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Correlating Bladder Cancer Risk Genes with Their Targeting MicroRNAs Using MMiRNA-Tar

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Genomics, Proteomics & Bioinformatics 2015年第3期13卷 177-182页

作者： Yang Liu steve Baker Hui Jiang Gary Stuart Yongsheng Bai Department of Electrical and Computer Engineering Rose-Hulman Institute of Technology Department of Math and Computer Science Indiana State University Department of Biostatistics University of Michigan Department of Biology Indiana State University The Center for Genomic Advocacy Indiana State University

The Cancer Genome Arias （TCGA）（http：//***） is a valuable data resource focused on an increasing number of well-characterized cancer genomes. In part, TCGA provides detailed information about cancer-dependent gene expression changes, including changes in the expression of transcription-regulating microRNAs. We developed a web interface tool MMiRNA-Tar （http：f/***-Tar） that can calculate and plot the correlation of expression for mRNA-microRNA pairs across samples or over a time course for a list of pairs under different prediction confidence cutoff criteria. Prediction confidence was estab- lished by requiring that the proposed mRNA-microRNA pair appears in at least one of three target prediction databases： TargetProfiler, TargetScan, or miRanda. We have tested our MMiRNA-Tar tool through analyzing 53 tumor and 11 normal samples of bladder urothelial carcinoma （BLCA） datasets obtained from TCGA and identified 204 microRNAs. These microRNAs were correlated with the mRNAs of five previously-reported bladder cancer risk genes and these selected pairs exhib- ited correlations in opposite direction between the tumor and normal samples based on the cus- tomized cutoff criterion of prediction. Furthermore, we have identified additional 496 genes （830 pairs） potentially targeted by 79 significant microRNAs out of 204 using three cutoff criteria, i.e.,false discovery rate （FDR）〈 0.1, opposite correlation coefficient between the tumor and normal samples, and predicted by at least one of three target prediction databases. Therefore, MMiRNA- Tar provides researchers a convenient tool to visualize the co-relationship between microRNAs and mRNAs and to predict their targeting relationship. We believe that correlating expression profiles for microRNAs and mRNAs offers a complementary approach for elucidating their interactions.

关键词： The Cancer Genome Atlas Bladder cancer MicroRNA mRNA Correlation Target prediction

Research on the atomic force microscopy-based fabrication of nanochannels on silicon oxide surfaces

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Chinese Science Bulletin 2010年第30期55卷 3466-3471页

作者： WANG ZhiQian JIAO NianDong TUNG steve DONG ZaiLi State Key Laboratory of Robotics Shenyang Institute of Automation Chinese Academy of Sciences Shenyang 110016 China Graduate University of the Chinese Academy of Sciences Beijing 100049 China Mechanical Engineering University of Arkansas Fayetteville Arkansas 72701 USA

The atomic force microscopy (AFM)-based nanomachining of nanochannels on silicon oxide surfaces is investigated both theoretically and experimentally. The relationships of nanochannel depth versus cutting velocity,nanochannel depth versus normal force,friction force versus cutting velocity,and friction force versus normal force are systematically studied. Using the derived theory and fabrication method,a nanochannel with an expected depth can be machined simply by controlling the vertical deflection signal on the position sensitive detector of AFM. The theoretical analysis and fabrication method can be effectively used for AFM-based fabrication of nanochannels.

关键词：原子力显微镜表面氧化硅氧化物基础位置敏感探测器制造纳米通道切割速度

Underworld-GT Applied to Guangdong,a Tool to Explore the Geothermal Potential of the Crust

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Journal of Earth Science 2015年第1期26卷 78-88页

作者： steve Quenette Yufei Xi John Mansour Louis Moresi David Abramson Monash e Research Centre Monash UniversityClayton 3800Australia The Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological Sciences School of Earth Sciences The University of MelbourneMelbourne 3010Australia Research Computing Centre The University of QueenslandSt Lucia 4072Australia

Geothermal energy potential is usually discussed in the context of conventional or engineered systems and at the scale of an individual reservoir. Whereas exploration for conventional reservoirs has been relatively easy, with expressions of resource found close to or even at the surface, exploration for non-conventional systems relies on temperature inherently increasing with depth and searching for favourable geological environments that maximise this increase. To utilitise the information we do have, we often assimilate available exploration data with models that capture the physics of the domi- nant underlying processes. Here, we discuss computational modelling approaches to exploration at a regional or crust scale, with application to geothermal reservoirs within basins or systems of basins. Target reservoirs have （at least） appropriate temperature, permeability and are at accessible depths. We discuss the software development approach that leads to effective use of the tool Underworld. We explore its role in the process of modelling, understanding computational error, importing and exporting geological knowledge as applied to the geological system underpinning the Guangdong Province, China.

关键词： Underworld-GT geothermal potential computational modelling approach Guangdong.

