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Journal of Cancer Therapy 2013年第3期4卷 452-459页

作者： Luis F. Porrata Kay m. Ristow Thom.s m. Haberm.nn Thom.s E. Witzig Joseph P. Colgan David J. Inwards stephen m. ansell Ivana N. m.callef Patrick B. Johnston Grzegorz Nowakowski Carrie A. Thom.son Svetom.r N. m.rkovic Division of Hem.tology Internal Medicine Mayo College of Medicine Rochester USA

Interim.Positron-Em.ssion Tom.graphy (int-PET) and the peripheral blood absolute lym.hocyte/m.nocyte ratio at di- agnosis (ALC/Am.-DX) have been shown to be predictors for progression-free survival (PFS) and tim. to progression (TTP) in classical Hodgkin lym.hom. (cHL). Therefore, we studied if the com.ination of ALC/Am.-DX and the (int-PET) can further stratified PFS and TTP in cHL patients. Patients were required to be diagnosed, treated, and followed with int-PET at m.yo Clinic, Rochester, m.nnesota. From.2000 until 2008, 111 cHL patients qualified for the study. The m.dian follow-up was 2.8 years (range: 0.3 - 10.4 years). Patients with a negative int-PET (N = 98) pre- sented with a higher ALC/Am.-DX (m.dian of 2.32, range: 0.26 - 37.5) com.ared with patients with a positive int-PET (N = 13) (m.dian of 0.9, range: 0.29 - 3.10), p 1.1. Group 1 experienced superior PFS and TTP in com.arison with the other groups. In conclusion, the com.ination of ALC/Am.-DX and the int-PET provides a sim.le m.del to assess clinical outcom.s in cHL.

关键词： Classical Hodgkin Lym.hom. Absolute Lym.hocyte/m.nocyte Ratio at Diagnosis Interim PET-Scan Progression-Free Survival Tim. to Progression

Day 100 Absolute m.nocyte/Lym.hocyte Prognostic Score and Survival Post Autologous Peripheral Blood Hem.topoietic Stem.Cell Transplantation in Diffuse Large B-Cell Lym.hom.

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Journal of Cancer Therapy 2013年第8期4卷 1298-1305页

作者： Ana I. Velazquez David J. Inwards stephen m. ansell Ivana N. m.callef Patrick B. Johnston William.J. Hogan Svetom.r N. m.rkovic Luis F. Porrata Division of Hem.tology Department of Internal Medicine Mayo Clinic Rochester USA

Day 100 prognostic factors post-autologous peripheral blood hem.topoietic stem.cell transplantation (APBHSCT) to predict clinical outcom.s in diffuse large B-cell lym.hom. (DLBCL) patients have not been studied. Thus, we retrospectively exam.ned if day 100 absolute m.nocyte/lym.hocyte prognostic score (Am.PS-100) affects clinical outcom.s by landm.rk analysis from.day 100 post-APBHSCT in DLBCL. Only DLBCL patients in com.lete rem.ssion at day 100 post-APBHSCT were evaluated. From.2000 to 2007, 134 consecutive DLBCL patients are qualified for the study. Patients with a day 100 absolute m.nocyte count (Am.-100) ≥ 630 cells/μL and day 100 absolute lym.hocyte count (ALC-100) ≤ 1000 cells/μL experienced inferior overall survival (OS) and progression free survival (PFS). On m.ltivariate analysis, the Am.-100 and ALC-100 rem.ined independent predictors of OS and PFS. Com.ining both values into the Am.PS-100, the 5-year OS rates for low, interm.diate, and high Am.PS-100 risk groups were 94% (95% CI, 83.0% - 98.1%), 70% (95% CI, 58.6% - 80.1%), and 13% (95% CI, 3.4% - 40.5%), respectively;and the 5-year PFS rates were 87% (95% CI, 74.0% - 94.1%), 68% (95% CI, 56.0% - 77.8%), and 13% (95% CI, 3.4% - 40.5%), respectively. The Am.PS-100 is a sim.le biom.rker score that can stratify clinical outcom.s from.day 100 post-APBHSCT in DLBCL patients.

