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The interaction of stem cells and vascularity in peripheral nerve regeneration

Neural Regeneration Research 2021年第8期16卷 1510-1517页

作者： Sara Saffari Tiam M.Saffari Dietmar J.O.Ulrich steven e.R.Hovius Alexander Y.Shin Division of Hand and Microvascular Surgery Department of Orthopedic SurgeryMayo ClinicRochesterMNUSA Department of Plastic and Reconstructive Surgery Radboud University Medical CenterNijmegenthe Netherlands

The degree of nerve regeneration after peripheral nerve injury can be altered by the microenvironment at the site of injury. Stem cells and vascularity are postulated to be a part of a complex pathway that enhances peripheral nerve regeneration;however, their interaction remains unexplored. This review aims to summarize current knowledge on this interaction, including various mechanisms through which trophic factors are promoted by stem cells and angiogenesis. Angiogenesis after nerve injury is stimulated by hypoxia, mediated by vascular endothelial growth factor, resulting in the growth of preexisting vessels into new areas. Modulation of distinct signaling pathways in stem cells can promote angiogenesis by the secretion of various angiogenic factors. Simultaneously, the importance of stem cells in peripheral nerve regeneration relies on their ability to promote myelin formation and their capacity to be influenced by the microenvironment to differentiate into Schwann-like cells. Stem cells can be acquired through various sources that correlate to their differentiation potential, including embryonic stem cells, neural stem cells, and mesenchymal stem cells. each source of stem cells serves its particular differentiation potential and properties associated with the promotion of revascularization and nerve regeneration. exosomes are a subtype of extracellular vesicles released from cell types and play an important role in cell-to-cell communication. exosomes hold promise for future transplantation applications, as these vesicles contain fewer membrane-bound proteins, resulting in lower immunogenicity. This review presents pre-clinical and clinical studies that focus on selecting the ideal type of stem cell and optimizing stem cell delivery methods for potential translation to clinical practice. Future studies integrating stem cell-based therapies with the promotion of angiogenesis may elucidate the synergistic pathways and ultimately enhance nerve regeneration.

关键词： angiogenesis exosomes nerve graft nerve regeneration peripheral nerve injury revascularization Schwann cells stem cells stem cell delivery vascularity

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Forecasting of in situ electron energy loss spectroscopy

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npj Computational Materials 2022年第1期8卷 2400-2408页

作者： Nicholas R.Lewis Yicheng Jin Xiuyu Tang Vidit Shah Christina Doty Bethany e.Matthews Sarah Akers steven R.Spurgeon Department of Chemical engineering University of WashingtonSeattleWA98195USA National Security Directorate Pacific Northwest National LaboratoryRichlandWA99352USA energy and environment Directorate Pacific Northwest National LaboratoryRichlandWA99352USA Department of Physics University of WashingtonSeattleWA98195USA

Forecasting models are a central part of many control systems,where high-consequence decisions must be made on long latency control *** models are particularly relevant for emerging artificial intelligence(AI)-guided instrumentation,in which prescriptive knowledge is needed to guide autonomous *** we describe the implementation of a long short-term memory model(LSTM)for forecasting in situ electron energy loss spectroscopy(eeLS)data,one of the richest analytical probes of materials and chemical *** describe key considerations for data collection,preprocessing,training,validation,and benchmarking,showing how this approach can yield powerful predictive insight into order-disorder phase ***,we comment on how such a model may integrate with emerging AI-guided instrumentation for powerful high-speed experimentation.

