检索结果-南通市图书馆

Assessment of Genetic Relationship and Application of Computational Algorithm to Assess Functionality of Non-Synonymous Sub.titutions in DQA2 Gene of Cattle, Sheep and Goats

引用

Open Journal of Genetics 2015年第4期5卷 145-158页

作者： steven b. Ugb. Ab.ulmojeed Yakub. Jude N. Omeje b.aseh S. b.b.nu Ib.ahim S. Musa Joseph O. Egahi N. I. Dim Department of Animal b.eeding and Physiology University of Agriculture Makurdi Nigeria Department of Animal Science Faculty of Agriculture Nasarawa State University Keffi Shabu-Lafia Campus Lafia Nigeria Department of Veterinary Medicine and Surgery University of Abuja Abuja Nigeria

The major histocompatib.lity complex (MHC) is a fundamental part of the immune system in nearly all verteb.ates. DQA2 is a memb.r of the MHC complex and an important candidate gene involved in susceptib.lity/resistance to various diseases. Therefore, the present study aimed at investigating computationally molecular genetic variation of DQA2 gene of cattle, sheep and goats especially on its evolution and differentiation within and among species as well as the attendant effects of the polymorphism on the function of DQA2 gene. A total of thirty three DQA2 nucleotide sequences comprising cattle (10), sheep (12) and goats (11) were retrieved from the Genb.nk. Forty seven amino acid sub.titutions of the wild type alleles located in the putative peptide coding region of caprine DQA2 alleles were ob.ained from the alignment of deduced amino acid sequences of goats. Out of these, eleven amino acid sub.titutions (H14L, H14R, L34M, E35L, G56S, G56R, 161V, A62E, D69Q, T72N and T72G) were returned neutral;an indication that they did not impair protein function. The Expected Accuracy (EA) ranged from 53% - 87%. For sheep, sixteen amino acid sub.titutions (A11P, A11T, A11G, A11M, L14S, L14T, V27L, V27S, G35S, S46T, D55E, L57T, L57A, L57G, K65Q and V68I) appeared b.neficial while the rest forty seven appeared harmful (EA ranged from 53% - 93%). Twenty four amino acid sub.titutions did not impair the function of protein while seventy seven sub.titutions appeared to have a negative effect on the function of protein of cattle (EA ranged from 53% - 94%). The phylogeny b.sed on nucleotide and amino acid sequences of DQA2 gene revealed the close relatedness of the caprine, ovine and b.vine species. The present knowledge would b. relevant for performing further genotype-phenotype research as well as pharmacogenetics studies in order to show association b.tween caprine, ovine and b.vine DQA2 allelic variation and the clinical progression of infectious diseases especially in a developing

关键词： DQA2 Genetic Relationship Amino Acid Sub.titution Phylogeny Ruminants

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

用以局部治疗青光眼的碳酸酐酶抑制剂

引用

眼科新进展 1992年第3期 63-64页

作者： steven M.PODOS JANET b.SERLE 秦虹潍坊市人民医院眼科

b.cker b.于1954年首次报道了口服500mg至100mg碳酸酐酶抑制剂醋氮酰胺能有效地降低人眼内压。一年后,Green和Leopold发现结膜下注射醋氮酰胺并不能降低家兔的眼内压。此后开始了时起时伏、长达35年的寻找局部用碳酸酐酶抑制剂的历程。... 详细信息

b.cker b.于1954年首次报道了口服500mg至100mg碳酸酐酶抑制剂醋氮酰胺能有效地降低人眼内压。一年后,Green和Leopold发现结膜下注射醋氮酰胺并不能降低家兔的眼内压。此后开始了时起时伏、长达35年的寻找局部用碳酸酐酶抑制剂的历程。这项工作的完成主要应归功于弗罗里达州立大学的Thomas Maren。

关键词：青光眼碳酸酶抑制剂碳化合物眼内压眼压

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Urinary Creatinine-Skeletal Muscle Mass Method:A Prediction Equation b.sed on Computerized Axial Tomography

引用

b.omedical and Environmental Sciences 1996年第2期9卷 185-190页

作者： ZI-MIAN WANG YUN-GAO SUN AND steven b. HEYMSFIELD (Department of Medicine, Ob.sity Research Center, St. Luke’s-Roosevelt Hospital, Columb.a University College of Physicians and Surgeons,Amsterdam Ave. 14C New York, N. Y., USA)(Ob.sity Research Center, We Department of Medicine St. Luke''s-Roosevelt Hospital Columbia University College of Physicians and Surgeons New York N.Y. USA

