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The effect of treatment package time in head and neck cancer patients treated with adjuvant radiotherapy and concurrent systemic therapy

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2019年第3期5卷 160-167页

作者： Ahmed I.Ghanem Matthew Schymick Souheyla Bachiri Aniruddh Mannari Jawad Sheqwara Charlotte Burmeister steven chang Tamer Ghanem Farzan Siddiqui Department of Radiation Oncology Henry Ford Hospital2799 W.Grand BlvdDetroitMI 48202USA Department of Medical Oncology Henry Ford Hospital2799 W.Grand BlvdDetroitMI 48202USA Department of Public Health Science Henry Ford Hospital2799 W.Grand BlvdDetroitMI 48202USA Department of Otolaryngology Henry Ford Hospital2799 W.Grand BlvdDetroitMI 48202USA Alexandria Clinical Oncology Department Alexandria UniversityQasm Bab SharqiAlexandria Governate00302Egypt

Objectives:In patients with head and neck carcinoma,“treatment package time”(TPT)was proven to impact outcomes in cases receiving adjuvant radiotherapy *** impact in patients receiving radiotherapy with concurrent systemic therapy has not been studied *** TPT influence on survival endpoints for patients treated with surgery followed by radiation and concurrent systemic therapy was ***:Institutional database to identify head and neck carcinoma cases treated with definitive surgery followed by concomitant chemo(bio)radiotherapy(CRT)was *** was the number of days elapsed between surgery and the last day of radiation.%FINDCUT SAS macro tool was used to search for the cutoff TPT that was associated with significant survival ***-Meier curves,log-rank tests as well as univariate and multivariate analyses were used to assess overall survival(OS)and recurrence free survival(RFS).Results:One hundred and three cases with a median follow up of 37 months were included in the *** tumors were 43%,oral cavity 40%and laryngeal 17%of *** systemic therapy included platinum and cetuximab in 72%and 28%,*** TPT was found to be<100 days with significantly better OS(P=0.002)and RFS(P=0.043)compared to TPT≥100 *** multivariate analysis;TPT<100 days,extracapsular nodal extension,high-risk score,iymphovascular space and perineural invasion were independent predictors for worse OS(P<0.05).T4,extracapsular nodal extension and high-risk score were all significantly detrimental to RFS(P<0.05).Conclusions:Addition of concomitant systemic therapy to adjuvant radiotherapy did not compensate for longer TPT in head and neck squamous cell *** coordinated care must be provided to ensure the early start of CRT with minimal treatment breaks.

关键词： Head and neck cancer Treatment package time Adjuvant radiation therapy Concomitant systemic therapy Survival

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Esophageal cancer:diagnosis and management

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Chinese Journal of Cancer 2010年第10期29卷 843-854页

作者： steven H.Lin Joe Y.chang Department of Radiation Oncology University of Texas M.D.Anderson Cancer Center

Esophageal cancer is the 7th leading cause of cancer deaths *** squamous cell carcinoma is the most prevalent histology internationally,adenocarcinoma of the distal esophagus accounts for nearly 50% of cases in developed countries due to the differences in the etiologic factors such as gastroesophageal reflux disease(GERD) and obesity that *** surgery is the mainstay of treatment of this disease,the utilization of chemoradiation,eitherused postoperatively or neoadjuvantly,has become a standard practice in the United *** is the optimal management approach is still an area of contention,however,and may be different in different regions around the *** article reviews some of these controversies,including the role for surgery in patients treated with definitive *** the end,we will also outline recommendations regarding radiotherapy procedures and techniques.

关键词：食管癌管理诊断放射治疗鳞状细胞癌发达国家组织学利用率

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Inhibition of ammonia-oxidizing bacteria promotes the growth of ammonia-oxidizing archaea in ammonium-rich alkaline soils

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Pedosphere 2022年第4期32卷 532-542页

作者： chang YIN Xiaoping FAN Hao CHEN Mujun YE Guochao YAN Tingqiang LI Hongyun PENG Shengzhe E Zongxian CHE steven AWAKELIN Yongchao LIANG Key Laboratory of Environment Remediation and Ecological Health Ministry of EducationCollege of Environmental&Resource SciencesZhejiang UniversityHangzhou 310058China Institute of Soil and Fertilizer and Water-Saving Agriculture Gansu Academy of Agricultural SciencesLanzhou 730070China Scion Research P.O.Box 29237Christchurch 8011New Zealand

