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白介素-10下调特应性皮炎抗微生肽的表达

世界核心医学期刊文摘（皮肤病学分册） 2006年第8期2卷 14-15页

作者： Howell m.D. Novak N. Bieber T. D.Y.m. Leung 任建文 National Jewish medical and Research Center Department of Pediatrics 1400 Jackson Street Denver CO 80206 United States Dr.

Recurrent skin infections in extrinsic atopic dermatitis (EAD)-may be because of the suppression of anti- microbial peptide (AmP) expression by interleukin (IL)- 4 and IL- 13. Twenty to thirty percent of AD, however, are classified as intrinsic atopic dermatitis (IAD). They exhibit normal serum IgE levels, no allergen-specific sensitization, and lower levels of IL- 4 and IL- 13 than EAD. Both forms of AD have increased propensity to skin infection, suggesting a novel mechanism for infection in IAD. In this study, we observed significantly decreased human β -defensin (HBD)- 2 gene expression in the skin of both IAD (p = 0.010) and EAD (p = 0.004), as compared with psoriasis patients. Conversely, IAD (p = 0.019) and EAD (p = 0.002) skin lesions exhibited elevated IL- 10 gene expression when compared with psoriasis. Using primary keratinocytes, we found that the deficiency in AmP expression is an acquired rather than a constitutive defect. Interestingly, neutralizing antibodies to IL- 10 augmented the production of tumor necrosis factor-α and interferon-γ by peripheral blood mononuclear cell from AD patients. Additionally, treatment of AD skin explants with anti-IL- 10 augmented the expression of both HBD-2 and LL- 37. Thus, increased levels of IL- 10 may contribute to the AmP deficiency in both IAD and EAD by reducing cytokines that induce AmP.

关键词：特应性皮炎白介素-10 IL-10基因肿瘤坏死因子α 外周血单核细胞 IL-13 IgE水平银屑病患者皮肤感染

Vitamin D Status, Autonomic Nervous System Activity, and Cardiometabolic Risk

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Open Journal of Internal medicine 2017年第3期7卷 37-51页

作者： Johanna Lopez Adriana Campa Fatma G. Huffman Juan P. Liuzzi Tan Li Ana H. martinez Serena m. Ferris Laura Lantigua Ashar Farooqi Ammar Rasul Steven E. Atlas Eduard Tiozzo Janet Konefal Judi m. Woolger Herbert G. Simoes John E. Lewis Department of Dietetics and Nutrition Florida International University Miami FL USA jackson memorial Hospital Miami FL USA Department of Psychiatry & Behavioral Sciences University of Miami Miller School of Medicine Miami FL USA Department of Biostatistics Florida International University Miami FL USA Department of Psychiatry & Behavioral Sciences University of Miami Miller School of Medicine Miami FL USA Department of medicine University of Miami Miller School of Medicine Miami FL USA Catholic University of Brasilia Taguatinga DF Brazil

Vitamin D and its association with cardiovascular disease (CVD) are currently a topic of investigation. The objective of this study was to explore the association between vitamin D status (serum 25-hydroxyvitamin D (25(OH)D)) and a cardiometabolic risk score (CmRS) derived from markers of cardiac autonomic nervous system activity, vascular dynamics, and body composition, using an innovative non-invasive technology. We found that individuals who were vitamin D sufficient ((25(OH)D) ≥ 30 ng/ml, n = 51), compared to those who were vitamin D insufficient (ml, n = 44), had significantly higher heart rate variability (as measured by time and frequency domain variables) and lower photoplethysmography analysis markers and CmRS. These outcomes show that vitamin D insufficient subjects had reduced cardio protective parasympathetic nervous system activity, increased endothelial dysfunction, and hence were at greater cardiometabolic risk, implying vitamin D may play a meaningful role in CVD.

关键词： Vitamin D Cardiometabolic Risk Autonomic Nervous System Endothelial Dysfunction

Impact of Iron Availability on <i>Bacillus amyloliquefaciens</i>Growth

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Advances in microbiology 2014年第13期4卷 962-967页

作者： D. Clark C. Youngblood m. Taplin E. Brown B. S. Williams C. Phillips B. Garner Biology Department Tougaloo College Tougaloo USA Department of Biology Jackson State University Jackson USA Department of Environmental Science Jackson State University Jackson USA

