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Comparison of five video-assisted intubation devices by novice and expert laryngoscopists for use in the aeromedical evacuation environment

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Military Medical Research 2017年第2期4卷 61-69页

作者： Matthew C.Wallace SSgt Tyler britton Robbie Meek Sharon Walsh-Hart Col Todd E.Carter steven J.Lisco University of Cincinnati Medical Center Department of Anesthesiology

background: The critically ill or injured patient undergoing military medical evacuation may require emergent intubation. Intubation may be life-saving, but it carries *** novice or infrequent laryngoscopist has a distinct disadvantage because experience is critical for the rapid and safe establishment of a secured airway. This challenge is compounded by the austere environment of the back of an aircraft under blackout conditions. This study determined which of five different video-assisted intubation devices(VAIDs) was best suited for in-flight use by U.S. Air Force Critical Care Air Transport Teams by comparing time to successful intubation between novice and expert laryngoscopists under three conditions, Normal Airway Lights on(NAL), Difficult Airway Lights on(DAL) and Difficult Airway blackout(DAb), using manikins on a standard military transport stanchion and the floor with a minimal amount of setup time and extraneous light ***: A convenience sample size of 40 participants(24 novices and 16 experts) attempted intubation with each of the 5 different video laryngoscopic devices on high-fidelity airway manikins. Time to tracheal intubation and number of optimization maneuvers used were recorded. Kruskal-Wallis testing determined significant differences between the VAIDs in time to intubation for each particular scenario. Devices with significant differences underwent pair-wise comparison testing using rank-sum analysis to further clarify the difference. Device assembly times, startup times and the amount of light emitted were recorded. Perceived ease of use was surveyed. Results: Novices were fastest with the Pentax AWS in all difficult airway scenarios. Experts recorded the shortest median times consistently using 3 of the 5 devices. The AWS was superior overall in 4 of the 6 scenarios tested. Experts and novices subjectively judged the Glide Scope Ranger as easiest to use. The light emitted by all the devices was less than the USAF-issued hea

关键词： simulation difficult airway novice expert military video laryngoscopy light emission

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FC-DIRECTED ANTIbODY CONJUGATION OF MAGNETIC NANOPARTICLES FOR ENHANCED MOLECULAR TARGETING

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Journal of Innovative Optical Health Sciences 2009年第4期2卷 387-396页

作者： RObAbEH REZAEIPOOR RENU JOHN steven G.ADIE ERIC J.CHANEY MARINA MARJANOVIC AMY L.OLDENbURG STEPHANIE A.RINNE STEPHEN A.bOPPART biophotonics Imaging Laboratory beckman Institute for Advanced Science and Technology University of Illinois at Urbana-Champaign UrbanaILUSA Departments of Electrical and Computer Engineering Bioengineeringand Internal Medicine University of Illinois at Urbana-Champaign UrbanaILUSA

In this study, we report the fabrication of engineered iron oxide magnetic nanoparticles (MNPs)functionalized with anti-human epidermal growth factor receptor type 2 (HER2) antibody totarget the tumor antigen HER2. The Fc-directed conjugation of antibodies to the MNPs aidstheir efficient immunospecific targeting through free Fab portions. The directional specificity ofconjugation was verified on a macrophage cell line. Immunofluorescence studies on macrophagestreated with functionalized MNPs and free anti-HER2 antibody revealed that the antibodymolecules bind to the MNPs predominantly through their Fc portion. Different cell lines with different HER2 expression levels were used to test the specificity of our functionalized nanoprobe formolecular targeting applications. The results of cell line targeting demonstrate that these engineered MNPs are able to differentiate between cell lines with different levels of HER2 expression.

关键词： Nanoprobe molecular imaging cancer

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Phase angle obtained by bioelectrical impedance analysis independently predicts mortality in patients with cirrhosis

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World Journal of Hepatology 2017年第7期9卷 401-408页

作者： Giliane belarmino Maria Cristina Gonzalez Raquel S Torrinhas Priscila Sala Wellington Andraus Luiz Augusto Carneiro D'Albuquerque Rosa Maria R Pereira Valéria F Caparbo Graziela R Ravacci Lucas Damiani steven b Heymsfield Dan L Waitzberg Department of Gastroenterology Surgical DivisionFaculdade de Medicina da Universidade de Sao Paulo Postgraduate Program in Health and behavior Universidade Católica de Pelotas Pennington biomedical Research Center Laboratory of bone Metabolism Rheumatology DivisionFaculdade de Medicina da Universidade de Sao Paulo Research Institute Hospital do Coracao de Sao Paulo