Disparities in the substrate affinity and tolerance threshold for ammonia have been believed to play a key role in driving niche differentiation between ammonia-oxidizing archaea (AOA) and bacteria (AOB);however, recent surveys argue that direct competition between AOA and AOB is also important in this phenomenon. Accordingly, it is reasonable to predict that diverse AOA lineages would grow in ammonium (NH_(4)^(+))-rich alkaline arable soils if AOB growth is suppressed. To test this hypothesis, a microcosm study was established using three different types of alkaline arable soils, in which a high NH_(4)^(+) concentration (200 μg N g^(-1) dry soil) was maintained by routinely replenishing urea and the activities of AOB were selectively inhibited by 1-octyne or 3,4-dimethylpyrazole phosphate (DMPP). Compared with amendment with urea alone, 1-octyne partially retarded AOB growth, while DMPP completely inhibited AOB. Both inhibitors accelerated the growth of AOA, with significantly higher ratios of abundance of AOA to AOB observed with DMPP amendment across soils. Nonmetric multidimensional scaling analysis (NMDS) indicated that different treatments significantly altered the community structures of both AOA and AOB and AOA OTUs enriched by high-NH_(4)^(+) amendment were taxonomically constrained across the soils tested and closely related to Nitrososphaera viennensis EN76 and N. garnensis. Given that these representative strains have been demonstrated to be sensitive to high ammonia concentrations, our results suggest that it is the competitiveness for ammonia, rather than disparities in substrate affinity and tolerance threshold for ammonia, that drives niche differentiation between these phylotypes and AOB in NH_(4)^(+)-rich alkaline soils.

关键词： community structure 3,4-dimethylpyrazole phosphate niche differentiation 1-octyne substrate affinity tolerance threshold

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Calcium/calcimimetic via calcium-sensing receptor ameliorates cholera toxin-induced secretory diarrhea in mice

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World Journal of Gastroenterology 2024年第3期30卷 268-279页

作者： Lie-Qi Tang Johnathan Fraebel Shi Jin steven P Winesett Jane Harrell Wen-Han chang Sam Xianjun Cheng Department of Pediatrics University of FloridaGainesvilleFL 32610United States College of Medicine University of FloridaGainesvilleFL 32610United States Applied Physiology and Kinesiology University of FloridaGainesvilleFL 32610United States Brain Rehabilitation Research Center Malcom Randall VA Medical CenterGainesvilleFL 32610United States Department of Medicine Endocrine Research UnitVeterans Affairs Medical CenterUniversity of CaliforniaSan FranciscoSan FranciscoCA 94121United States Department of Pediatric Gastroenterology Hepatologyand NutritionUniversity of Florida Shands Children’s HospitalGainesvilleFL 32608United States

BACKGROUND Enterotoxins produce diarrhea through direct epithelial action and indirectly by activating the enteric nervous ***-sensing receptor(CaSR)inhibits both *** latter has been well documented in vitro but not in *** hypothesis to be tested was that activating CaSR inhibits diarrhea in *** To determine whether CaSR agonists ameliorate secretory diarrhea evoked by cholera toxin(CTX)in *** CTX was given orally to C57BL/6 mice to induce *** and calci-mimetic R568 were used to activate *** maximize their local intestinal actions,calcium was administered luminally via oral rehydration solution(ORS),whereas R568 was applied serosally using an intraperitoneal *** verify that their actions resulted from the intestine,effects were also examined on Cre-lox intestine-specific CaSR *** outcome was measured biochemically by monitoring changes in fecal Cl-or clinically by assessing stool consistency and weight *** CTX induced secretory diarrhea,as evidenced by increases in fecal Cl-,stool consistency,and weight loss following CTX exposure,but did not alter CaSR,neither in content nor in ***,calcium and R568 were each able to ameliorate diarrhea when applied to diseased *** CaSR involvement is suggested by gene knockout experiments where the anti-diarrheal actions of R568 were lost in intestinal epithelial CaSR knockouts(villinCre/Casrflox/flox)and neuronal CaSR knockouts(nestinCre/Casrflox/flox).CONCLUSION Treatment of acute secretory diarrheas remains a global *** advances in diarrhea research,few have been made in the realm of diarrhea *** therapy has remained the standard of care,although it does not halt the losses of intestinal fluid and ions caused by *** is no cost-effective therapeutic for *** and other studies suggest that adding calcium to ORS or using calcimimetics to activate intestinal CaSR might

关键词： Cholera Enteric nervous system Secretory diarrhea Oral rehydration solution Calcium-sensing receptor Gene knockout

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Application of cattle placental stem cells for treating ovarian follicular cyst

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World Journal of Stem Cells 2020年第11期12卷 1366-1376页

作者： Shao-Yu Peng Tsung-Hsin Wu Tzu-Yi Lin Ling-Yien Hii Kok-Seong Chan Tzu-Yen Fu Shen-chang chang Perng-Chih Shen Kang-You Liu steven W.Shaw Department of Animal Science National Pingtung University of Science and TechnologyPingtung 912Taiwan College of Medicine Chang Gung UniversityTaoyuan 333Taiwan Department of Obstetrics and Gynecology Taipei Chang Gung Memorial HospitalTaipei 105Taiwan Kaohsiung Animal Propagation Station Livestock Research InstituteCouncil of AgricultureExecutive YuanPingtung 912Taiwan Prenatal Cell and Gene Therapy Group Institute for Women's HealthUniversity College LondonLondon WC1E 6HUUnited Kingdom

