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炼油技术与工程 2005年第2期35卷 25-29页

作者： steven f meyer Linda K Wibbenmeyer Kanson Xue 孟山都环境化学系统公司上海市200032

从脱除机理、操作条件、设计因素、材料选择等方面介绍了孟山都环境化学系统公司的动力波(DynaWave)逆喷洗涤塔技术。该技术用于炼油厂fCC尾气的除尘与脱硫,其效率均在99％以上。

关键词：炼油厂 fCC尾气脱硫除尘动力波逆喷洗涤塔

Constraints on what controls millennial-scale basin-wide denudation across mountain belts, Asia

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Science China Earth Sciences 2025年第1期68卷 74-93页

作者： Ye YANG steven A.BINNIE Sheng XU Cong-Qiang LIU Tibor J.DUNAI Institute of Surface-Earth System Science School of Earth System Science Tianjin University Institute of Geology and Mineralogy University of Cologne

The terrestrial cosmogenic nuclide dataset consisting of 123310Be measurements of fluvial sediment samples across the Asian mountain belts is used to constrain the influence of climate,tectonics and topography on Earth-surface denudation processes.10Be-derived basin-wide denudation rates were recalculated using a Monte Carlo simulation approach that relied on pixel-by-pixel production *** rates derived span four orders of magnitude,from 7.4±0.7 mm kyr-1（1σ;Central Tibetan Plateau） to 9,646744+777mm kyr-1（1σ;Southern Tibetan Plateau）,with a median of 186 mm *** our results with the traditional basin-wide production rate scaling model using a centroid coordinate and mean elevation,suggests that 96.6%of production rates will be underestimated using the latter method,especially for basins with a large *** bias between both methods reaches as large as 40%,caused by basin hypsometry and the nonlinear scaling of production rate with elevation and *** of the correlations between uniformly recalculated denudation rates and tectonics,climate,topography and rock lithology will facilitate the extrapolation of denudation rates in unknown basins using available *** the perspective of local scales,precipitation coupled with neotectonics-driven landslides is likely the most influential factor in subtropical Taiwan Island,while topography primarily constrains surface denudation rates in the eastern Tibetan Plateau within a narrow range of *** highland regions with glacier coverage,such as the Pamir,central and southern Tibetan Plateau high denudation rates are affected by glaciation,whereas lower precipitation and high erosion base level may limit river incision and evolving relief in the Central Tibetan *** contrast to local-scale findings highlighting a dominant factor constraining denudation rate,our large-scale quantitative analyses across the Asian mountain belts finds that （1） topographic metrics including

关键词： 10Be-derived denudation rate Climate change Tectonic uplift Topographic gradient Asian mountains

Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics

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Neural Regeneration Research 2025年第11期20卷 3179-3192页

作者： Pieter-Jan Serneels Julie D.De Schutter Lies De Groef Lieve Moons steven Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

Decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and ***,recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states,prompting a revision of the existing *** forward,the oligodendroglial lineage should be delineated into five distinct cell states:oligodendrocyte precursor cells,committed oligodendrocyte precursor cells,newly formed oligodendrocytes,myelin-forming oligodendrocytes,and mature *** new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological *** this uniform terminology will facilitate comparison and integration of data across ***,including the consolidation of findings from various demyelinating models,is essential to better understand the pathogenesis of demyelinating ***,comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination ***,by standardizing terminology and synthesizing data from diverse studies across different animal models,we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis,Alzheimer's disease,and amyotrophic lateral sclerosis,all of which involve oligodendroglial and myelin dysfunction.

