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INDOMETHACIN INHIBITS hCG AND GnRH AGONIST-INDUCED SECRETION OF PLASMINOGEN ACTIVATOR BY GRANULOSA AND THECA INTERSTITIAL CELLS OF HYPOPHYSECTOMIZED RATS

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Science China Chemistry 1988年第7期31卷 807-817页

作者：刘以训,CAJANDER stephen Laboratory of Reproductive Biology Institute of Zoology Academia Sinica Beijing Department of Reproductive Medicine M-025 University of California San Diego La Jolla CA 92093 USA

Considerable data have shown that plasminogen activator (PA) may play an important role in the mechanism of ovulation. A recent report argued that PA is not a primary proteoIytic enzyme for follicular rupture because a dose of indomethacin that blocked ovulation did not inhibit ovarian PA content. To further clarify the specific role of PA in the ovulation, we have carefully examined the effect of indomethacin on the secretion of PA in granulosa and theca-interstitial (TI) cells following hCG or GnRH agonist administration in PMSG-primed hypophysectomized immature rats. We have also studies in vitro action of this compound on PA secretion in granulosa cells. The results indicate that indomethacin can only suppress hCG- and GnRH agonist-induced PA secretion, but not suppress the ovarian content of these enzymes.

关键词： indomethacin hCG GnRH agonist plasminogen activator ovulation.

Improving the wind and temperature measurements of an airborne meteorological measuring system

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第10期13卷 723-746页

作者： stephen FOSTER P.W.CHAN Aventech Research Inc. BarrieON L4N 2E3Canada Hong Kong Observatory KowloonHong KongChina

The Aircraft Integrated Meteorological Measuring System 20 Hz(AIMMS-20) has been used by the Hong Kong Observatory(HKO),China in data collection for tropical cyclone situations over the South China Sea and windshear and turbulence measurement at the Hong Kong International Airport(HKIA).This paper discusses possible methods for further enhancing the quality of the wind and temperature measurements from the *** wind measurement,the enhancement methods include:error modelling of the accelerometer(e.g.,bias offset and cross-axis rate sensitivity),global positioning system(GPS) phase lag consideration,better representation of the inertial measurement unit(IMU) velocity based on the GPS velocities and considering their location differences,consideration of the slower update of GPS velocity,and wing *** temperature measurement,the methods include the consideration of the temperature sensor response and the sensor housing *** results of typical flights using AIMMS-20 show that the accuracy of the wind and temperature data could be improved by 20%-30%.Though the discussion in the present paper is related mainly to a specific meteorological measuring system on a particular aircraft,the techniques so employed should be a useful reference for similar systems installed on other aircraft.

关键词： Airborne meteorological measurements Kalman filter Comparison with radiosonde measurement

Distributed Majorization-Minimization for Laplacian Regularized Problems

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IEEE/CAA Journal of Automatica Sinica 2019年第1期6卷 45-52页

作者： Jonathan Tuck David Hallac stephen Boyd IEEE the Department of Electrical Engineering Stanford University

We consider the problem of minimizing a block separable convex function(possibly nondifferentiable, and including constraints) plus Laplacian regularization, a problem that arises in applications including model fitting, regularizing stratified models, and multi-period portfolio optimization. We develop a distributed majorization-minimization method for this general problem, and derive a complete, self-contained, general,and simple proof of convergence. Our method is able to scale to very large problems, and we illustrate our approach on two applications, demonstrating its scalability and accuracy.

关键词： Convex optimization distributed optimization graphical networks Laplacian regularization

Power plant selection in a carbon constrained world the TERA(technoeconomic environmental risk analysis)

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航空动力学报 2009年第4期24卷 896-902页

作者： stephen Ogaji Pericles Pilidis Vishal Sethi Department of Power and Propulsion School of Engineering Cranfield University

There is an increasing concern that current trends of consumption of natural resources cannot *** is imperative that major targeted investments are made into economical and reliable environment friendly propulsion and power *** novel and promising concepts are being *** selection of the best candidates to pursue for investment becomes a very difficult choice.A detailed TERA(techno-economic environmental risk analysis) framework is described here to quantify risks and to compare and rank competing schemes on a formal and consistent *** technique is based on detailed and rigorous thermodynamic representations of power plants.A layer of environment,economic,weather and other models to describe the appropriate local conditions is superimposed to *** outcome is a techno-economic environmental risk analysis framework with appropriate detail of each power plant as applied to the appropriate *** results for each concept can then be compared and contrasted to make appropriate selections.

