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Extensive adhesion formation in a total knee replacement in the setting of a gastrointestinal stromal tumor:A case report

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World Journal of Orthopedics 2022年第5期13卷 538-543页

作者： steven Mitchell Anderson Lee Ryan Stenquist David YatsonskyⅡ Megan L Mooney Vithal b Shendge Department of Orthopaedic Surgery The University of Toledo Medical CenterToledoOH 43614United States

bACKGROUND Gastrointestinal stromal tumors(GISTs)are rare primary neoplasms of the gastrointestinal tract,accounting for 1%to 2%of all gastrointestinal neoplasms *** are frequently discovered incidentally during workup for other diagnosis or intestinal obstruction,as they can present with few or no ***,GISTs confer a high degree of malignant transformation,with a progression in about 10%to 30%of *** SUMMARY A 63-year-old healthy female presented to our institution with complaints of right knee pain and limited passive and active motion in the setting of a previous right total knee arthroplasty(TKA).One year after TKA,the patient was incidentally diagnosed with a GIST,which was successfully *** removal,the patient continued to have limited range of motion of the right knee and subsequently underwent revision *** significant fibrotic adhesions were found encapsulating the femoral and tibial *** patient’s pain improved postoperatively,however,she continued to have decreased range of motion with difficulty *** We propose that this case may demonstrate a proinflammatory milieu arising from a GIST,which had a direct influence on the outcome of recent total knee *** proposed mechanism between neoplastic cytokinetic activity and adhesion formation could have implications on preoperative and postoperative orthopedic management of total knee arthroplasty.

关键词： Gastrointestinal stromal tumor Adhesion formation Total knee arthroplasty Inflammatory response Decreased range of motion Case report

Diabetes pathogenesis and management:the endothelium comes of age

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Journal of Molecular Cell biology 2021年第7期13卷 500-512页

作者： Kaitlin M.Love Eugene J.barrett steven K.Malin Jane E.b.Reusch Judith G.Regensteiner Zhenqi Liu Division of Endocrinology and Metabolism Department of MedicineUniversity of Virginia Health SystemCharlottesvilleVA 22908USA Department of Kinesiology and Health Rutgers UniversityNew BrunswickNJUSA Division of Endocrinology Metabolism and NutritionRutgers UniversityNew BrunswickNJUSA New Jersey Institute for Food Nutrition and HealthRutgers UniversityNew BrunswickNJUSA Institute of Translational Medicine and Research Rutgers UniversityNew BrunswickNJUSA Center for Women’s Health Research University of Colorado School of MedicineAuroraCOUSA Department of Medicine University of ColoradoAnschutz Medical CampusAuroraCOUSA Rocky Mountain Regional Veterans Affairs Medical Center AuroraCOUSA

Endothelium,acting as a barrier,protects tissues against factors that provoke insulin resistance and type 2 diabetes and itself responds to the insult of insulin resistance inducers with altered *** insulin resistance and vascular dysfunction occur early in the evolution of insulin resistance-related disease,can co-exist with and even contribute to the development of metabolic insulin resistance,and promote vascular complications in those *** impact of endothelial insulin resistance and vascular dysfunction varies depending on the blood vessel size and location,resulting in decreased arterial plasticity,increased atherosclerosis and vascular resistance,and decreased tissue *** with insulin resistance and diabetes are disproportionately impacted by cardiovascular disease,likely related to differential sex-hormone endothelium ***,reducing endothelial insulin resistance and improving endothelial function in the conduit arteries may reduce atherosclerotic complications,in the resistance arteries lead to better blood pressure control,and in the microvasculature lead to less microvascular complications and more effective tissue *** diabetes therapeutic modalities,including medications and exercise training,improve endothelial insulin action and vascular *** action may delay the onset of type 2 diabetes and/or its complications,making the vascular endothelium an attractive therapeutic target for type 2 diabetes and potentially type 1 diabetes.