关键词： animal models demyelination fish mammals multiple sclerosis myelin neurodegeneration oligodendrocytes oligodendroglial lineage remyelination

Proteasome inhibition-induces endoplasmic reticulum dysfunction and cell death of human cholangiocarcinoma cells

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World Journal of Gastroenterology 2007年第6期13卷 851-857页

作者： Yucel Ustundag steven f Bronk Gregory J Gores Mayo Clinic College of Medicine Rochester MN 55905 United States

AIM: To determine if proteasome inhibition induces apoptosis in human cholangiocarcinoma cells, and if so, to elucidate the cellular mechanisms. METHODS: Studies were performed in the human KMCH, KMBC, and Mz-ChA-1 cholangiocarcinoma, and normal rat cell lines. MG132, a peptide aldehyde, which inhibits the chymotrypsin-like activity of the proteaosome was employed for this study. Apoptosis was assessed morphologically by 4'-6-Diamidino-2-phenylindole (DAPI) nuclear staining and fluorescence microscopy. Mitochondrial membrane potential was examined using a fluorescent unquenching assay. Ultrastructural changes during cell death were examined using transmission electron microscopy (TEM). Caspase 3/7 activity was assessed using an enzymatic-based fluorescent assay. Cytosolic-free calcium concentrations were measured using fura-2 and digitized fluorescent microscopy. RESULTS: MG132, a proteasome inhibitor, induced apoptosis in all the cholangiocarcinoma cell lines examined. In contrast, minimal cytotoxicity was observed in normal rat cholangiocytes. Apoptosis was time-and -concentration-dependent. There was no change in the mitochondrial membrane potential between treated and untreated cells. Ultrastructural examination by transmission electron microscopy displayed the classic features of apoptosis, but in addition, there was also dramatic vacuolization of the endoplasmic reticulum (ER). Unexpectedly, no increase in caspase 3/7 activity was observed in MG132 treated cells, nor did the pancaspase inhibitor, Q-VD-OPh prevent cell death. The protein synthesis inhibitor, cycloheximide, blocked apoptosis induced by proteosome inhibitor indicating that ER dysfunction was dependent upon the formation of new proteins. CONCLUSION: Proteosome inhibition induces ERdysfunction and caspase-independent cell death selectively in human cholangiocarcinoma cells. Proteasome inhibitors warrant evaluation as anticancer agents for the treatment of human cholangiocarcinoma.

关键词： MG132 Cholangiocarcinoma Proteosome Apoptosis Calcium

Pharmacologic inhibition of mTORC1 mimics dietary protein restriction in a mouse model of lactation

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Journal of Animal Science and Biotechnology 2021年第2期12卷 729-738页

作者： Virginia L.Pszczolkowski steven J.Halderson Emma J.meyer Amy Lin Sebastian I.Arriola Apelo Department of Animal and Dairy Sciences University of Wisconsin-MadisonMadisonWIUSA Endocrinology and Reproductive Physiology Graduate Training Program University of Wisconsin-MadisonMadisonWIUSA

Background:Understanding the mechanisms of N utilization for lactation can lead to improved requirement estimates and increased efficiency,which modern dairy diets currently fail to *** mechanistic target of rapamycin complex 1(mTORC1)is a central hub of translation regulation,processing extra-and intra-cellular signals of nutrient availability and physiological state,such as amino acids and *** hypothesized that dietary amino acids regulate lactation through mTORC1,such that inhibition of mTORC1 will lead to decreased lactation performance when amino acids are not *** objectives were to assess lactation performance in lactating mice undergoing dietary and pharmacologic interventions designed to alter mTORC1 ***:first lactation mice(N=18;n=6/treatment)were fed an adequate protein diet(18%crude protein),or an isocaloric protein-restricted diet(9%crude protein)from the day after parturition until lactation day 13.A third group of mice was fed an adequate protein diet and treated with the mTORC1 inhibitor rapamycin(4 mg/kg every other day)intraperitoneally,with the first two groups treated with vehicle as *** and pups were weighed daily,and feed intake was recorded every other *** production was measured every other day beginning on lactation day 4 by the weigh-suckle-weigh *** were collected after fasting and ***:Milk production and pup weight were similarly decreased by both protein restriction and rapamycin treatment,with final production at 50%of control(P=0.008)and final pup weight at 85%of control(Pf mTORC1’s downstream targets were decreased by protein restriction and rapamycin treatment(Pffect was observed in the liver of rapamycin treated mice,and none by protein ***:Overall,sufficient supply of dietary amino acids was unable to maintain lactation performance status in mice with pharmacologically reduced mam

