018年第3期21卷 257-271页

作者： Gloria Bordogna steven Capelli Daniele E.Ciriello Giuseppe Psaila CNR IREA MilanoItaly DISCo Universitádegli studi di Milano BicoccaSesto San GiovanniItaly DIGIP University of BergamoDalmineItaly

The paper discusses the need of a high-level query language to allow analysts,geographers and,in general,non-programmers to easily cross-analyze multi-source VGI created by means of apps,crowd-sourced data from social networks and authoritative geo-referenced data,usually represented as j.ON data sets(nowadays,the de facto standard for data exported by social networks).Since an easy to use high-level language for querying and manipulating collections of possibly geo-tagged j.ON obj.cts is still unavailable,we propose a truly declarative language,named j.CO-QL,that is based on a well-defined execution model.A plug-in for a GIS permits to visualize geo-tagged data sets stored in a NoSQL database such as MongoDB;furthermore,the same plug-in can be used to write and execute j.CO-QL queries on those *** paper introduces the language by exemplifying its operators within a real study case,the aim of which is to understand the mobility of people in the neighborhood of Bergamo ***-analysis of data about transportation networks and VGI from travelers is performed,by means of j.CO-QL language,capable to manipulate and transform,combine and j.in possibly geo-tagged j.ON obj.cts,in order to produce new possibly geo-tagged j.ON obj.cts satisfying users’needs.

关键词： Cross-analysis framework comparing VGI crowd-sourced and authoritative geographical data j.ON data-sets declarative query language heterogeneous data-sets

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Building damage mapping based on Touzi decomposition using quad-polarimetric ALOS PALSAR data

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Frontiers of Earth Science 2020年第2期14卷 401-412页

作者： Shan LIU Fengli ZHANG Shiying WEI Qingbo LIU Na LIU Yun SHAO steven j.URIAN Institute of Remote Sensing and Digital Earth Chinese Academy of Sciences Beijing 100094China University of Chinese Academy of Sciences Beijing 100049China Laboratory of Target Microwave Properties Deqing Academy of Satellite ApplicationsHuzhou 313200China Beij.ng University of Civil Engineering and Architecture Beijing 100044China Department of Civil and Environmental Engineering University of UtahSalt Lake CityUT 84112USA

Building damage assessment is of great significance to disaster *** Synthetic Aperture Radar(SAR)can record the polarization scattering measurement matrix of ground obj.cts and obtain more abundant ground obj.ct information,meaning that they can be used for assessing damage to *** this paper,a new approach is proposed to assess building damage using the Touzi incoherent decomposition and SAR-based characteristics of buildings before and after *** March 11th,2011 earthquake that struck the coast of northeast j.pan serves as the demonstration of the technique using quad-polarimetric ALOS PALSAR data acquired before and after the *** analysis shows that after the buildings are damaged,there is a clear decrease in theαs1(the dominant scattering-type magnitude)components and the degree of this reduction corresponds to the degree of building *** means that theαs1 components obtained by Touzi decomposition can effectively reflect the degree of building *** this basis,a model based on Touzi decomposition was established to evaluate the degree of damage to buildings,and the accuracy of the model was validated using high-resolution optical data acquired before and after the *** experimental results show that Touzi decomposition can be effectively used for damage assessment mapping in built-up areas.

关键词： Touzi decomposition quad-polarization SAR buildings damage disaster management

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The advent of structural biology in situ by single particle cryo-electron tomography

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Biophysics Reports 2017年第Z1期3卷 17-35页

作者： j.sús G.Galaz-Montoya steven j.Ludtke National Center for Macromolecular Imaging Verna and Marrs McLean Department of Biochemistry and Molecular Biology Baylor College of Medicine

Single particle tomography(SPT), also known as subtomogram averaging, is a powerful technique uniquely poised to address questions in structural biology that are not amenable to more traditional approaches like X-ray crystallography, nuclear magnetic resonance, and conventional cryoEM single particle analysis. Owing to its potential for in situ structural biology at subnanometer resolution, SPT has been gaining enormous momentum in the last five years and is becoming a prominent, widely used technique. This method can be applied to unambiguously determine the structures of macromolecular complexes that exhibit compositional and conformational heterogeneity, both in vitro and in situ. Here we review the development of SPT, highlighting its applications and identifying areas of ongoing development.

