检索结果-南通市图书馆

Virologica Sinica 2015年第3期30卷 214-217页

作者： Harrison P Nguyen Hung Q Doan Peter Rady stephen k tyring Department of Dermatology Baylor College of Medicine Department of Dermatology University of Texas Houston Health Science Center Center for Clinical Studies

Dear Editor,Derived from green tea leaves,sinecatechins(Veregen)ointment,15%is a topical therapy that is FDA-approved to treat human papillomavirus(HPV)-induced external genital and perianal warts(EGW)in immunocompetent patients aged 18 years and *** two phase 3 trials enrolling over 1,000 participants with EGW,a 16-week treatment regimen with sinecatechins ointment resulted in higher rates of complete clearance of all warts—both

关键词： genital papillomavirus clearance older regimen approved signaling transcriptase salient biopsy

Valacyclovir for the Management of Herpes Viral Infections

在线全文

学校读者我要写书评

暂无评论

Valacyclovir for the Management of Herpes Viral Infections

依那西普对银屑病患者疲劳和抑郁症状的临床疗效:一项双盲、随机、安慰剂对照、III期试验

2009全国中西医结合皮肤性病学术会议

作者： A.Chakrabarty N.J.Anderson R.Beutner S.k.tyring Solano Research DavisCAUSA Department of Dermatology Loma Linda University School of MedicineLoma LindaCAUSA Department of Dermatology San Francisco Solano ResearchVallejoCAUSA University of Texas Health Sciences CenterHoustonTXUSA

The Herpesviridae family(Types 1-8)continues to inflict considerable morbidity and social stigma upon *** infected with the herpes viruses,especially Types 1-3,they establish permanent residencewithin our nervous system and reactivate during periods of stress,trauma,and/or other precipitating *** date,there is no cure for herpes viral infections but antivirals can attenuate *** and duration of episodic outbreaks. Prophylactic therapy can suppress *** first antiviral with selective activity against virus-infected cells is considered to be *** article will highlight the clinical indications of the current generation,valacyclovir,which is a prodrug of acyclovir. We consider valacyclovir as a second-generation antiviral,having taken into account the initial selectivity and safety profile of its progenitor,acyclovir.

关键词： herpes virus antiviral herpes simplex varicella-zoster

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（皮肤病学分册） 2006年第3期2卷 5-6页

作者： tyring S. Gottlieb A. Papp k. R. krishnan 王琼(译) 不详 Department of Psychiatry and Behavioral Sciences Box 3950 Duke University Medical Center South Durham NC 27710 United States

Background: Psoriasis has substantial psychological and emotional effects. We assessed the effect of etanercept, an effective treatment for the clinical symptoms of psoriasis, on fatigue and symptoms of depression associated with the condition. Methods: 618 patients with moderate to severe psoriasis received double-blind treatment with placebo or 50 mg twice-weekly etanercept. The primary efficacy endpoint was a 75% or greater improvement from baseline in psoriasis area and severity index score (PASI 75) at week 12. Secondary and other endpoints included the functional assessment of chronic illness therapy fatigue (FACIT-F) scale, the Hamilton rating scale for depression (Ham-D), the Beck depression inventory (BDI), and adverse events. Efficacy analyses were based on the allocated treatment. Analyses and summaries of safety data were based on the actual treatment received. This study is registered with *** with the identifier NCT00111449. Findings: 47% (147 of 311) of patients achieved PASI 75 at week 12, compared with 5% (15 of 306) of those receiving placebo (pk 12 compared with the placebo group; patients treated with etanercept also had significant and clinically meaningful improvements in fatigue (mean FACIT-F improvement 5.0 vs 1.9; pkin clearance or joint pain. Interpretation: Etanercept treatment might relieve fatigue and symptoms of depression associated with this chronic disease.

关键词：银屑病患者双盲治疗安慰剂对照临床疗效抑郁症状依那西普疲劳 Ⅲ期试验 Hamilton抑郁量表严重度指数

在线全文

学校读者我要写书评

暂无评论

前列腺癌的胸壁皮肤转移

世界核心医学期刊文摘（皮肤病学分册） 2006年第11期2卷 61-61页

作者： tyring S.k. 朱国兴 2060 Space Park Drive Houston TX 77058 United StatesDr.

Prostate cancer is the most common malignancy in men in the United States. However, skin metastasis from prostate carcinoma is extremely uncommon. Here, we present a 75-year-old Caucasian man with a history of metastatic prostate cancer developing multiple subcutaneous, erythematous nodules over the left anterior chest over a 3-month period. A fine needle aspiration of a subcutaneous nodule showed neoplastic cells consistent with metastatic prostate cancer. This case represents only the fourth reported case of cutaneous metastasis from prostate cancer to the chest wall and the ninth case outside the inguinal area.

关键词：胸壁皮肤皮下结节腹股沟区

委内瑞拉妇女中HLA-DQB1与宫颈癌的相关性

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（妇产科学分册） 2005年第6期1卷 45-45页

作者： Sierra-Torres C.H. Robazetti S.C. S.k. tyring 张家墅程金湘 Dept. of Microbiology and Immunology The Univ. of Texas Medical Branch Galveston TX 77555 United States

Cervical cancer represents a major health problem in Venezuela as well as in other Latin American countries. High- risk human papillomavirus (HR- HPV) infection is known as the major risk factor of cervical cancer. However, whether or not a HR- HPV- infected woman progresses to cervical cancer may depend on the immune system effectors induced by viral antigens presented by her specific human leukocyte antigens (HLA) alleles. The role of the HLA system in presenting peptides to antigenspecific T- cells may be critical for genetic susceptibility and genetic resistance to cervical carcinoma. We aimed to investigate the relationship between HLA- DQB1, HPV infection, and cervical cancer in Venezuelan women. Blood samples and cervical swabs were obtained from 36 patients and 79 healthy controls; additional cervical biopsies were obtained from all the patients. HPV DNA was detected by PCR and HLA- DQB1 genotyping was performed using a PCR- SSP protocol. A positive association with cervical cancer was observed for HLA- DQB1* 0201- 0202 and* 0402 alleles, however after Bonferroni correction only HLA- DQB1* 0402 remained statistically significant (P value = 0.004, RR = 5.067). This is the first report of HLA- DQB1 alleles associated with cervical carcinoma in Venezuelan women. Larger studies are needed to assess whether these HLA- DQB1* 0201- 0202 and* 0402 alleles have a direct effect on disease susceptibility.

关键词： HLA-DQB1 妇女宫颈癌人乳头瘤病毒癌易感性抗原特异性细胞反应遗传易感性免疫应答反应基因分型人白细胞抗原