Mercury concentrations in blood and feathers of nestling Bald Eagles in coastal and inland Virginia

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Avian Research 2019年第1期10卷 36-42页

作者： David E.Kramar Bill Carstensen steve Prisley Jim Campbell Department of Anthropology and Earth Science Minnesota State University Moorhead Department of Geography Virginia Tech National Council for Air and Stream Improvement

Background:Mercury(Hg) and methylmercury are widely considered significant issues for wildlife,and in particular,piscivorous birds due to their widespread availability and neurotoxic *** a substantial number of studies of Hg contamination of Bald Eagles(Haliaeetus leucocephalus) have been conducted throughout the east coast of the United States,little has been done that directly addresses Hg contamination in Bald Eagles in Virginia,particularly the inland ***:We collected blood and feather samples from nestling Bald Eagles in the coastal plain,piedmont,and western regions of Virginia in an effort to determine which areas of the state were more likely to contain populations showing evidence of Hg *** analyzed the samples for total Hg using a Milestone ***:Samples collected from individuals located in the coastal region exhibited low concentrations of Hg compared to those further inland located on freshwater rivers and *** collected from the inland population exhibited levels in some areas that are approaching what may be considered to be sub-lethal to avian health(blood:mean 0.324 mg/kg,SE = 0.13,range = 0.06-0.97 mg/kg;feather:mean = 8.433 mg/kg,SE = 0.3,range = 3.811-21.14 mg/kg).Conclusions:Even after accounting for known point-sources of Hg,the inland eagle population in Virginia is susceptible to concentrations of Hg that are significantly higher than their coastal ***,several locations besides those currently known to be impacted by point-sources are exhibiting concentrations that are approaching a sub-lethal level.

关键词： Bald Eagle Haliaeetus leucocephalus Mercury Methyl-mercury Virginia

A Study of the Energy Management System in the Georgetown Public Hospital Cooperation (GPHC) in Guyana

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A Study of the Energy Management System in the Georgetown Pu...

作者： steve Ramsarran 湖南大学

学位级别：硕士

医院是全球医疗健康系统的支柱,本文对位于圭亚那乔治敦市的乔治敦公立医院(GPHC)的能量管理系统进行了研究。能量管理可以描述为通过不断努力降低能耗来提高现有医院能量利用效率的一种方式,包括以维持所获得的能量效率收益的方式来运... 详细信息

医院是全球医疗健康系统的支柱,本文对位于圭亚那乔治敦市的乔治敦公立医院(GPHC)的能量管理系统进行了研究。能量管理可以描述为通过不断努力降低能耗来提高现有医院能量利用效率的一种方式,包括以维持所获得的能量效率收益的方式来运营和维护医院。该研究是从乔治敦公立医院能量管理系统的角度进行的,以证明实施能量管理计划的重要性。本文分析了2018年乔治敦公立医院能量载体及其消费结构,结果表明:日常用电折算的燃料消耗了855.5吨,用于产生蒸汽的燃料消耗了156.2吨,用于应急发电的液化石油气消耗了12.2吨,用于发电的柴油消耗了4.2吨。另外,本文还确定了能源消耗的总体指标和通用指数,结果表明:该医院2018年病人每日人均能源消费为8.20 kg,大约消费9.82美元(USD)。从温室气体排放(GHG)分析,等效CO对健康有害,同时,日常用电是最高的能量载体且明确了耗电量最多的设备。本文通过对往年数据进行分析,获得了每个能量载体的消耗率,并计算了能量载体每年的总成本,根据锅炉和柴油发电机计算了温室气体排放量。等效二氧化碳是影响最大的气体,质量为50153740 kg千克。

关键词：医院能源管理系统能量载体指标和温室气体

Fabrication and characteristic detection of graphene nanoelectrodes

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Science China(Technological Sciences) 2014年第10期57卷 1950-1955页

作者： XIE ShuangXi LIU ZengLei JIAO NianDong TUNG steve LIU LianQing State Key Laboratory of Robotics Shenyang Institute of Automation Chinese Academy of Sciences University of Chinese Academy of Sciences Department of Mechanical Engineering University of Arkansas

Graphene has the advantages of high electrical conductivity,high heat conductivity,and low noise,which makes it a potential option for integrated circuits interconnection and *** this paper,we present a novel fabrication method for graphene nanoeletrodes with ***,graphene grown by chemical vapor deposition(CVD)is assembled to a chip with ***,an atomic force microscopy(AFM)based mechanical cutting method is developed to cut the graphene into nanoribbons and nanoeletrodes with *** the electronic property of a single nanodot is characterized using the garphene nanoelectrodes,demonstrating the effectiveness of the graphene *** fabricated graphene nanoeletrode pairs can be used as probes to detect single molecule in micro-environment,and show an attractive prospect for future molecular electronics applications.

