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Sperm quality metrics were improved by a biomimetic microfluidic selection platform compared to swim-up methods

Microsystems & Nanoengineering 2023年第2期9卷 261-274页

作者： steven a.vasilescu Lin Ding Farin Yazdan Parast Reza Nosrati Majid Ebrahimi Warkiani NeoGenix Biosciences pty Itd SydneyNSW 2126Australia. School of Biomedical Engineering University of Technology SydneySydneyNSW 2007Australia Department of Mechanical&Aerospace Engineering Monash UniversityClaytonVIC 3800Australia institute for Biomedical Materials&Devices(IBMD) Faculty of ScienceUniversity of Technology SydneySydneyNSW.2007Australia

Sperm selection is an essential component of all assisted reproductive treatments(ARTs)and is by far the most neglected step in the ART workflow in regard to technological *** sperm selection methodologies typically produce a higher total number of sperm with variable motilities,morphologies,and levels of DNA ***-standard techniques,including density gradient centrifugation(DGC)and swim-up(SU),have been shown to induce DNA fragmentation through introducing reactive oxygen species(ROS)during ***,we demonstrate a 3D printed,biologically inspired microfluidic sperm selection device(MSSP)that utilizes multiple methods to simulate a sperms journey toward *** are first selected based on their motility and boundary-following behavior and then on their expression of apoptotic markers,yielding over 68%more motile sperm than that of previously reported methods with a lower incidence of DNA fragmentation and *** from the MsSP also demonstrated higher motile sperm recovery after cryopreservation than that of sU or neat *** were conducted side-by-side against conventional SU methods using human semen(n=33)and showed over an 85%improvement in DNA integrity with an average 90%reduction in sperm *** results that the platform is easy-to-use for sperm selection and mimics the biological function of the female reproductive tract during conception.

关键词： utilize yielding neglected

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Robot-assisted surgery for gastric cancer

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World Journal of Gastrointestinal Oncology 2016年第1期8卷 8-17页

作者： livia procopiuc stefan tudor mircea manuc mircea diculescu catalin vasilescu "carol davila"university of medicine and pharmacy 020022 BucharestRomania department of general surgery and liver transplantation fundeni clinical institute022238 BucharestRomania department of gastroen-terology and hepatology fundeni clinical institute022238 BucharestRomania

Minimally invasive surgery for gastric cancer is a rela-tively new research field, with convincing results mostly stemming from Asian countries. The use of the robotic surgery platform, thus far assessed as a safe procedure, which is also easier to learn, sets the background for a wider spread of minimally invasive technique in the treatment of gastric cancer. This review will cover the literature published so far, analyzing the pros and cons of robotic surgery and highlighting the remaining study questions.

关键词： Gastric cancer survival Robotic surgery Gastric cancer surgery Lymphadenectomy Minimallyinvasive surgery

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Relationship between plasma adipokines, inflammation, insulin resistance and subclinical atherosclerosis in newly diagnosed type 2 diabetes

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Journal of Diabetes Mellitus 2011年第2期1卷 17-25页

作者： Razvan vasilescu Silvi Ifrim Constantin Ionescu-Tirgoviste 不详

Background: The aim of this study was to investigate the occurrence of subclinical atherosclerosis, evaluated by carotid artery intima-media thickness (CIMT) in subjects with newly diagnosed type 2 diabetes. Methods: A total of 167 subjects, 50 newly diagnosed type 2 diabetic subjects and 117 non-diabetic subjects were included in the study. Obese and overweight newly diagnosed type 2 diabetic patients were matched for age and BMI with obese and overweight non-diabetic subjects. Only postmenopausal women were selected. The following biomarkers were analyzed: fasting glucose, HbA1c, fasting insulin, fasting proinsulin, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, adiponectin, leptin, hs-CRP, urine albumin/creatinine ratio. 75 g oral glucose tolerance test was performed in all subjects. Ultrasound imaging was used to evaluate IMT of the common carotid artery. Results: CIMT was greater in newly diagnosed type 2 patients compared to non-diabetic subjects. When analyzed by BMI, the difference regarding CIMT between diabetic and non-diabetic subjects was significant only in overweight subjects, in both sexes. In univariate analysis in men with newly diagnosed type 2 diabetes, CIMT was positively correlated with age, SBP, triglycerides, leptin and negatively correlated with HDL-cholesterol and in women CIMT was positively correlated with SBP and leptin. Independent determinants of CIMT in patients with newly diagnosed type 2 diabetes were in men age (β = 0.556, p = 0.0028) and log leptin (β = 0.393, p = 0.049) and in women systolic blood pressure (β = 0.48, p = 0.026). Conclusions: Subclinical atherosclerosis is present in newly diagnosed type 2 diabetic subjects. Body fat accumulation in men and hypertension in postmenopausal women have a primary role in increase carotid intima-media thickness.

