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Employment and Patient Satisfaction after Liver Transplantation

Journal of Clinical and Translational Hepatology 2020年第3期8卷 299-303页

作者： Christopher Cao Dina Halegoua-DeMarzio Shady Guirguis Crystal Chen Jonathan M.Fenkel steven herrine Department of Gastroenterology and Hepatology Thomas Jefferson University HospitalsPhiladelphiaPAUSA

Background and Aims:This study serves to revisit the effects of liver transplantation(LT)on employment in an era of improving survival outcomes post-transplant,and to identify areas of improvement in the transplant process to better optimize post-LT employment and patient ***:Prospectively,patients who had undergone LT at a single tertiary LT center were surveyed in person and by *** outcomes included employment rate pre-and post-LT,annual salary,weekly hours worked,barriers to re-employment,and patient ***:Responses were collected and analyzed from 121 patients who underwent ***-LT,68(56.1%)reported full-time employment,13(10.7%)part-time employment,and 40(33.1%)***-LT,26(21.4%)reported continued full-time employment,18(14.9%)part-time employment,and 77(63.6%)*** weekly work hours decreased post-LT(16.1 h/week vs.39.9 h/week).Mean annual salaries decreased post-LT(17 earning salary≥$40,000 vs.56 earning salary≥$40,000).These outcomes differed from patient pre-LT expectations,with 81.0%of previously employed patients believing they would return to employment,resulting in decreased patient *** working physically demanding jobs pre-LT were less likely to return to *** cited for lack of return to full employment included early fatigue and difficulty regaining physical ***:Re-employment rates remain low post-LT,which is particularly true for patients working physically active *** is a significant barrier to re-employment and increased physical rehabilitation post-LT may prove to be *** should be given realistic expectations about return to employment prior to their LT.

关键词： Liver Transplant Liver transplant Employment Patient satisfaction

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Hepatocellular carcinoma after Iocoregional therapy:Magnetic resonance imaging findings in falsely negative exams

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World Journal of Hepatology 2016年第16期8卷 685-690页

作者： David Becker-Weidman Jesse M Civan Sandeep P Deshmukh Christopher G Roth steven K herrine Laurence Parker Donald G Mitchell Department of Radiology Thomas Jefferson University Division of Gastroenterology and Hepatology Department of MedicineThomas Jefferson University

AIM:To elucidate causes for false negative magnetic resonance imaging(MRI)exams by identifying imaging characteristics that predict viable hepatocellular carcinoma(HCC)in lesions previously treated with locoregional therapy when obvious findings of recurrence are ***:This retrospective institutional review board-approved and Health Insurance Portability and Accountability Act-compliant study included patients who underwent liver transplantation at our center between 1/1/2000 and 12/31/2012 after being treated for HCC with locoregional *** selected patients had a contrast-enhanced MRI after locoregional therapy within 90 d of transplant that was prospectively interpreted as without evidence of residual or ***,2 radiologists,blinded to clinica and pathological data,independently reviewed the pre transplant MRIs for 7 imaging *** explan histopathology provided the reference standard,with clinically significant tumor defined as viable tumor≥1.0cm in maximum ***’s exact test was firs performed to identify significant imaging ***:Inclusion criteria selected for 42 patients with 65 treated *** of 42 patients(33%and 16 of 65 treated lesions(25%)had clinically significant viable tumor on explant *** o the 7 imaging findings examined could reliably and reproducibly determine which treated lesion had viable tumor when the exam had been prospectively read as without evidence of viable ***:After locoregional therapy some treated lesions that do not demonstrate any MRI evidence o HCC will contain viable *** such even patients with a negative MRI following treatment should receive regular short-term imaging surveillance because some have occult viable *** possibility of occult tumo should be a consideration when contemplating any action which might delay liver transplant.

关键词： Hepatocellular carcinoma Transarterial chemoembolization Tumor recurrence Locoregional therapy Imaging surveillance

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Hepatitis C risk assessment,testing and referral for treatment in urban primary care:Role of race and ethnicity

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World Journal of Gastroenterology 2007年第7期13卷 1074-1078页

作者： Stacey B Trooskin Victor J Navarro Robert J Winn David J Axelrod A Scott McNeal Maricruz Velez steven K herrine Simona Rossi Division of Gastroenterology and Hepatology Thomas Jefferson University Philadelphia PA 19107 United States Department of Family Medicine Thomas Jefferson University Philadelphia PA 19107 United States Division of Internal Medicine Thomas Jefferson University Philadelphia PA 19107 United States Delaware Valley Community Health Inc. Philadelphia PA 19107 United States