A classic b.dy composition method is estimation of total b.dy skeletal muscle mass (SM, kg) from 24 h urinary creatinine excretion (Cr, g). Two types of prediction equations were suggested: one assumes a constant SM/Cr ratio; and the other assumes a highly variab.e SM/Cr ratio. We explored these two extreme possib.lities b. measuring SM with whole-b.dy computerized axial tomography and collecting Cr during meat-free dietary conditions in 12 healthy young men. Prediction equations were developed in the men that fit these two equation types, SM = 21.8×Cr (SD and CV of SM/Cr ratio, 1.3 kg and 6.0%,respectively) and SM = 18.9 × Cr + 4.1 (r = 0.92, p = 2.55 × 10-5, and SEE = 1.9 kg). The validity of each model is reviewed. This is the first investigation of Cr-SM method using modern techniques for quantifying total b.dy SM mass

关键词： Mass Cr b.dy SM Urinary Creatinine-Skeletal Muscle Mass Method

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mycophenolate mofetil for maintenance of remission in steroid-dependent autoimmune pancreatitis

引用

World Journal of Gastroenterology 2012年第18期18卷 2287-2290页

作者： Jamie b.Sodikoff steven A Keilin Sheila J b.armal Melinda M Lewis Gottumukkala S Raju Field F Willingham Division of Digestive Diseases Department of MedicineEmory University School of MedicineAtlantaGA 30322United States Department of Pathology Emory University School of MedicineAtlantaGA 30322United States Department of Gastroenterology the University of Texas MD Anderson Cancer CenterHoustonTX 77030United States

Systemic corticosteroids represent the standard treatment for autoimmune pancreatitis with IgG4-associated *** steroid-dependent disease,azathioprine has b.en used for maintenance of *** mofetil has b.en used for transplant immunosuppression and more recently for autoimmune hepatitis;however,there are no case reports to date on the use of mycophenolate mofetil in adult patients with autoimmune pancreatitis.A patient with IgG4-mediated autoimmune pancreatitis and IgG4-associated cholangitis refractory to steroids and intolerant of azathioprine was treated with mycophenolate mofetil,which inhib.ts de novo guanosine synthesis and b.ockade of b.th b.and T lymphocyte *** of mycophenolate mofetil and uptitration to 1000 mg b. mouth twice daily over a treatment period of 4 mo was associated with improvement in the patient's energy level and b.ood glucose control and was not associated with any adverse *** patient was managed without a b.liary ***,there was a return of symptoms,jaundice,increase in transaminases,and hyperb.lirub.nemia when the prednisone dose reached 11 mg per *** the first report of mycophenolate mofetil use in an adult patient with IgG4-associated autoimmune pancreatitis and IgG4-associated cholangitis,the introduction of mycophenolate mofetil was safe and well-tolerated without adverse events,b.t it did not enab.e discontinuation of the *** mofetil and other immunomodulatory therapies should continue to b. studied for maintenance of remission in the large sub.et of patients with refractory or recurrent autoimmune pancreatitis.

关键词： Autoimmune diseases Pancreatitis Mycophenolate mofetil Recurrence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Overexpression of Galectin-1 and Galectin-3 in hepatocellular carcinoma

引用

Liver Research 2020年第4期4卷 173-179页

作者： Tahereh Setayesh steven D.Colquhoun Yu-Jui Yvonne Wan Department of Pathology and Lab.ratory Medicine University of California DavisSacramentoCAUSA Department of Surgery University of California DavisSacramentoCAUSA

Galectins(Gals)are evolutionarily conserved proteins that b.nd to b.galactoside containing *** expression of Gals is associated with the development,progression,and metastasis of different types of *** the 11 Gals identified in humans,the roles of Gal-1 and Gal-3 have b.en extensively investigated in various ***,we summarize the roles of overly expressed Gal-1 and Gal-3 in the pathogenesis of hepatocellular carcinoma(HCC).The overexpression of Gal-1 and Gal-3 correlates with tumor growth,HCC cell migration and invasion,tumor aggressiveness,metastasis,and poor prognosis.A potentially promising future treatment strategy for HCC may include the comb.nation of immunotherapy with Gal-1 *** research is warranted to investigate targeting Gal-1 and Gal-3 for HCC treatment.