关键词： TERA(techno-economic environmental risk analysis) techno-economic risk analysis gas turbine multi-disciplinary optimisation(MDO)

Surgery for Peyronie＇s disease

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Asian Journal of Andrology 2013年第1期15卷 27-34页

作者： Laurence A Levine stephen M Larsen Department of Urology Rush University Medical Center Chicago IL 60612 USA

Peymnie＇s disease （PD） is most simply referred to as a fibrotic wound-healing disorder of the tunica albuginea. It is both a physically and psychologically devastating disorder that causes penile deformity, curvature, hinging, narrowing and shortening, which may compromise sexual function. Although a variety of non-surgical treatments have been suggested, none to date offer a reliable and effective correction of the penile deformity. As a result, surgery remains the gold standard treatment option, offering the most rapid and reliable treatment which will be the focus of this article. We review the preoperative evaluation, surgical algorithm, graft materials and postoperative management of PD. Outcomes for tunical shortening, tunical lengthening and penile prosthesis placement for penile straightening are reviewed. Tunica albuginea plication is the preferred method of straightening for men with adequate rigidity and less severe disease defined as curvature less than 70° without narrowing/hinging. Men who have more severe, complex deformity, but maintain strong preoperative erectile function should be considered candidates for straightening with plaque incision or partial excision and grafting. Finally, for those men who have inadequate rigidity and PD, penile prosthesis placement with straightening is the best approach to address both problems.

关键词： penile prosthesis Peyronie's disease, penile reconstruction plaque excision and grafting plaque incision tunica albuginea plication

Androgen deprivation therapy and side effects:are GnRH antagonists safer?

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Asian Journal of Andrology 2021年第1期23卷 3-10页

作者： stephen J Freedland Per-Anders Abrahamsson Division of Urology Department of SurgeryCedars-Sinai Medical CenterLos AngelesCA 90048USA Section of Urology Durham VA Medical CenterDurhamNC 27705USA Department of Urology SkSne University HospitalLund UniversityMalmo 20502Sweden.

Androgen deprivation therapy(ADT)with gonadotropin-releasing hormone(GnRH)agonists and antagonists is the mainstay of advanced prostate cancer *** drug classes decrease levels of luteinizing hormone and follicle-stimulating hormones(FSH),thereby lowering testosterone to castrate *** is associated with adverse events(AEs),including cardiovascular(CV)disorders,bone fractures,metabolic dysfunction,and impaired cognitive *** literature review discusses these AEs,with a focus on CV and bone-related events.A hypothesis-generating meta-analysis of six clinical trials showed a potentially increased risk for CV disorders with GnRH agonists versus the GnRH antagonist *** no study has directly compared GnRH agonists versus antagonists with a primary CV outcome,one hypothesis for this observation is that GnRH agonists lead to initial surges in FSH that may negatively impact CV health,whereas antagonists do *** agonists are associated with metabolic and cognitive AEs and while data are lacking for GnRH antagonists,no differences in risk are *** common AEs with ADT include injection site reactions,which are much more common with degarelix than with GnRH agonists,which may reflect differing administration and injection *** studies are needed to further evaluate and compare the safety profiles of GnRH agonists and antagonists,especially in patients with pre-existing CV disease and other *** should carefully evaluate benefits and risks when prescribing ADT and ensure that side effects are well managed.

关键词： androgen antagonists metabolic syndrome prostate cancer safety

Differential seed removal,germination and seedling growth as determinants of species suitability for forest restoration by direct seeding–A case study from northern Thailand

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Forest Ecosystems 2023年第4期10卷 526-534页

作者： Khuanphirom Naruangsri Pimonrat Tiansawat stephen Elliott Forest Restoration Research Unit(FORRU) Department of BiologyFaculty of ScienceChiang Mai University239 Huaykeaw RoadMueang DistrictChiang Mai50200Thailand