BACKGROUND High humidity and temperature in Taiwan have significant effects on the reproductivity of Holstein cattle,resulting in the occurrence of bovine ovarian follicular cyst(OFC).Because of economic loss from OFC,manual rupture and hormone injection have been advocated for the management of ***,these incomplete treatments increase hormone resistance in *** stem cells(MSCs)derived from placental stem cells(PSCs)demonstrate potential properties for the treatment of several diseases via promoting angiogenesis and immune *** To establish the possibility of cattle placental stem cells(CPSCs)as a treatment modality for OFC of cows in *** The cows with OFC were divided into three groups:control(BC1 and BC2),hormone(H1 and H2),and CPSC(PS1 and PS2)treatment *** the hormone treatment group,the cows were given gonadotrophin-releasing hormone(GnRH)-prostaglandin-GnRH intramuscular injection with or without drainage of follicular *** the CPSC treatment group,CPSCs were isolated from the placenta after *** the identification of surface antigen on stem cells,the cows were administered ovarian injection of 1×106 or 6×106 CPSCs with *** all groups,OFC was scanned by ultrasound once a week for a total of seven *** concentrations of estradiol and progesterone in serum were tested in the same *** estrus cycle was analyzed by food intake and *** estrus was detected,artificial insemination was *** the cow was monitored by ultrasound for confirmation of *** After 7 d of culture,CPSCs were successfully isolated from placental *** significantly proliferated every 24 h and had high expression of MSC markers such as cluster of differentiation 44,as determined by flow *** showed lower numbers of OFCs with drainage of follicular *** achieved recovery rates of 0%,50%,50%,75%,75%and 75%in BC1,BC2,H1,H2,PS1,and PS2,*** concentrati

关键词： Cow Estrus rate Ovarian follicular cyst Placenta Recovery rate Stem cell

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Optimizing bus services with variable directional and temporal demand using genetic algorithm

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Journal of Central South University 2016年第7期23卷 1786-1798页

作者：瞿何舟 CHIEN steven I-Jy 刘晓波张培桐 BLADIKAS Athanassios School of Transportation and Logistics Southwest Jiaotong UniversityChengdu 610031China Sichuan Province Key Laboratory of Comprehensive Transportation Chengdu 610031China College of Automobile Chang'an UniversityXi'an 710064China John A.Reif Jr.Department of Civil and Environmental Engineering New Jersey Institute of TechnologyNewark 07102-1982USA Mechanical&Industrial Engineering New Jersey Institute of TechnologyNewark 07102-1982USA

As a major mode choice of commuters for daily travel, bus transit plays an important role in many urban and metropolitan areas. This work proposes a mathematical model to optimize bus service by minimizing total cost and considering a temporally and directionally variable demand. An integrated bus service, consisting of all-stop and stop-skipping services is proposed and optimized subject to directional frequency conservation, capacity and operable fleet size constraints. Since the research problem is a combinatorial optimization problem, a genetic algorithm is developed to search for the optimal result in a large solution space. The model was successfully implemented on a bus transit route in the City of Chengdu, China, and the optimal solution was proved to be better than the original operation in terms of total cost. The sensitivity of model parameters to some key attributes/variables is analyzed and discussed to explore further the potential of accruing additional benefits or avoiding some of the drawbacks of stop-skipping services.

关键词： bus transit cost travel time service patterns optimization genetic algorithm

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Reduction of neuroprogenitor cells in mice impedes functional recovery without increasing stroke size

Reduction of neuroprogenitor cells in mice impedes functiona...

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2014浙江省神经外科学学术年会

作者： Chongran Sun Hui Sun steven Wu Ting-Ju chang steven G.Kernie Jialing Liu Department of Neurosurgery of 2~(nd) Hospital of Zhejiang University Medical Collage Department of Neurological Surgery UCSF and SFVAMC Departments of Pediatrics and Developmental Biology University of Texas Southwestern Medical Center

Although there is a strong association between post-stroke functional recovery and neural regeneration,the causal relationship between the extent of neurogenesis and recovery of function has not been properly *** current study aimed to investigate how ischemia-induced regeneration is dependent on the survival and differentiation of early progenitor cells and to determine whether attenuation of neuroprogenitor cells affects

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Feasibility of shoulder use for highway work zone optimization

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Journal of Traffic and Transportation Engineering(English Edition) 2014年第4期1卷 235-246页

作者： Bo Du steven I-Jy Chien Department of Civil and Environmental Engineering New Jersey Institute of Technology School of Automobile Chang'an University