关键词： consequence autonomous transitions

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Real-world emission factors for Caterpillar 797B heavy haulers during mining operations

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Particuology 2016年第5期14卷 22-30页

作者： Xiaoliang Wang Judith C. Chow steven D. Kohl Kevin e. Percy Allan H. Legge John G. Watson Desert Research Institute 2215 Raggio Parkway Reno NV 895J2 USA Graduate Faculty University of Nevada Reno NV89503 USA The State Key Laboratory of Loess and Quaternary Geology Institute of Earth Environment Chinese Academy of Sciences Xi'an 710075 China Wood Buffalo environmental Association 330 Thickwood Boulevard Fort McMurray AB Canada 7DK 1 Y1 Biosphere Solutions 1610 1 lth Avenue N.W. Calgary AB Canada T2N IG9

Real-world fuel-based emission factors （eFs） from Caterpillar 797B diesel heavy haulers when used for oil sands mining operations were measured using an on-hoard portable emissions monitoring system. Average eFs （in g/kg fuel） for 16 separate tests on four trucks were 3150 ± 4 for CO2, 2.51 ± 1.30 for CH4, 10.28 ± 3.21 for CO, 0.61 ± 0.32 for non-methane hydrocarbons, 55.49 ± 9,75 for NOx （reported as NO2）, 0.70 ± 0.17 for PM2.s （mass of particles with aerodynamic diameter 〈2.5 μm）, and 0.34 ± 0.05 for black carbon （BC）. Ultrafine particle numbers averaged （4.7 ± 4.1 ） × 10^15 particleslkg fuel. Fuel-based eFs of NO, NO2, and particle numbers were higher during idling, whereas PM2.5 and BC eFs were higher during traveling without a load. A comparison of emissions with those reported by oil sands facilities showed large variations, both among the facilities and between the reported emissions and the real-world measurements.

关键词： Heavy hauler emission Nonroad Portable emissions measurement system Mining Oil sands

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H_∞ fault estimation for a class of linear time-delay systems in finite frequency domain

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Journal of Systems engineering and electronics 2010年第5期21卷 835-841页

作者： Quanchao Dong Maiying Zhong steven X. Ding School of Control Science and engineering Shandong University Jinan 250061 E R. China School of Instrumentation Science and Opto-electronics engineering Beihang University Beijing 100191 P. R. China Institute for Automatic Control and Complex Systems University of Duisburg-Essen Duisburg 47057 Germany

This paper deals with the problem of H∞ fault estimation for linear time-delay systems in finite frequency *** a generalized coordinate change is applied to the original system such that in the new coordinates all the time-delay terms are injected by the system＇s input and *** an observer-based H∞ fault estimator with input and output injections is proposed for fault estimation with known frequency *** the aid of Generalized Kalman-Yakubovich-Popov lemma,sufficient conditions on the existence of the H∞ fault estimator are derived and a solution to the observer gain matrices is obtained by solving a set of linear matrix ***,a numerical example is given to illustrate the effectiveness of the proposed method.

关键词： fault estimation time-delay generalized coordinate change generalized Kalman-Yakubovich-Popov lemma finite frequency domain.

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Processing, Recovery and Analysis of Precious Metals Using Molecular Recogntion Technology

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贵金属 2012年第A01期33卷 88-95页

作者： IZATT steven R. BRUeNING Ronald L. IZATT Nell e. IBC Advanced Technologies Inc.856 East Utah Valley DriveAmerican ForkUT 84003USA

IBC Advanced Technologies' Molecular Recognition Technology(MRT) products,trade named SuperLig,selectively and rapidly bind with target metal ions to remove them from *** MRT process can produce a high purity separation product of maximum added value at low *** this paper,applications of MRT in the precious metals industry,including selective commercial separations involving Au,Pd,Pt,Rh,and Ru,are described and *** of MRT to the analytical determination of precious metals is *** use of MRT in recovering precious metals from end-of-life(eOL) products is discussed.

关键词： selective metal separations molecular recognition technology metal recovery from waste electronics palladium platinum rhodium ruthenium gold analytical determinations

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基于FANS的温室风机通风性能测试

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农业机械学报 2014年第11期45卷 311-316页

作者：张智 steven e Ford Richard S Gates 邹志荣西北农林科技大学机械与电子工程学院陕西杨凌712100 伊利诺伊大学厄巴纳-香槟分校农业生物工程系厄巴纳6180l 西北农林科技大学园艺学院陕西杨凌712100

