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Blood biomarkers of Alzheimer’s disease:important considerations for use in clinical practice

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Neural Regeneration Research 2025年第1期20卷 205-206页

作者： Sarah Fullam Sean o’Dowd Antoinette o’connor Department of Neurology Tallaght University HospitalDublinIreland Academic Unit of Neurology Trinity College DublinIreland

Introduction:Fluid and positron emission tomography(PET)biomarkers that enable the detection of the hallmark proteins of Alzheimer’s disease(AD)(amyloid and tau)have revolutionized our approach to the diagnosis of *** evolution of AD diagnostic criteria to include biological characterization(Alzheimer’s Association Working Group,2023)provides an appropriate framework to reduce levels of clinico-pathologic mismatch and improve in-vivo diagnostic *** the therapeutic landscape for neurodegenerative disease evolves,it is increasingly incumbent on clinicians to provide timely,and pathologically precise diagnoses for ***,the expensive and invasive nature of these tests limits their scalability.

关键词： Blood Alzheimer diagnosis

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财务透明:云计算的起点

软件和信息服务 2010年第6期 78-79页

作者： steve o’connor BMC软件公司IT业务管理部

财务透明度可以帮助IT管理者做出更好的决策，比如透过云开展IT服务。

关键词：财务计算 IT服务管理者透明度

The electrochemical detection of bioterrorism agents: a review of the detection, diagnostics, and implementation of sensors in biosafety programs for Class A bioweapons

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Microsystems & Nanoengineering 2021年第1期7卷 21-39页

作者： connor o’Brien Kathleen Varty Anna Ignaszak Department of Chemistry University of New Brunswick30 Dineen DriveFrederictonNB E3B 5A3Canada

During the past year,disease has shown us the iron grip it can hold over a population of *** systems can be overwhelmed,economies can be brought into recession,and many people can be harmed or *** weaponized,diseases can be manipulated to create a detriment to health while becoming an economic burden on any *** is consequently prudent that easy detection of bioweapons is available to governments for protecting their *** sensing displays many distinct advantages,such as its low limit of detection,low cost to run,rapid generation of results,and in many instances *** therefore present a wide array of electrochemical sensing platforms currently being fabricated,a brief summary of Class A bioweapons,and the potential future of bioweapon detection and biosafety.

关键词： electrochemical instance programs

Mshpy23:a user-friendly,parameterized model of magnetosheath conditions

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Earth and Planetary Physics 2024年第1期8卷 89-104页

作者： Jaewoong Jung Hyunju connor Andrew Dimmock steve Sembay Andrew Read Jan Soucek NASA Goddard Space Flight Center GreenbeltMDUSA Department of Astronomy University of MarylandCollege ParkMDUSA Swedish Institude of Space Physics UppsalaSweden University of Leicester LeicesterUK Institute of Atmospheric Physics Academy of Sciences of the Czech Republic

Lunar Environment heliospheric X-ray Imager(LEXI)and Solar wind−Magnetosphere−Ionosphere Link Explorer(SMILE)will observe magnetosheath and its boundary motion in soft X-rays for understanding magnetopause reconnection modes under various solar wind conditions after their respective launches in 2024 and *** conditions,namely,plasma density,velocity,and temperature,are key parameters for predicting and analyzing soft X-ray images from the LEXI and SMILE *** developed a userfriendly model of magnetosheath that parameterizes number density,velocity,temperature,and magnetic field by utilizing the global Magnetohydrodynamics(MHD)model as well as the pre-existing gas-dynamic and analytic *** this parameterized magnetosheath model,scientists can easily reconstruct expected soft X-ray images and utilize them for analysis of observed images of LEXI and SMILE without simulating the complicated global magnetosphere ***,we created an MHD-based magnetosheath model by running a total of 14 openGGCM global MHD simulations under 7 solar wind densities(1,5,10,15,20,25,and 30 cm)and 2 interplanetary magnetic field Bz components(±4 nT),and then parameterizing the results in new magnetosheath *** compared the magnetosheath model result with THEMIS statistical data and it showed good agreement with a weighted Pearson correlation coefficient greater than 0.77,especially for plasma density and plasma ***,we compiled a suite of magnetosheath models incorporating previous magnetosheath models(gas-dynamic,analytic),and did two case studies to test the *** MHD-based model was comparable to or better than the previous models while providing self-consistency among the magnetosheath ***,we constructed a tool to calculate a soft X-ray image from any given vantage point,which can support the planning and data analysis of the aforementioned LEXI and SMILE missions.A release of the code has been uploaded to a Git