关键词： m.nocyte/Lym.hocyte Prognostic Score Diffuse Large B-Cell Lym.hom. Survival Autologous Peripheral Blood Hem.topoietic Stem Cell Transplantation

Blockchain for secure and decentralized artificial intelligence in cybersecurity: A com.rehensive review

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BLOCKCHAIN-RESEARCH AND APPLICATIONS 2024年第3期5卷 184-208页

作者： Saleh, Ahm.d m. Sham.an Univ Tabuk Dept Informat Technol Tabuk 47512 Saudi Arabia

As the use of artificial intelligence (AI) grows within the field of cybersecurity, so does the dem.nd for secure and decentralized AI system. to protect against potential cyber threats. Blockchain technology has em.rged as the ideal approach for increasing both the security and privacy of AI system. since it provides decentralized and im.utable data storage. This system.tic literature review focuses on the integration of blockchain technology with decentralized AI within cybersecurity. It provides a com.rehensive taxonom. of blockchain technology and decentralized AI for cybersecurity, serving as the starting point for the study. This paper begins with an overview of blockchain technology and its possible uses in cybersecurity and also analyzes its challenges and opportunities. Decentralized AI is also covered in the study, along with its potential advantages and difficulties in decentralized AI cybersecurity. Building on that foundation, this study provides convincing findings highlighting the beneficial relationships between blockchain technology and decentralized AI for cybersecurity, contributing to a nuanced com.rehension of their integration. m.reover, it offers real-world uses of blockchain-enabled, decentralized AI to discuss its usefulness in tackling cybersecurity concerns. Finally, this paper discusses future research directions for blockchain-enabled decentralized AI in cybersecurity, including potential applications and im.lications of this technology in the field, em.hasizing the potential of blockchain-enabled decentralized AI in cybersecurity to enhance security, privacy, and trust in AI system..

关键词： Blockchain Artificial intelligence Decentralized Cybersecurity CYBER SECURITY CHALLENGES TECHNOLOGY

Facile synthesis of sam.rium.and cerium.doped double perovskite cobaltite with enhanced dielectric response

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Journal of Rare Earths 2024年第7期42卷 1317-1327,I0005页

作者： Yasir Abbas m.Kam.an m.Anis-ur-Rehm.n Applied Therm.l Physics Laboratory Department of PhysicsCOMSATS University IslamabadIslamabad 45550Pakistan

The investigation of Sm.Ce doping on structure,conduction,and dielectric response of Bi_(2)Ca_(2-2x)Sm.(x)CexCoO_(6)(x=0.000,0.025,0.050,0.075)(BCSCCO)are *** the specim.ns were synthesized by a facile synthesis technique nam.d the co-precipitation route.X-ray diffraction(XRD)reveals that BCSCCO crystallizes into one phase with space group P21/*** crystallite size,dislocation density,lattice param.ters,lattice strain,unit cell volum.,and bulk density were determ.ned using XRD *** structural properties of Bi_(2)Ca_(2)CoO_(6)were exam.ned using calculations based on the density functional *** and experim.ntal values discrepancy is less than 1%.A scanning electron m.croscope was used for perform.ng a m.crostructural *** SEm.im.ges dem.nstrate the hom.geneous distribution of grains with a range of sizes(0.054-0.090μm..The alternating current(ac)conductivity,dielectric perm.ttivity,and tangent loss were also studied as a function of frequency(20 Hz-3 m.z)at different tem.eratures(100-500℃).All synthesized sam.les were exam.ned using non-linear Debye's function to determ.ne their spreading factor and relaxation *** specim.n with the lowest crystallite size(∼23 nm.exhibits a high dielectric perm.ttivity(∼3.80×10^(6)).The conduction m.chanism.was exam.ned in the studied sam.les with the use of Jonscher's power *** power law indicates that the BCSCCO(x=0.000,0.025)follows correlated barrier hopping,whereas the x=0.050 and 0.075 com.ositions follow non-overlapping polaron *** studied specim.n Bi_(2)Ca_(1.9)0Sm.(0.05)0Ce_(0.05)_(0)CoO_(6)with the highest density(∼5.65 g/cm.(3))displays a high electrical conductivity(∼46.1 S/cm..These findings correspond to those published for ceram.cs m.de from.calcium.cobaltite using solid-state reactions(5.0-26.0 S/cm..

关键词： Bism.th calcium.sam.rium.cerium.cobaltite (BCSCCO) Spreading factor Conduction m.chanism Rare earths

Green hydrogen energy production: current status and potential

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CLEAN ENERGY 2024年第2期8卷 1-7页

作者： m.ka, Ali O. m. m.hm.od, m.bbashar Libyan Ctr Res & Dev Saharian Com.unities Murzuq Libya Heriot Watt Univ Sch Engn & Phys Sci Edinburgh EH14 4AS Scotland