Bacillus amyloliquefaciens is a biocontrol agent whose genome has been sequenced. Within the genome of B. amyloliquefaciens are genes associated with iron chelation, but these genes are not found within all sequenced strains. The impact of iron availability on the B. amyloliquefaciens physiology was examined in this study. B. amyloliquefaciens ATCC 23843 was cultured under ironreplete and iron-deplete conditions for 48 hours, at 37°C. Final growth yields were dependent on iron concentration. Cultures grown in the absence of detectable iron were restricted in growth, but reached their highest yields at 48 hours. Iron restriction was confirmed by the presence of iron chelators in the filtrates. In contrast, B. amyloliquefaciens ATCC 23843 cultures grown with ferric ammonium citrate as the iron source research reached the highest yields at 24 hours. Iron chelator production was not detected in the ferric ammonium samples. A significant decrease in turbidity was observed for these cultures, which coincided with elevated spore production in B. amyloliquefaciens ATCC 23843. A decrease in turbidity was also observed on blood agar, where hemolysis was readily evident. We propose that iron impacts numerous physiological responses and further studies will elucidate the complex regulatory mechanisms governed by iron availability.

关键词： Bacillus Catechol Hemolysis Iron

measurement of integrated luminosities at BESⅢ for data samples at center-of-mass energies between 4.0 and 4.6 GeV

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Chinese Physics C 2022年第11期46卷 53-63页

作者： m.Ablikim m.N.Achasov P.Adlarson S.Ahmed m.Albrecht R.Aliberti A.Amoroso m.R.An Q.An X.H.Bai Y.Bai O.Bakina R.Baldini Ferroli I.Balossino Y.Ban V.Batozskaya D.Becker K.Begzsuren N.Berger m.Bertani D.Bettoni F.Bianchi J.Bloms A.Bortone I.Boyko R.A.Briere A.Brueggemann H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang W.L.Chang G.Chelkov C.Chen G.Chen H.S.Chen m.L.Chen S.J.Chen T.Chen X.R.Chen X.T.Chen Y.B.Chen Z.J.Chen W.S.Cheng X.Chu G.Cibinetto F.Cossio J.J.Cui H.L.Dai J.P.Dai A.Dbeyssi R.Ede Boer D.Dedovich Z.Y.Deng A.Denig I.Denysenko m.Destefanis F.De mori Y.Ding J.Dong L.Y.Dong m.Y.Dong X.Dong S.X.Du P.Egorov Y.L.Fan J.Fang S.S.Fang W.X.Fang Y.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng K Fischer m.Fritsch C.Fritzsch C.D.Fu H.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia P.T.Ge C.Geng E.m.Gersabeck A Gilman K.Goetzen L.Gong W.X.Gong W.Gradl m.Greco m.H.Gu C.Y Guan A.Q.Guo L.B.Guo R.P.Guo Y.P.Guo A.Guskov T.T.Han W.Y.Han X.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz Y.K.Heng C.Herold m.Himmelreich T.Holtmann G.Y.Hou Y.R.Hou Z.L.Hou H.m.Hu J.F.Hu T.Hu Y.Hu G.S.Huang K.X.Huang L.Q.Huang L.Q.Huang X.T.Huang Y.P.Huang Z.Huang T.Hussain N Husken W.Imoehl m.Irshad J.jackson S.Jaeger S.Janchiv Q.Ji Q.P.Ji X.B.Ji X.L.Ji Y.Y.Ji Z.K.Jia H.B.Jiang S.S.Jiang X.S.Jiang Y.Jiang J.B.Jiao Z.Jiao S.Jin Y.Jin m.Q.Jing T.Johansson N.Kalantar-Nayestanaki X.S.Kang R.Kappert m.Kavatsyuk B.C.Ke I.K.Keshk A.Khoukaz P.Kiese R.Kiuchi R.Kliemt L.Koch O.B.Kolcu B.Kopf m.Kuemmel m.Kuessner A.Kupsc W.Kuhn J.J.Lane J.S.Lange P.Larin A.Lavania L.Lavezzi Z.H.Lei H.Leithoff m.Lellmann T.Lenz C.Li C.Li C.H.Li Cheng Li D.m.Li F.Li G.Li H.Li H.Li H.B.Li H.J.Li H.N.Li J.Q.Li J.S.Li J.W.Li Ke Li L.J Li L.K.Li Lei Li m.H.Li P.R.Li S.X.Li S.Y.Li T.Li W.D.Li W.G.Li X.H.Li X.L.Li Xiaoyu Li Z.Y.Li H.Liang H.Liang H.Liang Y.F.Liang Y.T.Liang G.R.Liao L.Z.Liao J.Libby A.Limphirat C.X.Lin D.X.Lin T.Lin B.J.Liu C.X.Liu D.Liu F.H.Liu Fang Liu Feng Liu G.m.Liu H.Liu H.m.Liu Huanhuan Liu Huihui Liu J.B.Liu J.L.Liu J.Y.Liu K.L Institute of High Energy Physics Beijing 100049China Beihang University Beijing 100191China Beijing Institute of Petrochemical Technology Beijing 102617China Bochum Ruhr-University D-44780 BochumGermany Carnegie mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China China Center of Advanced Science and Technology Beijing 100190China COmSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China G.I.Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Hangzhou Normal University Hangzhou 310036China Helmholtz Institute mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University of Science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Institute of modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Ave.54BUlaanbaatar 13330Mongolia Jilin University Changchun 130012China Johannes Gutenberg University of mainz Johann-Joachim-Becher-Weg 45D-55099 MainzGermany Joint Institute for Nuclear Research 141980 DubnaMoscow regionRussia Justus-Liebig-Universitaet Giessen II.Physikalisches InstitutHeinrich-Buff-Ring 16

