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The impact of alpha-fetoprotein (AFP), child-turcotte-pugh (CTP) score and disease staging on the survival of hepatocellular carcinoma (HCC) patients: a retrospective cohort from single oncology center

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Oncology research 2025年第1期33卷 149-160页

作者： Nasser mulla Yousef Katib Asim m Almughamsi Duaa S Alkhayat mohamed mosaad Samir T Alfotih Rawan Alaofi Department of Internal medicine Faculty of Medicine Taibah University Madinah 42278 Saudi Arabia. Department of Radiology Faculty of Medicine Taibah University Madinah 42278 Saudi Arabia. Department of Surgery Faculty of Medicine Taibah University Madinah 42278 Saudi Arabia. Department of Endemic and Infectious Diseases Suez Canal University Ismailia 41522 Egypt. King Salman bin Abdulaziz medical City Madinah 42311 Saudi Arabia. Prince mohammed Bin Abdulaziz Hospital Madinah 41511 Saudi Arabia.

Background:Hepatocellular carcinoma (HCC) is the most common cause of cancer-related death in Saudi Arabia. Our study aimed to investigate the patterns of HCC and the effect of TNm staging, Alfa-fetoprotein (AFP), and Child-Turcotte Pugh (CTP) on patients' overall survival (OS).methods:A retrospective analysis was conducted on 43 HCC patients at a single oncology center in Saudi Arabia from 2015 to 2020. All patients had to fulfill one of the following criteria: (a) a liver lesion reported as definitive HCC on dynamic imaging and/or (b) a biopsy-confirmed diagnosis.Results:The mean patient age of all HCC cases was 66.8 with a male-to-female ratio of 3.3:1. All patients were stratified into two groups: viral HCC (n = 22, 51%) and non-viral HCC (n = 21, 49%). Among viral-HCC patients, 55% were due to HBV and 45% due to HCV. Cirrhosis was diagnosed in 79% of cases. Age and sex did not significantly statistically differ in OS among viral and non-viral HCC patients (-value > 0.05). About 65% of patients had tumor size >5 cm during the diagnosis, with a significant statistical difference in OS (-value = 0.027). AFP was >400 ng/ml in 45% of the patients. There was a statistically significant difference in the OS in terms of AFP levels (-value = 0.021). A statistically significant difference was also observed between the CTP score and OS (-value = 0.02). CTP class B had the longest survival. BSC was the most common treatment provided to HCC patients followed by sorafenib therapy. There was a significant statistical difference in OS among viral and non-viral HCC patients (-value = 0.008).Conclusions:The most common predictors for OS were the underlying cause of HCC, AFP, and tumor size. Being having non-viral etiology, a tumor size >5 cm, an AFP > 400 ng/mL, and a CTP score class C were all negatively associated with OS.

关键词： Alpha-fetoprotein (AFP) Child-turcotte-pugh Hepatocellular carcinoma Pattern Progression free survival

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Eisenstein series for SL(2)

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Science China mathematics 2010年第9期53卷 2275-2316页

作者： KUDLA stephen S. Department of mathematics University of TorontoTorontoOntarioM5S2E4Canada

This paper gives explicit formulas for the Fourier expansion of general Eisenstein series and local Whittaker functions over *** are used to compute both the value and derivatives of these functions at critical points.

关键词： Eisenstein series local Whittaker functions Weil representation derivative

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制造与再制造混合系统中库存与牛鞭效应的分析与优化

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上海交通大学学报 2005年第10期39卷 1587-1591页

作者：周莉许淑君 stephen m.Disney Logistics System Dynamics Group Cardiff Business School 上海交通大学工业工程与管理系

运用控制理论对一个简单的制造与再制造混合系统建立了动态数学模型,并定量分析了再制造过程的生产提前期和回收率对整个混合制造系统的动态特性之影响.结果表明,较高的产品回收率可以减少库存变化和牛鞭效应,回收量能够在一定程度上用... 详细信息

运用控制理论对一个简单的制造与再制造混合系统建立了动态数学模型,并定量分析了再制造过程的生产提前期和回收率对整个混合制造系统的动态特性之影响.结果表明,较高的产品回收率可以减少库存变化和牛鞭效应,回收量能够在一定程度上用于吸收需求波动,而较长的再制造提前期对于减小库存变化和牛鞭效应的作用则不明显.在该特定的系统中,供应链中有回收时的库存变化与牛鞭效应比没有回收时的要小.