Background Direct seeding is potentially a more cost-effective alternative to conventional tree planting for restoring tropical forest ***,seed loss,due to removal and damage by animals,can substantially reduce seedling ***,this study examined the impact of seed predation on seedling establishment of five tree species,native to upland evergreen forests of northern Thailand:Hovenia dulcis,Alangium kurzii,Prunus cerasoides,Choerospondias axillaris and Horsfieldia *** tested the hypothesis that excluding animals would significantly reduce seed removal,and increase both germination and seedling *** objective was to calculate a composite index of the relative suitability of the species studied for direct *** Seeds were placed on the ground in a deforested site and subjected to five predator-exclusion treatments:wire cage,insecticide,cage+insecticide,open cage and no exclusion(control).Results Seed loss was highest for ***(the largest seed tested).Across species,wire cages significantly reduced seed loss by 12.4%compared with controls(P<0.001)suggesting that vertebrates were the major seed *** germination ranged from 0 to 77%among the species *** on relative species-performance scores(combining measures of survival and seedling growth),*** was the most suitable species for direct seeding,followed by *** and ***,whilst *** and *** were *** had small seeds with low seed germination,whereas *** was subjected to high seed *** Exclusion of seed predators and the selection of suitable species may substantially increase the success of direct seeding,as a technique for restoring upland evergreen forest *** more species for their suitability is needed,to provide more diverse options for forest restoration.

关键词： Direct seeding Seed predation Seedling survival Species performance Northern Thailand

Bioleaching of trace elements and rare earth elements from coal fly ash

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International Journal of Coal Science & Technology 2019年第1期6卷 74-83页

作者： stephen Park Yanna Liang Department of Civil and Environmental Engineering Southern Illinois University Carbondale1230 Lincoln Drive CarbondaleIL 62901USA Department of Environmental and Sustainable Engineering State University of New York at Albany1400 Washington Ave Albany NY 12222 USA

Coal fly ash originated from coal combustion has high concentrations of metals. If suitable leaching techniques are identified, then coal fly ash could serve as a useful source of valuable minerals including rare earth elements (REEs). In this study, three microbial strains, Candida bombicola, Phanerochaete chrysosporium and Cryptococcus curvatus were tested on their performance of leaching trace elements and REEs from fly ash. Through comparing mineral loss and leaching efficiencies resulting from indirect leaching or use of the culture supernatant, C. bombicola was identified to be the best leading to the highest mineral loss and extracting efficiencies of trace elements and REEs among the three strains. The highest mineral loss observed from using the supernatant of this yeast strain was 59.7%. Among all trace elements, As and Mo had the highest leaching efficiency of 80.9% and 79.5%. respectively. The same leaching test led to 67.7% of Yb and 64.6% of Er dissolved from the ash. This study, thus, demonstrated that bioleaching is feasible for leaching metals out of fly ash. The C. bombicola strain deserves further investigation due to its robust actions on metal leaching.

关键词： Cryptococcus curvatus Candida bombicola Phanerochaete chrysosporium - Coal fly ash Bioleaching Rare earth elements Trace metals

Experimental and MD simulation of 3-dodecyloxypropanamine and 3-tetradecyloxypropylamine adsorbed onto quartz(101) surface

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International Journal of Mining Science and Technology 2021年第6期31卷 1033-1042页

作者： Zhouyueyang Cheng Yimin Zhu Yanjun Li stephen Butt a College of Resource and Civil Engineering Northeastern UniversityShenyang 110819China b National-Local Joint Engineering Research Center of Refractory Iron Ore Resources Efficient Utilization Technology Shenyang 110819China c Faculty of Engineering and Applied Science Memorial University of NewfoundlandSt.John’s A1C 5S7Canada

In this paper,two surfactants,3-dodecyloxypropanamine(DOPA) and 3-tetradecyloxypropylamine(TOPA),were synthesized and used as collectors in the quartz micro-flotation in the *** tests,FT-IR,XPS measurements,and ab initio Molecular Dynamics(MD) simulations were conducted to research DOPA,TOPA,and dodecylamine(DDA)'s adsorption mechanisms onto quartz(101)*** results of micro-flotation show that the adsorption of DOPA and TOPA onto quartz surface is more robust than that of *** zeta-potential result shows that the DOPA/TOPA was adsorbed on quartz through electrostatic ***,MD simulation adsorption models were built to compare the computational properties of the three surfactants,such as the radial distribution function,and the interaction energies between the collectors and the quartz cleavage *** interaction energies of surfactants(RNH_(3)^(+) or RNH_(2)) on the quartz surface explained why the pH range of DOPA/TOPA is wider than that of *** analyses and MD simulations confirmed that DOPA bonded with the(101) surface of quartz through three types of hydrogen bonds between the-NH_(2) of DOPA and the O atom of *** hydrogen bonds of type A and type C were the most likely type and more potent than those of type B.

关键词： Quartz(101)surface Flotation Molecular dynamics 3-Dodecyloxypropanamine Adsorption