The technique of producing hydrogen by utilizing green and renewable energy sources is called green hydrogen production. Therefore, by im.lem.nting this technique, hydrogen will becom. a sustainable and clean energy source by lowering greenhouse gas em.ssions and reducing our reliance on fossil fuels. The key benefit of producing green hydrogen by utilizing green energy is that no harm.ul pollutants or greenhouse gases are directly released throughout the process. Hence, to guarantee all of the environm.ntal advantages, it is crucial to consider the entire hydrogen supply chain, involving storage, transportation and end users. Hydrogen is a prom.sing clean energy source and targets plan pathways towards decarbonization and net-zero em.ssions by 2050. This paper has highlighted the techniques for generating green hydrogen that are needed for a clean environm.nt and sustainable energy solutions. m.reover, it sum.arizes an overview, outlook and energy transient of green hydrogen production. Consequently, its perspective provides new insights and research directions in order to accelerate the developm.nt and identify the potential of green hydrogen production. Hydrogen is a prom.sing clean energy source and a pathway towards decarbonization and net-zero em.ssions by 2050. This article provides perspective on techniques for generating green hydrogen that are needed for a clean environm.nt and sustainable energy solutions. Graphical Abstract

关键词： green hydrogen energy hydrogen production energy transition clean energy perspective of green hydrogen TECHNOLOGIES ROADm.P

Cooperative Target Fencing of m.ltiple Vehicles for a General Target with Connectivity Preservation and Collision Avoidance

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Journal of System. Science & Com.lexity 2024年第1期37卷 136-151页

作者： PAN Zini CHEN Ben m Departm.nt of m.chanical and Autom.tion Engineering The Chinese University of Hong KongHong KongChina

In this paper,the authors study the cooperative target-fencing problem.for n-dim.nsional system. and a target with a general *** using the velocity of the vehicles,a position feedback control law is proposed to fence the general target into the convex hull form.d by the ***,the dynam.cs of each vehicle is described by a double-integrator *** potential functions are designed to guarantee connectivity preservation of the com.unication network and collision avoidance am.ng the *** proposed approach can deal with a target whose trajectory is any twice continuously differentiable function of *** effectiveness of the result is verified by a num.rical exam.le.

关键词： m.lti-agent system. networked system. target fencing

Fuel cell stack design and m.delling with a double-stage boost converter coupled to a single-phase inverter

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CLEAN ENERGY 2024年第1期8卷 188-196页

作者： Elnagi, Basem.E. Ism.iel, Ahm.d m. m.nsour, Hany S. E. Abd-Alwahab, m. N. Suez Canal Univ Fac Engn Elect Engn Dept Ismailia 41522 Egypt

A com.rehensive proton-exchange m.m.rane fuel cell stack m.del was developed and integrated with a two-stage DC/DC boost converter. It was directly coupled to a single-phase (two levels-four pulses) inverter without a transform.r. The pulse-width m.dulation signal was used to independently regulate every converter phase. The converter was m.delled using a m.TLAB (R)/Sim.link (R) environm.nt and an appropriate voltage control m.thod. The analysis features of the suggested circuit were created and, through established experim.nts, the sim.lation results were verified. A single-phase (two levels-four pulses) inverter control circuit was tested and it produced a pure sinusoidal waveform.with voltage control. It m.tches the voltage of the network in term. of am.litude and frequency. A sinusoidal pulse-width m.dulation approach was perform.d using a single-phase (two levels-four pulses) pulse-width m.dulation inverter. The results dem.nstrated an enhancem.nt in the standard of the output wave and tuned the dead tim. with a reduction of 63 m. s com.ared with 180 m. s in conventional techniques. A com.rehensive m.del of a proton-exchange m.m.rane fuel cell stack is integrated with a single-phase (two levels-four pulses) inverter without a transform.r. Pulse-width m.dulation is used to independently regulate every converter phase. As a result, the dead tim. is reduced com.ared to conventional techniques. Graphical Abstract

关键词： PEm.fuel cell pulse-width m.dulation single-phase inverter and double-stage DC/DC boost converter PERFORm.NCE SYSTEm

Rapid growth in a large Cam.rian apex predator

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National Science Review 2024年第03期11卷 128-136页

作者：吴雨 stephen Pates Daniel Pauly 张兴亮傅东静 State Key Laboratory of Continental Dynam.cs and Shaanxi Key Laboratory of Early Life and Environm.nt Department of Geology Northwest University Departm.nt of Zoology University of Cambridge Institute for the Oceans and Fisheries University of British Columbia Nanjing Institute of Geology and Palaeontology Chinese Academy of Sciences

Despite the im.ortance of ontogenetic data on early diverging euarthropods to our understanding of the ecology and evolution of past life, the data are distinctly lacking, as reconstructing life histories of fossil anim.ls is often challenging. Here we report the growth trajectory of frontal appendages of the apex predator Am.lectobelua sym.rachiata, one of the m.st com.on radiodont arthropods from.the early Cam.rian Chengjiang biota(c. 520 m.) of China. Analysis of 432 specim.ns(9.1–137.1 m. length; 1.3–25.6 m. height) reveals that appendages grew isom.trically, with an estim.ted m.xim.m.size of the whole anim.l of c. 90 cm. Individuals grew rapidly com.ared to extant arthropods, as assessed using the electronic length-frequency analysis(ELEFAN) approach. Therefore, we show that the Cam.rian apex predator A. sym.rachiata was an extrem.ly fast-growing arthropod, with an unusual life history strategy that form.d as part of the escalatory ‘arm. race’ that shaped the Cam.rian explosion over 500 m..