关键词： Cryo-electron tomography Single particle tomography Subtomogram averaging Direct detection device Contrast transfer function

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An assessment of racial differences in epidemiological, clinical and psychosocial factors among head and neck cancer patients at the time of surgery

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World j.urnal of Otorhinolaryngology-Head and Neck Surgery 2020年第1期6卷 41-48页

作者： Anvesh Kompelli Kathleen B.Cartmell Katherine R.Sterba Anthony j.Alberg Christopher C.Xiao Amit j.Sood Elizabeth Garrett-Mayer Shai j.White-Gilbertson steven A.Rosenzweig Terry A.Day Department of Otoloryngology-Head and Neck Surgery Medical University of South Carolina(MUSC)CharlestonSC29425USA College of Nursing MUSCCharlestonSC29425USA Hollings Cancer Center MUSCCharlestonSC29425USA Department of Public Health Sciences MUSCCharlestonSC29425USA Cancer Resistry Hollings Cancer CenterMUSCCharlestonSC29425USA Department of Pharmacology MUSCCharlestonSC29425USA

Obj.ctive:Racial disparities have been well characterized and African American(AA)patients have 30%lower 5-year survival rates than European Americans(EAs)for head and neck squamous carcinoma(HNSCC).This poorer survival can be attributed to a myriad of different *** purpose of this study was to characterize AA-EA similarities and differences in sociodemographic,lifestyle,clinical,and psychosocial characteristics in HNSCC patients near the time of ***:Setting:Single tertiary care ***:Thirty-nine newly diagnosed,untreated HNSCC patients(n=24 EAs,n=15 AAs)who were to undergo surgery were *** Design:Cross-sectional study Sociodemographic,lifestyle factors,and disease factors(cancer site,Aj.C clinical and pathologic stage,and HPV status)were *** factors,leisure time,quality of life and social support were also assessed using validated ***:EA and AA patients were similar in the maj.rity of sociodemographic factors *** had a higher trend toward pathologically later stage disease compared to EAs and significantly increased time to ***:EA and AA patients were similar in the maj.rity of sociodemographic factors *** had a higher trend toward pathologically later stage disease compared to *** also had significantly increased time to treatment(P=0.05).The maj.rity of AA patients(62%)had later stage pathologic *** were less likely to complete high school or college(P=0.01)than their EA ***,AAs were more likely to report having a gap in health insurance during the past decade(37%vs.15%).Conclusions:This preliminary study demonstrates a similar profile of demographics,clinical and psychosocial characteristics preoperatively for AAs and *** differences were AAs tending to have later pathologic stage disease,educational status,delays in treatment initiation,and gaps in health insurance.

关键词： Head and neck cancer Healthcare disparities Treatment delay Health services Quality care HPV

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Effect of Ambient UV-B on Stomatal Density, Conductance and Isotope Discrimination in Four Field Grown Soybean [<i>Glycine max</i>(L.) Merr.] Isolines

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American j.urnal of Plant Sciences 2013年第12期4卷 100-108页

作者： Dennis C. Gitz III steven j. Britz j.seph H. Sullivan Department of PLSA College of Agriculture and Natural Resources University of Maryland College Park USA USDA-ARS# Cropping Systems Research Laboratory Lubbock USA USDA-ARS Food Components and Health Laboratory Beltsville USA

An experiment was designed to test whether ambient levels of UV-B radiation affect stomatal development, decrease stomatal density, and lead to increased water-use efficiency (WUE). Soybean [Glycine max (L.) Merr.] isolines with different stomatal distribution and flavonol expression patterns were field grown under shelters that either transmitted or blocked solar UV-B. All isolines exposed to solar UV-B accumulated higher concentrations of UV-screening phenolic pigments but other responses were isoline dependent. Solar UV-B decreased stomatal density and conductance in isolines expressing a unique branched kaempferol triglycoside. Decreased stomatal density was associated with increased season-long WUE and decreased internal CO2 concentration of leaf (estimated by δ13C discrimination). We concluded that photomorphogenic responses to UV-B affected stomatal density and WUE in field grown soybean;but that the magnitude and direction of these response were associated with isogenic pleiotropic differences in stomatal distribution and pigment expression. UV-B radiation had no effect on biomass accumulation or yield in a cultivar expressing only trace levels of kaempferol suggesting that flavonol expression is not prerequisite to UV-B tolerance.

关键词： Soybean UV-B Drought Stress Water Use Efficiency Isotope Discrimination Photomorphogenesis

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基因与命运

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作者： (加)斯蒂芬·j. 海涅(steven j. Heine)

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The US ESRD program-can we get the genie back in the bottle?