关键词： Galectin-1(Gal-1) Galectin-3(Gal-3) Liver cancer Hepatocellular carcinoma(HCC) Fib.osis Cirrhosis Non-alcoholic steatohepatitis(NASH) Metastasis Epithelial-mesenchymal transition(EMT)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Structure-specific nucleases in genome dynamics and strategies for targeting cancers

引用

Journal of Molecular Cell b.ology 2024年第5期16卷 3-18页

作者： Haitao Sun Megan Luo Mian Zhou Li Zheng Hongzhi Li R.steven Esworthy b.nghui Shen Medicinal Plant Resources and Protection Research Center Institute of Medicinal Plant DevelopmentChinese Academy of Medical SciencesPeking Union Medical CollegeBeĳing 100193China Department of Cancer Genetics and Epigenetics Beckman Research Institute of City of HopeDuarteCA 91010USA Department of Molecular and Cell b.ology University of CaliforniaBerkeleyBerkeleyCA 94720USA

Nucleases are a super family of enzymes that hydrolyze phosphodiester b.nds present in *** widely vary in sub.trates,causing differentiation in cleavage patterns and having a diversified role in maintaining genetic *** cellular evolution of prokaryotic to eukaryotic,nucleases b.come structure-specific in recognizing its own or foreign genomic DNA/RNA configurations as its sub.trates,including flaps,b.b.les,and Holliday *** special structural configurations are commonly found as intermediates in processes like DNA replication,repair,and *** structure-specific nature and diversified functions make them essential to maintaining genome integrity and evolution in normal and cancer *** this article,we review their roles in various pathways,including Okazaki fragment maturation during DNA replication,end resection in homology-directed recomb.nation repair of DNA doub.e-strand b.eaks,DNA excision repair and apoptosis DNA fragmentation in response to exogenous DNA damage,and HIV life *** the nucleases serve as key points for the DNA dynamics,cellular apoptosis,and cancer cell survival pathways,we discuss the efforts in the field in developing the therapeutic regimens,taking advantage of recently availab.e knowledge of their diversified structures and functions.

关键词： structure-specific nucleases DNA replication nuclease inhib.tors synthetic lethality

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Male Music Frogs Compete Vocally on the b.sis of Temporal Sequence Rather Than Spatial Cues of Rival Calls

引用

Asian Herpetological Research 2015年第4期6卷 305-316页

作者： Fan JIANG Guangzhan FANG Fei XUE Jianguo CUI steven E.b.AUTH Yezhong TANG Chengdu Institute of b.ology Chinese Academy of Sciences Department of Psychology University of Maryland

Male-male vocal competition in anuran species may b. influenced b. cues related to the temporal sequence of male calls as well b. internal temporal, spectral and spatial ones. Nevertheless, the conditions under which each type of cue is important remain unclear. Since the salience of different cues could b. reflected b. dynamic properties of male-male competition under certain experimental manipulation, we investigated the effects of repeating playb.cks of conspecific calls on male call production in the Emei music frog（b.b.na daunchina）. In b.b.na, most males produce calls from nest b.rrows which modify the spectral features of the cues. Females prefer calls produced from inside b.rrows which are defined as highly sexually attractive（HSA） while those produced outside b.rrows as low sexual attractiveness（LSA）. In this study HSA and LSA calls were b.oadcasted either antiphonally or stereophonically through spatially separated speakers in which the temporal sequence and/or spatial position of the playb.cks was either predictab.e or random. Results showed that most males consistently avoided producing advertisement calls overlapping the playb.ck stimuli and generally produced calls competitively in advance of the playb.cks. Furthermore males preferentially competed with the HSA calls when the sequence was predictab.e b.t competed equally with HSA and LSA calls if the sequence was random regardless of the availab.lity of spatial cues, implying that males relied more on availab.e sequence cues than spatial ones to remain competitive.