关键词： diabetes insulin resistance endothelium vascular function

bubbly shock propagation as a mechanism of shedding in separated cavitating flows

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Journal of Hydrodynamics 2017年第6期29卷 907-916页

作者： Harish Ganesh Simo A.Makiharju steven L.Ceccio University of Michigan Ann ArborUSA University of California BerkeleyUSA

Stable attached partial cavitation in separated flows can transition to cloud shedding, and the mechanism of transition has been attributed to the presence of a re-entrant liquid jet. Our findings have revealed the presence of propagating bubbly shock waves as an alternative dominant mechanism of shedding when the compressibility of the bubbly mixture is appreciable. In the present paper, we discuss dynamics associated with these bubbly shock waves, interaction of shock waves with obstacles in their path, and means to manipulate their properties to control the shedding process by non-condensable gas injection.

关键词： Partial cavitation bubbly shock waves cloud cavitation X-ray densitometry

New instability and mixing simulations using SPH and a novel mixing measure

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Journal of Hydrodynamics 2020年第4期32卷 684-698页

作者： Georgina Reece benedict D.Rogers steven Lind Georgios Fourtakas Department of Mechanical Aerospace and Civil EngineeringUniversityof ManchesterManchesterUK

This paper assesses the ability of smoothed particle hydrodynamics (SPH) to simulate mixing of two-phase flows and theirtransition to instabilities under different flow regimes. A new measure for quantification of the degree of mixing between phases in aLagrangian framework is also developed. The method is validated using the lid-driven cavity and two-phase Poiseuille flow cases. Thevelocity along the centre of the cavity is compared with results from the literature, whilst commercial volume-of-fluid codeSTAR-CCM+ provides a benchmark for the mixing and different mixing measures are considered. The velocity of two-phase Poiseuilleflow along the channel is compared to the analytical solution, and the appearance of interfacial instabilities with perturbation *** is the first time SPH has been used to investigate the onset and development of these instabilities. In particular, it is able to modelthe deforming shape of the interface, which is not given by analytical studies, while also offering improved predictions overconventional mesh-based computational fluid dynamics simulations.

关键词： Smoothed particle hydrodynamics(SPH) multi-phase mixing instability

Osteoclasts:New Insights

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bone Research 2013年第1期1卷 11-26页

作者： Xu Feng steven L.Teitelbaum Department of Pathology The University of Alabama at BirminghamBirminghamAlabama 35294USA Department of Pathology and Immunology Washington University School of MedicineSt.LouisMissouri 63110USA

Osteoclasts, the bone-resorbing cells, play a pivotal role in skeletal development and adult bone remodeling. They also participate in the pathogenesis of various bone disorders. Osteoclasts differentiate from cells of the monocyte/macrophage lineage upon stimulation of two essential factors, the monocyte/ macrophage colony stimulating factor （M-CSF） and receptor activation of NF-κb ligand （RANKL）. M-CSF binds to its receptor c-Fms to activate distinct signaling pathways to stimulate the proliferation and survival of osteoclast precursors and the mature cell. RANKL, however, is the primary osteoclast differentiation factor, and promotes osteoclast differentiation mainly through controlling gene expression by activating its receptor, RANK. Osteoclast function depends on polarization of the cell, induced by integrin avβ3, to form the resorptive machinery characterized by the attachment to the bone matrix and the formation of the bone-apposed ruffled border. Recent studies have provided new insights into the mechanism of osteoclast differentiation and bone resorption. In particular, c-Fms and RANK signaling have been shown to regulate bone resorption by cross-talking with those activated by integrin avβ3. This review discusses new advances in the understanding of the mechanisms of osteoclast differentiation and function.

关键词： osteoclast bone remodeling M-CSF RANKL integrin avβ3

NUMERICAL SIMULATION OF THE XZ TAURI SUPERSONIC ASTROPHYSICAL JET

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Acta Mathematica Scientia 2009年第6期29卷 1677-1683页

作者： Carl L. Gardner steven J. Dwyer School of Mathematical and Statistical Sciences Arizona State University Tempe AZ 85287 USA

Computational gas dynamical simulations using the WENO-LF method are applied to modeling the high Mach number astrophysical jet XZ Tauri, including the effects of radiative cooling. Mach 55 simulations of the pulsed proto-jet are presented and analyzed in terms of interacting nonlinear waves： terminal Mach disks, bow shocks, and Meshkov-Richtmyer instabilities of the leading jet contact boundary.