关键词：制造再制造库存变化牛鞭效应回收率提前期

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Kagome superconductors AV3Sb5(A = K, Rb, Cs)

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National Science Review 2023年第2期10卷 260-275页

作者： Kun Jiang Tao Wu Jia-Xin Yin Zhenyu Wang m.Zahid Hasan stephen D.Wilson Xianhui Chen Jiangping Hu Beijing National Laboratory for Condensed matter Physics and Institute of Physics Chinese Academy of Sciences School of Physical Sciences University of Chinese Academy of Sciences Hefei National Laboratory for Physical Sciences at the microscale University of Science and Technology of China CAS Key Laboratory of Strongly-coupled Quantum matter Physics Department of Physics University of Science and Technology of China Laboratory for Quantum Emergence Department of PhysicsSouthern University of Science and Technology Laboratory for Topological Quantum matter and Advanced Spectroscopy (B7) Department of PhysicsPrinceton University materials Department and California Nanosystems Institute University of California Santa Barbara Kavli Institute of Theoretical Sciences University of Chinese Academy of Sciences

The quasi-two-dimensional kagome materials AV3Sb5(A=K,Rb,Cs) were found to be a prime example of kagome superconductors,a new quantum platform to investigate the interplay between electron correlation effects,topology and geometric *** this review,we report recent progress on the experimental and theoretical studies of AV3Sb5and provide a broad picture of this fast-developing field in order to stimulate an expanded search for unconventional kagome *** review the electronic properties of AV3Sb5,the experimental measurements of the charge density wave state,evidence of time-reversal symmetry breaking and other potential hidden symmetry breaking in these materials.A variety of theoretical proposals and models that address the nature of the time-reversal symmetry breaking are ***,we review the superconducting properties of AV3Sb5,especially the potential pairing symmetries and the interplay between superconductivity and the charge density wave state.

关键词： kagome superconductor charge density wave time-reversal symmetry breaking topological metal

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Plurigenera of compact connected strongly pseudoconvex CR manifolds In memory of Salah Baouendi

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Science China mathematics 2015年第3期58卷 525-530页

作者： LIN KePao YAU stephen ZUO HuaiQing Department of Art and Science Chang Gung University of Science and Technology Department of mathematical Sciences Tsinghua University mathematical Sciences Center Tsinghua University

Strongly pseudoconvex CR manifolds are boundaries of Stein varieties with isolated normal *** introduce a series of new invariant plurigeneraδm,m∈Z+for a strongly pseudoconvex CR *** main purpose of this paper is to present the following result:Let X1and X2be two compact strongly pseudoconvex embeddable CR manifolds of dimension 2n-1 *** there is a non-constant CR morphism from X1to X2,thenδm(X2)δm(X1)whereδm(Xi)is the plurigeneus of Xi(see Definition 2.4).

关键词： plurigenera strongly pseudoconvex CR manifold

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Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam m.R.Groh moein Yaqubi Qiao-Ling Cui Jo Anne Stratton G.R.Wayne moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

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First report of small cell lung cancer with PTHrP-induced hypercalcemic pancreatitis causing disconnected duct syndrome

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World Journal of Clinical Oncology 2017年第5期8卷 420-424页

作者： Eric m montminy stephen W Landreneau Jordan J Karlitz Division of Gastroenterology Tulane University Medical Center Division of Gastroenterology LSU Health Sciences Center

Here we report a patient diagnosed with small cell lung cancer after first presenting with parathyroid hormonerelated peptide-induced hypercalcemic pancreatitis and developed walled-off necrosis that resulted in disruption of the main pancreatic *** duct syndrome (DDS) is a rare syndrome that occurs when the main pancreatic duct exocrine flow is disrupted resulting in leakage of pancreatic enzymes and further inflammatory *** date,no prior reports have described DDS occurring with paraneoplastic *** imaging techniques and therapeutic interventions are reviewed to provide insight into current approaches to DDS.