试验采用Fansassessmentnumerationsystem（FANs）为现场监测系统，利用位置上下移动持续运行的螺旋桨风速计和静压传感器对风机通风性能进行测试。试验共测定3个玻璃温室内3种类型共9个排风风机在不同工况下静压5．O～61．5Pa范围内的... 详细信息

试验采用Fansassessmentnumerationsystem（FANs）为现场监测系统，利用位置上下移动持续运行的螺旋桨风速计和静压传感器对风机通风性能进行测试。试验共测定3个玻璃温室内3种类型共9个排风风机在不同工况下静压5．O～61．5Pa范围内的通风量和能源消耗。结果显示，风机防护网的存在及清洁状况对通风量的影响低于5％；塑料百叶窗风机比相同配置的铝制百叶窗风机通风量和能效分别平均高13．1％、15．1％；参数完全相同的风机能效差异最高达12．7％；胶带驱动的风机转速减少16．1％时通风量平均降低38．7％；温室内静压超过30Pa时风机能耗显著增加。

关键词：温室风机性能 FANS 通风量能效

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Management and evaluation of bladder paragangliomas

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Asian Journal of Urology 2022年第1期9卷 94-96页

作者： Sagar Patel Judy Hamad Matthew e.Nielsen steven Johnson System Ringgold Standard Institution University of North CarolinaChapel HillNCUnited States

Dear editor,extraadrenal paragangliomas are tumors composed of neuroendocrine-derived,catecholamine-secreting chromaffin cells inducing hypertension,palpitations,and diaphoresis[1].Although extraadrenal paragangliomas are found in a variety of anatomic sites that normally host paraganglia—from the carotid body to the abdominal paraaortic region—the bladder is an uncommon location for *** paragangliomas represent approximately 6%of extraadrenal paragangliomas and only 0.05%of all bladder tumors[2,3].We present a rare case of primary paraganglioma affecting the bladder dome.

关键词： bladder glioma adrenal

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Long-term antifibrotic action of interferon-γ treatment in patients with chronic hepatitis B virus infection

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Hepatobiliary & Pancreatic Diseases International 2011年第2期10卷 151-157页

作者： Peter R Mertens steven Dooley Department of Nephrology and Hypertension Otto-von-Guericke-University First Affiliated Hospital Zhejiang University School of Medicine Molecular Hepatology-Alcohol Dependent Diseases II. Medical Clinic Faculty of Medicine at MannheimUniversity of Heidelberg

BACKGROUND:The first priority in treating fibrosis is to eliminate the causes that result in liver injury,e.g.,hepatitis B and C ***,in many liver diseases the cause is either unknown or *** present study was designed to investigate the long-term antifibrotic effect of interferon-gamma(IFN-γ)treatment in patients chronically infected with hepatitis B virus. MeTHODS:A total of 42 patients,30 treated with IFN-γand 12 controls,were enrolled from an original clinical trial(Clin Gastroenterol Hepatol 2005;3:819.).Three serial liver biopsies that were obtained at the initiation and end of IFN-γtreatment as well as 4 to 6 years after treatment discontinuation were assessed according to the modified Chevallier scoring system. ReSULTS:Twenty-five out of 30 IFN-γ-treated patients were followed up until 4 to 6 years after the treatment was stopped. However,all controls were excluded from follow-up due to death,loss and elevated virus level within 2 ***-five IFN-γ-treated patients had stable serum liver function and liver fibrosis indices without any further antiviral or anti-fibrotic *** inflammatory and fibrotic scores were found after nine months of IFN-γtreatment according to the modified Chevallier scoring system(inflammation:11.8±6.5 at the beginning of IFN-γtreatment vs.9.2±4.1 after 9 months, Peline vs.12.6±6.8 after 9 months, Pem,14 patients accepted a third serial liver biopsy 4 to 6 years after treatment discontinuation,and the fibrotic score was increased(14.2±8.3 vs.11.9±7.6 after 9 months, Pe-month IFN-γtreatment significantly improves the fibrosis score in patients with chronic HBV *** majority of patients demonstrate stable serum biochemical indices and quality of ***,they do not show a long-term benefit according to histological criteria. Given the limited sample size,long-term IFN-γtreatment regimens should be assessed in further

