检索结果-南通市图书馆

Augmenting MNK1/2 activation by c-FMS proteolysis promotes osteoclastogenesis and arthritic bone erosion

Bone Research 2021年第4期9卷 571-581页

作者： Se Hwan Mun Seyeon Bae steven zeng Brian Oh Carmen Chai Matthew Jundong Kim Haemin Kim George Kalliolias Chitra Lekha Dahia Younseo Oh Tae-Hwan Kim Jong Dae Ji Kyung-Hyun Park-Min Arthritis and Tissue Degeneration Program David Z.Rosensweig Genomics Research CenterNew YorkNYUSA Tissue Engineering Regeneration and RepairHospital for Special SurgeryNew YorkNYUSA Department of Cell and Developmental Biology Weill Cornell Medical CollegeNew YorkNYUSA BCMB allied program Weill Cornell Graduate School of Medical SciencesNew YorkNYUSA Hanyang University Institute for Rheumatology Research SeoulKorea Department of Rheumatology Hanyang University Hospital for Rheumatic DiseasesSeoulKorea Rheumatology College of MedicineKorea UniversitySeoulKorea Department of Medicine Weill Cornell Medical CollegeNew YorkNYUSA

Osteoclasts are bone-resorbing cells that play an essential role in homeostatic bone remodeling and pathological bone *** colony stimulating factor(M-CSF)is abundant in rheumatoid arthritis(RA).However,the role of M-CSF in arthritic bone erosion is not completely ***,we show that M-CSF can promote osteoclastogenesis by triggering the proteolysis of c-FMS,a receptor for M-CSF,leading to the generation of FMS intracellular domain(FICD)*** levels of FICD fragments positively regulated osteoclastogenesis but had no effect on inflammatory ***,myeloid cell-specific FICD expression in mice resulted in significantly increased osteoclast-mediated bone resorption in an inflammatory arthritis *** FICD formed a complex with DAP5,and the FICD/DAP5 axis promoted osteoclast differentiation by activating the MNK1/2/EIF4E pathway and enhancing NFATcl protein ***,targeting the MNK1/2 pathway diminished arthritic bone *** results identified a novel role of c-FMS proteolysis in osteoclastogenesis and the pathogenesis of arthritic bone erosion.

关键词： osteoclast stimulating 1/2

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fe doped aluminoborate PKU-1 catalysts for the ketalization of glycerol to solketal: Unveiling the effects of iron composition and boron

引用

Chinese Chemical Letters 2022年第3期33卷 1346-1352页

作者： Weilu Wang Xiangke zeng Yanliu Dang Ping Ouyang Haidong Zhang Guangming Jiang Fan Dong Tao Yang steven L.Suib Yang He Engineering Research Center for Waste Oil Recovery Technology and Equipment Ministry of EducationChongqing Technology and Business UniversityChongqing 400067China Institute of Materials Science University of ConnecticutStorrsCT 06269United States Yangtze Delta Region Institute(Huzhou)&Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaHuzhou 313001China College of Chemistry and Chemical Engineering Chongqing UniversityChongqing 401331China Department of Chemical Biological and Materials EngineeringUniversity of South FloridaTampaFL 33620United States

An inexpensive Fe doped aluminoborate consisted of 18% Fe in PKU-1 material that exhibits high selectivity of 4-hydroxymethy-2,2-dimethyl^(-1),3-dioxolane (Solketal, 98.3%), considerable activity (TOF 51.7 h-1), and recyclable ability in the ketalization of glycerol to Solketal with acetone at 318 K has been developed. Our study demonstrated that the structure of Fe (less agglomerated iron species vs. FeO clusters) can be tuned by changing Fe loading in the PKU-1 material, which correlated well with experimental observations. Furthermore, the surface boron sites were promoted by iron loading and behaved as Lewis-acid sites to facilitate the reaction process of glycerol ketalization, while the Solketal selectivity was closely related with the structure of iron species in PKU-1, which was proved by kinetic studies, density function theory (DFT) calculations, and a series of spectroscopy studies. This investigation demonstrates that the surface B sites can play important roles in the reaction instead of being spectators.