AIM To evaluate the prognostic value of the phase angle(PA)obtained from bioelectrical impedance analysis(bIA) for mortality prediction in patients with cirrhosis. METHODS In total, 134 male cirrhotic patients prospectively completed clinical evaluations and nutritional assessment by bIA to obtain PAs during a 36-mo follow-up period. Mortality risk was analyzed by applying the PA cutoff point recently proposed as a malnutrition marker(PA ≤ 4.9°) in Kaplan-Meier curves and multivariate Cox regression models. RESULTS The patients were divided into two groups according to the PA cutoff value(PA > 4.9°, n = 73; PA ≤ 4.9°, n = 61). Weight, height, and body mass index were similar in both groups, but patients with PAs > 4.9° were younger and had higher mid-arm muscle circumference, albumin, and handgrip-strength values and lower severe ascites and encephalopathy incidences, interleukin(IL)-6/IL-10 ratios and C-reactive protein levels than did patients with PAs ≤ 4.9°(P ≤ 0.05). Forty-eight(35.80%) patients died due to cirrhosis, with a median of 18 mo(interquartile range, 3.3-25.6 mo) follow-up until death. Thirty-one(64.60%) of these patients were from the PA ≤ 4.9° group. PA ≤ 4.9° significantly and independently affected the mortality model adjusted for Model for End-Stage Liver Disease score and age(hazard ratio = 2.05, 95%CI: 1.11-3.77, P = 0.021). In addition, Kaplan-Meier curves showed that patients with PAs ≤ 4.9° were significantly more likely to die. CONCLUSION In male patients with cirrhosis, the PA ≤ 4.9° cutoff was associated independently with mortality and identified patients with worse metabolic, nutritional, and disease progression profiles. The PA may be a useful and reliable bedside tool to evaluate prognosis in cirrhosis.

关键词： bioelectrical impedance analysis body composition Phase angle Nutritional assessment Liver disease Cirrhosis Mortality

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Predominance of non-adiabatic effects in zero-point renormalization of the electronic band gap

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npj Computational Materials 2020年第1期6卷 297-304页

作者： Anna Miglio Véronique brousseau-Couture Emile Godbout Gabriel Antonius Yang-Hao Chan steven G.Louie Michel Côté Matteo Giantomassi Xavier Gonze Institute of Condensed Matter and Nanosciences UCLouvainB-1348 Louvain-la-NeuveBelgium Département de Physique et Regroupement Québécois sur les Matériaux de Pointe Universitéde MontrealC.P.6128Succursale Centre-VilleMontréal H3C 3J7Canada Department of Physics University of California at BerkeleyBerkeleyCA 94720USA Materials Sciences Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Département de Chimie Biochimie et PhysiqueInstitut de recherche sur l’hydrogèneUniversitédu QuébecàTrois-RivièresTrois-Rivières G8Z 4M3Canada Skolkovo Institute of Science and Technology Skolkovo Innovation CenterNobel St.3Moscow 143026Russia

Electronic and optical properties of materials are affected by atomic motion through the electron–phonon interaction:not only band gaps change with temperature,but even at absolute zero temperature,zero-point motion causes band-gap *** present a large-scale first-principles evaluation of the zero-point renormalization of band edges beyond the adiabatic *** materials with light elements,the band gap renormalization is often larger than 0.3 eV,and up to 0.7 *** effect cannot be ignored if accurate band gaps are *** infrared-active materials,global agreement with available experimental data is obtained only when non-adiabatic effects are taken into *** even dominate zero-point renormalization for many materials,as shown by a generalized Fröhlich model that includes multiple phonon branches,anisotropic and degenerate electronic extrema,whose range of validity is established by comparison with first-principles results.

