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International Journal of Minerals,Metallurgy and Materials 2015年第11期22卷 1225-1231页

作者： Elisa lam Qinfen Gu Peter J.Swedlund Sylvie Marchesseau Yacine Hemar School of Chemical Sciences The University of Auckland Australian Synchrotron Université Montpellier 2 UMR IATE Pl.E Bataillon34095 Montpellier cedex 5 France

The changes in the crystal structures of synthetically prepared amorphous calcium phosphate（ACP） and hydroxyapatite（HAP） in water（1：1 mass ratio） were studied by synchrotron X-ray diffraction（XRD） under ultra-high hydrostatic pressures as high as 2.34 GPa for ACP and 4 GPa for HAP. At ambient pressure, the XRD patterns of the ACP and HAP samples in capillary tubes and their environmental scanning electron micrographs indicated amorphous and crystalline characteristics for ACP and HAP, respectively. At pressures greater than 0.25 GPa, an additional broad peak was observed in the XRD pattern of the ACP phase, indicating a partial phase transition from an amorphous phase to a new high-pressure amorphous phase. The peak areas and positions of the ACP phase, as obtained through fitting of the experimental data, indicated that the ACP exhibited increased pseudo-crystalline behavior at pressures greater than 0.96 GPa. Conversely, no structural changes were observed for the HAP phase up to the highest applied pressure of 4 GPa. For HAP, a unit-cell reduction during compression was evidenced by a reduction in both refined lattice parameters a and c. Both ACP and HAP reverted to their original structures when the pressure was fully released to ambient pressure.

关键词： calcium phosphate hydroxyapatite high hydrostatic pressure X-ray diffraction

Mechanistic connotations of restriction of intramolecular motions(RIM)

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National Science Review 2021年第6期8卷 10-13页

作者： Yujie Tu Zheng Zhao Jacky W.Y.lam Ben Zhong Tang Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionInstitute for Advanced Study and Department of Chemical and Biological EngineeringThe Hong Kong University of Science and Technology Center for Aggregation-Induced Emission SCUT-HKUST Joint Research InstituteState Key Laboratory of Luminescent Materials and DevicesSouth China University of Technology AIE Institute Guangzhou Development District Ming Wai Lau Centre for Reparative Medicine Karolinska Institutet

Molecules are all in constant motions,which influence their properties. For example, in photophysics, the light emission behavior of a luminogen is determined by its electronic and nuclear motions in the excited state. Flexible molecular motions usually favor nonradiative decay along with the transformation of excited-state energy to other forms such as thermal energy. Therefore,the restriction of intramolecular motions(RIM) is commonly adopted to achieve luminescent materials with high emission brightness.

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Fabrication of La,Ce co-doped ZnO nanorods for improving photodegradation of methylene blue

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Journal of Rare Earths 2024年第1期42卷 76-83,I0003页

作者： Erfan Hakim Azmal Zaid Jin-Chung Sin Sze-Mun lam Abdul Rahman Mohamed School of Chemical Engineering Universiti Sains Malaysia(USM)14300Nibong TebalPenangMalaysia College of Environmental Science and Engineering Guilin University of TechnologyGuilin541004China Guangxi Key Laboratory of Theory and Technology for Environmental Pollution Control Guilin University of TechnologyGuilin541004China Collaborative Innovation Center for Water Pollution Control and Water Safety in Karst Area Guilin University of TechnologyGuilin541004China Faculty of Engineering and Green Technology Universiti Tunku Abdul RahmanJalan UniversitiBandar Barat31900KamparPerakMalaysia

La,Ce co-doped ZnO nanorods(ZnLC)were synthesized through a one-step solvothermal *** photocatalysts were characterized by X-ray diffraction,Raman spectroscopy,field-emission scanning electron microscopy,energy dispersive X-ray,transmission electron microscopy,UV-vis diffuse reflectance spectroscopy and photo luminescence *** La and Ce doping enhanced the visible light absorption ability of ZnLC and a red shift was detected for *** simulated solar light irradiation,the ZnO doped with 3 at%La and 1 at%Ce(ZnLC1)degrades methylene blue(MB)more effectively than those of pure ZnO,La-doped ZnO(ZnL)and commercially available *** improved photocatalytic performance of ZnLC1 can be attributed to the high charge separation efficiency as demonstrated by the photoluminescence ***,the photocatalytic experiments reveal that several parameters have their own impact on the MB *** a variety of radical scavengers,it is discovered that superoxide anion radical plays a crucial role in the degradation of *** ZnLC1 is also reused several times without noticeable decrease of photoactivity,indicating that it has a substantial potential for environmental remediation applications.