关键词： Fe doping aluminoborate Glycerol recycling Ketalization Boron reaction sites Lewis-acid dominating catalyst

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Photothermal superhydrophobic copper nanowire assemblies: fabrication and deicing/defrosting applications

引用

International Journal of Extreme Manufacturing 2023年第4期5卷 472-484页

作者： Siyan Yang Qixun Li Bingang Du Yushan Ying Yijun zeng Yuankai Jin Xuezhi Qin Shouwei Gao steven Wang Zuankai Wang Rongfu Wen Xuehu Ma State Key Laboratory of Fine Chemicals&Frontier Science Center for Smart Materials School of Chemical EngineeringDalian University of TechnologyDalian 116024People’s Republic of China Department of Mechanical Engineering City University of Hong KongHong Kong 999077People’s Republic of China Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHong Kong 999077People’s Republic of China

Ice and frost buildup continuously pose significant challenges to multiple *** a promising de-icing/defrosting alternative,designing photothermal coatings that leverage on the abundant sunlight source on the earth to facilitate ice/frost melting has attracted tremendous attention ***,previous designs suffered from either localized surface heating owing to the limited thermal conductivity or unsatisfied meltwater removal rate due to strong water/substrate ***,we developed a facile approach to fabricate surfaces that combine photothermal,heat-conducting,and superhydrophobic properties into one to achieve efficient de-icing and *** copper nanowire assemblies,such surfaces were fabricated via the simple template-assisted electrodeposition method,allowing us to tune the nanowire assembly geometry by adjusting the template dimensions and electrodeposition *** highly ordered copper nanowire assemblies facilitated efficient sunlight absorption and lateral heat spreading,resulting in a fast overall temperature rise to enable the thawing of ice and *** promoted by the excellent water repellency of the surface,the thawed ice and frost could be spontaneously and promptly *** this way,the all-in-one design enabled highly enhanced de-icing and defrosting performance compared to other nanostructured surfaces merely with superhydrophobicity,photothermal effect,or the combination of *** particular,the defrosting efficiency could approach∼100%,which was the highest compared to previous ***,our approach demonstrates a promising path toward designing highly effective artificial deicing/defrosting surfaces.

关键词： nanowire photothermal superhydrophobic de-icing defrosting

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fault Detection of Networked Control Systems Subject to Access Constraints and Random Packet Dropout

引用

自动化学报 2009年第9期35卷 1230-1234页

作者： WANG Yong-Qiang YE Hao DING steven WANG Gui-zeng Department of Automation Tsinghua National Laboratory for Information Science and Technology (TNList) Tsinghua University Beijing 100084 P. R. China Institute for Automatic Control and Complex Systems University of Duisburg-Essen Duisburg 47057 Germany

In this paper,the problem of fault detection is addressed for networked control systems (NCSs) subject to both access constraints and random packet dropout,which to the best of our knowledge has not been considered *** residual generation and residual evaiuation as well as false alarm computation of the designated threshold are ***,based on a deterministic formulation,residual generation is carried out in the periodic system ***,residual evaluation is achieved by making full use of the stochastic properties of the random packet ***,performance evaluation of the designated threshold,i.e.,the computation of false alarm rate,is fulfilled with the assistance of Chebyshev's *** results are given to illustrate effectiveness of the proposed method.

关键词：故障检测网路控制接入约束残差

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fault Detection of Networked Control Systems Based on Optimal Robust Fault Detection Filter

引用

自动化学报 2008年第12期34卷 1534-1539页

作者： WANG Yong-Qiang YE Hao DING X. steven WANG Gui-zeng Department of Automation Tsinghua University Beijing 100084 P. R. China Institute for Automatic Control and Complex Systems University of Duisburg-Essen Duisburg 47057 Germany

有可能比一个采样时期大的随机、未知的导致网络的延期的联网的控制系统(NCS ) 的差错察觉在这份报纸被学习。首先，导致网络的延期引起的影响被转变成为错误建模组织，然后存在连续时间域基于引用，模型被扩大到分离时间领域并且适用... 详细信息

有可能比一个采样时期大的随机、未知的导致网络的延期的联网的控制系统(NCS ) 的差错察觉在这份报纸被学习。首先，导致网络的延期引起的影响被转变成为错误建模组织，然后存在连续时间域基于引用，模型被扩大到分离时间领域并且适用指责联网的控制系统的察觉的柔韧的差错察觉方法。建议方法能被 Matlab LMI 工具箱容易实现，并且它的表演被一个模拟例子最后评估。

关键词：检测方法网络控制系统最优鲁棒故障检测系统滤波器

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

MDGA2 Constrains Glutamatergic Inputs Selectively onto CA1 Pyramidal Neurons to Optimize Neural Circuits for Plasticity,Memory,and Social Behavior

引用

Neuroscience Bulletin 2024年第7期40卷 887-904页

作者： Xuehui Wang Donghui Lin Jie Jiang Yuhua Liu Xinyan Dong Jianchen Fan Lifen Gong Weida Shen Linghui zeng Tonghui Xu Kewen Jiang steven A.Connor Yicheng Xie School of Life Sciences Nanchang UniversityNanchang330031China Department of Neurology Children's HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Biology York University4700 Keele StreetTorontoON M3J 1P3Canada Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province School of MedicineHangzhou City UniversityHangzhou 310015China