Highway maintenance, often requiring lane closure, is very expensive in terms of the costs associated with transportation agencies （i. e. work zone setups） and road users （i. e. delay）. Longer work zones tend to increase the user delay but will be efficient because of fewer repeated setups. To increase road capacity and mitigate congestion impact for a short-term work zone, temporary shoulder use may be applied. This study develops an analytical model to optimize work zone length on a multi-lane highway considering time-varying traffic volume and road capacity affected by light condition, heavy vehicle percentage, and lane width. The results can be used to evaluate the work Zone impact （i. e. delay and cost） and assist engineers/planners to prepare and develop a cost-effective highway maintenance plan. A case study for a highway work zone in New Jersey has been conducted, in which the optimized solution is found. A guideline of using road shoulder under various circumstances is developed.

关键词： work zone lane closure shoulder use highway cost delay optimization

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Microcosm study on fate and dynamics of mangrove tannins during leaf litter leaching

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Ecological Processes 2023年第1期12卷 520-533页

作者： Hai-Chao Zhou Hui-Xing Kang Jian Wei chang-Jun Gao Muzammil Hussain Yi-Jian Fu Ming-Dang Li Feng-Lan Li steven Jing-Liang Xu Fred Wang-Fat Lee Ming-Guo Jiang Yi-Bing Wang Xiao-Xia Chen Nora Fung-Yee Tam Tao Lang Greater Bay Area Coastal Mangrove Wetland Research&Development Centre MNR Key Laboratory for Geo-Environmental Monitoring of Great Bay AreaCollege of Life Sciences and OceanographyShenzhen UniversityShenzhen 518060China Institute of Ecology College of Urban and Environmental Sciences and Key Laboratory for Earth Surface Processes of Ministry of EducationPeking UniversityBeijing 100091China Guangdong Provincial Key Laboratory of Silviculture Protection and UtilizationGuangdong Academy of ForestryGuangzhou 510520China School of Science and Technology The Hong Kong Metropolitan UniversityKowloonHong Kong 999077SARChina Guangxi Key Laboratory for Polysaccharide Materials and Modifications School of Marine Sciences and BiotechnologyGuangxi Minzu UniversityNanning 530008China State Key Laboratory of Marine Pollution City University of Hong KongKowloonHong Kong 999077SARChina

Background Mangrove tannins can participate in wetland biogeochemical ***,their fate and dynamics during leaf litter leaching have yet to be elucidated in coastal aquatic *** By using a simulated microcosm experiment,changes in leaf litter mass and tannin compounds,including total phenolics(TP),extractable condensed tannins(ECT),and bound condensed tannins(BCT),were examined in the litters and leachates of four common mangrove species:Kandelia obovata(Ko),Aegiceras corniculatum(Ac),Sonneratia apetala(Sa),and Avicennia marina(Am).Results Leaching caused a notable decline in litter mass,TP,and ECT in the leaf litter of Ko,Ac,Sa,and Am,while BCT increased significantly in Ko and *** in foliar TP was higher than in leaf litter mass,and loss in foliar ECT was higher than in TP of Ko and Ac,but Sa showed the opposite *** temporal changes of TP and ECT concentrations in leachates followed a similar trend,with an initial increase followed by a *** dynamics in Ko and Ac leachates correlated with their TP concentrations,while in Sa leachate,the peak ECT occurred 72 h later than its TP *** leachate ECT concentrations were highest in Ac,followed by Ko,and significantly lower in *** peak TP and ECT proportions in leachates accounted for 9.2-23.9%and 7.7-9.4%of the total decreases in foliar TP and ECT,*** During the leaching process,tannins’fate was species-specific,while the dynamics were almost similar.

关键词： Mangrove tannins Leaf litter decomposition Leaching Total phenolics Condensed tannins

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表展重启迭代更新

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钟表 2022年第3期53卷 38-47页

作者： Ova chang Jili(设计) steven River 不详

LVMH集团所主办的LVMH Watch Week钟表周自2019年首度登场至今,已发展成为一年一度国际钟表界的开季盛事。今年LVMH集团4大品牌:BVLGARI、HUBLOT、ZENITH及TAG HEUER联手发表今年多款最新作品。作为开年的第一场钟表大秀,LVMH Watch Wee... 详细信息

LVMH集团所主办的LVMH Watch Week钟表周自2019年首度登场至今,已发展成为一年一度国际钟表界的开季盛事。今年LVMH集团4大品牌:BVLGARI、HUBLOT、ZENITH及TAG HEUER联手发表今年多款最新作品。作为开年的第一场钟表大秀,LVMH Watch Week不仅可一窥该集团的整体战略,以及各品牌未来的发展规划,某种程度更反映出新一年钟表的趋势风向。

关键词： LVMH集团整体战略品牌迭代更新钟表

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