关键词： astrophysical jets ENO. method gas dynamics

第二次世界大战后英国乡村景观研究的脉络走向及启示

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地理科学 2020年第4期40卷 590-598页

作者：范建红梁肇宏 steven b Emery 广东工业大学建筑与城市规划学院广东广州510090 伯明翰大学地理地球与环境科学学院英国伯明翰B152TT

英国是全球乡村景观建设和发展的典范。从地理学、生态学及规划学等综合的视角出发,首先从社会背景上分析二战后英国乡村景观的演变轨迹;其次从学术背景梳理英国乡村景观的研究历程,并从学科角度提炼不同阶段的研究重点及研究特征;最后... 详细信息

英国是全球乡村景观建设和发展的典范。从地理学、生态学及规划学等综合的视角出发,首先从社会背景上分析二战后英国乡村景观的演变轨迹;其次从学术背景梳理英国乡村景观的研究历程,并从学科角度提炼不同阶段的研究重点及研究特征;最后从研究趋势方面讨论学者们最新的研究议题。在梳理和总结英国乡村景观研究的基础上,提出对中国乡村景观研究的启示和借鉴。

关键词：乡村景观乡村地理学乡村振兴二战后英国

Random forest machine learning models for interpretable X-ray absorption near-edge structure spectrum-property relationships

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npj Computational Materials 2020年第1期6卷 743-753页

作者： steven b.Torrisi Matthew R.Carbone brian A.Rohr Joseph H.Montoya Yang Ha Junko Yano Santosh K.Suram Linda Hung Accelerated Materials Design and Discovery Toyota Research InstituteLos AltosCA 94022USA Department of Physics Harvard UniversityCambridgeMA 02138USA Department of Chemistry Columbia UniversityNew YorkNY 10027USA Advanced Light Source Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Molecular biophysics and Integrated bioimaging Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA

X-ray absorption spectroscopy(XAS)produces a wealth of information about the local structure of materials,but interpretation of spectra often relies on easily accessible trends and prior assumptions about the ***,researchers have demonstrated that machine learning models can automate this process to predict the coordinating environments of absorbing atoms from their XAS ***,machine learning models are often difficult to interpret,making it challenging to determine when they are valid and whether they are consistent with physical *** this work,we present three main advances to the data-driven analysis of XAS spectra:we demonstrate the efficacy of random forests in solving two new property determination tasks(predicting bader charge and mean nearest neighbor distance),we address how choices in data representation affect model interpretability and accuracy,and we show that multiscale featurization can elucidate the regions and trends in spectra that encode various local properties.

关键词： property structure spectrum

bemisia tabaci： The current situation in the UK and the prospect of developing strategies for eradication using entomopathogens

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Insect Science 2011年第1期18卷 1-10页

作者： Andrew G. S. Cuthbertson Lisa F. blackburn Dominic P. Eyre Raymond J.C. cannon Judith Miller Phil Northing The Food and Environment Research Agency Sand Hutton York UK

The sweetpotato whitefly, bemisia tabaci （Gennadius）（Hemiptera： Aleyrodidae） remains a serious threat to crops worldwide. The damaging b-biotype is of specific economic concern because it is an effective vector of over 111 viruses from several fam- ilies, particularly geminiviruses. bemisia tabaci is regularly intercepted on plants coming into the UK where it is subjected to a policy of eradication. The UK maintains Protective Zone status against this pest. A main pathway of entry of b. tabaci into the Protected Zone involves propagating material, especially Poinsettia （Euphorbia pulcherrima）. With increased insecticide resistance continuously being recorded, b. tabaci is becoming more difficult to control/eradicate. Recent research involving both entomopathogenic nematodes and fungi is showing much potential for the development of control programs for this pest. both the nematode Steinernemafeltiae and the fungus Lecanicillium muscarium have been shown to be most effective against second instar b. tabaci. Fine-tuning of the environmental conditions required has also increased their efficacy. The entomopathogens have also shown a high level of compatibility with chemical insecticides, all increasing their potential to be incorporated into control strategies against b. tabaci.

关键词： biocontrol entomopathogenic nematodes entomopathogenic fungi insecticide resistance whitefly