关键词： adiabatic renormalization phonon

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产科动态:胎儿正常发育保证体系

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当代医学 2001年第4期7卷 18-21页

作者：陈宝英 steven b.Heymsfield WHO母婴及妇女保健研究培训合作中心美国哥伦比亚大学医学院医疗系

本文简要介绍了世界围产保健的现状,分析了中国目前在这一领域存在的问题,以及说明了在中国建立胎儿正常发育保证体系的必要性。文章叙述了与孕妇健康和胎儿发育相关的因素,简要介绍了胎儿正常发育保证体系,最后展望了这一体系在中国... 详细信息

本文简要介绍了世界围产保健的现状,分析了中国目前在这一领域存在的问题,以及说明了在中国建立胎儿正常发育保证体系的必要性。文章叙述了与孕妇健康和胎儿发育相关的因素,简要介绍了胎儿正常发育保证体系,最后展望了这一体系在中国的发展前景。

关键词：围产期保健胎儿发育质量保证体系产科

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地下储存CO_2泄漏胁迫下地表植被光谱变化特征及识别研究

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光谱学与光谱分析 2012年第7期32卷 1882-1885页

作者：陈云浩蒋金豹 Michael D steven 宫阿都李一凡北京师范大学资源学院北京100875 中国矿业大学(北京)地球科学与测绘工程学院北京100083 School of Geography University of NottinghamNG7 2RDUK 地表过程与资源生态国家重点实验室(北京师范大学) 北京100875

随着全球气候变暖,减少温室气体排放成为全世界所关注的问题,而碳捕捉与储存(carbon captureand storage,CCS)技术可以减少温室气体CO2排放量,但储存在地下的CO2有泄漏的风险。本工作的目的是通过野外模拟实验,研究地表植被(甜菜)在CO2... 详细信息

随着全球气候变暖,减少温室气体排放成为全世界所关注的问题,而碳捕捉与储存(carbon captureand storage,CCS)技术可以减少温室气体CO2排放量,但储存在地下的CO2有泄漏的风险。本工作的目的是通过野外模拟实验,研究地表植被(甜菜)在CO2轻微泄漏胁迫下其叶片叶绿素含量、水分含量及光谱变化特征,结果表明CO2泄漏胁迫的甜菜叶绿素与叶片含水量明显降低,叶片反射率在550nm减小,而在680nm增大。设计了比值指数R550/R680进行识别CO2泄漏胁迫的甜菜,发现该指数能够在胁迫发生7天后识别出胁迫的甜菜,且该指数具有较强的敏感性、稳健性及识别能力。研究结果对于未来CCS项目选址、地表生态监测评估、遥感监测CO2泄漏点等都具有重要的现实意义与应用价值。

关键词：光谱特征地下储存CO2 泄漏胁迫甜菜

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Disentangling multiple scattering with deep learning:application to strain mapping from electron diffraction patterns

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npj Computational Materials 2022年第1期8卷 2419-2433页

作者： Joydeep Munshi Alexander Rakowski benjamin H.Savitzky steven E.Zeltmann Jim Ciston Matthew Henderson Shreyas Cholia Andrew M.Minor Maria K.Y.Chan Colin Ophus Center for Nanoscale Materials Argonne National LaboratoryArgonne DrWoodridge60517ILUSA National Center for Electron Microscopy Molecular FoundryLawrence Berkeley National Laboratory1 Cyclotron RoadBerkeley94720CAUSA Department of Materials Science and Engineering University of California BerkeleyBerkeley94720CAUSA Scientific Data Division Lawrence Berkeley National Laboratory1 Cyclotron RoadBerkeley94720CAUSA

A fast,robust pipeline for strain mapping of crystalline materials is important for many technological *** electron nanodiffraction allows us to calculate strain maps with high accuracy and spatial resolutions,but this technique is limited when the electron beam undergoes multiple ***-learning methods have the potential to invert these complex signals,but require a large number of training *** implement a Fourier space,complex-valued deep-neural network,FCU-Net,to invert highly nonlinear electron diffraction patterns into the corresponding quantitative structure factor ***-Net was trained using over 200,000 unique simulated dynamical diffraction patterns from different combinations of crystal structures,orientations,thicknesses,and microscope parameters,which are augmented with experimental *** evaluated FCU-Net against simulated and experimental datasets,where it substantially outperforms conventional analysis *** code,models,and training library are open-source and may be adapted to different diffraction measurement problems.