Synapse organizers are essential for the development,transmission,and plasticity of *** as rare synapse suppressors,the MAM domain containing glycosylphosphatidylinositol anchor(MDGA)proteins contributes to synapse organization by inhibiting the formation of the synaptogenic neuroligin-neurexin complex.A previous analysis of MDGA2 mice lacking a single copy of Mdga2 revealed upregulated glutamatergic synapses and behaviors consistent with ***,MDGA2 is expressed in diverse cell types and is localized to both excitatory and inhibitory *** the network versus cell-specific effects of MDGA2 loss-of-function requires a cell-type and brain region-selective *** address this,we generated mice harboring a conditional knockout of Mdga2 restricted to CA1 pyramidal *** we report that MDGA2 suppresses the density and function of excitatory synapses selectively on pyramidal neurons in the mature *** deletion of Mdga2 in CA1 pyramidal neurons of adult mice upregulated miniature and spontaneous excitatory postsynaptic potentials,vesicular glutamate transporter 1 intensity,and neuronal *** effects were limited to glutamatergic synapses as no changes were detected in miniature and spontaneous inhibitory postsynaptic potential properties or vesicular GABA transporter ***,evoked basal synaptic transmission and AMPAR receptor currents were enhanced at glutamatergic *** a behavioral level,memory appeared to be compromised in Mdga2 cKO mice as both novel object recognition and contextual fear conditioning performance were impaired,consistent with deficits in long-term potentiation in the CA3-CA1 *** affiliation,a behavioral analog of social deficits in autism,was similarly *** results demonstrate that MDGA2 confines the properties of excitatory synapses to CA1 neurons in mature hippocampal circuits,thereby optimizing this network for plasticity,c

关键词： MDGA2 CA1 pyramidal neurons Glutamatergic inputs Synaptic plasticity Memory Social behaviors Autism Synapse organizers

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

HSV-1 H129-Derived Anterograde Neural Circuit Tracers:Improvements, Production, and Applications

引用

Neuroscience Bulletin 2021年第5期37卷 701-719页

作者： Hong Yang Feng Xiong Yi-Ge Song Hai-Fei Jiang Hai-Bin Qin Jing Zhou Sha Lu steven FGrieco Xiangmin Xu Wen-Bo zeng Fei Zhao Min-Hua Luo State Key Laboratory of Virology CAS Center for Excellence in Brain Science and Intelligence TechnologyCenter for Biosafety Mega-ScienceWuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China Shanghai Genechem Co.Ltd.Shanghai 201203 China Department of Anatomy and Neurobiology School of MedicineUniversity of CaliforniaIrvineCA 92697USA School of Basic Medical Sciences Capital Medical UniversityBeijing 100069China Chinese Institute for Brain Research Beijing 102206China Shanghai Public Health Clinical Center Fudan UniversityShanghai 200032China

Anterograde viral tracers are powerful and essential tools for dissecting the output targets of a brain region of interest. They have been developed from herpes simplex virus 1(HSV-1) strain H129(H129), and have been successfully applied to map diverse neural ***, the anterograde polysynaptic tracer H129-G4 was used by many groups. We then developed the first monosynaptic tracer, H129-dTK-tdT, which was highly successful, yet improvements are needed. Now, by inserting another tdTomato expression cassette into the H129-dTK-tdT genome, we have created H129-dTK-T2, an updated version of H129-dTK-tdT that has improved labeling intensity. To help scientists produce and apply our H129-derived viral tracers, here we provide the protocol describing our detailed and standardized procedures. Commonly-encountered technical problems and their solutions are also discussed in detail. Broadly, the dissemination of this protocol will greatly support scientists to apply these viral tracers on a large scale.

关键词： HSV-1 strain H129(H129) Anterograde transneuronal tracer Polysynaptic tracer Monosynaptic tracer Production Application Neural circuit Neural circuit tracing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pupil near response--a promising index to evaluate consciousness in patients with disorders of consciousness

Pupil near response--a promising index to evaluate conscious...