关键词： male-male competition advertisement call sequence cue spatial cue call timing.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Circadian Rhythm of Calling b.havior in the Emei Music Frog(b.b.na daunchina) is Associated with Hab.tat Temperature and Relative Humidity

引用

Asian Herpetological Research 2011年第3期2卷 149-154页

作者： Jianguo CUI Xiaoyan SONG Guangzhan FANG Fei XU steven E. b.AUTH Yezhong TANG Chengdu Institute of b.ology Chinese Academy of Sciences Sichuan Institute of Animal Sciences Department of Psychology University of MarylandCollege Park

Generally, the function of vocalizations made b. male anurans are to attract females or defend resources. Typically, males vocalize in choruses during one or more periods in a twenty-four-hour cycle, which varies, however, among species. Nevertheless, the causal factors influencing circadian variations of calling patterns in anuran species are not clear. In this study, male chorus vocalizations were monitored in the Emei music frog(b.b.na daunchina) for 17 consecutive days during the b.eeding season, while its hab.tat air temperature and relative humidity in the course of experiments were measured as well. The results revealed that the circadian calling patterns were characterized b. two periods of peak vocalization, which were ob.erved from 0500 h to 0700 h and from 1300 h to 2000 h, while the lowest activity period was found from 2100 h to 2200 h. b.th calls/h and notes/h were positively correlated with air temperature and negatively with relative humidity. Overall, our data indicate that the Emei music frogs(b. daunchina) could regulate their vocal activities b.sed on the changes of physical micro-environment(e. g., temperature or humidity) to maximize reproductive success.

关键词： rest-activity cycle advertisement call temperature humidity Emei music frog(b.b.na daunchina

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Orientation b.as of Self-Assemb.ed Alkanes and Their Derivatives Under Dynamic Lateral Nanoconfinement Conditions

引用

CCS Chemistry 2024年第4期6卷 1024-1033页

作者： Conditions Lihua Yu Yuanzhi Xia Tianze Hu b.ent Daelemans steven De Feyter Department of Chemistry Division of Molecular Imaging and PhotonicsKU LeuvenB-3001 Leuven

Self-assemb.ed molecular networks(SAMNs)formed on crystalline solid sub.trates result from the spontaneous arrangement of individual molecules into structured *** interaction b.tween molecules and the sub.trate leads to a nonrandom orientation of SAMNs with respect to the sub.trate’s *** the case of graphite,the sixfold rotational symmetry of the sub.trate results in an equivalent rotational degeneracy in the orientation of *** this study,we explored how nanoconfinement,that is,the restriction of SAMN formation to nanometersized areas,known as nanocorrals,could impact and potentially alleviate the orientational degeneracy of SAMNs,with emphasis on the influence of molecule symmetry,size,and intermolecular *** this end,we investigated the orientation distrib.tion of n-alkanes and functionalized alkanes within nanocorrals,which were fab.icated using scanning tunneling microscopy lithography(nanoshaving).We ob.erved lifting of orientational degeneracy for long alkanes,contrary to shorter alkanes,which did not exhib.t this orientation ***,functionalized alkanes with hydrogen b.nding groups demonstrated preferential alignment regardless of length,highlighting the significance of stab.lizing intermolecular interactions in the alignment *** study discussed the underlying principles of the molecular packing process and shed light on the complexity of molecular self-assemb.y in nanoconfined spaces.

关键词： self-assemb.y confinement condition nanocorral orientation b.as scanning tunneling microscopy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

二尖瓣修复手术图谱

引用

2008年

作者： Edward b.Savage steven F.b.lling原邓勇志译

本书首次详细而全面地复习和评估了二尖瓣成形的各种技术，是一部优秀的心脏外科专著。全书图文并茂，文字简练，广征博引，具有很高的临床实际指导意义。本书根据瓣膜的特定组成部分的修复技术组织材料。为相似的问题提供不同的解决方... 详细信息

ISBN: (纸本)9787117099684

本书首次详细而全面地复习和评估了二尖瓣成形的各种技术，是一部优秀的心脏外科专著。全书图文并茂，文字简练，广征博引，具有很高的临床实际指导意义。本书根据瓣膜的特定组成部分的修复技术组织材料。为相似的问题提供不同的解决方法，内容深入浅出、编排详略得当，并配有6例完整注解的、分成不同的特定片段的录像作为补充，很好地阐述了各种修复方法的关键技术，为国内外同类书籍中所罕见。

关键词：二尖瓣修复术图谱

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：