关键词： hepatic stellate cells hepatitis B virus liver fibrosis inflammation interferon-gamma

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Dual enzyme activated fluorescein based fluorescent probe

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Frontiers of Chemical Science and engineering 2020年第1期14卷 117-121页

作者： Maria L.Odyniec Jordan e.Gardiner Adam C.Sedgwick Xiao-Peng He steven D.Bull Tony D.James Department of Chemistry University of BathBathBA27AYUK Department of Chemistry University of Texas at AustinAustinTX 78712-1224USA Key Laboratory for Advanced Materials&Feringa Nobel Prize Scientist Joint Research Center East China University of Science and TechnologyShanghai 200237China

A simple dual analyte fluorescein-based probe(PF3-Glc)was synthesised containingβ-glucosidase(β-glc)and hydrogen peroxide(H2O2)trigger *** presence ofβ-glc,resulted in fragmentation of the parent molecule releasing glucose and the slightly fluorescent mono-boronate fluorescein(PF3).Subsequently,in the presence of glucose oxidase(GOx),the released glucose was catalytically converted to D-glucono-δ-lactone,which produced H2O2 as a *** GOx-produced H2O2,resulted in classic H2O2-mediated boronate oxidation and the release of the highly emissive fluorophore,*** unique cascade reaction lead to an 80-fold increase in fluorescence intensity.

关键词： chemosensors dual-activation GOx fluorescence β-glucosidase molecular logic

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Inhibition of ammonia-oxidizing bacteria promotes the growth of ammonia-oxidizing archaea in ammonium-rich alkaline soils

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Pedosphere 2022年第4期32卷 532-542页

作者： Chang YIN Xiaoping FAN Hao CHeN Mujun Ye Guochao YAN Tingqiang LI Hongyun PeNG Shengzhe e Zongxian CHe steven AWAKeLIN Yongchao LIANG Key Laboratory of environment Remediation and ecological Health Ministry of EducationCollege of Environmental&Resource SciencesZhejiang UniversityHangzhou 310058China Institute of Soil and Fertilizer and Water-Saving Agriculture Gansu Academy of Agricultural SciencesLanzhou 730070China Scion Research P.O.Box 29237Christchurch 8011New Zealand

Disparities in the substrate affinity and tolerance threshold for ammonia have been believed to play a key role in driving niche differentiation between ammonia-oxidizing archaea (AOA) and bacteria (AOB);however, recent surveys argue that direct competition between AOA and AOB is also important in this phenomenon. Accordingly, it is reasonable to predict that diverse AOA lineages would grow in ammonium (NH_(4)^(+))-rich alkaline arable soils if AOB growth is suppressed. To test this hypothesis, a microcosm study was established using three different types of alkaline arable soils, in which a high NH_(4)^(+) concentration (200 μg N g^(-1) dry soil) was maintained by routinely replenishing urea and the activities of AOB were selectively inhibited by 1-octyne or 3,4-dimethylpyrazole phosphate (DMPP). Compared with amendment with urea alone, 1-octyne partially retarded AOB growth, while DMPP completely inhibited AOB. Both inhibitors accelerated the growth of AOA, with significantly higher ratios of abundance of AOA to AOB observed with DMPP amendment across soils. Nonmetric multidimensional scaling analysis (NMDS) indicated that different treatments significantly altered the community structures of both AOA and AOB and AOA OTUs enriched by high-NH_(4)^(+) amendment were taxonomically constrained across the soils tested and closely related to Nitrososphaera viennensis eN76 and N. garnensis. Given that these representative strains have been demonstrated to be sensitive to high ammonia concentrations, our results suggest that it is the competitiveness for ammonia, rather than disparities in substrate affinity and tolerance threshold for ammonia, that drives niche differentiation between these phylotypes and AOB in NH_(4)^(+)-rich alkaline soils.

关键词： community structure 3,4-dimethylpyrazole phosphate niche differentiation 1-octyne substrate affinity tolerance threshold

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