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Are flexibility and muscle-strengthening activities associated with functional limitation?

Sports Medicine and Health Science 2022年第2期4卷 95-100页

作者： Craig E.Pfeifer Leanna M.Ross Samantha R.Weber Xuemei Sui steven n.blair Department of Exercise Science University of South Carolina921 Assembly StColumbiaSC29208United States Applied Sport and Exercise Sciences University of GloucestershireUniversity of Gloucestershire Oxstalls CampusOxstalls LnLonglevens GL29HWUnited Kingdom Duke Molecular Physiology Institute Duke University School of Medicine300 N Duke StDurhamNC27701United States Department of nursing and Health Sciences Limestone University1115 College DrGaffneySC29340United States

This retrospective cohort study examined the relationship between self-reported participation in flexibility and muscular strengthening activities and the development of functional limitation(i.e.,once an individual has difficulty with or becomes unable to perform activities of daily living).Data were obtained from 1318 adults(mean age 49.59.7 years;98.7%Caucasian;14.9%female)enrolled in the Aerobics Center Longitudinal Study from 1979 to 2004 and free of functional limitation at ***-back health surveys were used to prospectively determine incident functional *** in muscle-strengthening and flexibility activities was assessed via *** logistic regression analyses were used to determine the odds ratios(OR)and corresponding 95%confidence intervals for developing functional limitation during follow-up based on participation in general and specific categories of flexibility(‘Stretching’,‘Calisthenics’,or‘Exercise Class’)and musclestrengthening activities(‘Calisthenics’,‘Free Weights’,‘Weight Training Machines’,or‘Other’).Overall,42.6%of the sample reported incident functional *** adjusting for potential confounders(e.g.,age,sex,cardiometabolic risk factors),those who reported performing muscle-strengthening activities in general(n=685)were at lower risk of developing functional limitation[OR=0.79(0.63–1.00)].In addition,the specific flexibility activities of stretching(n=491)and calisthenics(n=122)were associated with 24%and 38%decreased odds of incident functional limitation,*** muscle-strengthening,stretching,and calisthenics activities are prospectively associated with decreased risk of incident functional limitation in generally healthy,middleaged and older ***,both public health and rehabilitation programs should highlight the importance of flexibility and muscle-strengthening activities during adulthood to help preserve functional capacity.

关键词： Functional capacity Quality of life Aging Exercise Independence Health

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Commentary on Wang Y et al.“An Overview of non-exercise Estimated Cardiorespiratory Fitness:Estimation Equations,Cross-Validation and Application”

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Journal of Science in Sport and Exercise 2019年第1期1卷 94-95页

作者： steven n.blair Departments of Exercise Science Arnold School of Public HealthUniversity of South Carolina921 Assembly StreetColumbiaSC 29208USA

Commentary for Wang et *** documented well by Wang and co-authors[8],cardiores-piratory fitness(CRF)is a very strong determinant of many health outcomes,such as cardiovascular disease(CVD),type 2 diabetes,several forms of cancer,functional disabili-ties,and other *** point has been well established over the past several decades in many populations in many countries[1,3-5,7].Despite the importance of CRF,it is not often measured in clinical medicine and health research,because of time constraints and economic factors[6].The gold standard for measuring CRF is by a maximal exercise test in a laboratory,in which respiratory gas analyses are used to calculate maximal oxygen consumption during the *** requires expensive equipment and considerable staff time and *** approach is to not measure respiratory gases,but to determine the maximal work load from a treadmill or cycle ergometer exercise ***,this approach also requires laboratory equipment and *** is also possible to estimate CRF from submaximal walk-ing or step tests,but these also require well trained staff and *** possible approach would be to obtain CRF data without doing an exercise *** may seem unreal-istic,but non-exercise test models to predict CRF have been available for over 30 years[2].Wang and colleagues present references for these early tests[8].