关键词： ZnO Lanthanum Cerium Co-doping Photodegradation Rare earths

Advances in discovery of novel investigational agents for functional cure of chronic hepatitis B:A comprehensive review of phases II and III therapeutic agents

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World Journal of Hepatology 2024年第3期16卷 331-343页

作者： Robert lam Joseph K Lim Section of Digestive Diseases Yale University School of MedicineNew HavenCT 06520United States

Chronic hepatitis B virus(HBV)infection affects over 295 million people globally and an estimated 1.6 million people in the United *** is associated with significant morbidity and mortality due to cirrhosis,liver failure,and liver *** therapy with oral nucleos(t)ide analogues is associated with high rates of virologic suppression,which in turn has been associated with a decreased risk of liver ***,current antiviral regimens are limited by concerns with adverse effects,adherence,resistance,long-term treatment,and ongoing risk for liver *** investigational agents are currently in development and are targeted at achieving functional cure with sustained hepatitis B surface antigen(HBsAg)loss and suppression of HBV *** we review key evidence from phases II and III trials defining the efficacy and safety profiles for key investigational agents for functional cure of chronic hepatitis B,including core/capsid inhibitors,entry inhibitors,RNA interference(siRNA/ASO),HBsAg inhibitors,Toll-like receptor agonists,checkpoint inhibitors,and therapeutic vaccines.

关键词： Hepatitis B virus Treatment Clinical trials RNA interference Entry inhibitors Core inhibitors Immunomodulators

The role of glutathione-mediated triacylglycerol synthesis in the response to ultra-high cadmium stress in Auxenochlorella protothecoides

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Journal of Environmental Sciences 2021年第10期33卷 58-69页

作者： Chao Xing Jinyu Li Sin Man lam Hongli Yuan Guanghou Shui Jinshui Yang State Key Laboratory of Agrobiotechnology and Key Laboratory of Soil Microbiology Ministry of AgricultureCollege of Biological SciencesChina Agricultural UniversityBeijing 100193China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Lipidall Technologies Company Limited Changzhou 213022China

Under ultra-high cadmium(Cd)stress,large amounts of glutathione are produced in Auxenochlorella protothecoides UTEX 2341,and the lipid content increases *** is the best reductant that can effectively remove Cd,but the relationship between lipid accumulation and the cellular response to Cd stress has not been *** analyses of the transcriptomes and lipidomes,the mechanism of lipid accumulation to Cd tolerance were studied from the perspectives of metabolism,transcriptional regulation and protein *** Cd stress,basic metabolic pathways,such as purine metabolism,translation and pre-m RNA splicing process,were inhibited,while the lipid accumulation pathway was significantly *** analysis revealed that the transcription factors(TFs)and genes related to lipid accumulation were also *** of the TF interaction sites showed that ABI5,MYBrel and NF-YB could further regulate the expression of diacylglycerol acyltransferase through glutathionylation/deglutathionylation,which led to increase of the triacylglycerol(TAG)*** analysis showed that TAG could help maintain lipid homeostasis by adjusting its saturation/unsaturation *** study for the first time indicated that glutathione could activate TAG synthesis in microalga ***,leading to TAG accumulation and glutathione accumulation under Cd ***,the accumulation of TAG and glutathione can confer resistance to high Cd *** study provided insights into a new operation mode of TAG accumulation under heavy metal stress.

关键词： Cd stress Microalgae Glutathionylation Transcription factors Triacylglycerol

Economic Growth, Energy Use, and Greenhouse Gases Emission in Macao SAR, China

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Chinese Journal of Urban and Environmental Studies 2022年第1期10卷 23-43页

作者： Wai Ming TO King Hang lam School of Business Macao Polytechnic Institute Department of Electrical and Electronic Engineering The University of Hong Kong

A city’s economic structure and energy mix would change when the city is developed to accommodate more residents, visitors, and activities. This paper reviews Macao’s economic growth, energy use, and greenhouse gases(GHG) emission from 1985 to 2020. Specifically, Macao’s gross domestic product(GDP), energy use, and GHG emission have surged after the gaming industry was liberalized in *** official data show that Macao’s GDP was MOP 11 billion in 1985, increased by four-fold to MOP54 billion in 2000, and then surged rapidly to MOP 445 billion in 2019. Additionally, Macao’s total energy use increased from 8,840 TJ in 1985 to 48,330 TJ in 2019 while Macao’s GHG emission increased from 0.70 Mt of CO2-equivalent in 1985 to 6.13 Mt of CO2-equivalent in 2019. Macao’s GHG emission from all local sources per capita and GDP per capita exhibit an inverted U-shaped relationship, showing an environmental Kuznets curve. Due to the negative impact of COVID-19pandemic, Macao’s GDP dropped by 56% to MOP 194 billion while its total energy use and GHG emission dropped by 33% and 17% to 32,198 TJ and 5.06 Mt of CO2-equivalent, respectively, in 2020.

