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International Journal of Mining Science and Technology 2017年第1期27卷 71-76页

作者： Johnson Josh Jacobs Curt Ferster Mark Tadolini stephen Stillwater Mining Company NyeMT 59061USA Minova GeorgetownKYUSA

Stillwater Mining Company is the only U.S. producer of platinum group metals （PGMs） and the largest producer outside of South Afiica and Russia. The company controls a considerable portion of the J-M reef and is currently developing the ＂Blitz Project,＂ which will provide a main haulage level, ore pass systems, backfill plants, and fiow-through ventilation to increase production and ensure sustainable extraction of this critical strategic mineral. While driving two sub-parallel footwall laterals 8125 m in length, one of the development drifts experienced a massive fall in a geologically disturbed area created by a mafic dike intrusion. Combinations of a void fill material （Tekseal）, polyurethane injection, fore poling coupled with steel arches, and supplemental bolting allow safe and efficient advance through this geologically dis- turbed zone. This paper presents the details of this project.

关键词： TBM Ground Dike Cutterhead

Non-canonical BRAF variants and rearrangements in hairy cell leukemia

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Oncology Research 2024年第9期32卷 1423-1427页

作者： stephen E.LANGABEER Cancer Molecular Diagnostics St.James’s HospitalDublinD08 W9RTIreland

Hairy cell leukemia(HCL)is an uncommon mature B-cell malignancy characterized by a typical morphology,immunophenotype,and clinical *** vast majority of HCL patients harbor the canonical BRAF V600E mutation which has become a rationalized target of the subsequently deregulated RAS-RAF-MEK-MAPK signaling pathway in HCL patients who have relapsed or who are refractory to front-line ***,several HCL patients with a classical phenotype display non-canonical BRAF mutations or *** include sequence variants within alternative exons and an oncogenic fusion with the IGH *** must be taken in the molecular diagnostic work-up of patients with typical HCL but without the BRAF V600E to include investigation of these uncommon ***,functional characterization,and reporting of further such patients is likely to provide insights into the pathogenesis of HCL and enable rational selection of targeted inhibitors in such patients if required.

关键词： Hairy cell leukemia BRAF Molecular diagnostics Targeted therapy

Development of systemic therapy for hepatocellular carcinoma at 2013:Updates and insights

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World Journal of Gastroenterology 2014年第12期20卷 3135-3145页

作者： stephen L Chan Winnie Yeo Department of Clinical Oncology The Chinese University of Hong KongPrince of Wales Hospital State Key Laboratory in Oncology in South China

A growing number of multi-targeted tyrosine kinase inhibitor (TKI) has undergone testing for hepatocellular carcinoma (HCC). Unfortunately, this enthusiasm has recently been discouraged by a number of negative phase III studies on several anti-angiogenic TKIs in HCC. Several postulations have been made to account for this phenomenon, namely the plateau effects of anti-angiogenesis approach, the heterogeneity of HCC in terms of background hepatitis/cirrhosis and tumor biology, as well as the way how clinical trials are designed. Regardless of the underlying reasons, these results suggested that alternative strategies are necessary to further develop systemic therapy for HCC. Several new strategies are currently evaluated: for examples, molecular agents with activities against targets other than vascular endothelial growth factor receptor are being evaluated in on-going clinical trials. In addition, different approaches of targeted agents in combination with various treatment modalities, such as concurrently with another molecular agent, cytotoxic chemotherapy or transarterial chemoembolization, are being developed. This review aims to give a summary on the results of recently released clinical trials on TKIs, followed by discussion on some of the potential novel agents and combinational approaches. Future directions for testing innovative systemic agents for HCC will also be discussed.