关键词： al. respiratory exercise

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The Promotion and Practice of Physical Activity in the United States

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中国运动医学杂志 2016年第10期35卷 957-965页

作者： Li Changqing steven n. blair Xiong Kaiyu Sport Science College Beijing Sport UniversityBeijing 100084 China Arnold School of Public Health University of South Carolina Columbia SC USA 29208 Teaching and Experimental Center Beijing Sport UniversityBeijing 100084 China

规律的体力活动有助于提高人的健康状况及生活质量。然而,美国《2020健康人群》中的数据显示,仅有18.8%的美国成年人达到了《2008美国人体力活动指南》(2008 Physical Activity Guidelines for Americans)中提出的有关有氧活动和强壮肌... 详细信息

规律的体力活动有助于提高人的健康状况及生活质量。然而,美国《2020健康人群》中的数据显示,仅有18.8%的美国成年人达到了《2008美国人体力活动指南》(2008 Physical Activity Guidelines for Americans)中提出的有关有氧活动和强壮肌肉活动的推荐量。为此,美国在提高居民体力活动水平上做出了不懈的努力。本文简要介绍美国为促进全民体力活动采取的主要策略、有助于体力活动干预研究的政策分析框架、行为改变理论及3项研究实例。2010年,美国出台了《全民体力活动促进计划》(The national Physical Activity Plan,nPAP),该计划包含了政策推荐、实践经验及措施等一系列增加居民体力活动的策略,试图通过在全国范围内营造"活跃的生活方式"的文化氛围,促进更多人达到《2008美国人体力活动指南》中的体力活动推荐量。《全民体力活动促进计划》的内容涉及公共卫生、教育、城市规划、医疗保健、企业及行业、休闲娱乐及运动健身、非营利机构和大众传媒在内的8个领域,共有5个总策略、52个特定部门的策略及相对应的215个分策略,且部分策略制定了一年及五年目标。2011年,专家组对《全民体力活动促进计划》进行了过程评价,以监督计划的实施情况,并为计划的改进提供建议。过程评价采用定性及定量研究方法,对一年内开展的活动、目标完成情况、经验教训等进行总结。这一年内,《全民体力活动促进计划》的实施取得了可喜成绩,但仍存在诸多挑战,如缺乏长期的资金支持、各领域之间需加强沟通及合作、计划内容需及时更新以保证与体力活动及公共卫生领域的发展同步等。人的体力活动是一种复杂的行为,按照不同行为改变理论,其影响因素亦不同。许多科学研究及实践已经采用行为改变理论为指导进行体力活动的干预,以保证干预效果。有些行为改变理论(如生态学模型)认为,支持性政策是促进行为改变的有效手段之一。在制定支持性政策的复杂过程中,政策分析框架将有助于政策的设计及对政策实施效果进行评估。本文简要介绍常用于促进体力活动增加的政策分析框架:社区行动模型(Community Action Model)、RE-AIM框架(RE-AIM Framework)和健康影响评估(Health Impact Assessment),以及常用于促进体力活动增加的行为改变理论:生态学模型(Ecological Model)、社会认知理论(Social Cognitive Theory)和跨理论模型(Transtheoretical Model)。本文还通过3项研究实例,增加读者对生活方式干预研究的进一步认识。本文希望通过对当前美国有关体力活动促进的经验介绍,为制定或完善体力活动计划及体力活动干预方案提供参考。

关键词：体力活动静坐少动行为活跃的生活方式

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能量平衡研究的10大问题

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北京体育大学学报 2015年第7期38卷 50-58页

作者： Robin P.Shook Gregory A.Hand steven n.blair 南卡莱罗纳大学 columbiasc29201

肥胖是较长时间段内热量摄入和消耗失衡导致的结果。两者之间的关系可以用能量平衡方程描述,能量储存的速率等于能量摄入减去消耗的速率。尽管这种基于简单数学运算的关系可能容易理解,但在现实中,各种已知和未知的系统影响能量平衡的... 详细信息

肥胖是较长时间段内热量摄入和消耗失衡导致的结果。两者之间的关系可以用能量平衡方程描述,能量储存的速率等于能量摄入减去消耗的速率。尽管这种基于简单数学运算的关系可能容易理解,但在现实中,各种已知和未知的系统影响能量平衡的各个组成部分(能量储存,能量摄入,能量消耗)。显然,如果对于能量平衡有完整的理解,有效的预防和治疗策略就不会让肥胖在世界范围内大规模流行。本文的目的是针对能量平衡的组成部分进行简要的概述,确定10个关键主题以及悬而未决的问题,如果这些问题得以解决,可以推动整个研究领域。这些主题涉及多个方面,从一般(方法学问题)到特定领域。这个列表并不是详尽无遗,但却为能量平衡领域的科学家制定了研究议程,为公共卫生专家制定肥胖干预的措施提供了建议。

关键词：体重能量消耗能量摄入肥胖

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Friction and wear performance of polyether ether ketone(PEEK)polymers in three lubrication regimes