关键词： Economic growth energy use greenhouse gases environmental Kuznets curve COVID-19

THREE NOVEL FOXL2 GENE MUTATIONS IN CHINESE PATIENTS WITH BLEPHAROPHIMOSIS-PTOSIS-EPICANTHUS INVERSUS SYNDROME

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Chinese Medical Journal 2006年第1期119卷 49-52页

作者： OR SIU-FONG JUNE TONG MING-FOR TONY LO FAI-MAN IVAN lam TAK-SUM stephen CLINICAL GENETIC SERVICE DEPARTMENT OF HEALTH HONG KONG SAR CHINA

Blepharophimosis-ptosis-epicanthus inversus Psyndrome （BPES, OMIM # 110100） is a rare autosomal dominant disorder affecting the eyelid and ovarian development. When co-occurred together, it is type Ⅰ and when only the eyelid abnormalities are present, it is type Ⅱ. Both types had been mapped to the same locus 3q23 on the basis of cytogenetic rearrangements 1-3 and linkage analyses. 4-6 Subsequently,

关键词： blepharophimosis-ptosis-epicanthus inversussyndrome FOXL2 gene mutation multiplex ligation-dependent probe amplification

Successful Vaginal Delivery after Implantable Cardiac Defibrillator Placement for Management of Ventricular Tachycardia

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Congenital Heart Disease 2021年第2期16卷 137-139页

作者： Sara Moufarrij Manisha Gandhi Wilson lam Angeline Opina Department of Obstetrics and Gynecology Baylor College of MedicineHoustonUSA Department of Pediatric Cardiology Baylor College of MedicineHoustonUSA

A 23-year-old female with Tetralogy of Fallot who is 30w6d pregnant presented with palpitations and syncope from an outside *** was found to have ventricular *** placement of a transvenous implantable cardiac defibril... 详细信息

关键词： Ventricular tachycardia pregnancy intracardiac defibrillatory

Analysis and behaviour of FRP-confined short concrete columns subjected to eccentric loading

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第1期9卷 38-49页

作者： Xing-fei YUAN Shao-hua XIA L. lam S.T. SMITH Department of Civil Engineering Zhejiang University Hangzhou 310027 China School of Civil and Environmental Engineering The University of Adelaide Adelaide SA 5005 Australia Department of Civil and Structural Engineering The Hong Kong Polytechnic University Hong Kong China Department of Civil Engineering Hong Kong University Hong Kong China

Fibre-reinforced polymer (FRP) composites were widely utilized in civil engineering structures as the retrofit of reinforced concrete (RC) columns. To design FRP jackets safely and economically, the behaviour of such columns should be predicted first. This paper is concerned with the analysis and behaviour of FRP-confined RC circular and rectangular short col- umns subjected to eccentric loading. A simple design-oriented stress-strain model for FRP-confined concrete in a section analysis was first proposed. The accuracy was then proved by two test data. Following that, a parametric study including amount of FRP confinement, FRP strain capacity, unconfined concrete strength and shape of column section is provided. Some conclusions were obtained at the end of the paper. The work here will provide a comprehensive understanding of the behaviour of FRP-confined concrete columns. The simplicity of the model also enables a simple equivalent stress block to be developed for direct use in practical design.

关键词： Column FRP confinement Stress-strain model Section analysis Strength Ductility

LARGE-EDDY SIMULATION OF FLOW AROUND CYLINDER ARRAYS AT A SUBCRITICAL REYNOLDS NUMBER

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Journal of Hydrodynamics 2008年第4期20卷 403-413页

作者： ZOU Lin LIN Yu-feng lam Kit School of Mechanical and Electronic Engineering Wuhan University of Technology Wuhan 430070 China Department of Mechanical Engineering The Hong Kong Polytechnic University Hong Kong China

The complex three-dimensional turbulent flows around a cylinder array with four cylinders in an in-line square configuration at a subcritical Reynolds number of 1.5 × 10^4 with the spacing ratio at L/D = 1.5 and 3.5 were investigated using the Large Eddy Simulation （LES）. The full field vorticity and velocity distributions as well as turbulent quantities were calculated in detail and the near wake structures were presented. The results show that the bi-stable flow nature was observed at L/D = 1.5 and distinct vortex shedding of the upstream cylinders occurred at L/D = 3.5 at Re = 1.5 × 10^4. The techniques of Laser Doppler Anemometry （LDA） and Digital Particle Image Velocimetry （DPIV） are also employed to validate the present LES method. The results show that the numerical predictions are in excellent agreement with the experimental measurements. Therefore, the full field instantaneous and mean quantities of the flow field, velocity field and vorticity field can be extracted from the LES results for further study of the complex flow characteristics.

关键词： four-cylinders array turbulent flow Large Eddy Simulation (LES) Laser Doppler Anemometry (LDA) Digital Particle Image Velocimetry (DPIV)