关键词： Liver neoplasms Systemic treatment Biologics Staging Clinical trial

Predicting crash injury severity at unsignalized intersections using support vector machines and naïve Bayes classifiers

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Transportation Safety and Environment 2020年第2期2卷 120-132页

作者： stephen A.Arhin Adam Gatiba Howard University Transportation Research Center 23006th Street NWWashingtonDC 20059United States

The Washington,DC crash statistic report for the period from 2013 to 2015 shows that the city recorded about 41789 crashes at unsignalized intersections,which resulted in 14168 injuries and 51 *** economic cost of these fatalities has been estimated to be in the millions of *** is therefore necessary to investigate the predictability of the occurrence of theses crashes,based on pertinent factors,in order to provide mitigating *** research focused on the development of models to predict the injury severity of crashes using support vector machines(SVMs)and Gaussian naïve Bayes classifiers(GNBCs).The models were developed based on 3307 crashes that occurred from 2008 to *** SVM models and a GNBC model were *** most accurate model was the SVM with a radial basis kernel *** model predicted the severity of an injury sustained in a crash with an accuracy of approximately 83.2%.The GNBC produced the worst-performing model with an accuracy of 48.5%.These models will enable transport officials to identify crash-prone unsignalized intersections to provide the necessary countermeasures beforehand.

关键词： crashes unsignalized intersection support vector machines Gaussian naïve Bayes classifier injury severity

Improved Carroll’s hyperelastic model considering compressibility and its finite element implementation

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Acta Mechanica Sinica 2021年第5期37卷 785-796,I0002页

作者： stephen Kirwa Melly Liwu Liu Yanju Liu Jinsong Leng Department of Astronautical Science and Mechanics Harbin Institute of Technology(HIT)Harbin 150001China Center for Composite Materials and Structures Harbin Institute of Technology(HIT)Harbin 150080China

In engineering component design,material models are increasingly used in finite element simulations for an expeditious and less costly analysis of the design *** such,researchers strive to formulate models that are less complex,robust,and *** the realm of hyperelastic materials,phenomenological-based Carroll’s model is highly promising due to its simplicity and *** work proposes its further improvement by modifying the strain energy density function to comply with the restriction that it should vanish at reference configuration and adding a compressible term to capture the practical behavior of elastomeric materials and to avoid numerical problems during finite element *** model constants for both the original and the modified versions were obtained by fitting their respective expressions to the classical Treloar’s experimental data using the Levenberg-Marquardt *** modified model was implemented using Abaqus CAE 2016 via a vectorized user material(VUMAT)*** of the model predictions with Treloar’s experimental data demonstrated the superiority of the modified version particularly in the equibiaxial loading ***,the simulated and the experimentally observed behavior agreed to a great accuracy thus making the modified model suitable for simulating the loading response of components fabricated of elastomeric materials.

关键词： Elastomers Rubber-like Strain energy function Finite deformation

DCFNet:Discriminant Correlation Filters Network for Visual Tracking

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Journal of Computer Science & Technology 2024年第3期39卷 691-714页

作者：胡卫明王强高晋李兵 stephen Maybank State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of Sciences Beijing 100190China Department of Computer Science and Information Systems Birkbeck CollegeLondon WC1E 7HXU.K.

CNN(convolutional neural network)based real time trackers usually do not carry out online network update in order to maintain rapid tracking *** inevitably influences the adaptability to changes in object *** filter based trackers can update the model parameters online in real *** this paper,we present an end-to-end lightweight network architecture,namely Discriminant Correlation Filter Network(DCFNet).A differentiable DCF(discriminant correlation filter)layer is incorporated into a Siamese network architecture in order to learn the convolutional features and the correlation filter *** correlation filter can be efficiently updated *** previous work,we introduced a joint scale-position space to the DCFNet,forming a scale DCFNet which carries out the predictions of object scale and position *** combine the scale DCFNet with the convolutional-deconvolutional network,learning both the high-level embedding space representations and the low-level fine-grained representations for *** adaptability of the fine-grained correlation analysis and the generalization capability of the semantic embedding are complementary for visual *** back-propagation is derived in the Fourier frequency domain throughout the entire work,preserving the efficiency of the *** evaluations on the OTB(Object Tracking Benchmark)and VOT(Visual Object Tracking Challenge)datasets demonstrate that the proposed trackers have fast speeds,while maintaining tracking accuracy.