关键词： magnetosheath python modeling

Integrative multi-omics and systems bioinformatics in translational neuroscience:A data mining perspective

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Journal of Pharmaceutical Analysis 2023年第8期13卷 836-850页

作者： Lance M.o'connor Blake A.o'connor Su Bin Lim Jialiu Zeng Chih Hung Lo College of Biological Sciences University of MinnesotaMinneapolisMN55455USA School of Pharmacy University of WisconsinMadisonWI53705USA Department of Biochemistry and Molecular Biology Ajou University School of MedicineSuwon16499South Korea Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore308232Singapore

Bioinformatic analysis of large and complex omics datasets has become increasingly useful in modern day biology by providing a great depth of information,with its application to neuroscience termed *** mining of omics datasets has enabled the generation of new hypotheses based on differentially regulated biological molecules associated with disease mechanisms,which can be tested experimentally for improved diagnostic and therapeutic targeting of neurodegenerative ***,integrating multi-omics data using a systems bioinformatics approach will advance the understanding of the layered and interactive network of biological regulation that exchanges systemic knowledge to facilitate the development of a comprehensive human brain *** this review,we first summarize data mining studies utilizing datasets from the individual type of omics analysis,including epigenetics/epigenomics,transcriptomics,proteomics,metabolomics,lipidomics,and spatial omics,pertaining to Alzheimer's disease,Parkinson's disease,and multiple *** then discuss multi-omics integration approaches,including independent biological integration and unsupervised integration methods,for more intuitive and informative interpretation of the biological data obtained across different omics *** further assess studies that integrate multi-omics in data mining which provide convoluted biological insights and offer proof-of-concept proposition towards systems bioinformatics in the reconstruction of brain ***,we recommend a combination of high dimensional bioinformatics analysis with experimental validation to achieve translational neuroscience applications including biomarker discovery,therapeutic development,and elucidation of disease *** conclude by providing future perspectives and opportunities in applying integrative multi-omics and systems bioinformatics to achieve precision phenotyping of neurodegenerative diseases and towards personaliz

关键词： Multi-omics integration Systems bioinformatics Data mining Human brain profile reconstruction Translational neuroscience

Role of radiation therapy in gastric adenocarcinoma

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World Journal of Gastroenterology 2006年第10期12卷 1511-1520页

作者： Lisa Hazard John o'connor Courtney Scaife Departments of Radiation oncology University of Utah School of Medicine Salt Lake CityUTUnited States Department of Radiation oncology Tulane University New OrleansLAUnited States Departments of Surgery University of Utah School of Medicine Salt Lake CityUTUnited States

outcomes in patients with gastric cancer in the United States remain disappointing, with a five-year overall survival rate of approximately 23%. Given high rates of local-regional control following surgery, a strong rationale exists for the use of adjuvant radiation therapy. Randomized trials have shown superior local control with adjuvant radiotherapy and improved overall survival with adjuvant chemoradiation. The benefit of adjuvant chemoradiation in patients who have undergone D2 lymph node dissection by an experienced surgeon is not known, and the benefit of adjuvant radiation therapy in addition to adjuvant chemotherapy continues to be defined. In unresectable disease, chemoradiation allows long-term survival in a small number of patients and provides effective palliation. Most trials show a benefit to combined modality therapy compared to chemotherapy or radiation therapy alone. The use of pre-operative, intra-operative, 3D conformal, and intensity modulated radiation therapy in gastric cancer is promising but requires further study. The current article reviews the role of radiation therapy in the treatment of resectable and unresectable gastric carcinoma, focusing on current recommendations in the United States.