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中国血液净化 2014年第12期13卷 851-853页

作者： steven j.Rosansky Dorn Research Institute William Jennings Bryan Dorn VA Medical Center

1972年美国社会保险立法修订案决定为终末期肾病(ESRD)治疗提供基金,并开始对其发病和患病情况进行监测。1988年美国建立了肾脏病数据系统(USRDS),使监测数据更为准确。美国大学的Rosansky教授着眼于ESRD开始透析时机,对美国ESRD管理系... 详细信息

1972年美国社会保险立法修订案决定为终末期肾病(ESRD)治疗提供基金,并开始对其发病和患病情况进行监测。1988年美国建立了肾脏病数据系统(USRDS),使监测数据更为准确。美国大学的Rosansky教授着眼于ESRD开始透析时机,对美国ESRD管理系统进行了回顾,并对美国未来几十年ESRD的发病和患病趋势进行了预测。慢性肾脏病(CKD)时患者肾功能逐渐下降,达到什么程度就能被叫做ESRD?在美国初始覆盖肾脏替代治疗(RRT)时,残余肾功能(RRF)下降到原始值的5%时,患者被称为ESRD,可以接受RRT。之后用作ESRD定义的RRF值逐渐提升到原始值的10%、15%。从1996年到2009年,RRF还剩超过10%的患者即开始RRT的患者占全部开始RRT治疗患者比例从19%上升到54%。但是,最新发表的一系列观察性研究均表明了早开始透析对患者的长期存活是有害的。也许是由于这些研究结果的发布,美国ESRD发病率自2010年后呈下降趋势,同时没有观察到RRT患者死亡率的增加,提示了避免过早透析的安全性和益处。美国ESRD治疗在1981年耗资仅16亿,而2011年高达近340亿元,花费骤增的原因与治疗人数的增加不无关系。较早开始RRT是ESRD发病率和患病率升高的一个重要原因,或许延迟透析会降低RRT发病和患病率,从而降低ESRD治疗成本。据USRDS统计,75岁以上ESRD患者多较早开始透析治疗,预计至2030年该人群患者人数将翻倍。相应的,美国ESRD报销计划纳入了排除RRT的保守治疗方案,这有利于十分危重的老年患者选择保守治疗,而减少RRT的使用。

关键词：肾病 ESRD 老年患者保守治疗

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Entropy and enthalpy for triggering cutaneous erythema

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j.urnal of Innovative Optical Health Sciences 2015年第4期8卷 54-57页

作者： steven L.j.cques j.seph T.Walsh Wellman Laboratories Massachusetts General Hospital BostonMAUSA Harvard Medical School-M.I.T. CambridgeMAUSA Oregon Health&Science University 3303 SW Bond Ave.PortlandORUSA 97239

The molar entropy(OS)and molar enthalpy(△H)for the denaturation event that triggers cutaneous erythema was determined to be △S=190j.(mole K)and△H=146.9×10^(3) j.*** experiment involved placing heated water against the skin of the forearm,for a range of termperatures and exposure *** the skin to 45℃ for 22 s was at the threshold for producing erythema,which was similar to the threshold for a slight degree of pain.

关键词： Skin erythema thermal entropy enthalpy

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Diabetes pathogenesis and management:the endothelium comes of age

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j.urnal of Molecular Cell Biology 2021年第7期13卷 500-512页

作者： Kaitlin M.Love Eugene j.Barrett steven K.Malin j.ne E.B.Reusch j.dith G.Regensteiner Zhenqi Liu Division of Endocrinology and Metabolism Department of MedicineUniversity of Virginia Health SystemCharlottesvilleVA 22908USA Department of Kinesiology and Health Rutgers UniversityNew BrunswickNJUSA Division of Endocrinology Metabolism and NutritionRutgers UniversityNew BrunswickNJUSA New j.rsey Institute for Food Nutrition and HealthRutgers UniversityNew BrunswickNJUSA Institute of Translational Medicine and Research Rutgers UniversityNew BrunswickNJUSA Center for Women’s Health Research University of Colorado School of MedicineAuroraCOUSA Department of Medicine University of ColoradoAnschutz Medical CampusAuroraCOUSA Rocky Mountain Regional Veterans Affairs Medical Center AuroraCOUSA

Endothelium,acting as a barrier,protects tissues against factors that provoke insulin resistance and type 2 diabetes and itself responds to the insult of insulin resistance inducers with altered *** insulin resistance and vascular dysfunction occur early in the evolution of insulin resistance-related disease,can co-exist with and even contribute to the development of metabolic insulin resistance,and promote vascular complications in those *** impact of endothelial insulin resistance and vascular dysfunction varies depending on the blood vessel size and location,resulting in decreased arterial plasticity,increased atherosclerosis and vascular resistance,and decreased tissue *** with insulin resistance and diabetes are disproportionately impacted by cardiovascular disease,likely related to differential sex-hormone endothelium ***,reducing endothelial insulin resistance and improving endothelial function in the conduit arteries may reduce atherosclerotic complications,in the resistance arteries lead to better blood pressure control,and in the microvasculature lead to less microvascular complications and more effective tissue *** diabetes therapeutic modalities,including medications and exercise training,improve endothelial insulin action and vascular *** action may delay the onset of type 2 diabetes and/or its complications,making the vascular endothelium an attractive therapeutic target for type 2 diabetes and potentially type 1 diabetes.

关键词： diabetes insulin resistance endothelium vascular function

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