关键词： correlation filter convolutional neural network(CNN) visual tracking

Kreps&Scheinkman with Product Differentiation

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Frontiers of Economics in China-Selected Publications from Chinese Universities 2019年第2期14卷 203-219页

作者： stephen Martin Department of Economics Purdue UniversityWest LafayetteIN 47906USA

Kreps and Scheinkman (1983)'s celebrated result is that in a two-stage model of a market with homogeneous products in which firms noncooperatively pick capacities in the first stage and set prices in the second stage, the equilibrium outcome is that of a one-shot Cournot game. This note derives capacity best response functions for the first stage and extends the Kreps and Scheinkman result to the case of differentiated products.

关键词： Kreps and Scheinkman capacity choice Cournot oligopoly product differentiation

The East London glaucoma prediction score: web-based validation of glaucoma risk screening tool

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International Journal of Ophthalmology(English edition) 2013年第1期6卷 95-102页

作者： Cook stephen Longo-Mbenza Benjamin The Eye Centre East London Eastern Cape Province Faculty of Health Sciences Walter Sisulu University

AIM:It is difficult for Optometrists and General Practitioners to know which patients are at risk. The East London glaucoma prediction score (ELGPS) is a web based risk calculator that has been developed to determine Glaucoma risk at the time of screening. Multiple risk factors that are available in a low tech environment are assessed to provide a risk assessment. This is extremely useful in settings where access to specialist care is difficult. Use of the calculator is educational. It is a free web based service. Data capture is user specific. METHODS:The scoring system is a web based questionnaire that captures and subsequently calculates the relative risk for the presence of Glaucoma at the time of screening. Three categories of patient are described:Unlikely to have Glaucoma; Glaucoma Suspect and Glaucoma. A case review methodology of patients with known diagnosis is employed to validate the calculator risk assessment. RESULTS:Data from the patient records of 400 patients with an established diagnosis has been captured and used to validate the screening tool. The website reports that the calculated diagnosis correlates with the actual diagnosis 82% of the time. Biostatistics analysis showed:Sensitivity = 88% ; Positive predictive value = 97%; Specificity = 75%. CONCLUSION:Analysis of the first 400 patients validates the web based screening tool as being a good method of screening for the at risk population. The validation is ongoing. The web based format will allow a more widespread recruitment for different geographic, population and personnel variables.

关键词： glaucoma score diagnosis tomography management South Africa

Trends in global semen parameter values

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Asian Journal of Andrology 2013年第2期15卷 169-173,I0004页

作者： Harry Fisch stephen R Braun Departments of Urology and Reproductive Medicine Weill Cornell Medical College New York PresbyterianHospital New York NY 10028 USA

Allegations for a worldwide decline in semen *** values have not withstood scientific scrutiny. Methodological flaws in an influential 1992 paper are summarized here, and studies that have been published since 1992 are reviewed. Of the 35 major studies of time trends in semen quality reviewed here, eight （a total of 18 109 men） suggest a decline in semen quality; 21 （112 386 men） show either no change or an increase in semen quality;, and six （26 007 men） show ambiguous or conflicting results. The cause （or causes） of the geographical and temporal variations in semen parameter values reported by these diverse studies deserve further investigation.

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Who Supports Redistribution? Subjective Income Inequality in Japan and China

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Economic and Political Studies 2015年第2期3卷 30-59页

作者： stephen TAY the Lee Kong Chian School of Medicine Nanyang Technological University

Governments reduce income inequality with redistribution policies. These policies are often contentious because people who live in the same country have different preferences for redistribution. Some prefer the government to do more while others prefer the government to do less. Hence what explains the difference in preferences? Using the methodologically suitable cases of Japan and China, this paper contributes to the redistributive preference literature by proposing an alternative theory of how a person's subjective evaluation of and experiences with income inequality—subjective income inequality—affect his/her redistributive preferences. Specifically, a person who feels that his/her country's level of income inequality is too high is more likely to support government redistribution. But contrary to extant studies, this paper finds that a spatial locality's level of objective income inequality does not systematically affect its citizens' preference for redistribution. This finding has implications for redistribution policies because government policies in Japan and China—as with other countries—narrowly frame income inequality in the objective dimensions by pegging it to "objective" income inequality indices(e.g., Gini ratio), thereby ignoring the more important subjective dimensions of income inequality.

关键词： redistributive preferences subjective income inequ