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Friction 2024年第4期12卷 670-682页

作者： Davide MASSOCCHI nora LECIS Marco LATTUADA Davide SCAGLIA steven CHATTERTOn Paolo PEnnACCHI Department of Mechanical Engineering Politecnico di MilanoMilan 20156Italy Eni SpA Downstream product R&DLombardia 20097Italy Eurobearings S.R.L. Lombardia 29016Italy

This experimental study investigates the friction and wear of three coatings commonly used in industrial applications,particularly in hydrodynamic *** three materials under investigation were Babbitt,polyether ether ketone(PEEK)reinforced with 15%carbon fibers,and PEEK reinforced with 20%carbon *** first polymer material was extruded,while the other was produced by fused deposition modelling(FDM).The materials were subjected to sliding tests in a pin-on-disc configuration,with a steel ball serving as the counter *** tests were conducted at room temperature,with a load of 10 n and under three different lubrication conditions:dry,grease,and *** linear speed was set at 0.3 m/s for the dry and semi-solid lubrication tests,while for the oil tests,the speed was set at 0.25 m/*** greases used had consistency grades of nGLI 000 and nGLI *** ISO VG 68 circulation oil was used for the oil lubrication ***,thermodynamic analyses were performed under the most severe conditions(i.e.,dry)to investigate the steel-Babbitt and steel-PEEK contact.

关键词： hydrodynamic bearings polyether ether ketone(PEEK)polymers additive manufacturing grease lubrication sliding oil lubrication ball-on-disk tribology

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Hepatic angiotensin-converting enzyme 2 expression in metabolic dysfunction-associated steatotic liver disease and in patients with fatal COVID-19

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World Journal of Gastroenterology 2024年第31期30卷 3705-3716页

作者： Angus K Jacobs steven D Morley Kay Samuel Katie Morgan Lyndsey Boswell Timothy J Kendall David A Dorward Jonathan A Fallowfield Peter C Hayes John n Plevris Hepatology Laboratory University of EdinburghEdinburgh EH164SBUnited Kingdom Scottish national Blood Transfusion Service Jack Copland CentreEdinburgh EH144BEUnited Kingdom Institute for Regeneration and Repair University of EdinburghEdinburgh EH164UUUnited Kingdom Edinburgh Pathology University of EdinburghEdinburgh EH164SBUnited Kingdom

BACKGROUnD Metabolic dysfunction-associated steatotic liver disease(MASLD),characterised by hepatic lipid accumulation,causes inflammation and oxidative stress accompanied by cell damage and *** injury(LI)is also frequently reported in patients hospitalised with coronavirus disease 2019(COVID-19),while preexisting MASLD increases the risk of LI and the development of COVID-19-associated *** of injury at the cellular level remain unclear,but it may be significant that severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)which causes COVID-19,uses angiotensin-converting expression enzyme 2(ACE2),a key regulator of the‘anti-inflammatory’arm of the renin-angiotensin system,for viral attachment and host cell *** To determine if hepatic ACE2 levels are altered during progression of MASLD and in patients who died with severe *** ACE2 protein levels and localisation,and histological fibrosis and lipid droplet accumulation as markers of MASLD were determined in formalin-fixed liver tissue sections across the MASLD pathological spectrum(isolated hepatocellular steatosis,metabolic dysfunction-associated steatohepatitis(MASH)+/-fibrosis,end-stage cirrhosis)and in post-mortem tissues from patients who had died with severe COVID-19,using ACE2 immunohistochemistry and haematoxylin and eosin and picrosirius red staining of total collagen and lipid droplet areas,followed by quantification using machine learning-based image pixel *** ACE2 staining is primarily intracellular and concentrated in the cytoplasm of centrilobular hepatocytes and apical membranes of bile duct ***,ACE2 protein levels are elevated in non-fibrotic MASH compared to healthy controls but not in the progression to MASH with fibrosis and in ***2 protein levels and histological fibrosis are not associated,but ACE2 and liver lipid droplet content are significantly correlated across the MASLD *** A

关键词： Metabolic dysfunction-associated steatotic liver disease Angiotensin-converting enzyme 2 Immunohistochemistry COVID-19 COVID-19-associated cholangiopathy

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Orientation Bias of Self-Assembled Alkanes and Their Derivatives Under Dynamic Lateral nanoconfinement Conditions