引用

作者： Yitao Gu Wentao zeng Gong Cheng Lizette Heine Xiaohua Hu Shan Jing steven Laureys Haibo Di Hangzhou Normal University International Vegetative State and Consciousness Science Institute University of Liege and University Hospital of LiegeCyclotron Research Center and Neurology DepartmentComa Science Group Hangzhou Wujing Hospital Department of Rehabilitation

Objective:To determine if pupil near response(PNR) can be added into Coma Recovery Scale Revised[CRS-R]as an index of consciousness to improve CRS-R’s diagnostic accuracy in patients with disorders of consciousness(DOC) by removing the influence of patients’ motor impairment and assessor’s personal ***:PNR was evaluated in 20 patients who had been diagnosed as UWS(by means of CRS-R).The outcome was assessed by CRS-R 3 months later to determine the prognosis value of the ***:4 of 20 patients showed PNR(PNR+ group) in this *** was better in these patients than in PNR-patients(4/4 versus 5/16 recovered to MCS at follow up,p=0.026).The detection of conscious visual behaviors at follow-up was more frequent among PNR+ patients than in PNR-patients(4/4 versus 2/16,p=0.003).Conclusions:The significant difference between PNR+ patients and PNR-patients’ outcome suggests that PNR could be considered as a sign of good prognosis for consciousness ***,PNR’s presence requires no motor function and the assessment of PNR by ratio of pupillary constriction(pupil diameter change/original pupil diameter before PNR test)needs no personal *** 2 features of PNR remove the influence of motor impairment and personal interpretation on the diagnostic accuracy of CRS-R in DOC patients,making it can be used as a supplementary index of CRS-R that improves its diagnostic accuracy.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

西南天山—塔里木盆地结合带浅深构造关系——深地震反射剖面的初步揭露

引用

地球物理学报 2012年第12期55卷 4116-4125页

作者：侯贺晟高锐贺日政蔡勋育刘金凯熊小松管烨曾令森 James H.Knapp steven Roecker 中国地质科学院地质研究所北京100037 中国地质科学院深部探测与地球动力学开放实验室北京100037 中国石油化工股份有限公司北京100078 南卡罗来纳大学地球与海洋科学学院美国南卡罗来纳州哥伦比亚29208 伦斯勒理工学院美国纽约州特洛伊121803590

盆山结合部的浅-深结构样式是进行陆内造山动力学研究与讨论的重要依据.2007年,在喀什东的天山与塔里木盆地之间的过渡带上,完成了一条近南北向的长度为121km的主动源深地震反射剖面,显示出盆山结合部现今地壳尺度的构造格架.剖面南部... 详细信息

盆山结合部的浅-深结构样式是进行陆内造山动力学研究与讨论的重要依据.2007年,在喀什东的天山与塔里木盆地之间的过渡带上,完成了一条近南北向的长度为121km的主动源深地震反射剖面,显示出盆山结合部现今地壳尺度的构造格架.剖面南部呈现出10～12km巨厚的沉积盖层,沉积盖层内发育滑脱断层;盆山结合部多排隆起构造以及天山山前上地壳显现出向北倾斜的断裂与地表地质观察吻合;盆山结合带展现出滑脱与逆冲推覆构造相关的断层褶皱;与塔里木盆地稳定沉积层相比,在南天山浅、中层地层受到强烈的变形改造,导致地层比较破碎,反射变弱、连续性较差;时间剖面上可以追踪到比较连续的Moho反射,从南向北有加深的趋势.深地震反射剖面揭露出的西南天山与塔里木盆地的这些浅-深构造,展现出塔里木盆地盖层向南天山滑脱与南天山向塔里木盆地逆冲推覆的特征,反映出陆内汇聚下的盆山耦合关系.

关键词：西南天山塔里木盆地盆山结合带深地震反射剖面浅深构造关系

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

重拾现代性:与史蒂文·夏平再谈《利维坦与空气泵》

引用

自然辩证法通讯 2022年第3期44卷 118-126页

作者：曾点北京师范大学哲学国际中心广东珠海519087

1985年,史蒂文·夏平和西蒙·沙弗合著的《利维坦与空气泵》出版,至今已有三十五年之久。该书对于STS而言,有着极为重大的学术意义,更能勾连起一段学术史。本文结合本文作者近期与夏平教授的学术通信,基于学术界对这本书之学术定位的传... 详细信息

1985年,史蒂文·夏平和西蒙·沙弗合著的《利维坦与空气泵》出版,至今已有三十五年之久。该书对于STS而言,有着极为重大的学术意义,更能勾连起一段学术史。本文结合本文作者近期与夏平教授的学术通信,基于学术界对这本书之学术定位的传统讨论,以"现代性"为指向,对拓展对该书的阅读可能性和研究价值提出了新的看法。本文认为,从《利维坦与空气泵》围绕"霍布斯-玻意耳争论"所呈现的历史出发,该书的现代性意义值得进一步开发,而这将突破一直以来STS对该书的习惯性阅读,也是发扬STS跨学科特色并增强其学术生命力的一种尝试。

关键词：《利维坦与空气泵》夏平现代性 “爱丁堡学派” STS

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：