AIM: To determine rates of hepatitis C (HCV) risk factor ascertainment, testing, and referral in urban primary care practices, with particular attention to the effect of race and ethnicity. METHODS: Retrospective chart review from four primary care sites in Philadelphia; two academic primary care practices and two community clinics was performed. Demographics, HCV risk factors, and other risk exposure information were collected. RESULTS: Four thousand four hundred and seven charts were reviewed. Providers documented histories of injection drug use (IDU) and transfusion for less than 20% and 5% of patients, respectively. Only 55% of patients who admitted IDU were tested for HCV. Overall, minorities were more likely to have information regarding a risk factor documented than their white counterparts (79% vs 68%, P < 0.0001). Hispanics were less likely to have a risk factor history documented, compared to blacks and whites (P < 0.0001). Overall, minorities were less likely to be tested for HCV than whites in the presence of a known risk factor (23% vs 35%, P = 0.004). Among patients without documentation of risk factors, blacks and Hispanics were more likely to be tested than whites (20% and 24%, vs 13%, P < 0.005, respectively). CONCLUSION: (1) Documentation of an HCV risk factor history in urban primary care is uncommon, (2)Racial differences exist with respect to HCV risk factor ascertainment and testing, (3) Minority patients, positive for HCV, are less likely to be referred for subspecialty care and treatment. Overall, minorities are less likely to be tested for HCV than whites in the presence of a known risk factor.

关键词： Hepatitis C Minority groups Urban health Primary health care Risk assessment

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Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics

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Neural Regeneration Research 2025年第11期20卷 3179-3192页

作者： Pieter-Jan Serneels Julie D.De Schutter Lies De Groef Lieve Moons steven Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

Decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and ***,recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states,prompting a revision of the existing *** forward,the oligodendroglial lineage should be delineated into five distinct cell states:oligodendrocyte precursor cells,committed oligodendrocyte precursor cells,newly formed oligodendrocytes,myelin-forming oligodendrocytes,and mature *** new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological *** this uniform terminology will facilitate comparison and integration of data across ***,including the consolidation of findings from various demyelinating models,is essential to better understand the pathogenesis of demyelinating ***,comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination ***,by standardizing terminology and synthesizing data from diverse studies across different animal models,we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis,Alzheimer's disease,and amyotrophic lateral sclerosis,all of which involve oligodendroglial and myelin dysfunction.

关键词： animal models demyelination fish mammals multiple sclerosis myelin neurodegeneration oligodendrocytes oligodendroglial lineage remyelination

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Applying machine learning to study fluid mechanics

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Acta Mechanica Sinica 2021年第12期37卷 1718-1726页

作者： steven L.Brunton Department of Mechanical Engineering University of WashingtonSeattleWA 98195USA

This paper provides a short overview of how to use machine learning to build data-driven models in fluid *** process of machine learning is broken down into five stages:(1)formulating a problem to model,(2)collecting and curating training data to inform the model,(3)choosing an architecture with which to represent themodel,(4)designing a loss function to assess the performance of the model,and(5)selecting and implementing an optimization algorithm to train the *** each stage,we discuss how prior physical knowledge may be embedding into the process,with specific examples from the field of fluid mechanics.

关键词： Machine learning Fluid mechanics Physics-informed machine learning Neural networks Deep learning

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肝硬化和门脉高压出血合并症的临床意义（上）

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传染病网络动态 2007年第2期 27-29页

作者： steven K. herrine 杨露绮（编译）

2006年的美国肝病研究协会（AASLD）年会内容丰富，资料新颖。病毒性肝炎等方面的发展令人兴奋，其中包括许多期待的有关新疗法的信息，在门静脉高压和慢性肝病合并症的领域中也出现了一些引人注目的进展。另外，研究提示门脉高压化学... 详细信息

2006年的美国肝病研究协会（AASLD）年会内容丰富，资料新颖。病毒性肝炎等方面的发展令人兴奋，其中包括许多期待的有关新疗法的信息，在门静脉高压和慢性肝病合并症的领域中也出现了一些引人注目的进展。另外，研究提示门脉高压化学介质可能具有治疗上的意义。连同关于非侵袭性手段到分级出血危险信息一起提出了患有静脉曲张出血的病人自然史得到改善的证据。关于对持续高危血管曲张进行适当的预防性套管结扎仍存在争议，作为本年会期间的重点进行了验证。最后，现在已阐明肝静脉压力梯度的诊断和预测的能力与新的手段之间的关系，并阐述了关于弹性检测仪其它使用方面的内容。本临床观察概述了一些更重要的新概念和资料，作为这些会议议程期间提交的主题。

关键词：门脉高压出血肝病合并症临床意义肝硬化肝静脉压力梯度静脉曲张出血危险信息病毒性肝炎

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Some highlights of the Gamma-ray first four years of the Fermi Space Telescope

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Frontiers of physics 2013年第6期8卷 693-713页

作者： steven Ritz Department of Physics and the SCIPP University of California Santa Cruz Santa Cruz CA 95064 USA

The Fermi Gamma-ray Space Telescope, formerly called GLAST, measures the cosmic gamma-ray flux in the energy range 8 keV to 〉 300 GeV. In addition to breakthrough capabilities in energy coverage and localization, the very large field of view enables observations of 20~ of the sky at any instant, and the entire sky on a timescale of a few hours. With its launch in 2008, Fermi opens a new and important window on a wide variety of phenomena, including pulsars, black holes and active galactic nuclei, gamma-ray bursts, supernova remnants and the origins of cosmic rays, and searches for hypothetical new phenomena such as particle dark matter annihilations. A brief overview and selected science highlights from the first four years are provided.