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CCS Chemistry 2024年第4期6卷 1024-1033页

作者： Conditions Lihua Yu Yuanzhi Xia Tianze Hu Brent Daelemans steven De Feyter Department of Chemistry Division of Molecular Imaging and PhotonicsKU LeuvenB-3001 Leuven

Self-assembled molecular networks(SAMns)formed on crystalline solid substrates result from the spontaneous arrangement of individual molecules into structured *** interaction between molecules and the substrate leads to a nonrandom orientation of SAMns with respect to the substrate’s *** the case of graphite,the sixfold rotational symmetry of the substrate results in an equivalent rotational degeneracy in the orientation of *** this study,we explored how nanoconfinement,that is,the restriction of SAMn formation to nanometersized areas,known as nanocorrals,could impact and potentially alleviate the orientational degeneracy of SAMns,with emphasis on the influence of molecule symmetry,size,and intermolecular *** this end,we investigated the orientation distribution of n-alkanes and functionalized alkanes within nanocorrals,which were fabricated using scanning tunneling microscopy lithography(nanoshaving).We observed lifting of orientational degeneracy for long alkanes,contrary to shorter alkanes,which did not exhibit this orientation ***,functionalized alkanes with hydrogen bonding groups demonstrated preferential alignment regardless of length,highlighting the significance of stabilizing intermolecular interactions in the alignment *** study discussed the underlying principles of the molecular packing process and shed light on the complexity of molecular self-assembly in nanoconfined spaces.

关键词： self-assembly confinement condition nanocorral orientation bias scanning tunneling microscopy

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nutritional epigenetics education improves diet and attitude of parents of children with autism or attention deficit/hyperactivity disorder

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World Journal of Psychiatry 2024年第1期14卷 159-178页

作者： Renee J Dufault Katherine M Adler David O Carpenter steven G Gilbert Raquel A Crider College of Graduate Health Studies A.T.Still UniversityKirksvilleMO 63501United States Department of Research Food Ingredient and Health Research InstituteNaalehuHI 96772United States Department of Health Sciences University of New HavenWest HavenCT 06516United States Institute for Health and the Environment School of Public HealthState University of New YorkAlbanyNY 12222United States Department of Research Institute of Neurotoxicology and Neurological DisordersSeattleWA 98105United States Department of Statistics Food Ingredient and Health Research InstituteNaalehuHI 96772United States

BACKGROUnD Unhealthy maternal diet leads to heavy metal exposures from the consumption of ultra-processed foods that may impact gene behavior across generations,creating conditions for the neurodevelopmental disorders known as autism and attention deficit/hyperactivity disorder(ADHD).Children with these disorders have difficulty metabolizing and excreting heavy metals from their bloodstream,and the severity of their symptoms correlates with the heavy metal levels measured in their *** may play a key role in helping parents reduce their ultra-processed food and dietary heavy metal intake by providing access to effective nutritional epigenetics *** To test the efficacy of nutritional epigenetics instruction in reducing parental ultra-processed food *** The study utilized a semi-randomized test and control group pretest-posttest pilot study design with participants recruited from parents having a learning-disabled child with autism or ***-two parents who met the inclusion criteria were randomly selected to serve in the test(n=11)or control(n=11)*** test group participated in the six-week online nutritional epigenetics tutorial,while the control group did *** efficacy of the nutritional epigenetics instruction was determined by measuring changes in parent diet and attitude using data derived from an online diet survey administered to the participants during the pre and post intervention *** intake scores were derived for both ultra-processed and whole/organic *** sample t-tests were conducted to determine any differences in mean diet scores within each *** There was a significant difference in the diet scores of the test group between the pre-and post-intervention *** parents in the test group significantly reduced their intake of ultra-processed foods with a preintervention diet score of 70(mean=5.385,SD=2.534)and a post-intervention diet score of 113(mean=8.692,SD=1.750)and the

关键词： Epigenomics Parenteral nutrition Autism Attention deficit/hyperactivity disorder Ultra-processed foods Heavy metals

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Development and application of photocatalytic coating for roadside nO_(x) mitigation in Hong Kong

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Chinese Chemical Letters 2024年第3期35卷 153-157页