关键词： valued adapted crystalline

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Elimination of Hepatitis C in Liver Transplant Recipients

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Journal of Clinical and Translational Hepatology 2018年第3期6卷 247-250页

作者： Sammy Saab Youssef Challita Phillip H.Chen Melissa A.Jimenez Alex D.Lee Elena G.Saab Timothy Ahn Gina Choi Francisco A.Durazo Mohamed M.El-Kabany steven-Huy b.Han Jonathan Grotts Vatche G.Agopian Ronald W.busuttil Department of Medicine University of California at Los AngelesLos AngelesCaliforniaUSA Department of Surgery at the University of California at Los Angeles Los AngelesCaliforniaUSA

background and Aims:Recurrent hepatitis C(HCV)disease in liver transplant(LT)recipients is associated with significant morbidity and *** the availability of noninterferon-based therapy,eliminating HCV may be achievable in LT ***:We studied all consecutive recipients who underwent LT at the University of California Los Angeles be-tween January 2005 and June *** collected data on date of transplant and last follow-up,as well as laboratory *** also recorded type and timing of antiviral therapy relative to *** were performed to assess the proportion of LT recipi-ents who are viremic after ***:Six hundred thirty-four patients underwent LTwith a diagnosis of *** was a statistically significant trend for patients to be cured be-fore(pble for therapy,8%and 74%were treated within 12 months of transplant for the study periods 2005 to 2013 and 2014 to 2016,*** was a significant decrease between the two study periods in the proportion of patients undergoing re-LT 1 year after the original LT:5.5%(n=28/510)and 1.5%(n=2/124)respec-tively for study periods 2005 to 2013 and 2014 to 2016 respec-tively(p=0.011).Conclusions:The proportion of LTrecipients who are viremic has decreased over *** HCV in LT recipients is feasible after the introduction of direct-acting *** HCV should translate to improved clinical out-comes in LT recipients who were transplanted for HCV infection with longer *** results suggest the de-creased need for transplant in the direct-acting agents era.

关键词： Hepatitis C Direct-acting agents Liver transplant Elimination

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Infiltration Study for Urban Soil： Case Study of Sungai Kedah Ungauged Catchment

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Journal of Environmental Science and Engineering(b) 2014年第6期3卷 291-299页

作者： steven Poh Tze Wei Khirluddin bin Abdullah Department of Irrigation and Drainage Division of Water Resources and Hydrology Kuala Lumpur 68000 Malaysia

The DID （Department of Irrigation and Drainage） in Malaysia has produced a manual on urban stromwater management specifically for the Malaysia region with usage of infiltration method towards controlling the quantity and quality of surface runoff. With this method, the volume of surface runoff can be reduced and flood problems in major cities can be eliminated. The study areas of Sungai Kedah ungauged catchment are located at the northern region of Malaysia. The Kota Setar sub-catchment is located at the downstream of Sungai Kedah with the newly completed development of control barrage at the upper Kota Setar. This paper will describe the analyses of the infiltration curves at Kota Setar. The resulting infiltration maps have developed based on the infiltration capacities.

关键词： Sungai Kedah ungauged catchment type of soil infiltration curve infiltration map.

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The subgenual cingulate gyrus exhibits lower rates of bifurcation in schizophrenia than in controls, bipolar disorder and depression

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Open Journal of Psychiatry 2012年第4期2卷 253-257页

作者： Matthew R. Williams Ronald K. b. Pearce steven R. Hirsch Olaf Ansorge Maria Thom Michael Maier Department of Neuropathology The Radcliffe Infirmary Oxford UK Institute of Neurology UCL London UK King’s College London Institute of Psychiatry De Crespigny Park London UK Neuropathology Unit Department of Clinical Neuroscience Division of Neuroscience & Mental Health Imperial College London Charing Cross Hospital London UK Trust HQ West London Mental Health NHS Trust Middlesex UK

The subgenual cingulate cortex has been found to be different in structure and function in mood and affective disorders compared to healthy individuals. Imaging studies have shown a decrease in function of the subgenual region in bipolar disorder and depression, with overall glial number shown to be decreased in these disorders. Decreases in subgenual grey matter in SZ have been observed also. In this neuropathological study upon formalin-fixed coronal brain sections we describe the morphological finding of de- creased frequency of subgenual cingulate crown bifurcation (p = 0.02) as compared to control, bipolar and depression cases. This suggests that the cingulate cortex in schizophrenia may be morphologically distinct in utero formation, potentially enabling an early identification of high-risk individuals.

关键词： Neuropathology Schizophrenia Cortical Flattening

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