关键词： high-energy gamma-ray astrophysics dark matter fundamental physics tests spacebased astrophysics space-based particle astrophysics gamma-ray bursts blazars pulsars

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What really happens in strongly correlated superconductors:insights from a quantum Monte-Carlo study of high temperature superconductivity in FeSe films

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Science Bulletin 2016年第12期61卷 911-913页

作者： steven A.Kivelson Department of Physics Stanford University

BCS theory and its extensions form the basis of a compelling and elegant understanding of the properties of conventional ***,it is a weak-coupling theory,organized around the infinitesimal‘‘Cooper’’instability of the Fermi *** is not merely a theoretical abstraction:Schrieffer(among others)has emphasized that it is only because the normal state above T_c is

关键词：高温超导电性蒙特卡罗方法超导体强关联薄膜量子 BCS理论扩展形式

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Seven possible states of geospatial data with respect to map projection and definition: a novel pedagogical device for GIS education

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Geo-Spatial Information Science 2018年第4期21卷 288-293页

作者： steven E.Greco Department of Human Ecology University of CaliforniaDavisCAUSA

Conceptually,the theory and implementation of“map projection”in geographic information system(GIS)technology is difficult to comprehend for most introductory students and novice *** this difficulty is the concept of a“map projection file”that defines map projection parameters of geo-spatial *** problem of the“missing projection file”appears ubiquitous for all users,especially in practice where data is widely *** common problem is inadvertent misapplication of the“Define Projection”tool that can result in a GIS dataset with an incorrectly defined map projection *** education should provide more guidance in differentiating the concepts of map projection versus projection files by increasing understanding and minimizing common errors.A novel pedagogical device is introduced in this paper:the seven possible states of GIS data with respect to map projection and *** seven possible states are:(1)a projected coordinate system(PCS)that is correctly defined,(2)a PCS that is incorrectly defined,(3)a PCS that is undefined,(4)a geographic coordinate system(GCS)that is correctly defined,(5)a GCS that is incorrectly defined,(6)a GCS that is undefined,and(7)a *** created automated troubleshooting tools to determine a missing map projection file are discussed.

关键词： GIS education map projection error map projection file define projection

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肝硬化和门静脉曲张高压出血合并症的临床意义（下）

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传染病网络动态 2007年第3期 32-34页

作者： steven K. herrine, MD 杨露绮（编译）

对于那些对内镜和药理学治疗预防再次出血无应答的病人，门静脉分流术是下一步治疗中最经常采用的。虽然经颈静脉肝内门体分流术（TIPS）已经能够大量取代外科分流术，但有资料支持在再次出血的预防中远侧脾肾分流术（DSRS）的应用。由... 详细信息

对于那些对内镜和药理学治疗预防再次出血无应答的病人，门静脉分流术是下一步治疗中最经常采用的。虽然经颈静脉肝内门体分流术（TIPS）已经能够大量取代外科分流术，但有资料支持在再次出血的预防中远侧脾肾分流术（DSRS）的应用。由亚利桑那州大学Boyer领导的小组发表了两份报道，多中心试验比较了TIPS与DSRS的长期的结果。第一项研究发现，虽然TIPS比DSRS更昂贵，但两者在效一价比之间没有差异。需要修改TIPS所导致的较高成本（甚至在调整带膜支架时），但是存活率轻微的升高使得2种介入的效一价比持平。在多变量分析中第二项研究显示，大多数以前的出血和凝血酶原时间与死亡危险有关的病人接受了TIPS或DSRS来治疗顽固性出血，因此，顽固性静脉曲张出血能够有效地用TIPS或DSRS治疗。随着在顽固性出血病人中TIPS的利用的增加，分流开放已经变为研究的重点。来自俄亥俄州克利夫兰临床基金会的Henderson等人通过多次直接测量分流术压力，在他们的减压介入脉管曲张再次出血试验（DIVERT）中能够维持低（11％超过4年）的再次出血率。他们的发现表明在利用门静脉末梢测量预测分流术开放中虽然多普勒超声是最精确的，但是总的说来对于这个目的它是一种较差的工具，诊断敏感性仅为0．63，特异性为0．77。在进行TIPS过程中和在肝静脉末梢进行多普勒检测甚至更差。该研究作者建议采用有规则的直接测量法来保证TIPS开放。是否使用带膜支架可减少这种需要还要进行研究。

关键词：门静脉曲张再次出血临床意义经颈静脉肝内门体分流术门静脉分流术合并症肝硬化药理学治疗

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