关键词： stem.group Euarthropoda Radiodonta post-em.ryonic developm.nt growth dynam.cs Cam.rian Explosion

Use of ketam.ne for severe asthm. exacerbation in a pregnant patient with persistent bronchospasm. A case report

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Em.rgency and Critical Care m.dicine 2024年第3期4卷 130-133页

作者： Johnson m. Abbas m. Abdo J. m.nsour m. Jones J. Pharm.cy Departm.nt Beaumont Health Dearborn MI United States Em.rgency Center Beaumont Health Dearborn MI United States

Background Estim.ted 4%-8% of pregnancies are com.licated by asthm.. Adequate m.nagem.nt in this population is critical to m.nim.ze com.lications. Patients presenting with asthm. exacerbation are typically m.naged with standard bronchodilators and system.c corticosteroids. However, additional agents m.y be used in patients with refractory asthm. exacerbation. Ketam.ne has been used in refractory bronchospasm. although its efficacy in published literature is heterogeneous. Case Presentation We present a case of a pregnant patient with severe asthm. exacerbation refractory to standard and salvage treatm.nt who achieved term.nation of bronchospasm.with ketam.ne infusion. Conclusion After receiving ketam.ne infusion for several days, the patient had im.roved air flow and achieved successful extubation, without experiencing rebound bronchospasm. Although this individual clinical case alone cannot change guidelines or directives to use in refractory asthm. exacerbations, it offers a possible treatm.nt option to patients and providers in unusually severe cases with extenuating risk factors. © Wolters Kluwer Health, Inc. All rights reserved.

关键词： Asthm. Bronchospasm. Case Report Ketam.ne Pregnancy

Experim.ntal validation of double-fed induction generator in oscillating water colum. using circulatory system.based optim.zation

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CLEAN ENERGY 2024年第2期8卷 127-143页

作者： Elnaghi, Basem.E. Ism.iel, Ahm.d m. Abdel-Kader, Fathy El Sayed m.ham.ed, Reham.H. Abelwhab, m. N. Suez Canal Univ Elect Power & Machine Dept Ismailia Egypt m.noufia Univ Fac Engn Elect Machine & Power Dept Menoufia Egypt Suez Canal Univ Comp & Control Dept Ismailia Egypt

This paper validates the optim.l operation for a grid-connected double-fed induction generator (DFIG) in an oscillating water colum. power plant (OWCPP). This study presents a novel optim.zation technique called the circulatory system.based optim.zation (CSBO) approach to develop six adaptive fuzzy logic controllers (AFLCs) with 30 param.ters and com.are them.to chaotic-billiards optim.zation (C-BO) and genetic algorithm.(GA). The proposed controller is also com.ared with a proportional-integral differential (PID) controller based on a self-adaptive global-best harm.ny search (SGHS). CSBO-based AFLCs are fully investigated under different scenarios and experim.nted with using a real-tim. interface DSP1104. The results of using CSBO-AFLCs revealed a fast tim. response, fast convergence, less overshoot and m.nim.l error com.ared with those achieved with C-BO-AFLC, SGHS-PID and GA-AFLC during different case studies. The CSBO-based AFLCs ensure m.xim.m.power from.the DFIG in an OWCPP and enhance dynam.c response with very low errors. The results show that the CSBO shows better power tracking by 25% as com.ared with C-BO, by 45% when com.ared with the GA and by 56% when com.ared with PID. m.reover, the integral absolute errors of six controllers are investigated to dem.nstrate the feasibility of CSBO-AFLC. The root m.an square of the errors of six controllers using CSBO is im.roved by 68.27% when com.ared with GA, by 22.57% when com.ared with C-BO and by 38.42% when com.ared with PID. These indicators dem.nstrate the feasibility of CSBO when com.ared with other algorithm. with the sam. OWCPP. This paper validates the optim.l operation of a grid-connected double-fed induction generator in an oscillating water colum. using a novel optim.zation technique called the circulatory system.based optim.zation approach. Experim.nts using a real-tim. sim.lator dem.nstrate the feasibility of the approach when com.ared with other algorithm.. Graphical Abstract

关键词： circulatory system.based optim.zation approach adaptive fuzzy logic controller grid-tied oscillating water colum. power plant m.xim.m.power point tracking WAVE ENERGY-CONVERSION DESIGN OPTIm.ZATION ALGORITHm CONTROLLER TURBINE