关键词： Amino acids Lactation Mammary Mouse model mTORC1 Rapamycin

Common-path interferometric label-free protein sensing with resonant dielectric nanostructures

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Light(Science & Applications) 2020年第1期9卷 1086-1094页

作者： Isabel Barth Donato Conteduca Christopher Reardon steven Johnson Thomas f.Krauss Department of Physics University of YorkYO105DD YorkUK Department of Electronic Engineering University of YorkYO105DD YorkUK

Research toward photonic biosensors for point-of-care applications and personalized medicine is driven by the need for high-sensitivity,low-cost,and reliable *** the most sensitive modalities,interferometry offers particularly high performance,but typically lacks the required operational simplicity and ***,we introduce a common-path interferometric sensor based on guided-mode resonances to combine high performance with inherent *** sensor exploits the simultaneous excitation of two orthogonally polarized modes,and detects the relative phase change caused by biomolecular binding on the sensor *** wide dynamic range of the sensor,which is essential for fabrication and angle tolerance,as well as versatility,is controlled by integrating multiple,tuned structures in the field of *** approach circumvents the trade-off between sensitivity and dynamic range,typical of other phase-sensitive modalities,without increasing *** sensor enables the challenging label-free detection of procalcitonin,a small protein(13 kDa)and biomarker for infection,at the clinically relevant concentration of 1 pg mL^(−1),with a signal-to-noise ratio of *** result indicates the utility for an exemplary application in antibiotic guidance,and opens possibilities for detecting further clinically or environmentally relevant small molecules with an intrinsically simple and robust sensing modality.

关键词： dielectric integrating simplicity

High-Throughput Chemotyping of Cannabis and Hemp Extracts Using an Ultraviolet Microplate Reader and Multivariate Classifiers

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Journal of Analysis and Testing 2018年第3期2卷 210-222页

作者： Zewei Chen Peter de Boves Harrington steven f.Baugh Clippinger Laboratories Department of Chemistry and BiochemistryCenter for Intelligent Chemical InstrumentationOhio UniversityAthensOH 45701USA Chemistry Mapping Inc.5902 McIntyre St.GoldenCO 80403USA

As the use of Cannabis products as natural medicines burgeons,it is also appearing as a food *** is important to screen Cannabis samples as ingredients by profiling their chemical compositions,which is referred to as *** sets of botanical extracts were *** first set is referred to as Cannabis contained plant materials from 15 samples of the sativa,indica,and hybrids of the two *** second set contained 20 extracts from the variety of Cannabis sativa with low tetrahydrocannabinol(THC)concentrations,i.e.,below 0.3%,and,henceforth,will be referred to as *** ultraviolet(UV)microplate reader provides a cost-effective and high-throughput method for identifying chemotypes of plant extracts by their *** microplate reader affords rapid measurements of small volumes,e.g.,50μL,which demonstrates a potential to significantly reduce the analysis time and cost for Cannabis and hemp chemotyping or chemi-cal *** samples were measured on different days to demonstrate the robustness of the *** difference resolution(PDR)maps were used to visualize the separations among the *** multivariate classifiers,fuzzy rule-building expert system(fuRES),super partial least squares-discriminant analysis(sPLS-DA),support vector machine(SVM),and two tree-based support vector machines(SVMtreeG and SVMtreeH)were *** classifiers were validated with ten bootstrapped Latin partitions(BLPs).for the Cannabis extracts,the SVMtreeG yielded the best performance and the classification accuracy was 99.1±0.4%for spectra collected in the nonlinear absorbance *** the hemp extracts,the SVM classifier performed the best with a 97.4±0.6%classification *** results demonstrate that the UV microplate reader coupled with multivariate classifiers can be used as a high-throughput and cost-effective approach for chemotyping Cannabis.