关键词： atomic force microscopy graphene nanoelectrodes nanogap molecular electronics

Reservoir Potential of Silurian Carbonate Mud Mounds in the Southern Sichuan Basin,Central China

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Acta Geologica Sinica(English Edition) 2006年第5期80卷 684-692页

作者： ZHAO Wenzhi YANG Xiaoping steve KERSHAW ZHANG Baomin Research Institute of Petroleum Exploration and Development CNPC Xueyuan Road Beijing 100083 China Department of Geography and Earth Science Brunel University Uxbridge UB8 3PH UK

Lower Silurian mud mounds of the Shinuilan Formation, located in the southern Sichuan Basin, China, have developed in open shelf settings in deeper water than shallow-water reef-bearing limestones that occur in the region. An integration of the outcrop, drill data and seismic profiles show that contemporaneous faults have controlled the boundary and distribution of the sedimentary facies of Lower Silurian rocks in the southern Sichuan Basin. Mounds appear to have developed in the topographic lows formed by synsedimentary faulting, on the sheff of the Yangtze Platform. Average mound thickness is 20 m, maximum 35 m. Mounds are composed mainly of micrite, possibly microbially bound, and are overlain by shales. Mound tops are preferentially dolomitized, with the Mg^2＋ source probably from the clay content of the mound-top carbonate. Microfacies analysis and reconstruction of the diagenetic history reveal that the mound tops have higher porosity, and are gas targets; in contrast, mound cores and limbs show pores filled by three generations of calcite cement, and therefore have a low gas potential.

关键词： sedimentary facies reservoir mud mound Early Silurian Sichuan Basin China

Applications of next-generation sequencing to the study of biological invasions

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Current Zoology 2015年第3期61卷 488-504页

作者： Marc RIUS steve BOURNE Harry Guy HORNSBY Mark A. CHAPMAN Ocean and Earth Science National Oceanography Centre Southampton University of Southampton SO 14 3ZH UK Centre for Biological Sciences Life Sciences Building 85 University of Southampton Southampton SO 17 1B J UK

Through the widespread implementation of next-generation sequencing （NGS）, analyses of the whole genome （the entire DNA content） and the whole transcriptome （the genes being expressed） are becoming commonplace. NGS enables the analysis of a vast amount of previously unattainable genetic information. Despite this potential, NGS has yet to be widely imple- mented in genetic studies of biological invasions. The study of the genomic causes and consequences of biological invasions al- lows a deeper understanding of the molecular mechanisms underpinning the invasion process. In this review, we present a brief introduction to NGS followed by a synthesis of current research in the genomics and transcriptomics of adaptation and coloniza- tion. We then highlight research opportunities in the field, including：（1） assembling genomes and transcriptomes of non-model organisms, （2） identifying genomic regions and candidate genes underlying evolutionary processes, and （3） studying the adaptive role of gene expression variation. In particular, because introduced species face a broad range of physiological and biotic chal- lenges when colonizing novel and variable environments, transcriptomics will enable the study of gene regulatory pathways that may be responsible for acclimation or adaptation. To conclude, we identify a number of research approaches that will aid our fu- ture understanding of biological invasions

关键词： Exotic species Genomics Genotype-environment interactions Invasive species Invasion genetics Invasion route Non-indigenous species Non-native species

Awareness and Impact of Intellectual Property Rights among E-Waste Recyclers in Ghana

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Awareness and Impact of Intellectual Property Rights among E...

作者： WEPIA steve 西南科技大学

学位级别：硕士

技术的快速发展、人民生活水平的提高等导致电子垃圾成为世界上增长最快的垃圾,其处理处置不当可能对环境和人类健康造成巨大的有害影响。电子垃圾的循环利用是电子废弃物管理及处理处置的最佳方法。但其循环利用过程受知识产权的限制... 详细信息

技术的快速发展、人民生活水平的提高等导致电子垃圾成为世界上增长最快的垃圾,其处理处置不当可能对环境和人类健康造成巨大的有害影响。电子垃圾的循环利用是电子废弃物管理及处理处置的最佳方法。但其循环利用过程受知识产权的限制。本研究以加纳电子垃圾回收者为研究对象,采用文献调研、实地调查、数据统计分析等方法,讨论加纳回收者对知识产权的认知及知识产权对电子废弃物回收的影响。加纳电子垃圾回收从业人员主要是男性,受教育程度不高;大多数人不知道电子垃圾循环利用中的知识产权问题,绝大部分也不清楚本国的知识产权法,知识产权信息的获取主要源于媒体和教育。加纳电子垃圾回收绝大部分都是非正规的;循环再利用的电子垃圾主要包括手机、冰箱、电视和电脑;回收活动主要包括清洗、分类,修复、翻新、焚烧以获得有价金属;知识产权在许多方面对电子废物的回收产生了影响,如无法获得某些用于修理和翻新的零件等;建议确保加纳电子垃圾无冲突回收。论文研究有助于认识加纳电子垃圾回收的现状,提高加纳电子垃回收从业者及民众对知识产权的认识,对国际电子垃圾回收管理具有一定的意义。

关键词：知识产权电子废物回收利用加纳