The integrated luminosities of data samples collected in the BESⅢ experiment in 2016-2017 at centerof-mass energies between 4.19 and 4.28 GeV are measured with a precision better than 1% by analyzing large-angle Bhabha scattering *** integrated luminosities of old datasets collected in 2010-2014 are updated by considering corrections related to detector performance,offsetting the effect of newly discovered readout errors in the electromagnetic calorimeter,which can haphazardly occur.

关键词： integrated luminosity e^(+)e^(-)annihilation Bhabha scattering

胶囊内镜与常规上消化道内镜检查诊断食管静脉曲张准确性的比较:一项前瞻性、3中心先导性研究

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世界核心医学期刊文摘（胃肠病学分册） 2006年第5期2卷 27-28页

作者： Eisen G.m. Eliakim R. Zaman A. 纪泛扑 Oregon Health and Science University 3181 SWSam Jackson Park Rd. Portland OR 97239-3980 United States Dr.

Background and study aims: Variceal bleeding is a major complication of cirrhosis, and is associated with a 20% mortality at 6 weeks. Current international guidelines recommend that patients with cirrhosis are screened by conventional upper endoscopy (esophagogastroduodenoscopy, EGD) in order to detect esophageal varices. The recently developed PillCam ESO esophageal capsule endoscope has been shown to be an accurate diagnostic tool in the investigation of patients with gastroesophageal reflux and Barrett’ s esophagus. We compared the PillCam ESO capsule endoscope with EGD for the detection of esophagogastric varices and portal hypertensive gastropathy in patients with cirrhosis. Patients and methods: A pilot trial was conducted at three sites. Patients with cirrhosis who were undergoing clinically indicated EGD for screening or surveillance for esophageal varices underwent a PillCam ESO study followed by an EGD within 48 hours. Capsule videos were assessed by an investigator who was blinded to the patient’ s medical history and EGD findings. Results: A total of 23 of the 32 enrolled patients were found to have esophageal varices at both EGD and PillCam ESO endoscopy. In one patient PillCam ESO detected small varices that were not seen at EGD. The overall concordance between PillCam ESO and EGD was 96.9 % for the diagnosis of esophageal varices and 90.6% for the diagnosis of portal hypertensive gastropathy. There were no adverse events related to PillCam ESO endoscopy. Conclusions: In a high-prevalence population, PillCam ESO may represent an accurate noninvasive alternative to EGD for the detection of esophageal varices and portal hypertensive gastropathy. A large-scale trial is underway to validate and expand these findings.

关键词：胶囊内镜检查上消化道内镜检查食管静脉曲张检查诊断准确食管胃底静脉曲张门脉高压性胃病肝硬化患者先导性 Barrett食管

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Introduction

World Journal of Otorhinolaryngology-Head and Neck Surgery 2018年第2期4卷 109-109页

作者： Ahmed m.S. Soliman Head & Neck Institute Voice Airway & Swallowing Center Lewis Katz School of Medicine at Temple University 3440 N. Broad Street Kresge West Suite 300 Philadelphia PA 19140 USA

Since its inception with the invention of the laryngeal mirror and the early work of Horace Green, Chevalier jackson, Johann Czermak, morrell mcKenzie, and others in the mid-19th Century, the field of laryngology has grown exponentially. With the introduction of suspension laryngoscopy and general anesthesia, surgeons were able to work with both hands. The addition of the operative microscope allowed visualization not previously possible. In the mid-20th Century, the CO2 laser permitted laryngeal surgery to performed with unprecedented precision and hemostasis. The 1970's saw the advent of flexible laryngoscopes and stroboscopy which took our diagnostic capabilities to new levels. The distal chip laryngoscopes which followed along with the fiber-based lasers, allowed procedures to be done in the office setting with superior visualization and exactness. And the story continues……