关键词： Cannabis extracts Hemp extracts Ultraviolet microplate reader Multivariate models High-throughput chemotyping Chemometrics Projected difference resolution map

Applying machine learning to study fluid mechanics

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Acta Mechanica Sinica 2021年第12期37卷 1718-1726页

作者： steven L.Brunton Department of Mechanical Engineering University of WashingtonSeattleWA 98195USA

This paper provides a short overview of how to use machine learning to build data-driven models in fluid *** process of machine learning is broken down into five stages:(1)formulating a problem to model,(2)collecting and curating training data to inform the model,(3)choosing an architecture with which to represent themodel,(4)designing a loss function to assess the performance of the model,and(5)selecting and implementing an optimization algorithm to train the *** each stage,we discuss how prior physical knowledge may be embedding into the process,with specific examples from the field of fluid mechanics.

关键词： Machine learning fluid mechanics Physics-informed machine learning Neural networks Deep learning

Constitutive androstane receptor agonist, TCPOBOP,attenuates steatohepatitis in the methionine choline-deficientdiet-fed mouse

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World Journal of Gastroenterology 2007年第42期13卷 5635-5641页

作者： Edwina S Baskin-Bey Akira Anan Hajime Isomoto steven f Bronk Gregory J Gores Department of Medicine Division of Gastroenterology and Hepatology Miles and Shirely Fitterman Center for Digestive Diseases Mayo Clinic College of Medicine Rochester MN 55905 United States

AIM： To ascertain whether constitutive androstane receptor （CAR） activation by 1,4-bis-[2-（3,5,- dichloropyridyloxy）] benzene （TCPOBOP） modulates steatohepatitis in the methionine choline-deficient （MCD） diet-fed ***： C57/BL6 wild-type mice were fed the MCD or standard diet for 2 wk and were treated with either the CAR agonist, TCPOBOP, or the CAR inverse agonist, ***： Expression of CYP2B10 and CYP3A11, known CAR target genes, increased 30-fold and 45-fold, respectively, in TCPOBOP-treated mice fed the MCD diet. TCPOBOP treatment reduced hepatic steatosis （44.6 ＋ 5.4% vs 30.4 ＋ 4.5%, P 〈 0.05） and serum triglyceride levels （48 ＋ 8 vs 20 ＋ 1 mg/dL, P 〈 0.05） in MCD diet- fed mice as compared with the standard diet-fed mice. This reduction in hepatic steatosis was accompanied by an increase in enzymes involved in fatty acid microsomal co-oxidation and peroxisomal p-oxidation, namely CYP4A10, LPBE, and 3-ketoacyI-CoA thiolase. The reduction in steatosis was also accompanied by a reduction in liver cell apoptosis and inflammation. In contrast, androstanol was without effect on any of the above ***： CAR activation stimulates induction of genes involved in fatty acid oxidation, and ameliorates hepatic steatosis, apoptosis and inflammation.

关键词： Apoptosis CYP4A fatty acid oxidation,Inflammation

Some highlights of the Gamma-ray first four years of the fermi Space Telescope

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frontiers of physics 2013年第6期8卷 693-713页

作者： steven Ritz Department of Physics and the SCIPP University of California Santa Cruz Santa Cruz CA 95064 USA

The fermi Gamma-ray Space Telescope, formerly called GLAST, measures the cosmic gamma-ray flux in the energy range 8 keV to 〉 300 GeV. In addition to breakthrough capabilities in energy coverage and localization, the very large field of view enables observations of 20~ of the sky at any instant, and the entire sky on a timescale of a few hours. With its launch in 2008, fermi opens a new and important window on a wide variety of phenomena, including pulsars, black holes and active galactic nuclei, gamma-ray bursts, supernova remnants and the origins of cosmic rays, and searches for hypothetical new phenomena such as particle dark matter annihilations. A brief overview and selected science highlights from the first four years are provided.

关键词： high-energy gamma-ray astrophysics dark matter fundamental physics tests spacebased astrophysics space-based particle astrophysics gamma-ray bursts blazars pulsars