关键词： Radiation therapy Gastric cancer Stomach cancer Chemoradiation Adjuvant therapy Neoadjuvant therapy Intra-operative radiation therapy 3D conformal radiation therapy Intensity modulated radiation therapy

Fabrication and in vivo 2-photon microscopy validation of transparent PEDoT:PSS microelectrode arrays

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Microsystems & Nanoengineering 2022年第4期8卷 183-190页

作者： Gerwin Dijk Attila Kaszas Jolien Pas Rodney Philip o’connor Mines Saint-Etienne Centre CMPDepartment of BioelectronicsGardanne 13541France Panaxium SAS Aix-en-Provence 13100France

Transparent microelectrode arrays enable simultaneous electrical recording and optical imaging of neuronal networks in the *** made of the conducting polymer poly(3,4-ethylenedioxythiophene)doped with polystyrene sulfonate(PEDoT:PSS)are transparent;however,device fabrication necessitates specific processes to avoid deterioration of the organic ***,we present an innovative fabrication scheme for a neural probe that consists of transparent PEDoT:PSS electrodes and demonstrate its compatibility with 2-photon *** electrodes show suitable impedance to record local field potentials from the cortex of mice and sufficient transparency to visualize GCaMP6f-expressing neurons underneath the PEDoT:PSS *** results validate the performance of the neural probe,which paves the way to study the complex dynamics of in vivo neuronal activity with both a high spatial and temporal resolution to better understand the brain.

关键词： material. transparent microelectrode

想象图书馆的未来:图书馆与信息机构情境规划

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内蒙古图书馆工作 2019年第1期 2-2页

作者： [澳]欧书亭 [澳]苏德毅李丹(译) 不详

内容提要《想象图书馆的未来:图书馆与信息机构情境规划》一书从情境的含义入手,探讨了情境的价值、未来对图书馆的影响等,在信息环境的复杂性一章中,作者考察了图书馆赖以存在的环境以帮助读者认清环境对图书馆的影响,随后通过阐述图... 详细信息

内容提要《想象图书馆的未来:图书馆与信息机构情境规划》一书从情境的含义入手,探讨了情境的价值、未来对图书馆的影响等,在信息环境的复杂性一章中,作者考察了图书馆赖以存在的环境以帮助读者认清环境对图书馆的影响,随后通过阐述图书馆运营模式的变化、情境规划的建立和执行过程中的选择问题为读者提供了规划未来可能的新方法,并具体探讨如何进行情境规划,最后通过具体案例展现情境规划的过程,从而为图情从业者提供了重新审视未来的工具。

关键词：图情图书馆情境规划规划未来具体案例内容提要从业者想象

Numerical investigation into water entry problems of a flat plate with air pockets

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Journal of ocean Engineering and Science 2023年第4期8卷 386-400页

作者： Casey o’connor Saeed Mohajernasab Nagi Abdussamie National Centre for Maritime Engineering and Hydrodynamics Australian Maritime CollegeUniversity of TasmaniaLauncestonTasmaniaAustralia

Computational Fluid Dynamics(CFD)investigations into water entry problems of a rigid flat plate with air pockets were systematically *** Volume of Fluid(VoF)model was utilised to capture localised slamming phenomena that occur during,and post-impact *** model’s geometry was modified to include a pocket on the slamming impact surface to investigate the effect of air entrapment on the magnitude and distribution of slamming forces and pressures.A parametric study was conducted on the geometric parameters of the modelled pocket by altering its area,depth,and volume to exam-ine the response of slamming force and pressure loading under several impact *** numerical results of slamming forces and pressures were in good agreement with experimental drop test measure-ments(with relative error of-6%and 7%for the magnitude of slamming force and pressure,respectively).The numerical results proved that the peak pressure is proportional to the magnitude of impact velocity squared(p maxαv^(2)).

关键词： Marine structures Slamming Air entrapment Computationalﬂuid dynamics Drop tests