作者： Xinwei Li Pengge Wang Shuwen Han Yu Huang Wingkei Ho steven Sai Hang Ho Shun-cheng Lee Meng Wang Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong KongChina State Key Laboratory of Loess and Quaternary Geology(SKLLQG)and Key Laboratory of Aerosol Chemistry and Physics Institute of Earth EnvironmentChinese Academy of SciencesXi'an 710061China Department of Science and Environmental Studies The Education University of Hong KongHong KongChina Division of Atmospheric Sciences Desert Research InstituteRenoNV 89512United States

A facile chemical method for the development of photocatalytic coating products was proposed based on practical application perspective for the Hong Kong roadside nitrogen oxides(nO_(x))***_(2)-based photocatalytic coating PC-C film with crystallized size of around 5–6 nm was synthesized with the peptization of H_(2)O_(2).The PC-C coating possesses a super-hydrophilicity surface and is proven to have a nO_(x)degradation rate of 46.8%with an optimum pH level of *** addition,the PC-C coating presents a promising photocatalytic nO_(x)degradation compared with other commercially available coating products and P25 when applied on two building materials of poly-methyl methacrylate(PMMA)and concrete surface.A weather resistance simulation and a 180-day on-site field trial were carried out the attenuation effects of photocatalytic coating applied in outdoor *** on epidemiological estimation and field investigation,hospital admissions for respiratory diseases(HARD)and mortality cases(MC)could be reduced with the application of PC-C coating along the street *** work demonstrates the feasibility of air pollution control measures for the local roadside nO_(x)using photocatalytic technology,offering promising health benefits with environmental remediation.

关键词： Photocatalysis Coating nO_(x) mitigation Hong Kong Roadside

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Development,validation,and transportability of several machine-learned,non-exercise-based VO_(2max)prediction models for older adults

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Journal of Sport and Health Science 2024年第5期13卷 611-620页

作者： Benjamin T.Schumacher Michael J.LaMonte Andrea Z.LaCroix Eleanor M.Simonsick steven P.Hooker Humberto Parada Jr. John Bellettiere Arun Kumar Herbert Wertheim School of Public Health and Human Longevity Science University of California San DiegoLa JollaCA 92093USA Department of Epidemiology and Environmental Health School of Public Health and Health ProfessionsUniversity at BuffaloState University of New YorkBuffaloNY 14214USA Translational Gerontology Branch Intramural Research ProgramNational Institute on AgingNational Institutes of HealthBaltimoreMD 21225USA College of Health and Human Services San Diego State UniversitySan DiegoCA 92182USA Division of Epidemiology and Biostatistics School of Public HealthSan Diego State UniversitySan DiegoCA 92182USA University of California San Diego Moores Cancer Center La JollaCA 92093USA Computer Science and Engineering and Halicioglu Data Science Institute University of California San DiegoLa JollaCA 92093USA

Background:There exist few maximal oxygen uptake(VO_(2max))non-exercise-based prediction equations,fewer using machine learning(ML),and none specifically for older *** direct measurement of VO_(2max)is infeasible in large epidemiologic cohort studies,we sought to develop,validate,compare,and assess the transportability of several ML VO_(2max)prediction ***:The Baltimore Longitudinal Study of Aging(BLSA)participants with valid VO2_(max)tests were included(n=1080).Least absolute shrinkage and selection operator,linear-and tree-boosted extreme gradient boosting,random forest,and support vector machine(SVM)algorithms were trained to predict VO_(2max)*** developed these algorithms for:(a)the overall BLSA,(b)by sex,(c)using all BLSA variables,and(d)variables common in aging ***,we quantified the associations between measured and predicted VO_(2max)and ***:The age was 69.0±10.4 years(mean±SD)and the measured VO_(2max)was 21.6±5.9 mL/kg/*** absolute shrinkage and selection operator,linear-and tree-boosted extreme gradient boosting,random forest,and support vector machine yielded root mean squared errors of 3.4 mL/kg/min,3.6 mL/kg/min,3.4 mL/kg/min,3.6 mL/kg/min,and 3.5 mL/kg/min,*** quartiles of measured VO_(2max)showed an inverse gradient in mortality *** VO_(2max)variables yielded similar effect estimates but were not robust to ***:Measured VO_(2max)is a strong predictor of *** ML can improve the accuracy of prediction as compared to simpler approaches but estimates of association with mortality remain sensitive to *** studies should seek to reproduce these results so that VO_(2max),an important vital sign,can be more broadly studied as a modifiable target for promoting functional resiliency and healthy aging.

关键词： Cardiorespiratory fitness Prediction algorithms Epidemiology Mortality

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