关键词： Disconnected duct syndrome Parathyroid hormone-related peptide Hypercalcemic pancreatitis

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Composite indicator for railway infrastructure management

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Journal of modern Transportation 2014年第4期22卷 214-224页

作者： stephen m.Famurewa Christer Stenstrm matthias Asplund Diego Galar Uday Kumar Division of Operation and maintenance Engineering Lule University of Technology Lule Sweden Lule Railway Research Centre Lule Sweden Trafikverket (the Swedish Transport Administration) LuleSweden

The assessment and analysis of railway infra structure capacity is an essential task in railway infra structure management carried out to meet the required quality and capacity demand of railway transport. For sustainable and dependable infrastructure management, it is important to assess railway capacity limitation from the point of view of infrastructure performance. However, the existence of numerous performance indicators often leads to diffused information that is not in a format suitable to support decision making. In this paper, we demonstrated the use of fuzzy inference system for aggregating selected railway infrastructure performance indicators to relate maintenance function to capacity situation. The selected indicators consider the safety, comfort, punctuality and reliability aspects of railway infrastructure performance. The resulting composite indicator gives a reliable quanti fication of the health condition or integrity of railway lines. A case study of the assessment of overall infrastructure performance which is an indication of capacity limitation is presented using indicator data between 2010 and 2012 for five lines on the network of Trafikverket （Swedish Trans port Administration）. The results are presented using cus tomised performance dashboard for enhanced visualisation,quick understanding and relevant comparison structure conditions for strategic management. This gives additional information on capacity status and limitation from maintenance management perspective.

关键词： Composite indicator Infrastructure capacityFuzzy logic Performance dashboard Strategic decisionsLine integrity

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Imbalanced Classification in Diabetics Using Ensembled machine Learning

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Computers, materials & Continua 2022年第9期72卷 4397-4409页

作者： m.Sandeep Kumar mohammad Zubair Khan Sukumar Rajendran Ayman Noor A.stephen Dass J.Prabhu School of Information Technology and Engineering Vellore Institute of TechnologyVelloreTamil Nadu632014India Department of Computer Science and Information Taibah UniversityMedinaSaudi Arabia College of Computer Science and Engineering Taibah UniversityMedinaSaudi Arabia

Diabetics is one of the world’s most common diseases which are caused by continued high levels of blood *** risk of diabetics can be lowered if the diabetic is found at the early *** recent days,several machine learning models were developed to predict the diabetic presence at an early *** this paper,we propose an embedded-based machine learning model that combines the split-vote method and instance duplication to leverage an imbalanced dataset called PImA Indian to increase the prediction of *** proposed method uses both the concept of over-sampling and under-sampling along with model weighting to increase the performance of *** measures such as Accuracy,Precision,Recall,and F1-Score are used to evaluate the *** results we obtained using K-Nearest Neighbor(kNN),Naïve Bayes(NB),Support Vector machines(SVm),Random Forest(RF),Logistic Regression(LR),and Decision Trees(DT)were 89.32%,91.44%,95.78%,89.3%,81.76%,and 80.38%*** SVm model is more efficient than other models which are 21.38%more than exiting machine learning-based works.

关键词： Diabetics classification imbalanced data split-vote instance duplication

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Some Penrose transforms in complex differential geometry Dedicated to Professor Sheng GONG on the occasion of his 75th birthday

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Science China mathematics 2006年第11期49卷 1599-1610页

作者： ANCO stephen BLAND John EASTWOOD michael Department of mathematics Brock University 500 Glenridge AvenueSt. CatharinesON L2S 3A1Canada Department of mathematics University of Toronto 100 St. George StreetTorontoON M5S 3G3Canada Department of mathematics University of Adelaide SA 5005Australia

In this article, we review a construction in the complex geometry often known as the Penrose transform. We then present two new applications of this transform. One concerns the construction of symmetries of the massless field equations from mathematical physics. The otherconcerns obstructions to the embedding of CR structures on the three-sphere.

关键词： Penrose transform, symmetries, massless fields, CR embedding.

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