关键词： Newly Diagnosed Type 2 Diabetes Atheroscleorsis Common Carotid Artery Intima-Media Thickness

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New parameters of surface electromyography and mechanography for the evaluation of the muscle fatigue at athletes

New parameters of surface electromyography and mechanography...

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第29届FIMS世界运动医学大会

作者： vasilescu M Rusu L University of Craiova Romania

Purpose: The phenomenon of localized muscle fatigue is most commonly described as occurring when there is a decrement in the amount of tension a muscle can generate, or when the muscle can no longer maintain the required force level due to exercise. The present study was designed to examine the relationship between the development of muscle fatigue and the effect it has on sport performance, especially during maximal voluntary contraction, with the help of the surface electromyography (EMGS) and mechanography (MMG).

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Mycotoxins Incidence in Romanian Malting Barley （Harvest 2009）

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Journal of Agricultural Science and Technology(B) 2011年第6期1卷 831-838页

作者： M. Begea E. Balauta L. vasilescu A. Sirbu ICA Research ＆ Development Bucharest 060021 Romania National Agricultural Research and Development Institute Fundulea Calarasi County 915200 Romania Constantin Brancoveanu University FMMAE Ramnicu Valcea Ramnicu Valcea 240210 Valcea County Romania

The presence of deoxynivalenol （DON）, total aflatoxins, ochratoxin （OTA） and zearalenone （ZEA） was investigated in malting barley samples harvested in Romania using an ELISA method （VERATOX, Neogen）. In 7 out of 14 barley samples the aflatoxins were not found at detectable levels （50%）. In 9 out of 14 barley samples the OTA was not found at detectable levels （64.29%）. In 1 out of 14 barley samples the DON was not found at detectable levels （7.14%）. In 13 out of 14 barley samples （92.86%） the ZEA was above the acceptable limit （100μg/kg）. For all barley samples the aflatoxins, DON and OTA were in line with European Union regulations in force （4.0 μg/kg for aflatoxins, 1,250.0μg/kg for DON, 5.0 μg/kg for OTA, respectively）.

关键词： Mycotoxins barley food safety ELISA.

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能量桩温度及变形特性现场实测研究

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安徽理工大学学报（自然科学版） 2022年第3期42卷 36-43页

作者：尹可心 Roxana.vasilescu 南京航空航天大学土木与机场工程系江苏南京211106 南特中央理工学院土木工程系大西洋卢瓦尔省南特44321 PINTO建筑工程公司特殊基础工程部伊勒-维莱讷省富热尔35300

能量桩技术作为一种利用浅层地热能的新技术,可以有效降低建筑物能源消耗,减少二氧化碳排放。为研究能量桩系统在运行前后的较长时期内的进/出口换热液体温度、桩身温度以及轴向变形等特征,对位于法国塞纳-马恩省的Sept Sorts镇某新建... 详细信息

能量桩技术作为一种利用浅层地热能的新技术,可以有效降低建筑物能源消耗,减少二氧化碳排放。为研究能量桩系统在运行前后的较长时期内的进/出口换热液体温度、桩身温度以及轴向变形等特征,对位于法国塞纳-马恩省的Sept Sorts镇某新建污水预处理厂房的能量桩系统开展了现场全尺监测试验。监测结果显示,换热管网进口(T_(inlet))和出口(T_(outlet))液体之间的平均温度差约为5℃,表明该能量桩系统具有良好的换热能力。在能量桩运行前,随深度增加,桩身温度先减小然后趋于稳定,最终保持在13℃左右(桩体深度>5m)。在能量桩运行后,在装有换热管的7m深度范围内桩身温度基本保持恒定。此外,能量桩运行前后的桩身温度变化幅度相差不大,均小于10℃。由能量桩运行引起的桩身轴向变形与由季节性土体温度变化引起的轴向变形具有相同的数量级,但前者沿桩体上的区域分布更加均匀。在监测期间,桩身轴向应变变化范围为-50μm/m~+30μm/m,数值虽小但在设计中不应忽略。

关键词：能量桩温度变化轴向应变现场试验

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常染色体显性遗传多囊肾病肾脏体积CT的准确性、重复性和放射剂量

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国际医学放射学杂志 2019年第4期 487-488页

作者：高天阳 M.U.Bevilacqua C.J.Hague A.Romann H.Sheitt D.M.vasilescu T.W.Yi Division of Nephrology University of British Columbia British Columbia Provincial Renal Agency

摘要常染色体显性遗传多囊肾病的总肾容量评估是有价值的,但MRI平面法的参考标准需要MRI检查和耗时的测量。目的确定可否通过使用替代方法(低剂量CT和省时

关键词：常染色体显性遗传多囊肾病低剂量 MRI 放射剂量 CT 肾脏体积

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