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使用他克莫司软膏4年治疗特应性皮炎的安全性和疗效

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世界核心医学期刊文摘(皮肤病学分册) 2005年第11期 61-62页

作者： Hanifin J.m. Paller A.S. Eichenfield L. 刘芯 Dr.Oregon Health and Science University Department of Dermatology OP06 3181 SW Sam Jackson Park Rd Portland OR 97239 United States

Objective: This study was designed to evaluate the long-term safety and efficacy of 0.1%tacrolimus ointment in adult and pediatric patients with atopic dermatitis (AD). methods: A total of 408 adult and 391 pediatric patients with AD who had participated in a previous clinical trial of tacrolimus ointment were enrolled in this long-term, open-label, noncomparative trial. Tacrolimus ointment 0.1%was applied twice daily either intermittently or continuously to the affected areas. Efficacy and safety assessments included percent body surface area affected, Eczema Area and Severity Index score, individual signs of AD, and the incidence of adverse events. Results: A total of 799 patients were evaluated, of whom 300 (37.5%) were followed for more than 3 years (maximum 49 months). Improvements in efficacy parameters were observed within 1 week of treatment and continued for the duration of the study. Common adverse events included skin burning, pruritus, skin infection, skin erythema, flu-like symptoms, and headache. The incidence of adverse events, including cutaneous infections, did not increase with time on study. Conclusion: Tacrolimus ointment therapy is a rapidly effective and safe treatment for the management of AD in pediatric and adult patients for up to 4 years.

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Surface Water Quality Response to Land Use Land Cover Change in an Urbanizing Catchment: A Case of Upper Chongwe River Catchment, Zambia

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Time Series Analysis on Selected Rainfall Stations Data in Louisiana Using ARImA Approach

Journal of Geographic Information System（地理信息系统） 2021年第5期

作者： Alick Nguvulu Agabu Shane Claude S. mwale Tewodros m. Tena Phenny mwaanga John Siame Brian Chirambo musango Lungu Frank mudenda Dickson mwelwa Sydney Chinyanta jackson Kawala Victor mwango Bowa Levi S. mutambo Nicholas Okello Charles musonda

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Open Journal of Statistics 2021年第5期11卷 655-672页

作者： Yaw A. Twumasi Jacob B. Annan Edmund C. merem John B. Namwamba Tomas Ayala-Silva Zhu H. Ning Abena B. Asare-Ansah Judith Oppong Diana B. Frimpong Priscilla m. Loh Faustina Owusu Lucinda A. Kangwana Olipa S. mwakimi Brilliant m. Petja Ronald Okwemba Caroline O. Akinrinwoye Hermeshia J. mosby Joyce mcClendon-Peralta Department of Urban Forestry and Natural Resources Southern University and A&M College Baton Rouge Louisiana USA Department of Urban and Regional Planning Jackson State University Jackson Mississippi USA USDA-ARS Tropical Agriculture Research Station Mayaguez Puerto Rico USA Institute of Resource Assessment University of Dares Salam Dares Salam Tanzania Water Research Commission (WRC) Private Bag X03 Gezina South Africa

Precipitation is very important for both the environment and its inhabitants. Agricultural activities mostly depend on precipitation and its availability. Therefore, the ability to predict future precipitation values at specific stations is key for environmental and agricultural decision making. This research developed Autoregressive Integrated moving Average (ARImA) models for selected stations with Integrated component and Autoregressive moving Average (ARmA) for selected stations without Integrated component at Louisiana State. The ARImA module is represented as ARImA(p, d, q)(P,D,Q). The selected lag order for the Autoregressive (AR) component is represented with p and P for seasonal AR component, while the integrated form (number of times data were differenced) is d and D for seasonal differencing, and the moving Average (mA) lag order is q and Q for seasonal mA component. Data from 1950 to 2020 were employed in this research. Results of the analysis indicated that Baton Rouge (ARImA (0,1,1) (0,0,2)12), Abbeville (ARMA (0,0,1) (0,0,2)12), Monroe Regional (ARMA (0,0,1) (0,0,0)12), New Orleans Airport (ARMA (1,0,0) (0,0,2)12), Alexandria (ARMA (1,0,1) (0,0,0)12), Logansport (ARIMA (0,1,2) (0,0,0)12), New Orleans Audubon (ARMA (1,0,0) (0,0,0)12), Lake Charles Airport (ARMA (2,0,2) (0,0,0)

关键词： Precipitation ARImA models Time Series Lowess Louisiana